Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Cognitive function of idiopathic childhood epilepsy

  • You, Su-Jeong (Department of Pediatrics, Epilepsy Center, Sanggye Paik Hospital, Inje University College of Medicine)
  • Received : 2012.02.10
  • Accepted : 2012.02.26
  • Published : 2012.05.15
Download PDF
⟨ Previous Next ⟩

Abstract

Most children with epilepsy are of normal intelligence. However, a significant subset will have temporary or permanent cognitive impairment. Factors that affect cognitive function are myriad and include the underlying neuropathology of the epilepsy, seizures, epileptiform discharges, psychosocial problems, age at seizure onset, duration of epilepsy, and side effects associated with antiepileptic drugs. This review article discusses cognitive function in children with idiopathic epilepsy and the effects of antiepileptic drugs on cognitive function in children.

Keywords

References

  1. MacAllister WS, Schaffer SG. Neuropsychological deficits in childhood epilepsy syndromes. Neuropsychol Rev 2007;17:427-44. https://doi.org/10.1007/s11065-007-9048-4
  2. Bhise VV, Burack GD, Mandelbaum DE. Baseline cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy. Dev Med Child Neurol 2010;52:22-6. https://doi.org/10.1111/j.1469-8749.2009.03404.x
  3. Bourgeois BF, Prensky AL, Palkes HS, Talent BK, Busch SG. Intelligence in epilepsy: a prospective study in children. Ann Neurol 1983;14:438-44. https://doi.org/10.1002/ana.410140407
  4. Hommet C, Billard C, Motte J, Passage GD, Perrier D, Gillet P, et al. Cognitive function in adolescents and young adults in complete remission from benign childhood epilepsy with centro-temporal spikes. Epileptic Disord 2001;3:207-16.
  5. Henkin Y, Sadeh M, Kivity S, Shabtai E, Kishon-Rabin L, Gadoth N. Cognitive function in idiopathic generalized epilepsy of childhood. Dev Med Child Neurol 2005;47:126-32. https://doi.org/10.1017/S0012162205000228
  6. Pinton F, Ducot B, Motte J, Arbues AS, Barondiot C, Barthez MA, et al. Cognitive functions in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Epileptic Disord 2006;8:11-23.
  7. Danielsson J, Petermann F. Cognitive deficits in children with benign rolandic epilepsy of childhood or rolandic discharges: a study of children between 4 and 7 years of age with and without seizures compared with healthy controls. Epilepsy Behav 2009;16:646-51. https://doi.org/10.1016/j.yebeh.2009.08.012
  8. Pascalicchio TF, de Araujo Filho GM, da Silva Noffs MH, Lin K, Caboclo LO, Vidal-Dourado M, et al. Neuropsychological profile of patients with juvenile myoclonic epilepsy: a controlled study of 50 patients. Epilepsy Behav 2007;10:263-7. https://doi.org/10.1016/j.yebeh.2006.11.012
  9. Farwell JR, Dodrill CB, Batzel LW. Neuropsychological abilities of children with epilepsy. Epilepsia 1985;26:395-400. https://doi.org/10.1111/j.1528-1157.1985.tb05670.x
  10. Bailet LL, Turk WR. The impact of childhood epilepsy on neurocognitive and behavioral performance: a prospective longitudinal study. Epilepsia 2000;41:426-31. https://doi.org/10.1111/j.1528-1157.2000.tb00184.x
  11. Mirsky AF, Primac DW, Marsan CA, Rosvold HE, Stevens JR. A comparison of the psychological test performance of atients with focal and nonfocal epilepsy. Exp Neurol 1960;2:75-89. https://doi.org/10.1016/0014-4886(60)90049-2
  12. Jambaque I, Dellatolas G, Dulac O, Ponsot G, Signoret JL. Verbal and visual memory impairment in children with epilepsy. Neuropsychologia 1993;31:1321-37. https://doi.org/10.1016/0028-3932(93)90101-5
  13. Aldenkamp AP, Arends J. Effects of epileptiform EEG discharges on cognitive function: is the concept of "transient cognitive impairment" still valid? Epilepsy Behav 2004;5 Suppl 1:S25-34.
  14. Sonmez F, Atakli D, Sari H, Atay T, Arpaci B. Cognitive function in juvenile myoclonic epilepsy. Epilepsy Behav 2004;5:329-36. https://doi.org/10.1016/j.yebeh.2004.01.007
  15. Devinsky O, Gershengorn J, Brown E, Perrine K, Vazquez B, Luciano D. Frontal functions in juvenile myoclonic epilepsy. Neuropsychiatry Neuropsychol Behav Neurol 1997;10:243-6.
  16. Iqbal N, Caswell HL, Hare DJ, Pilkington O, Mercer S, Duncan S. Neuropsychological profiles of patients with juvenile myoclonic epilepsy and their siblings: a preliminary controlled experimental video-EEG case series. Epilepsy Behav 2009;14:516-21. https://doi.org/10.1016/j.yebeh.2008.12.025
  17. Pulsipher DT, Seidenberg M, Guidotti L, Tuchscherer VN, Morton J, Sheth RD, et al. Thalamofrontal circuitry and executive dysfunction in recent-onset juvenile myoclonic epilepsy. Epilepsia 2009;50:1210-9. https://doi.org/10.1111/j.1528-1167.2008.01952.x
  18. Pavone P, Bianchini R, Trifiletti RR, Incorpora G, Pavone A, Parano E. Neuropsychological assessment in children with absence epilepsy. Neurology 2001;56:1047-51. https://doi.org/10.1212/WNL.56.8.1047
  19. Weglage J, Demsky A, Pietsch M, Kurlemann G. Neuropsychological, intellectual, and behavioral findings in patients with centrotemporal spikes with and without seizures. Dev Med Child Neurol 1997;39:646-51.
  20. Staden U, Isaacs E, Boyd SG, Brandl U, Neville BG. Language dys function in children with Rolandic epilepsy. Neuropediatrics 1998;29: 242-8. https://doi.org/10.1055/s-2007-973569
  21. Yung AW, Park YD, Cohen MJ, Garrison TN. Cognitive and behavioral problems in children with centrotemporal spikes. Pediatr Neurol 2000; 23:391-5. https://doi.org/10.1016/S0887-8994(00)00220-4
  22. Baglietto MG, Battaglia FM, Nobili L, Tortorelli S, De Negri E, Calevo MG, et al. Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes. Dev Med Child Neurol 2001;43:407- https://doi.org/10.1017/S0012162201000755
  23. Günduz E, Demirbilek V, Korkmaz B. Benign rolandic epilepsy: neuropsychological findings. Seizure 1999;8:246-9. https://doi.org/10.1053/seiz.1999.0293
  24. Bulgheroni S, Franceschetti S, Vago C, Usilla A, Pantaleoni C, D'Arrigo S, et al. Verbal dichotic listening performance and its relationship with EEG features in benign childhood epilepsy with centrotemporal spikes. Epilepsy Res 2008;79:31-8. https://doi.org/10.1016/j.eplepsyres.2007.12.016
  25. Northcott E, Connolly AM, Berroya A, Sabaz M, McIntyre J, Christie J, et al. The neuropsychological and language profile of children with benign rolandic epilepsy. Epilepsia 2005;46:924-30. https://doi.org/10.1111/j.1528-1167.2005.62304.x
  26. Deonna T, Zesiger P, Davidoff V, Maeder M, Mayor C, Roulet E. Benign partial epilepsy of childhood: a longitudinal neuropsychological and EEG study of cognitive function. Dev Med Child Neurol 2000;42:595-603. https://doi.org/10.1017/S0012162200001122
  27. Northcott E, Connolly AM, McIntyre J, Christie J, Berroya A, Taylor A, et al. Longitudinal assessment of neuropsychologic and language function in children with benign rolandic epilepsy. J Child Neurol 2006;21:518-22. https://doi.org/10.1177/08830738060210062601
  28. Holmes GL. Epilepsy in the developing brain: lessons from the laboratory and clinic. Epilepsia 1997;38:12-30. https://doi.org/10.1111/j.1528-1157.1997.tb01074.x
  29. Metz-Lutz MN, Kleitz C, de Saint Martin A, Massa R, Hirsch E, Marescaux C. Cognitive development in benign focal epilepsies of childhood. Dev Neurosci 1999;21:182-90. https://doi.org/10.1159/000017397
  30. D'Alessandro P, Piccirilli M, Tiacci C, Ibba A, Maiotti M, Sciarma T, et al. Neuropsychological features of benign partial epilepsy in children. Ital J Neurol Sci 1990;11:265-9. https://doi.org/10.1007/BF02333856
  31. Chilosi AM, Brovedani P, Moscatelli M, Bonanni P, Guerrini R. Neuropsychological findings in idiopathic occipital lobe epilepsies. Epilepsia 2006;47 Suppl 2:76-8. https://doi.org/10.1111/j.1528-1167.2006.00696.x
  32. Germano E, Gagliano A, Magazu A, Sferro C, Calarese T, Mannarino E, et al. Benign childhood epilepsy with occipital paroxysms: neuropsychological findings. Epilepsy Res 2005;64:137-50. https://doi.org/10.1016/j.eplepsyres.2005.03.004
  33. Gulgonen S, Demirbilek V, Korkmaz B, Dervent A, Townes BD. Neuropsychological functions in idiopathic occipital lobe epilepsy. Epilepsia 2000;41:405-11. https://doi.org/10.1111/j.1528-1157.2000.tb00181.x
  34. Jeong MH, Yum MS, Ko TS, You SJ, Lee EH, Yoo HK. Neuropsychological status of children with newly diagnosed idiopathic childhood epilepsy. Brain Dev 2011;33:666-71. https://doi.org/10.1016/j.braindev.2010.11.003
  35. Hermann B, Jones J, Sheth R, Dow C, Koehn M, Seidenberg M. Children with new-onset epilepsy: neuropsychological status and brain structure. Brain 2006;129(Pt 10):2609-19. https://doi.org/10.1093/brain/awl196
  36. Farwell JR, Lee YJ, Hirtz DG, Sulzbacher SI, Ellenberg JH, Nelson KB. Phenobarbital for febrile seizures: effects on intelligence and on seizure recurrence. N Engl J Med 1990;322:364-9. https://doi.org/10.1056/NEJM199002083220604
  37. Tonekaboni SH, Beyraghi N, Tahbaz HS, Bahreynian SA, Aghamohammadpoor M. Neurocognitive effects of phenobarbital discontinuation in epileptic children. Epilepsy Behav 2006;8:145-8. https://doi.org/10.1016/j.yebeh.2005.09.001
  38. Eddy CM, Rickards HE, Cavanna AE. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disord 2011;4:385-407. https://doi.org/10.1177/1756285611417920
  39. Wesnes KA, Edgar C, Dean AD, Wroe SJ. The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy. Epilepsy Behav 2009;14:522-8. https://doi.org/10.1016/j.yebeh.2008.11.012
  40. Sun W, Wang Y, Wang W, Wu X. Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by eventrelated potential. Int J Psychophysiol 2008;68:235-41. https://doi.org/10.1016/j.ijpsycho.2008.02.003
  41. Donati F, Gobbi G, Campistol J, Rapatz G, Daehler M, Sturm Y, et al. The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures. Seizure 2007;16:670-9. https://doi.org/10.1016/j.seizure.2007.05.006
  42. Stores G, Williams PL, Styles E, Zaiwalla Z. Psychological effects of sodium valproate and carbamazepine in epilepsy. Arch Dis Child 1992; 67:1330-7. https://doi.org/10.1136/adc.67.11.1330
  43. Capovilla G, Beccaria F, Veggiotti P, Rubboli G, Meletti S, Tassinari CA. Ethosuximide is effective in the treatment of epileptic negative myoclonus in childhood partial epilepsy. J Child Neurol 1999;14:395-400. https://doi.org/10.1177/088307389901400609
  44. Browne TR, Dreifuss FE, Dyken PR, Goode DJ, Penry JK, Porter RJ, et al. Ethosuximide in the treatment of absence (peptit mal) seizures. Neurology 1975;25:515-24. https://doi.org/10.1212/WNL.25.6.515
  45. Blum D, Meador K, Biton V, Fakhoury T, Shneker B, Chung S, et al. Cognitive effects of lamotrigine compared with topiramate in patients with epilepsy. Neurology 2006;67:400-6. https://doi.org/10.1212/01.wnl.0000232737.72555.06
  46. Kim SY, Lee HW, Jung DK, Suh CK, Park SP. Cognitive effects of lowdose topiramate compared with oxcarbazepine in epilepsy patients. J Clin Neurol 2006;2:126-33. https://doi.org/10.3988/jcn.2006.2.2.126
  47. Aikia M, Kalviainen R, Sivenius J, Halonen T, Riekkinen PJ. Cognitive effects of oxcarbazepine and phenytoin monotherapy in newly diagnosed epilepsy: one year follow-up. Epilepsy Res 1992;11:199-203. https://doi.org/10.1016/0920-1211(92)90099-F
  48. Tzitiridou M, Panou T, Ramantani G, Kambas A, Spyroglou K, Panteliadis C. Oxcarbazepine monotherapy in benign childhood epilepsy with centrotemporal spikes: a clinical and cognitive evaluation. Epilepsy Behav 2005;7:458-67. https://doi.org/10.1016/j.yebeh.2005.07.012
  49. Pressler RM, Binnie CD, Coleshill SG, Chorley GA, Robinson RO. Effect of lamotrigine on cognition in children with epilepsy. Neurology 2006;66:1495-9. https://doi.org/10.1212/01.wnl.0000216273.94142.84
  50. von Stulpnagel C, Kluger G, Leiz S, Holthausen H. Levetiracetam as addon therapy in different subgroups of "benign" idiopathic focal epilepsies in childhood. Epilepsy Behav 2010;17:193-8. https://doi.org/10.1016/j.yebeh.2009.10.024

Cited by

  1. Cognitive Function in Childhood Epilepsy: Importance of Attention Deficit Hyperactivity Disorder vol.11, pp.1, 2015, https://doi.org/10.3988/jcn.2015.11.1.20
  2. An unaware agenda: interictal consciousness impairments in epileptic patients vol.2017, pp.1, 2012, https://doi.org/10.1093/nc/niw024
  3. Brain responses to auditory oddball task in children with benign childhood epilepsy with centrotemporal spikes: Quantitative analysis and correlation with neuropsychological assessment scores vol.80, pp.None, 2012, https://doi.org/10.1016/j.yebeh.2018.01.017
  4. Assessment of higher mental functions in patients with idiopathic (genetic) generalized epilepsies vol.65, pp.5, 2012, https://doi.org/10.21508/1027-4065-2020-65-5-152-157