• 한국임상약학회지
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• 제11권2호
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• pp.49-56
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• 2001

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is a naturally existing molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioefuivalence of two ALC tablets, $Nicetile^{TM} (Dong-A Pharmaceutical Co.) and $L-Cartin^{TM}$ (Kuhn Il Pharmaceutical Co.), according to the guidelines of Korea Food and Drug Administration (KFDA). The ALC release from the two ALC tablets in vitro was tested using KP VII Apparatus II method in various dissolution media (pH 1.2, 6.0 and 6.8). Twenty six normal male volunteers, $24.46\pm3.67$ years in age and $64.45\pm5.54$ kg in body weight, were divided into two groups and a randomized $2\times2$cross-over study was employed. After one tablet containing 500 mg of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. The dissolution profiles of the two ALC tablets were similar in all the dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets were $0.35\%,\;0.93\%\;and\;2.34\%$ respectively, when calculated against the $Nicetile^{TM} tablet. The powers $(1-\beta)\;for\;AUC_t$ , and Cmax were $98.72\%\;and\;85.48\%$, respectively. Minimum detectable differences $(\Delta)\;at\;\alpha=0.05\;and\;1-\beta=0.8$ were less than $20\%,\;(e.g.,\;13.21\%\;and\;18.42\%\;for\;AUC_t,\;and\;C_{max}$ respectively). The $90\%$ confidence intervals were within $\pm20\%\;(e.g.,\;-7.38\sim8.09\;and\;-9.86\sim11.72\;for\;AUC_t,\;and\;C_{max}$, respectively). These two parameters met the criteria of KFDA for bioequivalence, indicating that $L-Cartin^{TM}$ tablet is bioequivalent to $Nicetile^{TM} tablet.

• 한국디지털건축인테리어학회논문집
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• 제12권1호
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• pp.81-88
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• 2012

According to the survey results of the Ministry of Land, Transport and Maritime Affairs in the end of December 2011, the residential buildings was reported as 67.3% of 4,529,464 buildings. Reflected in the national energy policy, the residential building is expected that greater energy savings. To have realized the Passive House Project used the Autoclaved Lightweight Concrete(ALC) material on exterior wall, we take advantage of a very large energy savings. Therefore, this study investigate the patent documents of three major companies, SUMITOMO, CLION, ASAHI KASEI, in Japan. and analyze technical flow and benchmarking patent. As a result, the Sliding method or the Rocking method of ALC panels how to install is to be superior to high-performance drift and safety by a earthquake. And the embedded anchor in panel needs to improve the shape and the strength of bearing. Thus installation technology of the ALC exterior wall investigated in japanese patent documents is expected to the fastening units and anchors.

• 콘크리트학회지
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• 제9권2호
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• pp.137-144
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• 1997

발수제의 유무와 알루미늄분말의 분말도 및 첨가량을 조절하여 비중을 0.4에서 0.7로 변화시켜 비중과 ALC의 기초물성, 내동해성 및 내구성과의 관계를 조사하였다. 압축 및 인장강도는 비중이 0.4에서 0.7로 증가함에 따라 발수제의 첨가량에 관계없이 증가하였고 발수제의 첨가량이 증가하면 내동해성은 개선되었으며 흡수율은 감소하였다. 입경이 작은 AI분말을 이용항 제조한 ALC의 박리에 의한 체적감소율은 낮게 나타났으며 일면동결지속시험 및 기중동결수중융해시험에서도 내동해성이 우수한 것으로 나타났다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2003년도 가을 학술발표논문집 Vol.30 No.2 (1)
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• pp.892-894
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• 2003

IT 시스템 평가과정은 시스템의 보안기능과 이에 적용된 보증수단이 요구사항들을 만족하는지에 대한 신뢰도를 확인하는 것이며, 평가결과는 소비자가 IT 제품이나 시스템이 주어진 환경에 적용하기에 충분히 안전한지, 사용상 내재하는 보안위험이 허용가능한지를 결정하는데 도움이 될 수 있다. 평가를 통하여 평가보증등급(EAL： Evaluation Assurance Level) 3 이상으로 인증받기 위해서는 ALC_DVS. 1 컴포넌트의 요구사항을 만족하여야 하며, 이들 요구사항은 개발현장에 대한 실사를 요구하게 된다. 본 논문에서는 ALC_DVS. 1 컴포넌트에서 요구하는 현장 실사의 중요성을 파악하고, 국내에 적용가능한 ALC_DVS. 1 컴포넌트 패밀리를 제안하고 실사 준비에 필요한 절차를 도출하였다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.227.1-227.1
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• 2003

Acetyl-L-carnitine (ALC), an endogenous component of L-Carnitine, is the acetyl ester of carnitine that has been reported to be beneficial in depressive disorders and Alzheimer's disease.ALC is so hygroscopic that deliquescence took place when it absorbed moisture by 15%(w/w) in a week and then reached steady-state at 45%(w/w) in 40$^{\circ}C$, 75% RH storage condition. Therefore it is necessary to prevent ALC from absorbing atmospheric moisture. For this purpose, we chose hydroxypropylmethylcellulose phthalate (HPMCP) an enteric polymer, as a film former. (omitted)

• 한국세라믹학회지
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• 제31권2호
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• pp.194-200
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• 1994

Pitchstone(Volcanic ejecta) reacts with CaO in hot water and increases its sedimentary volume by forming Ca(OH)2 and calcium silicate hydrates. ALC was prepared from the various gelling and curing conditions using the ratio of pitchstone/CaO was 2(CaO/SiO2 mol ratio=0.81), and then the products, crystalline phases and physical properties of ALC with experimental conditions was investigated. The crystalline phase of tobermorite with laths and plate type and the porosity were increased, the thermal conductivity was decreased with increasing gelling temperature and time. But modulus of rupture has maximum value when gelling time was 2 hrs. Othwrwise the bulk density nearly unchanged with increasing curing temperature, but the modulus of rupture was increased.

• 환경위생공학
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• 제16권1호
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• pp.102-107
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• 2001

This research was carried out investigate the removed T-P, T-N and anion surfactants using Autoclaved Lightweight Concrete(ALC) in wastewater treatment system. Effects of pH, TDS on aqueous solution was measured. Specific area which measured by BET was $27.66m^2/g$. The phosphorous, nitrogen and anion surfactants removal efficiencies were examined by using artificial waste water(T-P : 66~73mg/L, T-N : 56~136mg/L and anion surfactants : 10~31mg/L). The results showed that the ALC was effective material as a adsorbent due to the structure and porosity. It was found that anion surfactants removed was 85~95%, phosphate removed was 92% and nitrogen removed was 90% in artificial wastewater. Agitation process was more effective than aeration process in that case of nitrogen removal system using ALC.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2019년도 춘계 학술논문 발표대회
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• pp.10-11
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• 2019

Interior stone walls are using commonly in non-bearing lightweight walls of apartments. The stones of interior wall were two types, one is a granite stone, another is a marble stone. Granite stone is attached by the epoxy adhesive and marble stone is attached by dedicated anchor and fastener. The impact resistance test was carried out interior stone walls in accordance with KS F 2613. The test methods included the impact resistance tests by each of soft impact body and hard impact body. The results of the test have proved that interior stone walls can withstand the soft impact bodies and hard impact bodies that are likely to happen in everyday life.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2015년도 춘계 학술논문 발표대회
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• pp.28-29
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• 2015

Although there are many applications with gypsum board because of its economical and construction advantages, four-layer construction technique, (hollow area between two-layer panel sets) is the general case to achieve the insulation, and resistance of horizontally applied force. Since this construction method has many problems such as complicate construction steps and increased cost, it is needed that the two-layer panel for improved construction and economical advantage for lightweight pane: thick panel with favorable performances. Therefore, in this research, based on the ALC panel with 10 to 30mm depth, feasibility of the paper reinforced panel as a lightweight wall material. As a result, favorable performance with increased flexural strength were achieved with paper reinforcement.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 추계 학술발표회 논문집
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• pp.749-752
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• 2006

Autoclaved lightweight concrete (ALC) have high water absorption, low compressive strength and popout the origin of the low surface strength in its properties. These properties make troubles under construction such as cracking and popout. Thus, this study is to improve the fundamental strength by control of $SO_3$ ratio's and Sand Sulrry grain size. From the test result, Improved ALC have a good fundamental properties. Compressive strength, and abrasion's ratio were improved depending on increasing $SO_3$ ratio's and Sand Sulrry grain size control.