• Journal of the Korean Society of Radiology
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• v.12 no.1
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• pp.53-64
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• 2018

Using the AUDIT-K (Korean versions of alcohol use disorders identification test), it was able to select a large number of potential danger drinkers who routinely live. There were no statistically significant differences in age, religion, marital status, occupation, family history of alcohol drinking, age at onset of alcohol use, smoking, and BMI (body mass index). However, only education and drinking periods were statistically significant. These results are consistent with the previous study, which suggests that alcohol consumption is higher among men who are educated. The level of education also suggests that there is a need to look at the differences depending on what you learned and how. Alcohol consumption by education also shows different results. Also, drinking at a young age will lead to a longer drinking period, which is consistent with previous studies on the age at onset of drinking. In this study, drinking period was the most important factor of alcohol use disorder and it is considered that measures and education of national government system which can delay drinking age as much as possible is needed as a method to shorten drinking period.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.18 no.1
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• pp.23-29
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• 2015

Purpose: To describe the clinical characteristics of celiac disease (CD) among Saudi children and to determine the adherence rate to gluten free diet (GFD) and its determinant factors among them. Methods: A cross-sectional study was conducted, in which all the families registered in the Saudi Celiac Patients Support Group were sent an online survey. Only families with children 18 years of age and younger with biopsy-confirmed CD were included. Results: The median age of the 113 included children was 9.9 years, the median age at symptom onset was 5.5 years and the median age at diagnosis was 7 years, the median time between the presentation and the final diagnosis was 1 year. Sixty two of the involved children were females. Ninety two percent of the patients were symptomatic at the diagnosis while eight percent were asymptomatic. The commonest presenting symptoms included: chronic abdominal pain (59.3%), poor weight gain (54%), abdominal distention, gases, bloating (46.1%) and chronic diarrhea (41.6%). Sixty percent of the involved children were reported to be strictly adherent to GFD. Younger age at diagnosis and shorter duration since the diagnosis were associated with a better adherence rate. Conclusion: CD has similar clinical presentations among Saudi children compared to other parts of the ward; however, the adherence to GFD is relatively poor. Younger age at diagnosis and shorter duration since the diagnosis were associated with a better adherence rate.

• Advances in pediatric surgery
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• v.2 no.1
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• pp.1-7
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• 1996

Clinical experiences of 833 hydrocele children presented at Hanyang University Hospital, of whom 456 children were operated by one pediatric surgeon from September 1979 to December 1993, were analyzed. Eight hundred and twenty three children were boys(right 476, left 279, bilateral 49, and unknown 19), and 10 were girls(8 right and 2 left). Operation was performed on 446 boys and all girls. Of boys diagnosed before the age of 6 months, 15.6% was operated and 68.7% of those after 6 months of age was operated. Among the boys operated after 2 years old, 16.5% had had hydrocele before 6 months of age, 20.4% before 1 year old and 34.6% before 2 years old. On the other hand, 28.8% of boys diagnosed after 2 years of age did not undergo hydrocelectomy. Sixteen children with hydroceles had contralateral hernias at the same time. After repair of unilateral hydroceles, contralateral hydroceles developed in 7 and hernias in 3 children. After disappearance of unilateral hydroceles, it reappeared at the same site in 4 and contralateral hydroceles or hernias developed in 2 children each. Hydroceles converted to hernias in 6 children before treatment. Hydroceles developed after ventriculo-peritoneal shunt in 5 children. The pathophysiology of hydrocele and inguinal hernia seems to be the same because of the similar distribution of onset age between them but hydrocele has various clinical courses. The results that 34.6% of boys operated after 2 years old had had hydrocele before 2 years of age and 28.8% of boys diagnosed after 2 years old did not undergo hydrocelectomy could not imply the proper age when hydrocelectomy could be performed. But operative repair of hydroceles after the age of 6 months seems to be recommendagle.

• Clinical and Experimental Pediatrics
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• v.55 no.5
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• pp.159-163
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• 2012

Most children with epilepsy are of normal intelligence. However, a significant subset will have temporary or permanent cognitive impairment. Factors that affect cognitive function are myriad and include the underlying neuropathology of the epilepsy, seizures, epileptiform discharges, psychosocial problems, age at seizure onset, duration of epilepsy, and side effects associated with antiepileptic drugs. This review article discusses cognitive function in children with idiopathic epilepsy and the effects of antiepileptic drugs on cognitive function in children.

• Annals of Clinical Neurophysiology
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• v.23 no.1
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• pp.53-55
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• 2021

Congenital myasthenic syndromes (CMSs) are rare genetic disorders characterized by weakness and fatigue resulting from impaired neuromuscular transmission. Genetic testing can confirm the diagnosis for some types of CMS; however, variations in genotype, clinical phenotypes, age at disease onset, and responses to treatment make diagnosis very difficult. Here we present two adult patients who had significant decremental responses in repetitive nerve stimulation testing and multi-minicore pathology, and who responded to treatment with a cholinesterase inhibitor.

• Archives of Pharmacal Research
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• v.25 no.6
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• pp.923-931
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• 2002

Sopungsungi-won (SP) is a known for\mula for senile constipation and diabetes mellitus, based on traditional Korean medicine. The preventive effect of SP on the development of overt diabetes in Zucker diabetic fatty (ZDF) rats was evaluated. When administered orally through a diet for 8 weeks, diabetic conditions such as hyperglycemia, polydipsia and hypertriglyceridemia were all ameliorated in SP-treated rats. In parallel with the onset and progression of hyperglycemia in the ZDF control rats; there was a marked decline in plasma insulin concentrations from 26.1 $\mu$U/ml, at age 7 weeks, to 14.8 $\mu$U/ml at age 15 weeks. In the SP-treated rats, however, the plasma insulin concentrations did not decline, and SP at a dose of 5 g/kg significantly increased the insulin levels to 31.9 $\mu$U/ml. Early normalization of plasma insulin and a retained ability to subsequently increase plasma insulin were indicative of a pancreatic $\beta$ cell protective action by the SP for\mula. In addition, expressions of an insulin-responsive gene and corresponding protein, glucose transporter 4 (GLUT4), in skeletal \muscle, were also determined in SP- and rosiglitazone-treated ZDF rats. mRNA and protein levels of GLUT4 in SP-treated rats were upregulated in a dose dependent manner. Furthermore, when ZDF rats were treated with 2 g/kg of the SP for\mula, the activity of glucose-6-phosphatase was decreased by 49%, whereas the activity of glucokinase was increased by 196%, compared to the ZDF control rats. Taken together, these data provide evidence that the SP for\mula markedly lowered the plasma glucose levels, probably through an effect not only on improvement of insulin action, but through a combined sti\mulation of glycolysis and an inhibition of gluconeogenesis in the liver, and also suggest the validity of SP's clinical use in the treatment of type 2 diabetes mellitus following further toxicological investigation.

• Asian-Australasian Journal of Animal Sciences
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• v.10 no.2
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• pp.192-195
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• 1997

Thirty adults Desi and Khaki Campbell ducks were distributed to 6 farmers of Chakcharpur village of Mymensingh district. These ducks were subjected 3 types of mating e.g. Desi ${\times}$ Desi, Khaki Campbell ${\times}$ Khaki Campbell and Khaki Campbell ${\times}$ Desi-having 10 ducks (male : female = 1 : 4) in each mating group. Each mating group was then divided into two having 5 ducks(male : female = 1 : 4) and distributed to 2 farmers. After collecting eggs from each mating category, these were hatched by broody hens from which a total of 90 day old ducklings, 30 from each genotype were raised from birth to 90 days after the onest of laying. Although the weight of the day old chicks were similar in all genotypes (40-43 g), body weight was the highest (p <0.01) for Khaki Campbell ${\times}$ Desi (1,543) before the onset of laying followed by Khaki Campbell (1,552 g) and Desi (1,448 g) ducks. Khaki Campbell attained maturity at an earlier (p < 0.01) age (147 days) followed by Khaki Campbell ${\times}$ Desi, (154 days) and Desi (161 days) ducks. Khaki Campbell laid maximum (p < 0.01) number of eggs (46) compared to Khaki Campbell ${\times}$ Desi, (30) and Desi (18) ducks 90 days after the onset of laying. However, eggs were heavier (p < 0.01) in Desi (61.9) ducks compared to other genotypes. Fertility and hatchability were also higher in Desi ducks than the other two genotypes. Mortality was also lover in Desi ducks (3.33%) followed by Khaki Campbell ${\times}$ Desi (6.66%) and Khaki Campbell (16.66%) ducks. The results presented here indicated the superiority of Desi ducks over the other two genotypes with respect to egg weight, fertility, hatchability and mortality under village condition. Pure and crossbreds, on the other hand, were heavier at sexual maturity at relatively younger age and laid more eggs.

• Journal of the Korean Dietetic Association
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• v.9 no.2
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• pp.106-113
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• 2003

The purpose of this study was to compare the growth development between age-matched 51 postmenarcheal girls (mean age 153.1$\pm$5.8 month) who were rapidly maturing and 51 premenarcheal girls (mean age 153.1$\pm$5.7 month) who were slowly maturing. Anthropometirc measurements were taken for height, body weight, body fat(%), waist and hip circumferences of subjects. These measurements of menarcheal girls were significantly higher than those of nonmenarcheal girls. There was no significant difference in BMI distribution between two groups. However, 43.2% and 20.0% respectively in the menarcheal and nonmenarcheal girls had body fat levels of 30% or above. There were significant differences in the anthropometric measurements during past 4 years from 3rd grade elementary school to present. The greatest difference between the two groups were the amount and the rate of increased height and body weight from age 9 to 10. Among menarcheal girls, height, body weight, BMI, and Röhrer index were positively related to the onset of menarche. Distinctively, there was a stronger relationship between age at menarche and anthropometric measurements when the girls were 5th grade elementary school children. These findings support that during childhood and puberty, obese girls grow faster and have earlier menarche. Furthermore, the importance of prevention of obesity was recognized in order to accelerate growth of height among the girls by delaying the age of menarche.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.6
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• pp.531-538
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• 2020

Purpose: Our aim was the longitudinal assessment of cyst size in fetuses with biliary cystic malformation (BCM) to explore its etiology and the possibility of antenatal differentiation between biliary atresia (BA) and congenital biliary dilatation (CBD). Methods: We conducted a retrospective review of all patients diagnosed antenatally with BCM from 1994 to 2014 at our institutions. Results: The study cohort comprised of three patients with BA and six with CBD. There were no significant differences in the gestational age and cyst size at the first detection of BCM between the two groups. In fetuses with CBD, the cyst size steadily increased as the gestational age advanced, while it fluctuated around 1.5 cm and remained below 2.1 cm in those with BA. However, the ratio of cystic area to fetal trunk area was approximately constant due to linear fetal growth in fetuses with CBD. Conclusion: Fetuses with BCM <2.1 cm in the late gestation period were more likely to have BA than CBD. Our observation of cyst enlargement with advancing gestational age in the CBD group was attributed solely to fetal growth. Biliary dilatation in fetuses with CBD and BA might be completed at the onset of BCM.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3779-3784
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• 2013

Aims: To determine the clinical, pathological and prognostic features associated with triple-negative breast cancer (TNBC). Methods: Clinical and histologic data of 21,749 breast cancer patients who were treated at Tianjin Medical University Cancer Institute and Hospital between July 2002 and December 2011 were collected. Patients were divided into two groups: those with TNBC and those with other types of breast cancer. Patients and tumor characteristics were compared between the two groups using the Chi-square test. The prognostic results of 9,823 patients in the study population were also analyzed to determine long-term survival rates in the two groups of breast cancer patients. Results: Among the breast cancer patients treated in our hospital between 2003 and 2011, 10.4%-13.5% of them had triple-negative breast cancers. Data analyses revealed significant differences in disease onset age, family history of breast cancer, tumor size, tumor histologic grade, lymph note positivity and metastatic status between TNBC and non-TNBC patients. There were also significant differences in 5-year, 7-year and 9-year disease-free and 7-year and 9-year overall survival probability between the groups. Conclusions:TNBC are associated with younger disease onset age, larger tumor size, higher rate of axillary lymph node positivity, and higher tumor histologic grade. TNBC is also related to family history of breast cancer, increased metastatic risk and poor prognosis.