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The Extract of Limonium tetragonum Protected Liver against Acute Alcohol Toxicity by Enhancing Ethanol Metabolism and Antioxidant Enzyme Activities  

Kim, Na-Hyun (Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology)
Sung, Sang Hyun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
Heo, Jeong-Doo (Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology)
Jeong, Eun Ju (Department of Agronomy & Medicinal Plant Resources, College of Life Sciences and Natural Resources, Gyeongnam National University of Science and Technology)
Publication Information
Natural Product Sciences / v.21, no.1, 2015 , pp. 54-58 More about this Journal
Abstract
The protective effect of EtOAc fraction of Limonium tetragonum extract (EALT) against alcohol-induced hepatotoxicity was assessed following acute ethanol intoxication in Spraque-Dawley rats. EALT (200 mg/kg p.o.) was administrated once before alcohol intake (8 g/kg, p.o.). Blood ethanol concentration, and the activities of alcohol metabolic enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver were measured. Also, the formation of malondialdehyde (MDA) and the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSH-px), catalase were determined after acute alcohol exposure. Pretreatment of rats received ethanol with EALT significantly decreased blood ethanol concentration and elevated the activities of ADH and ALDH in liver. The increased MDA level was decreased, and the reduced activities of SOD, GSH-px and catalase were markedly preserved by the treatment with EALT. This study suggests that EALT prevent hepatic injury induced by acute alcohol which is likely related to its modulation on the alcohol metabolism and antioxidant enzymes activities.
Keywords
Limonium tetragonum; halophyte; Alcohol; Alcohol dehydrogenase; Aldehyde dehydrogenase; Antioxidant;
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1 McCord, J. M.; Fridovich, I. J. Biol. Chem. 1969, 244, 6056-6063.
2 An, S. W., Kim, Y. G., Kim, M. H., Lee, B. I., Lee, S. H., Kwon, I. H., Hwang, B., Lee, H. Y. Korean J. Med. Crop. Sci. 1999, 7, 263-268.
3 Hyun, T. K.; Eom, S. H.; Yu, C. Y.; Roitsch, T. Planta Med. 2010, 76, 943-949.   DOI   ScienceOn
4 Buege, J. A.; Aust, S. D. Methods Enzymol. 1978, 52, 302-310.   DOI
5 Flohe, L.; Gunzler, W. A. Methods Enzymol. 1984, 105, 114-121.   DOI
6 Smith, P. K.; Krohn, R. I.; Hermanson, G. T.; Mallia, A. K.; Gartner, F. H.; Provenzano, M. D.; Fujimoto, E. K.; Goeke, N. M.; Olson, B. J.; Klenk, D. C. Anal. Biochem. 1985, 150, 76-85.   DOI   ScienceOn
7 Tietz, F. Anal. Biochem. 1969, 27, 502-522.   DOI   ScienceOn
8 Seth, D.; Haber, P. S.; Syn, W. K.; Diehl, A. M.; Day, C. P. J. Gastroenterol. Hepatol. 2011, 26, 1089-1105.   DOI   ScienceOn
9 Zakhari, S. Alcohol Res. Health. 2006, 29, 245-254.
10 Thomasson, H. R.; Beard, J. D.; Li, T. K. Alcohol Clin. Exp. Res. 1995, 19, 1494-1499.   DOI   ScienceOn
11 Koop, D. R. Alcohol Res Health. 2006, 29, 274-280.
12 Preiss, D.; Sattar, N. Clin. Sci. 2008, 115, 141-150.   DOI   ScienceOn
13 Augustyniak, A.; Michalak, K.; Skrzydlewska, E. Postepy. Hig. Med. Dosw. 2005, 59, 464-471.
14 Sid, B.; Verrax, J.; Calderon, P. B. Free Radic. Res. 2013, 47, 894-904.   DOI   ScienceOn
15 Tinoco, M. T.; Ramos, P.; Candeias, M. F. Fitoterapia 2009, 80, 130-133.   DOI   ScienceOn
16 Ksouri, R.; Megdiche, W.; Debez, A.; Falleh, H.; Grignon, C.; Abdelly, C. Plant Physiol. Biochem. 2007, 45, 244-249.   DOI   ScienceOn
17 Ksouri, R.; Megdiche, W.; Falleh, H.; Trabelsi, N.; Boulaaba, M.; Smaoui, A.; Abdelly, C. C. R. Biol. 2008, 331, 865-873.   DOI   ScienceOn
18 Tepe, B.; Sokmen, A. Bioresour. Technol. 2007, 98, 3076-3079.   DOI   ScienceOn
19 Kuo, Y. C.; Lin, L. C.; Tsai, W. J.; Chou, C. J.; Kung, S. H.; Ho, Y, H. Antimicrob. Agents Chemother. 2002, 46, 2854-2864.   DOI
20 Nostro, A.; Filocamo, A.; Giovannini, A.; Catania, S.; Costa, C.; Marino, A.; Bisignano, G. Nat. Prod. Res. 2012, 26, 2132-2136.
21 Kozhamkulova, Z. A.; Radwan, M. M.; Zhusupova, G. E.; Abilov, Z. Zh.; Rahadilova, S. N.; Ross, S. A. Nat. Prod. Commun. 2010, 5, 1061-1062.
22 Cha, J. Y.; Kim, H. S.; Kang, S. C.; Cho, Y. S. Food Sci. Biotechnol. 2009, 18, 1411-1416.
23 Senthilkumar, R.; Viswanathan, P.; Nalini, N.; Pol. J. Pharmacol. 2003, 55, 603-611.   DOI   ScienceOn
24 Murray, A. P.; Rodriguez, S.; Frontera, M. A.; Tomas, M. A.; Mulet, M. C. Z. Naturforsch. C. 2004, 59, 477-480.   DOI
25 Padhye, S.; Dandawate, P.; Yusufi, M.; Ahmad, A.; Sarkar, F. H. Med. Res. Rev. 2012, 32, 1131-1158.   DOI   ScienceOn
26 Yang, M. H.; Kim, N. H.; Heo, J. D.; Sung, S. H.; Jeong, E. J. Pharmacogn. Mag. 2014, 10, S563-568.   DOI
27 Diehl, A. M. 2002. Alcohol. 2002, 27, 7-11.   DOI   ScienceOn
28 Smirnova, G. V.; Vysochina, G. I.; Muzyka, N. G.; Samolova, Zlu.; Kukushkina, T. A.; Oktiabr'ski, O. N. Prikl. Biokhim. Mikrobiol. 2009, 45, 705-709.