• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권3호
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• pp.384-389
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• 1994

A female child with unilateral midpalatal cleft was successfully treated by Wardill V-Y pushback palatal flap and superiorly based pharyngeal flap simultaneously. The advantages of this method are to prepare the favorable background of postoperative speech correction and additional nasal lining. We can try this simultaneous operation in delayed cleft palate repair.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제18권1호
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• pp.31-37
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• 2007

Objectives : A voxel based investigation of cerebral blood flow was conducted to identify functional differences during resting state between children with early-onset schizophrenia and normal controls. Methods : 19 children and adolescents with early-onset schizophrenia(8 boys and 11 girls, mean age $14.0{\pm}1.7$ years old) and 17 comparison children(13 boys and 4 girls, mean age $11.0{\pm}1.9$ years old) were examined by HMPAO-SPECT. The SPECT images were compared using statistical parametric mapping analyses, controlling for age and sex. Results : Increased cerebral blood flow in left medial and inferior frontal gyrus, right superior and middle frontal gyrus, both inferior temporal gyrus, and right cerebellar tonsil was found in children and adolescents with early-onset schizophrenia compared to control subjects. In addition, decreased cerebral blood flow in right thalamus, left posterior cingulate gyrus, right anterior cingulate gyrus and relatively wide areas from left medical frontal gyrus to superior parietal lobule were found in children and adolescents with early-onset schizophrenia compared to control subjects. Conclusion : The results of the current study provide additional evidences for brain areas involving the onset of schizophrenia in early age.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제28권2호
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• pp.115-122
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• 2017

Objectives: Executive dysfunctions including working memory deficit have been suggested to be one of the major neuropsychological etiologies of attention-deficit hyperactivity disorder (ADHD). The purpose of this study was to investigate the augmentative effects of working memory training on the behavioral problems, quality of life, and parental stress of medicated children with ADHD. Methods: Twenty-five children with ADHD, aged 9 to 19 years, who were being treated with ADHD medication, were included. The participants were trained with a commercially available and computerized working memory program ($Cogmed^{(R)}$) for 5 weeks without any alteration of their medication. The Child Behavior Checklist (CBCL), KIDSCREEN-52 quality of life measure, and Parenting Stress Index-Short Form (PSI-SF) were administered before training, and 4 weeks and 7 months after training, respectively. Results: After completing the training, the anxiety/depression, social problems, thought problems, attention problems, aggressive behavior, and externalizing problems scores in the CBCL were significantly reduced. The score on the Parent-child dysfunctional interaction in the PSI-SF was also decreased. However, the scores related to the quality of life were not changed. These changes were still observed 7 months after the training. Conclusion: Cogmed working memory training can be a promising training option for the additional improvement of behavioral problems and parental stress in medicated children with ADHD.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 춘계학술대회
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• pp.152-154
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• 2015

대부분의 청각장애를 가진 부모들이 육아를 하면서 가장 힘든 점은 아이의 울음소리를 듣지 못한다는 점이다. 그래서 아이가 배가 고파서 울거나 귀저기를 갈아달라고 소리 내어 울 때에도 즉각적으로 대처가 불가능하기 때문에 별도의 장비나 다른 사람의 도움을 받아야 한다. 또한 아이를 방에 재워두고 일을 하려고 해도 수시로 아이의 방을 체크해야하고 긴장을 늦추지 못해 마음 놓고 집안일이나 개인 업무를 할 수 없다. 이러한 육아의 어려움을 해결하기 위해 IT기술을 이용하여 부모의 귀 대신 아이의 울음소리를 측정하는 마이크를 장착한 아두이노를 이용한 디바이스와 사용자에게 알림을 제공하는 안드로이드 애플리케이션을 개발하여 해결하고자 한다. 본 시스템은 아이와 부모가 떨어져 있어도 아이의 소리를 알려줌으로써 청각장애를 가진 부모와 아이의 커뮤니케이션에 도움이 될 수 있다.

• Journal of the Korean Data and Information Science Society
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• 제28권1호
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• pp.1-10
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• 2017

경시적 자료를 이용한 아동 학업성취도에 영향을 주는 요인을 찾기 위한 기존의 분석들은 각 아동의 반복 측정된 자료들이 독립이라고 가정한 모형을 주로 이용하였다. 본 연구에서는 기존 연구들에서 고려한 아동 학업성취도에 영향을 주는 변수들을 선택하여 반복 측정된 경시적 자료의 종속성을 고려한 고정효과와 임의효과를 포함하는 선형혼합모형으로 분석하여 아동 학업성취도에 영향을 주는 변수들은 무엇인지, 각 아동의 특성들이 반영되는 임의절편과 임의기울기가 있는지를 파악하는 것이 연구의 목적이다. 본 연구에 사용된 자료는 한국복지패널 1, 4, 7차 부가조사 중에서 아동용 설문문항에 대한 자료이고, 국어, 영어와 수학의 학업성취도 점수의 합을 아동 학업성취도로 한다. 선형혼합모형을 이용한 분석 시에 다중공선성의 검토와 결측치의 특성을 파악하고 적절한 오차의 상관행렬을 선택한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7357-7362
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• 2014

Interleukin-6 (IL-6), a central proinflammatory cytokine, maintains immune homeostasis and also plays important roles in cervical cancer. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms at positions -174 and -572 with predisposition to cervical cancer in a Chinese population. The present hospital-based case-control study comprised 518 patients with cervical cancer and 518 healthy controls. Polymorphisms of the IL-6 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Patients with cervical cancer had a significantly higher frequency of the IL-6 -174 CC genotype [odds ratio (OR) =1.52, 95% confidence interval (CI) = 1.06-2.19; p=0.02], IL-6 -572 CC genotype (OR =1.91, 95% CI = 1.16-3.13; p=0.01) and IL-6 -174 C allele (OR =1.21, 95% CI = 1.02-1.44; p=0.03) compared to healthy controls. When stratifying by the FIGO stage, patients with III-IV cervical cancer had a significantly higher frequency of IL-6 -174 CC genotype (OR =1.64, 95% CI =1.04-2.61; p=0.04). The CC genotypes of the IL-6 gene polymorphisms at positions -174 and -572 may confer a high risk of cervical cancer. Additional studies with detailed human papillomavirus (HPV) infection data are warranted to validate our findings.

• Clinical and Experimental Pediatrics
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• 제57권3호
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• pp.117-124
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• 2014

Purpose: Administration of antiretroviral drugs to mothers and infants significantly decreases mother-to-child human immunodeficiency virus (HIV) transmission; cesarean sections and discouraging breastfeeding further decreases this risk. The present study confirmed the HIV status of babies born to mothers infected with HIV and describes the characteristics of babies and mothers who received preventive treatment. Methods: This study retrospectively analyzed medical records of nine infants and their mothers positive for HIV who gave birth at Korea University Ansan Hospital, between June 1, 2003, and May 31, 2013. Maternal parameters, including HIV diagnosis date, CD4+ count, and HIV ribonucleic acid (RNA) copy number, were analyzed. Infant growth and development, HIV RNA copy number, and HIV antigen/antibody test results were analyzed. Results: Eight HIV-positive mothers delivered nine babies; all the infants received antiretroviral therapy. Three (37.5%) and five mothers (62.5%) were administered single- and multidrug therapy, respectively. Intravenous zidovudine was administered to four infants (50%) at birth. Breastfeeding was discouraged for all the infants. All the infants were negative for HIV, although two were lost to follow-up. Third trimester maternal viral copy numbers were less than 1,000 copies/mL with a median CD4+ count of $325{\mu}L$ ($92-729{\mu}L$). Among the nine infants, two were preterm (22.2%) and three had low birth weights (33.3%). Conclusion: This study concludes that prophylactic antiretroviral therapy, scheduled cesarean section, and prohibition of breastfeeding considerably decrease mother-to-child HIV transmission. Because the number of infants infected via mother-to-child transmission may be increasing, studies in additional regions using more variables are necessary.

• 대한한의학원전학회지
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• 제26권1호
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• pp.131-150
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• 2013

Subject : The Imminent Labor Pulse(臨産 離經脈, extra-meridian pulse approaching labor) is one of many practical clinical knowledges, unique to Traditional Korean(Eastern) Medicine. Objective : This research explores the origin and change of perception on the subject throughout history, with objective to sort out practical knowledge applicable in the clinic of today. Also, it draws clinical meaning of pulse diagnosis according to the physiological theories, and suggests directions for future clinical researches. Method : First, the Imminent Labor Pulse was examined based on major publications such as the "Nanjing", "Maijing" and theories of major doctors. Second, this previous study was examined through clinical observation research. Third, further research was carried out on pulse theory according to the Traditional Medical theories. Fourth, their clinical practicality and points of further research were sorted out. These points need to be examined through additional clinical research. Conclusion : The following conclusions could be drawn from study of the Imminent Labor Pulse. From the Imminent Labor Pulse which indicated the beginning of the first period of labor in the "Maijing", it developed into trying to grasp the beginning of the second period of labor which is the actual time of labor, through "Zhubingyuanhoulun" and "Shizaizhifang". By Xueji, another pulse that could be felt on the middle finger of the mother had been discovered. The middle finger is where the Pericardium Meridian flows. The child's connection to the uterus becomes disconnected on the first period, but that with the Pericardium meridian which provides blood meridian to the Taichongmai of the child continues throughout labor until the umbilicus chord is cut. Therefore, this middle finger pulse could serve as showing the heart condition of the mother and child during labor. The time of its appearance and disappearance, and their correlation with the child's heartbeat need to be clinically examined.

• 아동학회지
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• 제34권6호
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• pp.97-122
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• 2013

The aim of this study was to develop and validate measures of a mother's reaction to children's negative emotions. After construct factors of a mother's reaction to children's negative emotions based on the theoretical basis and existing scales were explored, the first preliminary items were extracted. After the content validity was confirmed by expert opinions, the second preliminary items were composed, and the initial survey was carried out. Using exploratory factor analysis, three principal factors and 21 items were revealed to be most suitable. The factors of the scale consist of emotion-coaching-reactions, oversensitive reactions, and emotion-minimizing-reactions, respectively. In addition, the reliability analysis and validation analysis of the scale was conducted, by means of surveying 413 elementary students. The internal coherence reliability and test-retest reliability were verified as was the general internal coherence and timing stability of the scale. There were three additional verifications to validate the scale. (1)For the evidence based on internal structure, the confirmatory factor analysis and convergent-discriminant evidence; this resulted in confirming the factor structure of the scale as being reliable. (2)In order to understand the relationships to other variables, the correlation analysis came in effect to the overall scale and each of its sub-factors, showing that they are significantly correlated with the scale of the child's perception on rearing attitudes of the mother. (3)As for evidence based on the consequences of the test, the correlation analysis produced a result showed that sub-factors of the scale have as significant correlation with the child's emotional intelligence and resilience.

• Clinical and Experimental Pediatrics
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• 제62권7호
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• pp.281-285
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• 2019

Purpose: To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE). Methods: An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE included all children with a history of SE; control included all children with febrile seizure. Blood samples of patients were drawn within 24 hours after admission. SE patients also underwent cranial MRI with additional DTI sequencing. The Mann-Whitney test and Spearman test were used for statistical analysis. Results: Fifty-three patients were enrolled the study. In the 24 children with SE who met the inclusion criteria, serum S100B and cranial MRI findings were assessed. Twenty-two children admitted with febrile seizures became the control group. Most patients were male (66.7%); the mean age was 35.8 months (standard deviation, 31.09). Mean S100B values of the SE group ($3.430{\pm}0.141{\mu}g/L$) and the control group ($2.998{\pm}0.572{\mu}g/L$) were significantly different (P<0.05). A significant difference was noted among each level of encephalopathy based on the cranial MRI results with serum S100B levels and the correlation was strongly positive with a coefficient value of 0.758 (P<0.001). Conclusion: In SE patients, there is an increase of serum S100B levels within 24 hours after seizure, which has a strong positive correlation with brain damage seen in head MRI and DTI.