• Journal of Korean Ophthalmic Optics Society
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• v.16 no.2
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• pp.201-207
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• 2011

Purpose: This study was to find out the influence on eyes of indoor air quality in college students taking course, such as Sick-building syndrome symptoms and effects on the eye in new-built university buildings. Methods: We selected a new building in a university located in Metro Seoul and college students in a department for the study. The number of total participants was 33, to whom questionnaire surveys were conducted in advance to check individual traits (gender, age, whether to smoke, whether to wear contact lenses, or whether to drink). The first questionnaire surveys and checking of ocular symptoms to first indoor hazardous materials were conducted in October and two months later the second surveys and checking were carried out in December. The indoor air quality was measured when conducting the first questionnaire surveys and the second questionnaire surveys; especially measurements of gaseous materials such as aldehydes and VOCs in the indoor air were conducted. Results: Indoor air quality of the new building was as follows: formaldehyde level was 22.90 ${\mu}g/m^3$ in the first measurement and 16.79 ${\mu}g/m^3$ in the second measurement. In addition, most materials showed higher value in the first measurement. The level of TVOC was statistically significant (p<0.05) decreased on 448.54 ${\mu}g/m^3$ in the first and 62.55 ${\mu}g/m^3$ in the second. In clinical assessments to check ocular symptoms caused by eye irritations, dry eye syndrome was found in the first and second exposures. When comparing the first and second assessments, dry eyes deteriorated in the morning of the second attempt compared to the first one. Conclusions: In the survey of ocular symptoms and the measurement of indoor air quality, the level of formaldehyde was measured higher in the second attempt than the first; thus, it was confirmed the influence of indoor air quality in a new building upon ocular symptoms of occupants.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.647-656
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• 2017

Purpose: This study investigated the relationship between vitamin D level and dyslipidemia in Korean adults aged 19 years and older. The data for analysis were obtained from the sixth Korea National Health Nutrition Examination Survey 2013 and 2014. Result: This study showed that 74.4% of the specified adult population had vitamin D deficiency. Moreover, the prevalence of dyslipidemia was found to be 39.6% in the same population. Dyslipidemia differed significantly according to gender (p<0.001), age (p<0.001), smoking status (p<0.001), subjective health status (p<0.001), BMI (p<0.001), blood pressure (p<0.001), FBS (p<0.001), physical activity (p<0.001), and vitamin D level (p<0.001). When vitamin D deficiency was less than 20.0 ng/mL, there was a significant risk of dyslipidemia with an odds ratio of 1.29 (95% Cl, 1.11-1.51). The relationship between vitamin D level and a diagnosis index of dyslipidemia with controlled status of physical activity was statistically significant; in Korean adults, the odds ratio for total cholesterol was 1.41 (95% CI, 1.04-1.81) and for triglyceride was 1.36 (95% CI, 1.11-1.66). Conclusion: Our results showed the relationship between vitamin D level and dyslipidemia was significant in Korean adults, and total cholesterol and triglycerides, which are indicators of dyslipidemia, was significant. Future studies, such as a more systematic cohort study investigating the relationship between vitamin D level and dyslipidemia may be helpful in confirming the causal relationship between vitamin D and dyslipidemia.

• Pediatric Infection and Vaccine
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• v.15 no.2
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• pp.152-161
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• 2008

Purpose : Staphylococcal scalded skin syndrome (4S) is uncommon, but reports of 4S are on the increase during the recent years. The purpose of this study is to determine the clinical features and associated factors of 4S during the recent 10 years. Methods : We retrospectively reviewed the medical records and microbiologic results of 63 patients (27 neonates and 36 children) from January 1998 to December 2007. Results : Since 2003, the incidence of 4S has increased. The mean age of the patients was 16.3 months and the gender ratio was 1:1. The clinical types of 4S were 38 cases of the abortive type (60%), 19 cases of the intermediate type (30%) and 6 cases of the generalized type (10%). The culture results were 36 cases of Methicillin resistant S. aureus (MRSA), 4 cases of Methicillin sensitive S. aureus and 17 cases of no growth. The patients were treated with semi-synthetic penicillin. For the 9 patients who had MRSA isolated and who didn't improve with penicillin, they were treated with vancomycin instead of penicillin. All the patients had no complications. 4S abruptly increased in 2005, and especially in neonates, due to an MRSA outbreak at a local nursery room. The associated factors of 4S in neonates were hospitalization (27 cases), including nursery infection in 2005 (18 cases) and dermatitis (1 case). There was an unknown origin for some children, and the suggested factors for their infection were community acquired infection (24 cases), atopic dermatitis (9 cases) and hospitalization (3 cases). Conclusion : 4S has recently been increasing. The major associated factors of 4S are a history of hospitalization, an outbreak in a nursery room, atopic dermatitis and community acquired infection.

• Pediatric Infection and Vaccine
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• v.20 no.1
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• pp.9-16
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• 2013

Purpose : This study aims to investigate preexposure prophylaxis and postexposure prophylaxis of rabies that the National Medical Center (NMC) handled and to check whether appropriate measures were performed according to the recent domestic and overseas guidelines after animal bites. Methods : This study surveyed 41 people who were 18 years or under and received preexposure and postexposure prophylaxis of rabies at the NMC from November 2006 to December 2011. Their medical records were reviewed for their age, gender, the reason for preexposure prophylaxis, the body sites of animal bite, the kind of the animal that bit children, the region where the biting occurred and rabies vaccination and inoculation of immunoglobulin. Results : Eleven children took rabies vaccination for preexposure prophylaxis and 30 children received post exposure prophylaxis of rabies. Of patients who were bitten by unvaccinated animals including wild animals or by animals which were not certain to be vaccinated, 50% (13 of 26 children) received postexposure prophylaxis, while 75% (3 of 4 children) of patients who were bitten by vaccinated animals received postexposure prophylaxis of rabies. Ten of 30 bitten patients knew whether or not the biting animals had received rabies vaccination. Of them, four people (40%) were bitten by animals which had received rabies vaccination. Conclusion : To prevent the occurrence of rabies, people and health care providers need to correctly understand latest guideline for rabies preexposure and postexposure prophylaxis and the information for bitten patient, biting animal and area at bitten by animal should be accurately recorded.

• Korean Journal of Biological Psychiatry
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• v.21 no.3
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• pp.99-106
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• 2014

Objectives Previous studies suggest that the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. According to linkage studies, this gene is located on chromosome 6q14-q15, which is known to harbor the schizophrenia susceptibility locus (locus 5, SCZ5, OMIM 803175). The pharmacological agent delta-9-tetrahydrocannabinol (${\Delta}$-9-THC) seems to elicit the symptoms of schizophrenia. The association between CNR1 polymorphisms and schizophrenia is actively being investigated, and some studies have linked the AAT-trinucleotide repeats in CNR1 to the onset of schizophrenia. In this study, we have investigated the association between the AAT-trinucleotide repeats in CNR1 and schizophrenia by studying schizophrenia patients and healthy individuals from Korea. Methods DNA was extracted from the blood samples of 394 control subjects and 337 patients diagnosed with schizophrenia (as per the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria). After polymerase chain reaction amplification, a logistic regression analysis, with age and gender as the covariates, was performed to study the variations in the AAT-repeat polymorphisms between the two groups. Results In total, 8 types of trinucleotide repeats were identified, each containing 7, 8, 10, 11, 12, 13, 14, and 15 repeats, respectively. $(AAT)_{13}$ allele was most frequently observed, with a frequency of 33.6% and 31.6% in the patient and control groups, respectively. The frequency of the other repeat alleles in the patient group (in the decreasing order) was as follows : $(AAT)_{13}$ 33.6%, $(AAT)_{14}$ 21.6%, $(AAT)_{12}$ 18.5%, and $(AAT)_{7}$ 11.1%. The frequency of the repeat alleles in the control group (in the decreasing order) was as follows : $(AAT)_{13}$ 31.6%, $(AAT)_{14}$ 24.5%, $(AAT)_{12}$ 17.2%, and $(AAT)_{7}$ 11.6%. However, there were no significant differences in the AAT-repeat polymorphisms of the CNR1 gene between the patient group and the control group. Conclusions Although our study revealed no significant association of the AAT-repeat polymorphism of the CNR1 gene with schizophrenia, it will serve as a good reference for future studies designed to examine the cannabinoid hypothesis of schizophrenia.

• Journal of Korean Society of Forest Science
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• v.87 no.2
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• pp.131-144
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• 1998

Understanding of the reasons why users in recreation settings select particular trails may provide useful information for effective recreation resources management. This study investigated the present use of the major trails in Mudeung-san Provincial Park and the major influential factors on trail selection. This study was conducted in Mudeung-san Provincial Park stretching over Hwasun-gun and Damyang-gun of Chonnam Province and Kwang-ju city during August in 1996. Data were collected through on-site survey and mail-back questionnaire. 519(44.2%) out of 1173 survey samples were used for analysis. Reasons for selecting a particular trail were classified into 8 major factors. In overall, the order of the importance degree of the factors was 1) aesthetics of landscape, 2) safety(from physical and crime), 3) conditions for health, 4) quietness, 5) familiarity, 6) on the way to the destination, 7) convenience/social, 8) others' intention. There were differences in the degree of importance of each factor depending on trails, users' characteristics(eg., gender, age, group size, visit experience, etc.) and users' behavioral patterns. Recreation motivations were classified into 5 major factors. The order of the importance degree of the factors was 1) contacting with nature, 2) self-training, 3) solitude, 4) social interaction, 5) appreciating cultural properties. Regardless of trails, 'contacting with nature' was the most important factor, and the degree of importance in the other 4 motivational factors showed only a little differences in order according to the trails. There were correlations between major factors for trail selection and recreation motivations. The results of this study may provide foundational information for establishing effective management strategies through better understanding of the present use of trails and influential factors on trail selection. It can be used for reducing the present social and ecological problems caused by use concentration on certain trails and providing users with better quality of diverse recreational experiences. This study discussed the findings, and suggested some management strategies based on these information.

• Journal of Nutrition and Health
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• v.41 no.8
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• pp.733-741
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• 2008

In the present study, we comprehensively examined the associations of plasma levels of total adiponectin and high molecular weight (HMW) adiponectin with the features of cardiometabolic risks including body fat distribution, dyslipidemia, insulin resistance and inflammatory markers in a cross-sectional study of 110 treated hypertensive patients. Blood lipid profiles, high sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA- IR) derived from fasting glucose and insulin concentrations were determined. Plasma levels of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) were analyzed using ELISA. The results showed that plasma levels of HMW-adiponectin were negatively associated with body mass index (BMI, r = - 0.203, p < 0.05) and waist circumference (r = -0.307, p < 0.01), which was not shown in total adiponectin. Plasma levels of HMW-adiponectin were negatively associated with triglyceride (r = -0.223, p < 0.05) and positively associated with HDL-cholesterol (r = 0.228, p < 0.05). Plasma levels of adiponectin were positively associated with HDL-cholesterol (r = 0.224, p < 0.05). Plasma levels of HMW-adiponectin were negatively associated with hsCRP (r = -0.276, p < 0.01) and IL-6 (r = -0.272, p < 0.01). In addition, there were weak associations between plasma levels of HMWadiponectin and TNF-${\alpha}$ (r = -0.163, p = 0.07) and ICAM-1 (r = -0.158, p = 0.09). However, there were no significant associations of total adiponectin with inflammatory markers except hsCRP (r = -0.203, p < 0.05). Stepwise multiple linear regression analysis showed that only plasma levels of HMW-adiponectin was an independent factor influencing serum levels of hsCRP, a marker of systemic low grade inflammation, after adjusting for age, gender, BMI, waist circumference, alcohol intake, smoking status, blood lipids, total adiponectin and drug use (p < 0.01). These results suggest that HMW-adiponectin, rather than total adiponectin, is likely to be closely associated with the features of cardiometabolic risks in treated hypertensive patients and might be effective biomarker for the prediction of cardiovascular disease.

• Tuberculosis and Respiratory Diseases
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• v.62 no.2
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• pp.113-118
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• 2007

Background: Paraquat is known to induce oxidant injury that results in multiorgan failure and lung fibrosis. Iron has been considered to play a key role in paraquat-induced oxidant lung injury. This study examined the effect of deferoxamine, an iron-chelating agent, in the treatment of paraquat poisoning. Methods: From September, 2001 to April, 2005, 28 patients with paraquat poisoning who were admitted at a medical intensive care unit of a University-affiliated hospital, were enrolled in this study. Sixteen patients were treated according to the paraquat poisoning treatment guidelines and 12 received an intravenous infusion of deferoxamine in addition to the treatment guidelines. Results: There were no differences between the two groups in terms of age, gender, severity of paraquat poisoning, and the time elapsed from ingestion to presentation at hospital. There was no difference in overall mortality between the two groups but the incidence of respiratory failure in the deferoxamine group was higher than in the conventional group(4/7 versus 0/9, p=0.019). Conclusion: Deferoxamine seems to have no clinical benefit compared with the conventional treatment.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.5
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• pp.15-29
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• 2021

This study is based on ERIS model for start-up performance, and aims to derive the main reason for start-up sustainability centered on organizational resilience. To this end, systematic literature examination and modified Delphi method were used to investigate start-up sustainability factors based on ERIS Model focused on organizational resilience. The results showed that ERIS model-based entrepreneurial continuity factors were divided into four categories: entrepreneur, resource, industrial environment, strategy, subdivision 8 and detailed factors 54. In addition, the ERIS model-based continuity factors were structured around organizational resilience, and the continuity factors were structured according to ERIS model under five categories: leadership, culture, people, system and environment. The results of this study are as follows. First of all, the results of existing research and analysis show that the concept of successful start-up and sustainability of start-up are used in various fields. Second, it is confirmed that there are common factors of influence on start-up performance and start-up sustainability based on ERIS model. Third, Delphi method's results showed that the general characteristics of entrepreneurs, such as academic background, education level, gender, age, and business experience did not affect the sustainability of entrepreneurship. This study is significant in that it is based on ERIS model focused on organization resilience, and ERIS-R, which integrates Strategy into System and Organization resilience into R in the field of gradually expanding start-up development and support. It is expected that the results of this study will improve the sustainability of start-up that can predict, prevent, and overcome various crises at any time.

• 한국체육학회지인문사회과학편
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• v.54 no.5
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• pp.867-876
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• 2015

This study was intended to closely examine an effect that the level of physically challenged person's participation in community sports had on positive psychological capital. In order to accomplish the purpose of study, data on 212 physically challenged persons who lived in B city and participated in community sports were analyzed. Korean version of positive psychological capital created by Taehong Lim (2014) through the reconstruction of scales developed by Luthans, Youssef and Avolio(2007) and Sangwan Jeon and Jonghun Yang's (2009) level of participation in community sports was reconstructed through modification·improvement as measurement instrument. An exploratory factor analysis, reliability test, paired difference test, and multiple regression analysis was carried out by using SPSS 18.0 program for data processing. First, It was shown that there was a significant difference in positive psychological capital according to gender, age, and disability grade among physically challenged persons' socio-demographic characteristics. Second, it was shown that, among sub-variables (period, frequency and intensity) of level of physically challenged persons' participation in community sports, the frequency of participation and the intensity of participation had a significant effect on self efficacy. On the other hand, it was shown that the period of participation didn't have a significant effect. Third, it was shown that the frequency of participation had a significant effect on optimism. On the other hand, it was shown that the period of participation and the intensity of participation didn't have a significant effect. Fourth, it was shown that the frequency of participation and the intensity of participation had a significant effect on hope. On the other hand, it was shown that no significant effect was produced on the period of participation. Fifth, it was shown that the frequency of participation had a significant effect on resilience. On the other hand, it was shown that no significant effect was produced on the period of participation and the intensity of participation. Sixth, it was shown that the frequency of participation and the intensity of participation had a significant effect on positive psychological capital. And it was shown that no significant effect was produced on the period of participation.