• Parasites, Hosts and Diseases
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• 제60권5호
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• pp.309-315
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• 2022

Inflammatory bowel disease (IBD) is a chronic and recurrent illness of the gastrointestinal tract. Treatment of IBD traditionally involves the use of aminosalicylic acid and steroids, while these drugs has been associated with untoward effects and refractoriness. The absence of effective treatment regimen against IBD has led to the exploration of new targets. Parasites are promising as an alternative therapy for IBD. Recent studies have highlighted the use of parasite-derived substances, such as excretory secretory products, extracellular vesicles (EVs), and exosomes, for the treatment of IBD. In this report, we examined whether EVs secreted by Giardia lamblia could prevent colitis in a mouse model. G. lamblia EVs (GlEVs) were prepared from in vitro cultures of Giardia trophozoites. Clinical signs, microscopic colon tissue inflammation, and cytokine expression levels were detected to assess the effect of GlEV treatment on dextran sulfate sodium (DSS)-induced experimental murine colitis. The administration of GlEVs prior to DSS challenge reduced the expression levels of pro-inflammatory cytokines, including tumor necrosis factor alpha, interleukin 1 beta, and interferon gamma. Our results indicate that GlEV can exert preventive effects and possess therapeutic properties against DSS-induced colitis.

• 정보보호학회논문지
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• 제32권4호
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• pp.673-689
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• 2022

본 연구에서는 APT 공격을 탐지하고 대응하기 위한 과정의 하나로 APT 공격을 스코어링하는 방안을 제안한다. 먼저, 사이버 공격을 스코어링하는 과정에서 비일관적인 전문가의 주관적인 판단 요소를 고려한 기존의 연구와는 달리, MITRE ATT&CK^Ⓡ의 공격기술을 구성하는 여러 구성요소 중 정량화할 수 있는 요소들을 식별하고 이를 정량화하는 방안을 제시한다. 또한, 정량화된 요소들을 이용하여 단위 공격기술의 스코어를 도출하고, 나아가 여러 공격 기술로 구성된 전체 APT 공격의 스코어를 산출하는 방안을 제안한다. 제안한 스코어링 방법을 APT 공격 사례 보고서에 적용하여 APT 공격을 포함한 다양한 사이버 공격의 위협 수준 및 시급성을 판단하기 위한 정량화 가능성을 제시한다. 본 연구를 이용하여 APT 공격을 탐지하는 과정에서 실제 공격 여부를 판단하고, 공격의 우선순위를 산정함으로써 더욱 시급하고 중요한 사이버 공격에 대응할 수 있을 것이다.

• 한국동물위생학회지
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• 제46권1호
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• pp.35-45
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• 2023

Pathogenic Escherichia coli is the cause of a wide range of diseases in pigs, including diarrhea, edema disease, and septicemia. Diarrhea caused E. coli may result in significant economic losses, making pathogenic E. coli an important pathogen for the swine industry. This study investigated the prevalence of virulence factor genes, antimicrobial resistance phenotypes, and resistance genes in E. coli isolated from feces of piglets in Korea between 2017 and 2020. As a result, 119 pathogenic E. coli isolates were obtained from 601 fecal samples. The F4 adhesin gene and the STb enterotoxin gene were commonly present in E. coli isolated from diarrhea samples. The dominant virulotypes of isolates from diarrhea samples were STb, Stx2e, and F4:LT:STb. More than 80% of the screened isolates were resistant to ampicillin, sulfisoxazole, chloramphenicol, or tetracycline. To confirm the resistance mechanisms for β-lactam or quinolone, we investigated the genotypic factors of resistance. Each of the ceftiofur-resistant E. coli produced an extended-spectrum β-lactamase encoded by bla_CTX-M-14, bla_CTX-M-27, and bla_CTX-M-55. And all ciprofloxacin-resistant E. coli harbored mutations in quinoloneresistance-determining-regions. In addition, some of the ciprofloxacin-resistant E. coli contained the plasmid-mediated-quinolone-resistance genes such as qepA, qnrB1, or qnrD. This study has confirmed that the F4 fimbria and the STb enterotoxin are the most predominant in pathogenic E. coli isolated from piglets with diarrhea in Korea and there is a great need for responsible and prudent use of antimicrobials to treat colibacillosis.

• Annals of Occupational and Environmental Medicine
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• 제34권
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• pp.5.1-5.10
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• 2022

Background: Some epidemiological studies have estimated exposure among flight attendants with and without breast cancer. However, it is difficult to find a quantitative evaluation of occupational exposure factors related to cancer development individually in the case of breast cancer in flight attendants. That is, most, if not all, epidemiological studies of breast cancer in flight attendants with quantitative exposure estimates have estimated exposure in the absence of individual flight history data. Case presentation: A 41-year-old woman visited the hospital due to a left breast mass after a regular check-up. Breast cancer was suspected on ultrasonography. Following core biopsy, she underwent various imaging modalities. She was diagnosed invasive ductal carcinoma of no special type (estrogen receptor positive in 90%, progesterone receptor positive in 3%, human epidermal growth factor receptor 2/neu equivocal) with histologic grade 3 and nuclear grade 3 in the left breast. Neoadjuvant chemotherapy was administered to reduce the tumor size before surgery. However, due to serious chemotherapy side effects, the patient opted for alternative and integrative therapies. She joined the airline in January, 1996. Out of all flights, international flights and night flights accounted for 94.9% and 26.2, respectively. Night flights were conducted at least four times per month. Moreover, based on the virtual computer program CARI-6M, the estimated dose of cosmic radiation exposure was 78.81 mSv. There were no other personal triggers or family history of breast cancer. Conclusions: This case report shows that the potentially causal relationship between occupational harmful factors and the incidence of breast cancer may become more pronounced when night shift workers who work continuously are exposed to cosmic ionizing radiation. Therefore, close attention and efforts are needed to adjust night shift work schedules and regulate cosmic ionizing radiation exposure.

• 한국산업보건학회지
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• 제24권3호
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• pp.393-403
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• 2014

Objectives: Korean Occupational Safety and Health Agency(KOSHA) intended to provide guidance to respirator program administrators on respirator selection. The purpose of this project is to suggest a preliminary respirator selection guide(PRSG) for the final guidance certified by KOSHA for the correct selection of respirators in the workplace. Materials: This PRSG was made on the based of current status of respirator usage including respirators available in Korea, foreign documents search and so on. PRSG was partially modified NIOSH pocket guide to chemical hazards, 3M Respirator Protection Resource Guide(RPRG) and OSHA Assigned Protection Factor(APF) rulemaking. Results: Respirators for chemicals having Korean Occupational Exposure Limits(KOELs) can be recommended in PRSG. For the others chemicals that have no KOELs, PRSG tells you what respirators you can select, using a simple step-by-step approach after health hazard assessment like HSE procedure. Conclusions: PRSG helps you to decide the right level of protection for a given hazardous substance and how to select the right respirators. PRSG is thus expected to reduce significant misuses of respirators for the work environment.

• 방사성폐기물학회지
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• 제13권1호
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• pp.63-72
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• 2015

우리나라의 중·저준위 방사성폐기물은 월성환경관리센터를 이용하여 처분된다. 처분시설의 안전성을 확인하기 위하여 자연현상에 의한 시나리오뿐만 아니라 인간침입에 의한 시나리오도 고려하여 평가한다. 인간침입 시나리오는 제도적관리기간 이후 처분시설의 존재를 모르는 인간에 의해 시추 등과 같은 행위로 인해 일어나는 시나리오로서, 우물이용 시나리오는 처분부지 내 우물의 시추확률이 수십 년 생애기간에 시나리오에 의한 피폭을 한번이라도 경험할 수 있는 가능성이 낮음을 보여 인간침입 사건범주로 구분하였으며, 보수적인 가정을 사용하여 평가하였다. 이를 위하여 우물의 위치 및 처분시설로부터 누출된 오염물질의 우물 유입비율을 지하수 유동 모델링을 통하여 계산되었으며, 이에 대한 방법론을 소개하였다. 또한, 이 방법론을 핵종이동 모델링에 적용하여 처분시설에 미치는 영향을 평가하여, 평가된 시나리오는 성능목표치를 만족하고 있음을 보였다.

• 한국자기학회지
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• 제23권5호
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• pp.159-165
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• 2013

능동형 자기센서는 근거리에서 정확한 표적 탐지가 가능하지만 대상 표적 관점에서는 이러한 센서의 위협을 극복할 수 있는 마땅한 대항책이 없기 때문에 세계 각국의 수중유도무기에서 기폭신관용 센서로 널리 사용하고 있다. 하지만 근래에는 표적의 명중률 향상을 위한 목적으로 능동형 자기센서의 표적 탐지거리를 증대시키는 것에 대한 요구가 끊임없이 제기되고 있다. 표적 탐지거리를 증대시키는 방법 중의 하나는 송신기의 코어 형상 최적화를 통한 송신 코어의 자기소거인자를 최소화하고, 이를 통해서 송신기 출력을 향상시키는 것이다. 따라서 본 논문에서는 수중유도무기에 적용되는 능동형 자기센서의 송신출력 향상을 위한 송신기 코어 형상 설계와 관련하여 유한요소해석 및 실세 제작된 송신기를 대상으로 비교 시험을 수행하였고, 그 결과 송신기 코어의 형상은 송신 출력 향상에 매우 중요한 인자임을 확인하였다.

• 아태비즈니스연구
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• 제12권1호
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• pp.41-56
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• 2021

Purpose - This empirical study examined the influence of post-communist countries sociol-political factor of freedom of expression preconditioning, and trust in agency, mediating performance expectancy of social media users representing the citizens' behavioural intention to utilize social media in a post-communist country, the case of Mongolia. Design/methodology/approach - This research collected 403 valid survey data from citizens those who use social media in Mongolia. The study used Partial Least Squire (PLS) analysis with the research conceptual model founded on the UTAUT model. Findings - The study shown that citizens in post-communist, they strongly willing freedom of expression, which driving as a positive precondition factor, and this has an indirect positive influence, and trust in agency mediates to enhance performance expectancy. Social influence, and effort expectancy factors have direct positive influence on the intention to use of social media systems in the public sector domain of Mongolia. Research implications or Originality - This research proposed a new model to test citizens' intention to use social media as a communication tool to engage with public organizations in the pre-adoption stage of post-communist countries. Theoretically, this research builds up to the unique theoretical contribution with social media by examining a new social media-based third-party intercommunication medium, incorporating intent to utilize for citizens with government in post-communist countries. Practically, this article lays out the directions to aid social media usage for government sector with concerning citizens intentions in the post-communist situation.

• Nuclear Engineering and Technology
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• 제54권2호
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• pp.608-616
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• 2022

Power peaking factors (PPF) is an important parameter for safe and efficient reactor operation. There are several methods to calculate the PPF at TRIGA research reactors such as MCNP and TRIGLAV codes. However, these methods are time-consuming and required high specifications of a computer system. To overcome these limitations, artificial intelligence was introduced for parameter prediction. Previous studies applied the neural network method to predict the PPF, but the publications using the ANFIS method are not well developed yet. In this paper, the prediction of PPF using the ANFIS was conducted. Two input variables, control rod position, and neutron flux were collected while the PPF was calculated using TRIGLAV code as the data output. These input-output datasets were used for ANFIS model generation, training, and testing. In this study, four ANFIS model with two types of input space partitioning methods shows good predictive performances with R² values in the range of 96%-97%, reveals the strong relationship between the predicted and actual PPF values. The RMSE calculated also near zero. From this statistical analysis, it is proven that the ANFIS could predict the PPF accurately and can be used as an alternative method to develop a real-time monitoring system at TRIGA research reactors.

• Journal of Radiation Protection and Research
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• 제44권4호
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• pp.128-148
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• 2019

Massive environmental monitoring has been conducted continuously since the Fukushima Daiichi Nuclear Power accident in March of 2011 by different monitoring methods that have different features together with migration studies of radiocesium in diverse environments. These results have clarified the characteristics of radiological environments and their temporal change around the Fukushima site. At three months after the accident, multiple radionuclides including radiostrontium and plutonium were detected in many locations; and it was confirmed that radiocesium was most important from the viewpoint of long-term exposure. Radiation levels around the Fukushima site have decreased greatly over time. The decreasing trend was found to change variously according to local conditions. The air dose rates in environments related to human living have decreased faster than expected from radioactive decay by a factor of 2-3 on average; those in pure forest have decreased more closely to physical decay. The main causes of air dose rate reduction were judged to be radioactive decay, movement of radiocesium in vertical and horizontal directions, and decontamination. Land-use categories and human activities have significantly affected the reduction tendency. Difference in the air dose rate reduction trends can be explained qualitatively according to the knowledge obtained in radiocesium migration studies; whereas, the quantitative explanation for individual sites is an important future challenge. The ecological half-lives of air dose rates have been evaluated by several researchers, and a short-term half-life within 1 year was commonly observed in the studies. An empirical model for predicting air dose rate distribution was developed based on statistical analysis of an extensive car-borne survey dataset, which enabled the prediction with confidence intervals. Different types of contamination maps were integrated to better quantify the spatial data. The obtained data were used for extended studies such as for identifying the main reactor that caused the contamination of arbitrary regions and developing standard procedures for environmental measurement and sampling. Annual external exposure doses for residents who intended to return to their homes were estimated as within a few millisieverts. Different forms of environmental data and knowledge have been provided for wide spectrum of people. Diverse aspects of lessons learned from the Fukushima accident, including practical ones, must be passed on to future generations.