• Biomolecules & Therapeutics
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• 제17권2호
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• pp.113-124
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• 2009

Aging is a multifaceted biological process that affects all organs and organ systems of the body. This review provides an up-to-date analysis of this highly exciting, rapidly changing field of science. The aging process is largely under genetic control but is highly responsive to diverse environmental influences. The genes that control aging are those that are involved with cell maintenance, cell damage and repair. The environmental factors that accelerate aging are those that influence either damage of cellular macromolecules, or interfere with their repair. Prominent among these are chronic inflammation, chronic infection, some metallic chemicals, ultraviolet light, and others that heighten oxidative stress. Other environment factors slow the aging process. Included among these agents are resveratrol and vitamin D. In addition, dietary restriction and exercise have been found to extend human lifespan. The various mechanisms whereby all these agents exert their influence on aging include epigenetic modification, chromatin maintenance, protection of telomeres, and anti-oxidant defense, among others. The complex process of aging remains under continued, intense investigation.

• Nuclear Engineering and Technology
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• 제53권4호
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• pp.1357-1368
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• 2021

This paper presents thermal aging effect on fracture toughness properties of GTAW (gas tungsten arc welding) and SMAW (shielded metal arc welding) of 316L stainless steels, and investigates the applicability of the existing three thermal aging models for CASS (cast stainless steels). Thermal aging was carried out at 350 ℃ for up to 15,000h and at 400 ℃ up to 8,000h. After aging, tensile and fracture toughness tests using 0.5T C(T) specimens were carried out at room temperature and at 288 ℃. Comparing with the predictions using three (ANL, French and H3T) thermal aging models for CASS show that the predictions can be very non-conservative at operating temperature, and thus that the existing thermal aging models for CASS cannot be applied to the welded stainless steels.

• Molecules and Cells
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• 제45권11호
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• pp.763-770
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• 2022

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.

• 한국보건간호학회지
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• 제29권1호
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• pp.29-39
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• 2015

Purpose: The purpose of this study was to investigate the aging anxiety, factors of successful aging, and preparation for aging in early and late middle-aged people. Methods: The study subjects were 140 middle-aged people aged from 40 to 59. Data were collected using a self-administered questionnaire from August 16 to September 30, 2013. The collected data were analyzed with descriptive statistics, t-test, ${\chi}^2$-test and Pearson correlation coefficient using IBM SPSS 21.0 program. Results: Between early and late middle age, there were statistically significant differences in the subcategories of aging anxiety: fear of loss (t=2.93, p=.004), fear of old people (t=-2.33, p=.021), physical appearance (t=2.32, p=.022), and psychological concerns (t=2.04, p=.043). A statistically significant difference was found between two groups in one subscale of preparation for aging: physical preparation (t=-2.02, p=.045). In early midlife, significant associations were observed between preparation for aging and both aging anxiety (r=.56, p<.001) and factors of successful aging (r=.54, p<.001). In late midlife, preparation for aging and factors of successful aging showed positive correlation (r=.50, p<.001) Conclusion: Results of this study indicate that programs for successful transition to old age in middle-aged people should consider their aging anxiety level and preparation for aging at their stage of life.

• 한국콘텐츠학회논문지
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• 제15권9호
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• pp.210-222
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• 2015

본 연구의 목적은 노인의 노화불안이 성공적 노화에 미치는 영향에서 사회적 지지의 매개효과를 검증하는 것이다. 연구결과, 첫째, 노인의 노화불안이 증가할수록 성공적 노화는 감소되는 것으로 나타났다. 둘째, 노인의 노화불안과 사회적 지지 관계에서 노화불안이 증가할수록 사회적 지지는 감소되는 것으로 나타났다. 셋째, 사회적 지지와 성공적 노화 관계에서 사회적 지지의 증가는 성공적 노화를 증가시키는 것으로 나타났다. 넷째, 노인의 노화불안과 성공적 노화의 관계에서 사회적 지지의 부분매개효과를 확인하였다. 이에 본 연구는 고령화 사회에서 노인의 노화불안 감소와 성공적 노화를 위한 방안과 후속연구를 위한 제언을 하였다.

• 한방안이비인후피부과학회지
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• 제17권1호
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• pp.16-33
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• 2004

In Oriental medicine, aging is just a natural process like change of seasons. Ancient Oriental people accepted it as a natural thing to be growing older and to die at last. The science of aging has advanced dramatically. In the last 2 decades, advances in genetics and molecular biology have led to extraordinary new understandings in how cells age, how apoptosis programs cells to die, and how neuroendocrinology plays a role in the lifespan of organisms. Today, the matter of primary concern about aging is a cellular and mitochondrial damage of human body induced by reactive oxygen species(ROS). The skin aging can be divided into two areas, intrinsic(chronologic)-aging and photo-aging. There are lots of photo damage about skin aging. The skin is increasingly exposed to ultraviolet(UV) irradiation in life. Therefore, the risk of photo-oxidative damage of the skin induced by reactive oxygen species(ROS) has increased substantially. Nowadays, many people believe that they can stop or at least delay the process of aging. There are lots of treatments that promise to slow the process of aging and the associated ailments. Many of these treatments, for example, exercise, Vit E, Vit C therapy, hormone therapy, restrict diet, are gradually being subjected to clinical trials. But in spite of all efforts, researches and investigations, there is no single method or treatment which is revealed to be truly effective for delaying progress of aging. Every methods insisted on effect for delaying aging process, has its dark side. All we can do is just keeping ourself healthy until the time of death.

• 한국축산식품학회지
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• 제39권4호
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• pp.655-667
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• 2019

The present study aimed at investigating the effects of dry- and wet-aging methods on flavor compounds and sensory properties of low fat Hanwoo beef muscles. All the beef samples were obtained from 2-grade carcasses of Hanwoo cows. The beef samples used in the dry- and wet-aging methods were prepared in the forms of quarter beef (bone-in) and cuts (boneless), respectively. The dry-aging was carried out at $2^{\circ}C-4^{\circ}C$ and humidity of 65%-85%, while the wet-aging was done at $1^{\circ}C$ for 0, 20, 40, and 60 d. At each aging time, three muscles: longissmus thoracis (LT), glutaeusmedus (GM) and semimembranosus (SM) were taken from the corresponding quarters and cuts, and used for the flavor compounds and sensory analyses. Results showed that both aging methods significantly increased the concentrations of flavor compounds and total amount of all classes of the flavor compounds as the aging time increased (p<0.05). In the dry-aging method, the GM and SM muscles presented significantly higher total amounts of pyrazines and sulfur-containing compounds compared to the LT muscle (p<0.05). Both the aging methods improved the eating quality attributes, indicating by increased scores of sensorial attributes with increased aging time for all the muscles studied (p<0.05). However, compared to the wet-aging, the dry-aging method resulted in significantly higher scores of tenderness and flavor for the GM and SM muscles after 40 to 60 d. Thus, postmortem aging, especially the dry-aging method could be used to improve eating quality attributes (tenderness and flavor) of low fat beef muscles such as GM and SM.

• 한국지반공학회논문집
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• 제20권6호
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• pp.137-150
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• 2004

모래의 aging 현상은 점성토에 비하여 무시할 정도로 매우 작아서 최근까지 연구되지 않았다. 그러나 퇴적이나 교란 후 시간경과에 따라 관입저항치의 증가가 관찰되면서 현장시험을 중심으로 모래의 aging 효과에 대하여 활발한 조사가 이루어졌고, 최근에는 현장시험뿐만 아니라 실내시험에서도 여러 연구자들에 의해 모래의 aging 효과가 규명 되어지고 있다. 본 연구에서는 모래의 비배수 정적전단거동에 대한 aging 효과를 살펴보기 위해 낙동강 모래를 이용하여 상대밀도 $(D_r)$, 압밀응력비$(K_c)$ 그리고 압밀시간을 달리하여 비배수 정적삼축압축시험을 실시하였다. 그 결과 응력-변형률의 탄성구간내 탄성계수가 압밀시간 경과에 따라 증가하는 것으로 나타났으며, 또한 상전이점 강도$(S_{PT})$와 한계응력비점 강도$(S_{CSR})$도 압밀시간 경과에 따라 증가하였다. 그러나 간극수압비$(u/{p_c}')$는 압밀시간에 비례하게 감소하는 등 모래의 정적전단에서 나타나는 aging 효과를 관찰할 수 있었다.

• Bulletin of the Korean Chemical Society
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• 제35권3호
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• pp.811-814
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• 2014

Bio-oil instability, or aging, is a significant problem for the long-term storage of fast pyrolysis oils. We investigated bio-oil aging at the molecular level using Fourier-transform ion cyclotron resonance mass spectrometry. Petroleomic analysis suggests that bio-oil aging is resulted from the oligomerization of phenolic lignin products whereas 'sugaric' cellulose/hemicellulose products have negligible effect.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2008년도 춘계학술대회 논문집
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• pp.173-174
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• 2008