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Evaluation of electron dose distribution obtained from ADAC Pinnacle system against measurement and Monte Carlo method for breast patients

  • Lee, S.;Lee, R.;Park, D.;S. Suh
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2003.09a
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    • pp.82-82
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    • 2003
  • Introduction: With the development of dose calculation algorithms for electron beams, 3D RTP systerns are available for electron beam dose distribution commercially. However, no studies evaluated the accuracy of dose calculation with ADAC Pinnacle system for electron beams. So, the accuracy of the ADAC system is investigated by comparing electron dose distributions from ADAC system against the BEAMnrc/DOSXYZnrc. Methods: A total of 33 breast cancer patients treated with 6, 9, and 12MeV electrons in our institution was selected for this study. The first part of this study is to compare the dose distributions of measurement, TPS and the BEAMnrc/DOSXYZnrc code in flat water phantom at gantry zero position and for a 10 ${\times}$ 10 $\textrm{cm}^2$ field. The second part is to evaluate the monitor unit obtained from measurement and TPS. Adding actual breast patient's irregular blocks to the first part, monitor units to deliver 100 cGy to the dose maximum (dmax) were calculated from measurement and 3D RTP system. In addition, the dose distributions using blocks were compared between TPS and the BEAMnrc/DOSXYZnrc code. Finally, the effects of tissue inhomogeneities were studied by comparing dose distributions from Pinnacle and Monte Carlo method on CT data sets. Results: The dose distributions calculated using water phantom by the TPS and the BEAMnrc/ DOSXYZnrc code agreed well with measured data within 2% of the maximum dose. The maximum differences of monitor unit between measured and Pinnacle TPS in flat water phantom at gantry zero position were 4% for 6 MeV and 2% for 9 and 12 MeV electrons. In real-patient cases, comparison of depth doses and lateral dose profiles calculated by the Pinnacle TPS, with BEAMnrc/DOSXYZnrc code has generally shown good agreement with relative difference less than +/-3%. Discussion: For comparisons of real-patient cases, the maximum differences between the TPS and BEAMnrc/DOSXYZnrc on CT data were 10%. These discrepancies were due in part to the inaccurate dose calculation of the TPS, so that it needs to be improved properly. Conclusions: On the basis of the results presented in this study, we can conclude that the ADAC Pinnacle system for electron beams is capable of giving results absolutely comparable to those of a Monte Carlo calculation.

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Application of ZVI/TiO2 towards Clean-up of the Contaminated Soil with Polychlorinated Biphenyls (ZVI/TIO2를 이용한 폴리염화비페닐로 오염된 토양 정화)

  • Jae Wook Park;Yun Jin Jo;Dong-Keun Lee
    • Clean Technology
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    • v.29 no.2
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    • pp.118-125
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    • 2023
  • Once a site is contaminated with polychlorinated biphenyls (PCBs), serious environmental and human health risks are inevitable. Therefore, innovative but economical in situ remediation technologies must be immediately applied to the contaminated site. Recently, nanoscale zero-valent iron (nano-ZVI) particles have successfully been applied for the dechlorination of various chlorinated organic compounds like TCE, PCE and DDT, and they are considered to be environmentally safe due to the high abundance of iron in the earth's crust. Nano-ZVIs are much more reactive than granular ones, but tend to agglomerate due to their high surface energy and magnetic properties. In order to prevent them from being agglomerated toward larger particles, TiO2 was used as a support to immobilize the nano-ZVI particles as much as possible. 10wt% ZVI/TiO2 was prepared by adding NaBH4 slowly into an FeSO4/TiO2 aqueous slurry. In spite of their non-uniformity in size, the nano-ZVI particles were quite successfully dispersed onto the exterior surface of a non-porous TiO2 powder. The ZVI/TiO2 was then employed to degrade Aroclor 1242, a kind of PCBs standard, in spiked soil, and its reactivity towards the degradation of Aroclor 1242 was investigated. The fabricated ZVI/TiO2 degraded Aroclor 1242 in soil quite effectively, but the creation of remaining dechlorinated compounds, possibly high molecular weight hydrocarbons, in the soil was unavoidable.

Bioequivalence of Mepiril Tablet to Amaryl Tablet (Glimepiride 2 mg) by Liquid Chromatography/Electrospray Tandem Mass Spectrometry

  • Lee, Heon-Woo;Cho, Sung-Hee;Park, Wan-Su;Im, Ho-Taek;Rew, Jae-Hwan;Lee, Kyung-Tae
    • Journal of Pharmaceutical Investigation
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    • v.35 no.4
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    • pp.287-293
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    • 2005
  • The purpose of the present study was to evaluate the bioequivalence of two glimepiride tablets, Amaryl tablet (Handok & Aventis Korea, reference drug) and Mepiril tablet (Myungmoon Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (glibenclamide) to human plasma, plasma samples were extracted using 1mL of methyl tertiary butyl ether. Compounds extracted were analyzed by reverse-phase HPLC with multiple reaction monitoring (MRM) mode analyte detection. This method for determination glimepiride proved accurate and reproducible, with a limit of quantitation of 2 ng/mL in human plasma. Twenty-four healthy male Korean volunteers received each medicine at the glimepiride dose of 2 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of glimepiride were monitored by a LC-MS/MS for over a period of 12 hr after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Amaryl/Mepiril were log 0.9583-log 1.1357 and log 1.0570-log 1.2376, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Taken together, our study demonstrated the bioequivalence of Amaryl and Mepiril with respect to the rate and extent of absorption.

A Novel ZCS PWM Boost Converter with operating Dual Mode (Dual 모드로 동작하는 새로운 ZCS PWM Boost 컨버터)

  • 김태우;김학성
    • The Transactions of the Korean Institute of Power Electronics
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    • v.7 no.4
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    • pp.346-352
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    • 2002
  • A novel Zero Current Switching(ZCS) Pulse Width Modulation(PWM) boost converter with dual mode for reducing two rectifiers reverse recovery related losses is proposed. The switches of the proposed converter are operating to work alternatively turn-on and turn-off with soft switching condition In the every cycle and the proposed converter reduces the reverse recovery current, which is related switching losses and EMI problems, of the free-wheeling diode$(D_1, D_2)$ by adding the resonant inductor Lr, in series with the switch $S_1$. The switching components$(S_1, S_2, D, D_1)$ in the proposed boost converter are subjected to minimum voltage and current stresses same as those in their PWM counterparts because there are no additional active switches and resonant elements compared with the conventional ZVT PWM $converters^{[2]}$. The operation of the proposed converter, in this paper, is analyzed and to verify the feasibility of the characteristics is built and tested.

Performance of the CDMA Receiver with PN Sequence Orthogonal Reception Process (PN 부호의 직교 수신 방식을 이용한 CDMA 수신기 성능)

  • Hyun, Kwang-Min;Yoon, Dong-Weon;Park, Sang-Kyu
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.28 no.4A
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    • pp.200-207
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    • 2003
  • This paper proposes a CDMA receiver structure with time-shifted m-sequence orthogonal reception process, and analyzes the output SNR performance and the characteristics of the orthogonal receiver. This structure can be simply implemented with the converntional receiver adding an additional integrator path in parallel and an adder sums the conventional path and the new path output signals. The structure provides to reference user signal not only increment of signal component but also perfect orthogonal characteristic, canceling the accumulated cross-correlated value out to zero between the reference user and other user signals. Hence, the proposed structure can be applied for channel impulse response measurement, and used for multi-user interference signal cancellation and channel capacity increment by flexible structural inter-working operation of the added path, connection or disconnection, to conventional receiver structure.

A Study on Development of Food Delivery Platform based on O2O -Focusing on Domestic and Overseas Cases (O2O 기반 식품 배달 플랫폼 발전 방안 연구 -국내외 사례를 중심으로-)

  • Park, Seojin;Kim, Seung-In
    • Journal of the Korea Convergence Society
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    • v.9 no.9
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    • pp.159-165
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    • 2018
  • In this research, the researcher is seeking how to develop growing O2O food delivery platform service. The food delivery platform is newly creating the profit system which wasn't exist before by adding up IT and new technologies, and young generations who are used to mobile environment have became main consumers. For the methodology of research, internal and external delivery platform cases research is used to suggest the development idea. Food delivery platform market is showing an active development like business expansion by M&A of IT, distribution, manufacturing, circulation and it still has to attract the constant use of consumer through zero commission, discount events. Further research is required for various delivery platform channel and consumer's value of overall experience, above hereafter food delivery platform based on this research.

A Study on Comparing Elementary Mathematics Textbooks of Korea and Yanbian Centered on Number Area (우리나라와 연변의 초등학교 수학 교과서의 비교 연구: 수 영역을 중심으로)

  • Park, Kyo-Sik
    • Journal of Elementary Mathematics Education in Korea
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    • v.16 no.1
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    • pp.21-38
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    • 2012
  • In this study, elementary mathematics textbooks from grade 1 to grade 6 of Korea and Yanbian Korean Autonomous Prefecture are compared. This study is limited to number area. In this study, textbooks of Korea are developed according to the 2007 curriculum and published between 2009 and 2011 and textbooks of Yanbian are published between 2009 and 2010. Seven implications for developing Korean textbooks can be drew from Yanbian textbooks as conclusions. First, it is necessary to consider using counters to teach place values. Second, it is necessary to consider reading inequalities in style of one to one correspondence between signs and words. Third, it is necessary to consider mentioning explicitly that it is possible to express the concrete whole which has a continuous quantity as natural number 1. Fourth, it is necessary to consider introducing term of fraction line that separates the numerator and denominator. Fifth, it is necessary to consider mentioning explicitly the properties of the fraction. Sixth, it is necessary to consider broadening examples to use decimals. Seventh, it is necessary to consider stating clearly that it is possible to make an additional place of decimals by adding a zero at the right end of the decimals.

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A Study on the Prediction Model for International Trade Payment Using Logistic Regression

  • Joo, Hye-Young;Lee, Dong-Jun
    • Journal of Korea Trade
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    • v.25 no.2
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    • pp.111-133
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    • 2021
  • Purpose - Although remittance payment in international trade settlements has played a bigger role in recent years, scant research is being done. This study is to zero in on analyzing determinants of international trade payments focused on remittance by constructing a payment prediction model. Design/methodology - This study categorizes the types of trade payments into advance remittance, post remittance, linked remittance, letter of credit, and mixed payment, and analyzes these after constructing a logit model. For empirical analysis, 147 survey data were collected for export manufacturers in Korea, and binominal logistic regression analysis was used to analyze the type of payment method the exporter chooses for trade transactions. Findings - The likelihood of choosing advance remittance increased as the exporters had non-recovery experiences with payments, and decreased as the market power of importers increased. The possibility of post remittance increased when the export amount was large and the character of the buyer was reliable. In the case of linked remittance, it was highly likely to be selected when payment efficiency was important in trade settlement. In addition, when competition among companies in the global market is intense and market uncertainty is high, the possibility of using a letter of credit decreases. It was also found that the greater the export amount, the greater the possibility of choosing advance remittance, and even if the transaction period was longer, exporters using a letter of credit continued to use it. Originality/value - Despite the high proportion of remittances in international trade settlements, it has been hard to find studies that reflect the practical characteristics of remittances. This study classified the types of remittance into advance remittance, post remittance, and linked remittance, and built a trade payment prediction model by adding a letter of credit and mixed payment. In addition, the originality of this study is recognized in that a logistic model was constructed and meaningful results were derived.

A Study of Critical Items and Related Standards on Designing for Passive Apartments (패시브 공동주택 계획을 위한 설계 중점항목 및 관련 기준 연구)

  • Lee, Myoung-Ju
    • Journal of the Architectural Institute of Korea Planning & Design
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    • v.34 no.7
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    • pp.21-29
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    • 2018
  • This study aimed to find and suggest the purpose of future plans, critical items on designing and Related standards to amend construction standards for domestic energy saving and environmentally friendly housings. It would also activate and increase the supplies of passive house minimizing the problems on current apartment housings in winter and reducing heating energy which brings fine dust pollution. After defining the standard model of Korean apartment housings(reference model), this study calculated the amount of heating energy demand per unit area annually as applying the yearly changed standards from 2008 to 2017 to existing standard model. It turned out that applying 2017 construction standards of energy saving and eco-friendly housings to reference model has saved up to 75% of heating energy demand comparing to the one applied 2008's. However, it still could not solve the fundamental problems such as winter fungus, condensation, freezing, freeze and burst, and insulation weakness space, and could not be free from fine dust particles. To solve them, this study suggested improved standards adding critical items on design related to outside insulation, cut off the heat-bridge, enforce air-tightness and heat change efficiency on heat recovery ventilator. As a result, it has reduced more than 10% of heat demand from 2017. It would be more than 90% of savings from 2008 if we make the amount of heat loss be zero on heat bridge on designing stage in the future.

SPIHT-based Subband Division Compression Method for High-resolution Image Compression (고해상도 영상 압축을 위한 SPIHT 기반의 부대역 분할 압축 방법)

  • Kim, Woosuk;Park, Byung-Seo;Oh, Kwan-Jung;Seo, Young-Ho
    • Journal of Broadcast Engineering
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    • v.27 no.2
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    • pp.198-206
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    • 2022
  • This paper proposes a method to solve problems that may occur when SPIHT(set partition in hierarchical trees) is used in a dedicated codec for compressing complex holograms with ultra-high resolution. The development of codecs for complex holograms can be largely divided into a method of creating dedicated compression methods and a method of using anchor codecs such as HEVC and JPEG2000 and adding post-processing techniques. In the case of creating a dedicated compression method, a separate conversion tool is required to analyze the spatial characteristics of complex holograms. Zero-tree-based algorithms in subband units such as EZW and SPIHT have a problem that when coding for high-resolution images, intact subband information is not properly transmitted during bitstream control. This paper proposes a method of dividing wavelet subbands to solve such a problem. By compressing each divided subbands, information throughout the subbands is kept uniform. The proposed method showed better restoration results than PSNR compared to the existing method.