• Molecules and Cells
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• 제42권12호
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• pp.821-827
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• 2019

Aging is the most important single risk factor for many chronic diseases such as cancer, metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might, therefore, be a better strategy than targeting each chronic disease individually for enhancing human health. Although much should be achieved for completely understanding the biological basis of aging, cellular senescence is now believed to mainly contribute to organismal aging via two independent, yet not mutually exclusive mechanisms: on the one hand, senescence of stem cells leads to exhaustion of stem cells and thus decreases tissue regeneration. On the other hand, senescent cells secrete many proinflammatory cytokines, chemokines, growth factors, and proteases, collectively termed as the senescence-associated secretory phenotype (SASP), which causes chronic inflammation and tissue dysfunction. Much effort has been recently made to therapeutically target detrimental effects of cellular senescence including selectively eliminating senescent cells (senolytics) and modulating a proinflammatory senescent secretome (senostatics). Here, we discuss current progress and limitations in understanding molecular mechanisms of senolytics and senostatics and therapeutic strategies for applying them. Furthermore, we propose how these novel interventions for aging treatment could be improved, based on lessons learned from cancer treatment.

• Physical Therapy Rehabilitation Science
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• 제12권1호
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• pp.72-79
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• 2023

Objective: Despite known associations between negative body image and health declines in chronic pain patients, few studies have examined longitudinal associations between psychological stress and perceived hand deformities. This study examined whether psychological distress was associated with hand deformities 4 years later and if rural and urban adults differed in the association. Design: A community-based cohort study. Methods: Community dwelling adults (mean age=51.97, 52.3% women) in a rural (n=2968) and urban area (n=2784) provided demographic data at baseline and, in the 4-year follow-up, responded to questionnaires about psychological distress. Perceived hand deformities were assessed at the 8-year follow-up. Linear regression was conducted to examine the effects of psychological distress on hand deformities and moderation by residential areas. Results: The perceived hand deformities were more likely among those with severe psychological stress, hand osteoarthritis, or any chronic disease condition (p<0.01) but less likely among those with younger age, higher education, or income (p<0.01). The regression results showed that psychological distress predicted more perceived hand deformities 4 years later even after adjusting for demographic and health covariates (p<0.01). The residential areas did not significantly moderate the association between distress and hand deformities. Conclusions: This study suggected that psychological distress may trigger later perception of hand deformities in both urband and rural adults. The findings indicate that stress management interventions that are customizable to regional contexts may be effective at preventing negative body image related health problems of community-dewelling adults.

• 기본간호학회지
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• 제14권3호
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• pp.331-339
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• 2007

Purpose: This study aimed to investigate LDQOL (Liver Disease Quality of Life) and its related factors of patients with Hepatitis B. Method: A cross-sectional descriptive study. The LDQOL was formally translated to Korean and reliability was examined. One hundred thirty eight patients following gastroenterology outpatient clinic of S. hospital in Seoul, Korea participated. Results: The mean age of the patients was 45.43 years and 87.7% were men. The mean score of LDQOL was 77.34, and mean scores of subscale were followed; symptom of liver disease (SxLD) (82.12), effect of liver disease (ELD) (25.50), concentration (Conc) (84.47), memory (Mem) (83.24), health discomfort, (HD) (75.18), sexual function (SFun) (75.71), sexual problem (SProb) (84.70), Loneliness (85.50), Hopeless (67.43), and stigma of liver disease (SLD) (91.64). Women had a lower LDQOL score for Loneliness (p=.034), and over 45 year-old patients had a lower LDQOL overall score (p=.000). Patients who were HBV carriers, or who had Chronic Hepatitis B or Liver Cirrhosis reported lower QOL respectively(p=.032). Conclusion: Although the liver disease itself seemed to be stable, patients with HBV experienced poor QOL in ELD, SProb, SFun, and Hopeless. Therefore nursing interventions in these aspects are needed.

• The Korean Journal of Pain
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• 제31권2호
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• pp.116-124
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• 2018

Background: We aimed to investigate the prevalence of unrecognized depression in patients with chronic pain, but with no history of psychiatric diseases. Methods: Patients with chronic pain who did not have a history of psychiatric disease were selected for this study. The Beck Depression Index (BDI) was used to evaluate depression. Participants' socio-demographic characteristics and pain-related characteristics were also recorded. Results: The study included 94 consecutive patients with chronic pain (28 men and 66 women). Based on the BDI scores, 33/94 (35.1%) patients with chronic pain had comorbid depression. The prevalence of depression was significantly higher in our cohort than it was in the general population (P < 0.001). The standardized incidence ratio, adjusted for age and sex, was 2.77 in men and 2.60 in women. Patients who were unmarried (odds ratio [OR] = 3.714, P = 0.044), and who had subjective sleep disturbance (OR = 8.885, P < 0.001), were more likely to have moderate to severe depression. Patients with high education levels (OR = 0.244, P = 0.016), and who were economically active (OR = 0.284, P = 0.023), were less likely to have moderate to severe depression. Conclusions: Our results indicate that unrecognized depression in patients with chronic pain is common. Therefore, pain physicians should actively seek to identify these problems rather than relying on the patient to volunteer such information.

• Journal of Korean Biological Nursing Science
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• 제19권1호
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• pp.38-47
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• 2017

Purpose: This study was undertaken to examine the relationship between airflow obstruction and subjective health status reported by stable patients with chronic obstructive pulmonary disease (COPD) residing in the community. Methods: A cross-sectional descriptive study was conducted with 78 stable COPD patients aged 69.7 years old on average and selected by a convenient sampling from an outpatient department of pulmonology in tertiary hospitals. They completed a constructed questionnaire including general characteristics, smoking history, dyspnea by modified medical research council (mMRC) scale, and health status by COPD assessment test (CAT). Anthropometric measurements were performed for body mass index (BMI) and pulse oxymetry for $O_2$ saturation (Sat $O_2$). Medical records were reviewed to obtain disease-related characteristics including duration of the disease, cardiovascular comorbidity, and forced expiratory volume in 1 second ($FEV_1$). Data were analyzed using PASW statistics 20.0. Results: Mean $FEV_1%$ and CAT scores were 55.11% and 17.73, respectively. Those in the lower stage of mMRC showed significantly higher $FEV_1$ and lower CAT. $FEV_1$ and CAT showed significant negative correlations; age and BMI with $FEV_1$, and Sat $O_2$ with CAT. Conclusion: The findings suggest that the less airway obstruction was, the better health status was, and provide the support for using subjective measures in clinical practices for COPD patients.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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• pp.24-36
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• 2004

Polyphenolic flavonoids are among a wide variety of phytochemicals present in the human diet. Basic research, animal model, and human studies suggest flavonoid intake may reduce the risk of several age-related chronic diseases. The vast number of flavonoids and mixtures of their subclasses, including flavonols, flavones and flavanones, and the variety of agricultural practices that affect their concentration in foods have presented a challenge to the development of adequate food composition databases for these com-pounds. Nonetheless, dietary assessments have been applied to cohort and case-control epidemiological studies and several reveal an inverse association with risk of some forms of cancer, cardiovascular disease, and other chronic conditions. Those observational studies that have examined these relationships with regard to flavonols, flavones, and flavanones are reviewed. The requirement for caution in interpreting these studies is discussed with regard to the limited information available on the bioavailability and biotransformation of these flavonoids. As the totality of the available evidence on these flavonoids suggests a role in the prevention of cancer and cardiovascular disease, further research is warranted, particularly in controlled clinical trials.

• Clinical and Experimental Pediatrics
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• 제54권1호
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• pp.1-5
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• 2011

Asthma in childhood is a heterogeneous disease with different phenotypes and variable clinical manifestations, which depend on the age, gender, genetic background, and environmental influences of the patients. Several longitudinal studies have been conducted to classify the phenotypes of childhood asthma, on the basis of the symptoms, triggers of wheezing illness, or pathophysiological features of the disease. These studies have provided us with important information about the different wheezing phenotypes in young children and about potential mechanisms and risk factors for the development of chronic asthma. The goal of these studies was to provide a better insight into the causes and natural course of childhood asthma. It is well-known that complicated interactions between genes and environmental factors contribute to the development of asthma. Because childhood is a period of rapid growth in both the lungs and the immune system, developmental factors should be considered in the pathogenesis of childhood asthma. The pulmonary system continues to grow and develop until linear growth is completed. Longitudinal studies have reported significant age-related immune development during postnatal early life. These observations suggest that the phenotypes of childhood asthma vary among children and also in an individual child over time. Improved classification of heterogeneous conditions of the disease will help determine novel strategies for primary and secondary prevention and for the development of individualized treatment for childhood asthma.

• 융합정보논문지
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• 제8권3호
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• pp.17-24
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• 2018

본 연구는 도시지역 근로자 5,638명을 대상으로 건강행태와 만성질환 유병률과의 관련성을 파악하고자 하였다. 자료분석은 빈도, 백분율, 교차분석을 실시하고 만성질환에 미치는 영향을 분석하기 위하여 다중로지스틱 회귀분석을 사용하였다. 연구 결과 대상자의 건강행태는 남자가 흡연과 음주가 높게 나타났고, 운동은 남녀 모두 추천건강운동량 기준으로 낮게 나타났으며 만성질환 유병률은 비만과 고지혈증이 높게 나타났다. 만성질환에 영향을 미치는 중요 인자는 연령, 운동, 음주로 확인되었다. 본 연구의 결과는 국가, 지역사회 및 산업현장에서 바람직한 건강행태 형성을 위한 체계적인 건강관리프로그램을 운영할 필요가 있음을 시사한다.

• International Journal of Contents
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• 제13권3호
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• pp.65-74
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• 2017

Women's menopause is a natural process that every woman must eventually experience, but changes in hormones before and after menopause can serve to produce life-threatening crises in some situations, with individual differences. Data for the study was elicited from 22,610 Korean women ranging in age from 45 to 55 years in the 2013 Korean Community Health Survey. Statistical analyses was performed using descriptive, t-test, ANOVA, and hierarchical regression analysis using SPSS IBM 20.0 version. Individual characteristics, lifestyle, history of chronic disease(s), psychological and environmental factors were included as independent and EQ5D weights of Koreans were used as dependent variables. The survey subjects consisted of a total 15,505(58.3%) in their 50s, 1,765 (66.5%) in middle and high school dropouts or graduates, 22,174 (83.3%) living in spouses and 10,534(39.6%) in wages. There was a significant difference in HRQOL among all independent variables except drinking and residential areas. Hierarchical regression analysis showed that age, smoking, obesity and other incidental disease factors (fall, angina, asthma, arthritis, osteoporosis, stroke) had a negative effect on HRQOL. The selected independent variables accounted for 22.7% of HRQOL. It is necessary to find a way to improve HRQOL of Korean perimenopausal women, focusing on the significant variables revealed by the study results.

• 기본간호학회지
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• 제16권3호
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• pp.353-361
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• 2009

Purpose: The purpose of this study was to examine the relationship of adult the women's satisfaction with their appearance, self-esteem, depression and stress to health related quality of life (HRQOL) across the lifespan. Method: In this study a convenience sample of Korean women aged 20 years and over was used. There were 1152 women and data were collected from November 2007 to February 2008. Results: There was no difference in satisfaction with appearance in all age group. Elderly women reported lowest self esteem and HRQOL and highest depression and stress. There were statistical significances between satisfaction with appearance, self-esteem, depression, stress and HRQOL for all age groups. The most significant predictors of HRQOL in early adulthood women were stress and depression. The most significant predictors of HRQOL in middle adulthood women were stress, disease, depression, self-esteem, and monthly income. The most significant predictors of HRQOL in elderly women were stress, disease, depression, and satisfaction with appearance. Conclusion: The results indicate that HRQOL of Korean women is associated with psychological distress as with stress and depression. When developing programs to enhance health in elderly women, consideration should be given to body image as well as psychological distress and chronic conditions.