• 약학회지
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• 제27권4호
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• pp.263-270
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• 1983

Effective BuOH fraction was extracted from Puerariae radix (Pueraria thunbergiana), and several pharmacological activities were examined. From several pharmacological examinations, it was found that BuOH fraction has an antipyretic activity against typhoid vaccine pyrexia in rabbit, a papaverine-like antispasmodic activity on isolated ileum and jejunum of rat, an analgesic effects on mice treated by 0.7% HAc, and an anti-inflammatory activity of carrageenin edema in rat. It was found that BuOH fraction has detoxication effects on acute and subacute toxic rat induced by alcohol in consequence of biochemical tests of serum. Therefore it was considered that BuOH fraction has preventive and therapeutic effects in alcohol intoxication.

• 약학회지
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• 제45권5호
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• pp.500-505
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• 2001

Puerariae Radix is one of the medicinal plants used in oriental medicine for hangover, It has been claimed for several pharmacological effects including anti-alcohol abuse, antidipsotropic activity and anti-alcohol intoxication. In connection with Puerariae Radix effects, an activity-guided purification of active substance on alcohol dehydrogenase (hnH) was carried-out. The most active compound was isolated as puerarin (C$_{21}$H$_{20}$ O$_{9}$ ), molecular weight 416. Puerarin inhibited ADH noncompetitively against ethanol or NAD$^{+}$./.

• Natural Product Sciences
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• 제21권1호
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• pp.54-58
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• 2015

The protective effect of EtOAc fraction of Limonium tetragonum extract (EALT) against alcohol-induced hepatotoxicity was assessed following acute ethanol intoxication in Spraque-Dawley rats. EALT (200 mg/kg p.o.) was administrated once before alcohol intake (8 g/kg, p.o.). Blood ethanol concentration, and the activities of alcohol metabolic enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver were measured. Also, the formation of malondialdehyde (MDA) and the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSH-px), catalase were determined after acute alcohol exposure. Pretreatment of rats received ethanol with EALT significantly decreased blood ethanol concentration and elevated the activities of ADH and ALDH in liver. The increased MDA level was decreased, and the reduced activities of SOD, GSH-px and catalase were markedly preserved by the treatment with EALT. This study suggests that EALT prevent hepatic injury induced by acute alcohol which is likely related to its modulation on the alcohol metabolism and antioxidant enzymes activities.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1984년도 학술대회지
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• pp.63-74
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• 1984

한국산 인삼 (Panax ginseng C. A. Meyer) 뿌리에서 추출한 사포닌 분획이 쥐의 간에 미치는 에탄올 독성을 예방하는 효력이 있음을 생화학적 및 현미경적으로 관찰하였다. 본 연구실의 연구 결과에 의하면 적당량(반응액에서의 농도 : $10^{-5}\%$내외)의 인삼 사포닌은 여러가지 효소를 비 특이적으로 활성화하며 1mg의 사포닌 분획을 쥐에게 경구 투여하면 2시간후의 간에서의 인삼 사포닌 분획의 농도가 약 $10^{-5}\%$ 수준이고 간에서의 사포닌 분획의 반감기는 약 5시간으로 추정되었다. 본 연구에서도 인삼 사포닌 분획이 에탄올 대사에 관여하는 alcohol dehydrogenase, aldehyde dehydrogenase 그리고 microsomal ethanol oxilizing system을 시험관 내에서나 생체에서 다같이 촉진한다는 것을 알게 되었고 인삼 사포닌 분획이 에탄올 산화 과정에서 생성되는 유독한 acetadizing를 체내에서 신속히 제거하고 과량의 수소를 생합성에 효과적으로 이용함으로서 에탄올 독성으로부터 간을 보호하는 것으로 생각되었다. 전자현미경적 관찰도 물대신 $12{\%}$ ethanol만을 6일간 투여한 쥐의 간세포가 크게 손상되었는데 비하여 인삼 사포닌을 $12{\%}$ethanol과 함께 같은 기간 투여한 쥐의 간세포는 손상되지 않았음을 나타내고 있으며, 인삼 사포닌 분획이 에탄올 특성에 예방적 효력이 있음을 확인할 수 있었다.

• 한국식품영양과학회지
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• 제25권1호
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• pp.46-52
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• 1996

The present study was undertaken to investigate the effect of the water extract of the puffer fish Fugu xanthopterus(FXH) on the alcohol induced hyperuricemia. The normal group and the FXH treated group showed no sigbificant changes in the levels of blood uric acid but, the blood uric acid significantly decreased in the FXh treated rats with 100mg/kg for two weeks compared to the ethanol treated group. There were no significant changes in the activities of uricase, adenosine deaminase, guanine deaminase, and purine uncleoside phosphorylase, among all the test group. But the activitis of liver xanthine oxidase were recovered to the normal level in ethanol +FXH treated group comparing to the ethanol treated group. Furthermore, ethanol+FXH treated rats showed the similar pattern in the levels of blood uric acid and urinary allantoin with normal group. These results indicate that the decreased blood uric acid by the FXH treatment of the alcohol induced hyperuricemia rats may result from decreased activity of hepatic xanthine oxidase.

• 대한임상독성학회지
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• 제15권2호
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• pp.101-106
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• 2017

Purpose: This study examined the patterns of drugs, poisons, and chemicals detected in autopsy samples performed in the Seoul Institute and other regional forensic offices of the National Forensic Service (NFS) between 2014 and 2016. Methods: The investigation carried out using the laboratory information management system. Forensic toxicological identification and quantitation were performed in autopsy samples, including heart blood, peripheral blood, liver, kidney, vitreous humor and etc. Gas chromatography/mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were used to analyze the drugs and poisons. Results: Forensic autopsies were performed on 9,674 cases in this period. Based on the autopsy reports, 699 cases (7.2%) were considered as unnatural deaths caused by fatal intoxication. The number of male deaths was higher than that of female deaths, with the age of 50-59 being the most common age group. Conclusion: Drugs comprised the largest number of deaths due to poison, followed by alcohol, agrochemicals, drug with alcohol, carbon monoxide, and cyanide, in that order. Zolpidem was the most frequently used drug in all drug-related intoxication cases.

• 한국식품영양과학회지
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• 제30권5호
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• pp.954-958
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• 2001

감은 종기, 염증질환, 부스럼 화상을 치료하고 고혈압을 예방하고 동맥경화에 효과가 있고 숙취해소에 효능이 있다고 알려져있다. 감과육에 알콜대사에 관여하는 acetaldehyde dehydrogenase(ALDH)의 활성을 촉진하는 물질이 존재하므로ALDH의 활성을 촉진하는 물질을 감의 계절별, 품종별 측정을 했고 또 감을 이용한 가공식품에 농도를 측정하였다. ALDH의 활성을 촉진하는 물질은 부유의 경우 11월에 수확한 과일에서 가장 높고 품종별로는 부유가 가장 높았고 갑주백목은 부유와 유사하였고 청도반시, 서촌조생의 순이었다. 가공식품은 감건조품, 곶감, 감즙은 대체로 ALDH의 활성을 촉진하는 물질의 활성이 높게 유지되나 감음료, 감식초와 같은 음료는 ALDH의 활성을 촉진하는 물질의 활성이 낮았다. 감 자체뿐만 아니라 감가공식품에서도 ALDH의 활성을 촉진하는 물질의 활성이 어느 정도 유지되므로 이를 이용한 숙취해소작용이 기대된다.

• 한국사회복지학
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• 제63권1호
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• pp.187-215
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• 2011

본 연구는 긴장감소가설과 독성가설을 토대로 우울수준이 음주행위에 미치는 영향과 음주행위가 우울수준에 미치는 영향의 경로를 동시에 고려하여 우울수준과 음주행위의 종단적상호관계를 파악하고, 심리사회행동적 요인들(흡연량,자아존중감,가족관계만족,사회적친분관계만족)이 우울수준과 음주행위에 미치는 영향은 어떠한지를 살펴보았다. 본 연구는 한국복지패널 1,2,3차년도 자료를 활용하여, 변수들간의 종단적인 변화 관계를 추정하는데 적합한 잠재성장모형을 이용하여 분석하였다. 분석결과 음주행위 초기값이 우울수준 변화율에 미치는 영향과 우울수준 초기값이 음주행위 변화율에 미치는 영향 모두 정적으로 유의한 것으로 나타났으나, 음주행위 초기값이 우울수준 변화율에 미치는 경로의 영향력이 더 크게 나타났다. 심리사회행동적 요인들 중에서 자아존중감과 가족관계만족수준은 우울수준의 초기값과 변화율에 가장 큰 영향을 미치는 변수로 나타난 반면, 흡연량과 사회적친분관계만족은 음주행위 초기값과 변화율에 가장 큰 영향을 미치는 변수로 나타났다. 본 연구는 음주행위와 우울수준 간의 복합적 관계 기제를 밝히었다는데 그 의의가 있으며, 분석결과를 통해 연구의 정책 및 실천적 함의를 제시하였다.

• 대한의생명과학회지
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• 제10권3호
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• pp.299-303
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• 2004

The number of acute drug intoxication who visiting to emergency department which is located near urban and rural area concomitantly is inclined to increase slightly, The purpose of this study was the investigation of methods and strategies of management of acute drug intoxication in emergency department Clinical trials were done on 92 cases of acute drug intoxication visiting to Emergency Department of Chungnam National University Hospital during 4 months from April to July 2003. 1. The total number of acute drug intoxication during this period was 92 patients, which presented 0.95％ of all the emergency department visiting patients during the study. The intentional ingestions were observed in 84 cases (91.3％). 2. The maximal point of age distribution was 4th decade. The number of that was 21 cases (22.8％). 3. The number of patients who had ingested benzodiazepines and doxylamine succinates was 26 cases (28.2％), organophosphorus was 20 (21.7％), paraquat was 10 (10.8％), others were 36 (39.3％). 4. Five kinds of po1ydrug ingestion was observed in 3 cases, four kinds was observed in 3, three kinds was observed in 5 and co-ingestion of alcohol was observed in 28 cases (30.4％). 5. The mortality was occurred in 4 cases, 2 of them were caused by paraquat, 1 of them was caused by organophosphorus (OP), 1 of them was caused by acetic acid. 6. The gastric larvage as a mean of treatment modality was done in 57 cases (61.9％). The use of activated charcoal was done in 8 (8.69％). The maintenance of tracheal intubation was done in 6 (6.52％). 7. The mean observational period in emergency department was 8 hours 42 minutes in benzodiazepine and doxylamine succinate group, 21 hours 46 minutes in OP, 20 hours 39 minutes in other germicidal except OP, 23 hours 9 minutes in paraquat group. Without a drug information and intoxication center in Korea, We should minimize the exhaustion of medical resources by establishment of determinant criteria which can be seen in relatively less-complicated cases of acute drug intoxication. Thus, we should consider the introduction of simple toxicology treatment protocol and toxicologic observation unit in emergency department as possible means to reduce economical and social burdens.

• 동의생리병리학회지
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• 제16권5호
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• pp.1055-1059
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• 2002

Liuweidihuang-tang has been traditionally used for the treatment of delayed mental and physical development in children, complications of diabetes. and glomerulonephritis. In the present study, the effect of Liuweidihuang-tang on cell proliferation in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats was investigated via 5-bromo-2' -deoxyuridine (BrdU) immunohistochemistry. Alcohol administration was shown to decrease the number of BrdU-positive cells in the dentate gyrus, while Liuweidihuang-tang treatment increased new cell formation in the dentate gyrus under normal conditions and alcohol intoxication. It was thus demonstrated that aqueous extract of Liuweidihuang-tang exerts a protective effect against alcohol-induced decrease in new cell formation.