• Parasites, Hosts and Diseases
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• 제47권1호
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• pp.25-29
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• 2009

Paragonimus harinasutai metacercariae were found in a species of freshwater crab, Indochinamon ou, collected in a small stream of Namback District, Luang Prabang Province, Lao PDR. Adult flukes were recovered after experimental infection of the metacercariae to dogs. Metacercariae were round or slightly elliptical, $0.666{\times}0.626\;mm$ in average size, and had a thin cyst wall of about $20{\mu}m$ in thickness, a black excretory bladder, convoluted ceca, and some pinkish materials in the body. Adults were somewhat elongated, $95.2{\times}36.5\;mm$ in average size, covered with single-tipped tegumental spines, had a smaller oral sucker than the ventral sucker, a moderately branched ovary, and 5-6 lobulated testes. Eggs were ovoid and bilaterally symmetrical in shape, $79{\times}45{\mu}m$ in average size, and had a uniformly thickened shell. By the present study, it has been confirmed that I. ou is a new second intermediate host for P. harinasutai.

• Ocean and Polar Research
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• 제38권1호
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• pp.81-88
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• 2016

In many fish species, including Nile tilapia (Oreochromis niloticus), gonadal development occurs at the expense of stored energy and nutrients. Therefore, reproductive systems are inhibited by limited food supply. It has been well established that reproductive function is highly sensitive to both metabolic status and energy balance. Nothing is known about the possible mediated connection between energy balance and reproduction. Kisspeptin, a neuropeptide product of the Kiss gene has emerged as an essential gatekeeper of reproduction and may be possibly be linked to energy balance and reproduction in non-mammalians. Thus, in this study, the effect of fasting (10 days) on the expression of kisspeptin and the gonadotropin-releasing hormone (GnRH) gene were assessed in Nile tilapia (male and female) using qRT-PCR. In addition, plasma levels of estradiol-$17{\beta}$ ($E_2$) and 11-ketotestosterone (11-KT) in adult tilapia were measured by ELISA. In male tilapia, fasting reduced Kiss2 and GnRH I mRNA expression in the brain and 11-KT level in comparison with the fed tilapia (p < 0.05). In females, however, there were no significant differences in GnRH I mRNA expression and $E_2$ between fish subjected to fasting and those fed (p > 0.05). These data indicate the impact of nutritional states on kisspeptin as a potential regulatory mechanism for the control of reproduction in male Nile tilapia.

• 대한한의진단학회지
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• 제14권2호
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• pp.101-109
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• 2010

Objectives: This study intends to identify the Effects of Oriental Medicine Gigong Exercise on patients with the metabolic syndrome. Method: The study was performed with one group in a pre-test/post-test design. The subjects were patients with metabolic syndrome in K city, Kyung-Nam. A total of 24 subjects were selected by convenience sampling. The data were collected by using questionnaires and measured values from March, 2009, to May, 2009. The Oriental Medicine Gigong Exercise program consists of 90-minute sessions three times a week over 12 weeks. Prior and post surveys were measured before and after experiment a treatment. The date were analyzed by SPSS/WIN 12.0 program with descriptive statistics, paired t-test, wilcoxon rank sums test. Results: The results were as follows : 1) In of physical strength, body fat %(p=0.014) was decreased significantly, 'agility'(p=0.004) & 'flexibility'(p=0.031) were increased significantly after program. 2) In blood function, systolic blood pressure (P=0.013), diastolic blood pressure (P=0.001) were decreased significantly, HDL (P=0.001) was increased significantly after program. Conclusions: The Oriental Medicine Gigong Exercise program improve their physical strength and blood function, therefore this program is strongly recommended for adult with metabolic syndrome in community.

• 산업융합연구
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• 제16권3호
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• pp.1-7
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• 2018

본 연구는 지역사회 노인의 일반적 특성 및 건강관련 특성을 조사하여, 낙상두려움 요인을 규명하고, 낙상두려움, 낙상태도 및 낙상효능감과의 관계를 파악하기 위한 서술적 조사연구이다. 연구대상자는 D시의 복지관을 이용하는 노인 140명이었다. SPSS 21.0 프로그램을 이용하여 분석하였다. 연구결과 성별, 동거인, 주관적 건강상태, 통증, 불안전한 걸음걸이에서 낙상두려움의 차이가 있었다. 낙상두려움과 낙상태도(r=-.396, p<.001), 낙상두려움과 낙상효능감(r=-.184, p=.030)은 유의한 음의 상관관계를 보였고, 낙상태도와 낙상효능감(r=.411, <,001)은 양의 상관관계를 보였다. 본 연구결과에 기초하여 낙상두려움, 낙상태도 및 낙상효능감을 향상시킬 수 있는 낙상예방프로그램 개발 및 적용이 필요하다.

• 디지털융복합연구
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• 제20권4호
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• pp.759-768
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• 2022

본 연구의 목적은 코로나 19 장기화로 지역사회주민 만성질환 예방 관리를 위해 온라인 기반 만성질환관리 비대면 프로그램을 적용하여 그 효과를 확인하기 위한 단일군 전후 설계 유사실험 연구이다. 본 연구의 프로그램은 간호, 영양, 운동 프로그램으로 12주간 실시하였다. 대상자는 보건소 만성질환 관리센터를 이용하는 성인 남녀 69명으로 2021년 5월 3일부터 8월 6일까지 프로그램 적용 전후 수축기압, 이완기압, 공복 혈당, BMI와 우울, 삶의 질의 설문 도구를 사용하여 조사하였다. 자료 분석은 SPSS 20.0을 이용하여 분석하였다. 연구 결과, 수축기압, 이완기압, 공복혈당이 유의하게 감소하였으며, 삶의 질에서도 유의하게 나타났다. 우울은 유의하지 않았으나 경중 우울이 감소하였다. 따라서 위드 코로나 시대에 지속적인 만성 질환 관리를 위해 다양한 비대면 프로그램 프로그램을 개발하여 적용 관리한다면 심뇌혈관질환으로 이행을 방지하고 만성질환 예방 및 건강 유지 증진에 기여할 것이라 사료된다.

• Fisheries and Aquatic Sciences
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• 제25권8호
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• pp.450-461
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• 2022

A randomized, double-blind, and placebo-controlled clinical study was used to determine the cognitive functions related to working memory (WM) and antioxidant properties of fermented Laminaria japonica (FLJ) on healthy volunteers. Eighty participants were divided into a placebo group (n = 40) and FLJ group (n = 40) that received FLJ (1.5 g/day) for 6 weeks. Memory-related blood indices (brain-derived neurotrophic factor, BDNF; angiotensin-converting enzyme; human growth hormone, HGH; insulin-like growth factor-1, IGF-1) and antioxidant function-related indices (catalase, CAT; malondialdehyde, MDA; 8-oxo-2'-deoxyguanosine, 8-oxo-dG; thiobarbituric acid reactive substances, TBARS) were determined before and after the trial. In addition, standardized cognitive tests were conducted using the Cambridge Neuropsychological Test Automated Batteries. Furthermore, the Korean Wechsler Adult Intelligence Scale (K-WAIS)-IV, and the Korean version of the Montreal Cognitive Assessment (MoCA-K) were used to assess the pre and post intake changes on WM-related properties. According to the results, FLJ significantly increased the level of CAT, BDNF, HGH, and IGF-1. FLJ reduced the level of TBARS, MDA, and 8-oxo-dG in serum. Furthermore, FLJ improved physical activities related to cognitive functions such as K-WAIS-IV, MoCA-K, Paired Associates Learning, and Spatial Working Memory compared to the placebo group. Our results suggest that FLJ is a potential candidate to develop functional materials reflecting its capability to induce antioxidant mechanisms together with WM-related indices.

• 대한한방소아과학회지
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• 제36권3호
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• pp.1-18
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• 2022

Objectives The purpose of this study was to investigate the current status of interventional clinical trial registration for children with precocious puberty and to secure basic data for the design of clinical trials for traditional Korean medicine treatment of precocious puberty. Methods The following resources were used to search for data: Clinicaltrial.gov, World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), and Clinical Research Information Service (CRIS), using the search terms, 'Precocious puberty', 'child'. All clinical trials which were registered as of June 2022 were used. Results For the intervention and clinical trial design, gonadotropin releasing hormone (GnRH) analog was reported in 41.7% of trials, and single group assignment was performed in 66.7% of the studies. Prior consent had not been reported in 50% of the studies. Tanner stage and GnRH stimulation tests were reported by multiple trials as inclusion criteria, and prior treatment experiences for trial drugs were reported as exclusion criteria. The peak serum concentration of luteinizing hormone following GnRH stimulation test was used as a primary outcome in 45.8% of clinical trials, and other growth-related indicators such as growth rate, height, and predicted adult height were also reported. Conclusions In consideration of the design, eligibility criteria, and outcome measurement of the existing clinical trials identified in this study, it should be referred to in the design of clinical trials for traditional Korean medicine treatment of precocious puberty.

• Tuberculosis and Respiratory Diseases
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• 제86권3호
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• pp.216-225
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• 2023

Background: Tuberculosis (TB)-related stigma has been well-documented. Since the emergence of the coronavirus disease 2019 (COVID-19), different organizations have been alerted to the fact that stigma could arise again. Due to stigma's negative effects, this qualitative study aimed to explore the stigma felt by patients by evaluating the following: COVID-19 stigma and its temporal progression through the pandemic; stigma perceived by different patients with TB before and during COVID-19 pandemic; and difference perceived by individuals who contracted both diseases. Methods: A semi-structured interview was developed according to the available literature on the theme. It was performed individually in 2022 upon receiving signed informed consent. Participants were recruited with a purposive sampling approach by searching medical records. Those who currently or previously had pulmonary TB and/or COVID-19 were included. Data were subjected to thematic analysis. Results: Nine patients were interviewed, including six (66.7%) females. The median age of patients was 51±14.7 years. Four participants (44.4%) had completed high school and four (44.4%) were never smokers. Three had both TB and COVID-19. Four only had TB and two only had COVID-19. Interviews identified eight main themes: knowledge and beliefs, with several misconceptions identified; attitudes towards the disease, varying from social support to exclusion; knowledge and education, assumed as of extreme importance; internalized stigma, with self-rejection; experienced stigma, with discrimination episodes; anticipated stigma, modifying actions for avoiding stigma; perceived stigma, with judgment by others prevailed; and temporal evolution of stigma. Conclusion: Individuals expressed strong stigma for both diseases. De-stigmatization of respiratory infectious diseases is crucial for limiting stigma's negative impact.

• 한국간호교육학회지
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• 제30권2호
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• pp.101-112
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• 2024

Purpose: The study aimed to examine doctoral students' degree acquisition paths and postgraduate research achievements and explore whether there are differences in the research achievements of doctoral degree holders in relation to the dissertation format. Methods: This study is a retrospective cohort study of nursing doctoral graduates whose degree conferral dates were between August 2013 and August 2023 that compared two dissertation tracks: traditional and publication. We evaluated the proportion of graduates in each track, publication of their dissertations, time to graduation, and the number of peer-reviewed journal publications after graduation. Results: Of the sample, 160 (87.4%) graduated in the traditional track, with only 56 (35.0%) of them publishing their dissertations after graduation. Excluding dissertations, 114 of the graduates (71.3%) published first-authored articles in the traditional track, while 12 (52.2%) did so in the publication track. The time to graduation was significantly shorter in the traditional track, with an average of 5.47±2.45 years, compared to 6.61±2.57 years in the publication track (z=2.26, p=.023). In the traditional track, 64 of graduates (40.0%) majored in adult health nursing, whereas in the publication track, 8 (34.8%) studied community health nursing. Conclusion: This study emphasizes the significance of the publication track for nursing doctoral dissertations in terms of research dissemination. Despite its numerous advantages, it is not yet the preferred choice for both students and faculty. Maintaining the publication track as an additional graduation option is worthwhile, as it allows students to gain research publishing experience before graduation and to effectively disseminate scientific findings in nursing.

• 한국산학기술학회논문지
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• 제15권8호
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• pp.5009-5022
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• 2014

본 연구는 한 대학병원 건강검진센터에서 종합건강검진을 받은 일반 성인들을 대상으로 생활습관에 따른 혈청지질치의 수준을 알아보고, 생활습관 인자들이 혈청지질치에 미치는 영향을 파악하고자 하였다. 조사대상은 2012년 1월부터 2013년 12월까지의 기간에 대전광역시에 소재하고 있는 C대학교병원 건강검진센터에서 건강검진을 받았던 4,112명을 대상으로 하였다. 자료 수집은 건강검진 시에 수검자들에게 배포하여 기입하도록 한 문진표와 건강검진결과표로부터 인구사회학적 특성, 생활습관 및 혈청지질치 등의 자료를 수집하여 분석하였다. 연구결과, 조사대상자의 TC, HDL-C. LDL-C 및 TG 등의 혈청지질치나 동맥경화지수(AI)의 평균치는 남녀 모두 연령, 음주, 흡연, 규칙적인 운동, 과식 및 육류섭취 등의 생활습관 특성에 따라 유의한 차이를 보였다. 조사대상자의 TC, HDL-C. LDL-C, TG 및 AI는 남녀 모두 연령, AUDIT점수와 유의한 양의 상관관계를 나타낸 반면, HPI점수와는 유의한 음의 상관관계를 보였다. 조사대상자의 혈청지질치에 대한 생활습관의 영향요인으로 TC, HDL-C. LDL-C, TG 및 AI가 비정상치에 속할 위험비는 남녀 모두 과식을 매일 한다는 군, 육류섭취를 매일 한다는 군, 흡연군, 규칙적인 운동을 하지 않는다는 군, HPI가 낮은 군에서 그렇지 않다는 군보다 유의하게 증가하였다. 이상과 같은 결과는 조사대상자의 혈청지질치나 AI는 연령증가와 함께 음주, 흡연, 규칙적인 운동, 과식 및 육류 섭취 등의 생활습관 특성에 따라 영향을 받고 있음을 시사한다.