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Effect of Liuweidihuang-tang on Alcohol-induced Decrease in New Cell Formation in Rat Dentate Gyrus  

Bahn Goon Ho (Department of Psychiatry, College of Medicine, Kyunghee University)
Yoon Doh Joon (Department of Psychiatry, College of Medicine, Kyunghee University)
Park Jin Kyung (Department of Psychiatry, College of Medicine, Kyunghee University)
Lee Taeck Hyun (Department of Physiology. College of Medicine, Kyunghee University)
Jang Mi Hyoon (Department of Physiology. College of Medicine, Kyunghee University)
Shin Min Chul (Department of Physiology. College of Medicine, Kyunghee University)
Kim Chang Ju (Department of Physiology. College of Medicine, Kyunghee University)
Paik Eun Kyung (Doorhii Oriental Medical Clinic)
Park Jae Hyung (Doorhii Oriental Medical Clinic)
Cho Son Hae (Oriental Medicine Research Institute, Kyungwon University)
Lee Choong Yool (Oriental Medicine Research Institute, Kyungwon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.5, 2002 , pp. 1055-1059 More about this Journal
Abstract
Liuweidihuang-tang has been traditionally used for the treatment of delayed mental and physical development in children, complications of diabetes. and glomerulonephritis. In the present study, the effect of Liuweidihuang-tang on cell proliferation in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats was investigated via 5-bromo-2' -deoxyuridine (BrdU) immunohistochemistry. Alcohol administration was shown to decrease the number of BrdU-positive cells in the dentate gyrus, while Liuweidihuang-tang treatment increased new cell formation in the dentate gyrus under normal conditions and alcohol intoxication. It was thus demonstrated that aqueous extract of Liuweidihuang-tang exerts a protective effect against alcohol-induced decrease in new cell formation.
Keywords
Liuweidihuang-tang; alcohol; 5-bromo-2'-deoxyuridine; dentate gyrus; immunohistochenmistry; cell proliferation;
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