Browse > Article
http://dx.doi.org/10.5223/pghn.2015.18.1.23

Clinical Characteristics of Celiac Disease and Dietary Adherence to Gluten-Free Diet among Saudi Children  

Al Sarkhy, Ahmed (Division of Gastroenterology, Department of Pediatrics, King Khalid University Hospital, King Saud University)
El Mouzan, Mohammad I. (Division of Gastroenterology, Department of Pediatrics, King Khalid University Hospital, King Saud University)
Saeed, Elshazaly (Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University)
Alanazi, Aziz (Division of Gastroenterology, Department of Pediatrics, King Abdulaziz Medical City, National Guard Health Affairs)
Alghamdi, Sharifa (Division of Gastroenterology, Department of Pediatrics, King Faisal Specialist Hospital and Research Center)
Anil, Shirin (College of Medicine, King Saud University)
Assiri, Asaad (Division of Gastroenterology, Department of Pediatrics, King Khalid University Hospital, King Saud University)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.18, no.1, 2015 , pp. 23-29 More about this Journal
Abstract
Purpose: To describe the clinical characteristics of celiac disease (CD) among Saudi children and to determine the adherence rate to gluten free diet (GFD) and its determinant factors among them. Methods: A cross-sectional study was conducted, in which all the families registered in the Saudi Celiac Patients Support Group were sent an online survey. Only families with children 18 years of age and younger with biopsy-confirmed CD were included. Results: The median age of the 113 included children was 9.9 years, the median age at symptom onset was 5.5 years and the median age at diagnosis was 7 years, the median time between the presentation and the final diagnosis was 1 year. Sixty two of the involved children were females. Ninety two percent of the patients were symptomatic at the diagnosis while eight percent were asymptomatic. The commonest presenting symptoms included: chronic abdominal pain (59.3%), poor weight gain (54%), abdominal distention, gases, bloating (46.1%) and chronic diarrhea (41.6%). Sixty percent of the involved children were reported to be strictly adherent to GFD. Younger age at diagnosis and shorter duration since the diagnosis were associated with a better adherence rate. Conclusion: CD has similar clinical presentations among Saudi children compared to other parts of the ward; however, the adherence to GFD is relatively poor. Younger age at diagnosis and shorter duration since the diagnosis were associated with a better adherence rate.
Keywords
Celiac disease; Gluten-free diet; Child; Saudi Arabia;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S, et al; Coeliac EU Cluster, Project Epidemiology. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 2010;42:587-95.   DOI
2 Al Attas RA. How common is celiac disease in Eastern Saudi Arabia? Ann Saudi Med 2002;22:315-9.   DOI
3 Saadah OI. Celiac disease in children and adolescents at a singe center in Saudi Arabia. Ann Saudi Med 2011;31:51-7.   DOI
4 Khayyat YM. Serologic markers of gluten sensitivity in a healthy population from the western region of Saudi Arabia. Saudi J Gastroenterol 2012;18:23-5.   DOI
5 Aljebreen AM, Almadi MA, Alhammad A, Al Faleh FZ. Seroprevalence of celiac disease among healthy adolescents in Saudi Arabia. World J Gastroenterol 2013;19: 2374-8.   DOI
6 Pantaleoni S, Luchino M, Adriani A, Pellicano R, Stradella D, Ribaldone DG, et al. Bone mineral density at diagnosis of celiac disease and after 1 year of gluten-free diet. ScientificWorldJournal 2014;2014:173082.
7 Rostami Nejad M, Aldulaimi D, Ishaq S, Ehsani-Ardakani MJ, Zali MR, Malekzadeh R, et al. Geographic trends and risk of gastrointestinal cancer among patients with celiac disease in Europe and Asian-Pacific region. Gastroenterol Hepatol Bed Bench 2013;6:170-7.
8 Stevens L, Rashid M. Gluten-free and regular foods: a cost comparison. Can J Diet Pract Res 2008;69:147-50.   DOI
9 Wagner G, Berger G, Sinnreich U, Grylli V, Schober E, Huber WD, et al. Quality of life in adolescents with treated coeliac disease: influence of compliance and age at diagnosis. J Pediatr Gastroenterol Nutr 2008;47: 555-61.   DOI
10 Kokkonen J, Viitanen A, Simila S. Coping with a coeliac diet after adolescence. Helv Paediatr Acta 1989;43:261-5.
11 Rashid M, Cranney A, Zarkadas M, Graham ID, Switzer C, Case S, et al. Celiac disease: evaluation of the diagnosis and dietary compliance in Canadian children. Pediatrics 2005;116:e754-9.   DOI
12 Kurppa K, Collin P, Maki M, Kaukinen K. Celiac disease and health-related quality of life. Expert Rev Gastroenterol Hepatol 2011;5:83-90.   DOI
13 Altobelli E, Paduano R, Gentile T, Caloisi C, Marziliano C, Necozione S, et al. Health-related quality of life in children and adolescents with celiac disease: survey of a population from central Italy. Health Qual Life Outcomes 2013;11:204.   DOI
14 El-Mouzan MI, Al-Salloum AA, Al-Herbish AS, Qurachi MM, Al-Omar AA. Regional variations in the prevalence of consanguinity in Saudi Arabia. Saudi Med J 2007;28:1881-4.
15 Mustalahti K, Sulkanen S, Holopainen P, Laurila K, Collin P, Partanen J, et al. Coeliac disease among healthy members of multiple case coeliac disease families. Scand J Gastroenterol 2002;37:161-5.   DOI
16 Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003;163:286-92.   DOI
17 Ganji A, Esmaielzadeh A, Aafzal Aghayee M, Goshayeshi L, Ghaffarzadegan K. The clinical presentation of celiac disease: experiences from northeastern iran. Middle East J Dig Dis 2014;6:93-7.
18 Chauhan JC, Kumar P, Dutta AK, Basu S, Kumar A. Assessment of dietary compliance to gluten free diet and psychosocial problems in Indian children with celiac disease. Indian J Pediatr 2010;77649-54.
19 Charalampopoulos D, Panayiotou J, Chouliaras G, Zellos A, Kyritsi E, Roma E. Determinants of adherence to gluten-free diet in Greek children with coeliac disease: a cross-sectional study. Eur J Clin Nutr 2013; 67:615-9.   DOI
20 Singh J, Whelan K. Limited availability and higher cost of gluten-free foods. J Hum Nutr Diet 2011;24:479-86.   DOI
21 Rajani S, Sawyer-Bennett J, Shirton L, DeHaan G, Kluthe C, Persad R, et al. Patient and parent satisfaction with a dietitian-and nurse-led celiac disease clinic for children at the Stollery Children's Hospital, Edmonton, Alberta. Can J Gastroenterol 2013;27:463-6.   DOI
22 Nelson M, Mendoza N, McGough N. A survey of provision of dietetic services for coeliac disease in the UK. J Hum Nutr Diet 2007;20:403-11.   DOI