• Title/Summary/Keyword: aging

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Distribution Dynamics and Proposed Determinants: Exploring Morphological, Clinical Laboratory, and Lifestyle Factors in the Coexistence of Age-Related Skeletal Muscle Mass Loss and Obesity among Young Men: A Nationwide Cross-Sectional Study

  • Jongseok Hwang
    • Journal of the Korean Society of Physical Medicine
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    • v.19 no.1
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    • pp.31-41
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    • 2024
  • PURPOSE: This study examined the distribution dynamics and proposed determinants, including morphological measurements, clinical laboratory tests, and lifestyle factors among young Korean men aged 20 to 29 years with the coexistence of age-related loss of skeletal muscle mass and obesity (CALSMO). METHODS: Six hundred and sixty-six participants were divided into two groups based on their skeletal muscle mass index, with 12 individuals categorized in the CALSMO group and the remaining 654 in the normal group. The proposed determinants variables consisted of three main components: morphological measurements, clinical laboratory tests, and lifestyle factors. The morphological measurement variables were height, weight, body mass index, waist circumference, and skeletal muscle mass index. The clinical laboratory tests were fasting glucose, triglyceride, total cholesterol levels, and systolic and diastolic blood pressure. The lifestyle factors considered were alcohol consumption and tobacco use. Complex sampling analysis was performed for the evaluation. RESULTS: The distribution dynamics were determined to be 1.81(1.02-3.18) %. Morphological factors, such as height, weight, body mass index, waist circumference, and skeletal muscle mass index, showed significant differences (p < .05). The clinical laboratory test variables, specifically the fasting glucose, triglyceride, and total cholesterol levels, also exhibited significant differences (p < .05). The lifestyle factor, alcohol consumption, also showed a significance (p < .05). CONCLUSION: This study provides insights into the distribution dynamics. The proposed determinants in young Korean individuals with CALSMO are height, weight, body mass index, waist circumference, skeletal muscle mass index, fasting glucose, triglyceride, total cholesterol levels, and alcohol consumption.

Genome-wide identification of histone lysine methyltransferases and their implications in the epigenetic regulation of eggshell formation-related genes in a trematode parasite Clonorchis sinensis

  • Min-Ji Park;Woon-Mok Sohn;Young-An Bae
    • Parasites, Hosts and Diseases
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    • v.62 no.1
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    • pp.98-116
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    • 2024
  • Epigenetic writers including DNA and histone lysine methyltransferases (DNMT and HKMT, respectively) play an initiative role in the differentiation and development of eukaryotic organisms through the spatiotemporal regulation of functional gene expressions. However, the epigenetic mechanisms have long been suspected in helminth parasites lacking the major DNA methyltransferases DNMT1 and DNMT3a/3b. Very little information on the evolutionary status of the epigenetic tools and their role in regulating chromosomal genes is currently available in the parasitic trematodes. We previously suggested the probable role of a DNMT2-like protein (CsDNMT2) as a genuine epigenetic writer in a trematode parasite Clonorchis sinensis. Here, we analyzed the phylogeny of HKMT subfamily members in the liver fluke and other platyhelminth species. The platyhelminth genomes examined conserved genes for the most of SET domain-containing HKMT and Disruptor of Telomeric Silencing 1 subfamilies, while some genes were expanded specifically in certain platyhelminth genomes. Related to the high gene dosages for HKMT activities covering differential but somewhat overlapping substrate specificities, variously methylated histones were recognized throughout the tissues/organs of C. sinensis adults. The temporal expressions of genes involved in eggshell formation were gradually decreased to their lowest levels proportionally to aging, whereas those of some epigenetic tool genes were re-boosted in the later adult stages of the parasite. Furthermore, these expression levels were significantly affected by treatment with DNMT and HKMT inhibitors. Our data strongly suggest that methylated histones are potent epigenetic markers that modulate the spatiotemporal expressions of C. sinensis genes, especially those involved in sexual reproduction.

A Development of Unbalanced Box Stacking System with High Stability using the Center of Gravity Measurement (무게중심 측정을 이용한 불평형 상자의 고안정 적재 시스템 개발)

  • Seong-Woo Bae;Dae-Gyu Han;Jae-Ho Ryu;Hyeon-hui Lee;Chae-Hun An
    • Journal of the Korean Society of Industry Convergence
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    • v.27 no.1
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    • pp.229-237
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    • 2024
  • The logistics industry is converging with digital technology and growing into various logistics automation systems. However, inspection and loading/unloading, which are mainly performed in logistics work, depend on human resources, and the workforce is shrinking due to the decline in the productive population due to the low birth rate and aging. Although much research is being conducted on the development of automated logistics systems to solve these problems, there is a lack of research and development on load stacking stability, which has the potential to cause significant accidents. In this study, loading boxes with various sizes and positions of the center of gravity were set up, and a method for stacking that with high stability is presented. The size of the loading box is measured using a depth camera. The loading box's weight and center of gravity are measured and estimated by a developed device with four loadcells. The measurement error is measured through various repeated experiments and is corrected using the least squares method. The robot arm performs load stacking by determining the target position so that the centers of gravity of the loading boxes with unbalanced masses with a random sequence are transported in alignment. All processes were automated, and the results were verified by experimentally confirming load stacking stability.

Study of Electronic Hardware Integrated Failure Rate: Considering Physics of Failure Rate and Radiation Failures Rate (물리 고장률과 방사선 고장률을 반영한 전자 하드웨어 통합 고장률 분석 연구)

  • Dong-min Lee;Chang-hyeon Kim;Kyung-min Park;Jong-whoa Na
    • Journal of Advanced Navigation Technology
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    • v.28 no.2
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    • pp.216-224
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    • 2024
  • This paper presents a method for analyzing the reliability of hardware electronic equipment, taking into account failures caused by radiation. Traditional reliability analysis primarily focuses on the wear out failure rate and often neglects the impact of radiation failure rates. We calculate the wear out failure rate through physics of failure analysis, while the radiation failure rate is semi-empirically estimated using the Verilog Fault Injection tool. Our approach aims to ensure reliability early in the development process, potentially reducing development time and costs by identifying circuit vulnerabilities in advance. As an illustrative example, we conducted a reliability analysis on the ISCAS85 circuit. Our results demonstrate the effectiveness of our method compared to traditional reliability analysis tools. This thorough analysis is crucial for ensuring the reliability of FPGAs in environments with high radiation exposure, such as in aviation and space applications.

A study on the use of reserve power in wartime by private guards (민간경비원 전시 예비전력 활용에 대한 연구)

  • JaeKeak Jung
    • Convergence Security Journal
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    • v.23 no.4
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    • pp.153-158
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    • 2023
  • Massacres of civilians are being committed in the Russia-Ukraine war, and the war is becoming a long-term war due to a lack of support for reserve combat forces. Considering the reality that South Korea is experiencing a rapid population decline and is rapidly entering an aging society, we are at a point where the nature of the war with North Korea must change. Among them, if private security guards are placed under the control of the police as regular security and crime prevention personnel and used as an alternative resource for reserve forces to ensure the safety of wartime areas and residents and prepare for long-term wars, it will help preserve combat power and maintain sustainability.Regarding private security, considering Japan's further development, we compared it with ours and looked into ways to utilize it as a reserve force for a divided country. In a future where low birth rates will lead to a decrease in military strength, if private security guards are used in local security vacuums during peacetime and participate in local defense during wartime, it could help improve the Korean military's reserve force.

Water demand forecasting at the DMA level considering sociodemographic and waterworks characteristics (사회인구통계 및 상수도시설 특성을 고려한 소블록 단위 물 수요예측 연구)

  • Saemmul Jin;Dooyong Choi;Kyoungpil Kim;Jayong Koo
    • Journal of Korean Society of Water and Wastewater
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    • v.37 no.6
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    • pp.363-373
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    • 2023
  • Numerous studies have established a correlation between sociodemographic characteristics and water usage, identifying population as a primary independent variable in mid- to long-term demand forecasting. Recent dramatic sociodemographic changes, including urban concentration-rural depopulation, low birth rates-aging population, and the rise in single-person households, are expected to impact water demand and supply patterns. This underscores the necessity for operational and managerial changes in existing water supply systems. While sociodemographic characteristics are regularly surveyed, the conducted surveys use aggregate units that do not align with the actual system. Consequently, many water demand forecasts have been conducted at the administrative district level without adequately considering the water supply system. This study presents an upward water demand forecasting model that accurately reflects real water facilities and consumers. The model comprises three key steps. Firstly, Statistics Korea's SGIS (Statistical Geological Information System) data was reorganized at the DMA level. Secondly, DMAs were classified using the SOM (Self-Organizing Map) algorithm to consider differences in water facilities and consumer characteristics. Lastly, water demand forecasting employed the PCR (Principal Component Regression) method to address multicollinearity and overfitting issues. The performance evaluation of this model was conducted for DMAs classified as rural areas due to the insufficient number of DMAs. The estimation results indicate that the correlation coefficients exceeded 0.9, and the MAPE remained within approximately 10% for the test dataset. This method is expected to be useful for reorganization plans, such as the expansion and contraction of existing facilities.

The Vicious Cycle of Regional Exodus: Examining the Economic Environment of Birthplace and the Out-migration of Young Individuals (지역이탈의 악순환: 출생지의 경제 환경과 청년 취업자의 지역이탈)

  • Wonchang Hur;Song Hyun Seo;Bogang Jun
    • Journal of the Korean Regional Science Association
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    • v.40 no.1
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    • pp.53-67
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    • 2024
  • Regional migration is a problem faced by all non-metropolitan areas in Korea, but the extent of migration varies depending on regional economic conditions. This study examines how the extent of youth migration varies depending on the economic conditions of their birthplaces. The results showed that youth migration was more severe in areas suffering from population decline and aging problems. The smaller the economy and the weaker the financial independence of the region, the more severe the youth migration. In particular, commercial, educational, and cultural facilities, except for medical facilities, were not able to curb youth migration. In addition, there was a significant wage gap between those employed in the metropolitan area and those employed in the regions, regardless of their origin. This suggests that non-metropolitan areas are caught in a vicious cycle of regional economic deterioration and youth migration.

Study on Applicability of Village Extinction Index Through Comparative Study with Regional Extinction Index (지방소멸지수와의 비교 연구를 통한 마을소멸지수의 적용 가능성 검토 연구)

  • Yun, Jeong-mi
    • Journal of Korean Society of Rural Planning
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    • v.30 no.1
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    • pp.1-13
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    • 2024
  • There is a serious risk of regional extinction due to low birth rate and aging in Korea. Accordingly, the regional extinction index is applied to diagnose the extinction status of cities, counties, and districts. However, when the regional extinction index was applied to rural villages, most villages were found to be at 'high risk of extinction'. There is no differentiation in the level of extinction of rural villages. Therefore, a village extinction index was developed to apply to rural villages. This study applies and compares the existing regional extinction index and the newly developed village extinction index to rural villages. The purpose is to propose an index that can better diagnose the extinction of rural villages. As a research method, the regional extinction index and village extinction index are applied to all villages in Haengjeong-ri villages in South Chungcheong Province. And the adequacy of the index suitable for rural villages is diagnosed. For this purpose, ➂ stage distribution for each two indices, ➂ demographic aspect diagnosis, and ➂ resident awareness survey were analyzed. When the village extinction index was used, the discrimination problems seen in the regional extinction index were overcome. As a result of the demographic analysis, the regional extinction index showed that villages with a population of 200 or more were at 'high risk of extinction', but the village extinction index was derived as 'high risk of extinction' for villages with underpopulated populations. Lastly, the results of the residents' awareness survey also showed that the village extinction index was well reflected in the actual situation of rural villages when applied. When the village extinction index was applied to rural villages rather than the regional extinction index, it was found to reflect the actual state of rural extinction better.

Development of Deep Learning-based Automatic Classification of Architectural Objects in Point Clouds for BIM Application in Renovating Aging Buildings (딥러닝 기반 노후 건축물 리모델링 시 BIM 적용을 위한 포인트 클라우드의 건축 객체 자동 분류 기술 개발)

  • Kim, Tae-Hoon;Gu, Hyeong-Mo;Hong, Soon-Min;Choo, Seoung-Yeon
    • Journal of KIBIM
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    • v.13 no.4
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    • pp.96-105
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    • 2023
  • This study focuses on developing a building object recognition technology for efficient use in the remodeling of buildings constructed without drawings. In the era of the 4th industrial revolution, smart technologies are being developed. This research contributes to the architectural field by introducing a deep learning-based method for automatic object classification and recognition, utilizing point cloud data. We use a TD3D network with voxels, optimizing its performance through adjustments in voxel size and number of blocks. This technology enables the classification of building objects such as walls, floors, and roofs from 3D scanning data, labeling them in polygonal forms to minimize boundary ambiguities. However, challenges in object boundary classifications were observed. The model facilitates the automatic classification of non-building objects, thereby reducing manual effort in data matching processes. It also distinguishes between elements to be demolished or retained during remodeling. The study minimized data set loss space by labeling using the extremities of the x, y, and z coordinates. The research aims to enhance the efficiency of building object classification and improve the quality of architectural plans by reducing manpower and time during remodeling. The study aligns with its goal of developing an efficient classification technology. Future work can extend to creating classified objects using parametric tools with polygon-labeled datasets, offering meaningful numerical analysis for remodeling processes. Continued research in this direction is anticipated to significantly advance the efficiency of building remodeling techniques.

Comparison of fracture strength, surface hardness, and color stain of conventionally fabricated, 3D printed, and CAD-CAM milled interim prosthodontic materials after thermocycling

  • Mesut Yildirim;Filiz Aykent;Mahmut Sertac Ozdogan
    • The Journal of Advanced Prosthodontics
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    • v.16 no.2
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    • pp.115-125
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    • 2024
  • PURPOSE. The purpose of this in vitro study was to investigate the fracture resistance, surface hardness, and color stain of 3D printed, CAD-CAM milled, and conventional interim materials. MATERIALS AND METHODS. A total of 80 specimens were fabricated from auto polymerizing polymethyl methacrylate (PMMA), bis-acryl composite resin, CAD-CAM polymethyl methacrylate resin (milled), and 3D printed composite resin (printed) (n = 20). Forty of them were crown-shaped, on which fracture strength test was performed (n = 10). The others were disc-shaped specimens (10 mm × 2 mm) and divided into two groups for surface hardness and color stainability tests before and after thermal cycling in coffee solution (n = 10). Color parameters were measured with a spectrophotometer before and after each storage period, and color differences (CIEDE2000 [DE00]) were calculated. The distribution of variables was measured with the Kolmogorov Smirnov test, and one-way analysis of variance (ANOVA), Tukey HSD, Kruskal-Wallis, Mann-Whitney U tests were used in the analysis of quantitative independent data. Paired sample t-test was used in the analysis of dependent quantitative data (P < .05). RESULTS. The highest crown fracture resistance values were determined for the 3D printed composite resin (P < .05), and the lowest were observed in the bis-acryl composite resin (P < .05). Before and after thermal cycling, increase in mean hardness values were observed only in 3D printed composite resin (P < .05) and the highest ΔE00 value were observed in PMMA resin for all materials (P < .05). CONCLUSION. 3D printing and CAD-CAM milled interim materials showed better fracture strength. After the coffee thermal cycle, the highest surface hardness value was again found in 3D printing and CAD-CAM milled interim samples and the color change of the bis-acryl resin-based samples and the additive production technique was higher than the PMMA resin and CAD-CAM milled resin samples.