• Molecules and Cells
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• v.40 no.6
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• pp.379-385
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• 2017

Drug addiction is a severe psychiatric disorder characterized by the compulsive pursuit of drugs of abuse despite potential adverse consequences. Although several decades of studies have revealed that psychostimulant use can result in extensive alterations of neural circuits and physiology, no effective therapeutic strategies or medicines for drug addiction currently exist. Changes in neuronal connectivity and regulation occurring after repeated drug exposure contribute to addiction-like behaviors in animal models. Among the involved brain areas, including those of the reward system, the striatum is the major area of convergence for glutamate, GABA, and dopamine transmission, and this brain region potentially determines stereotyped behaviors. Although the physiological consequences of striatal neurons after drug exposure have been relatively well documented, it remains to be clarified how changes in striatal connectivity underlie and modulate the expression of addiction-like behaviors. Understanding how striatal circuits contribute to addiction-like behaviors may lead to the development of strategies that successfully attenuate drug-induced behavioral changes. In this review, we summarize the results of recent studies that have examined striatal circuitry and pathway-specific alterations leading to addiction-like behaviors to provide an updated framework for future investigations.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.35 no.1
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• pp.66-74
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• 2024

Food addiction refers to a condition in which individuals exhibit addictive-like behaviors toward food, like those observed in substance abuse. Although still debated, evidence supporting the validity and usefulness of the concept of food addiction is growing. Food addiction is particularly associated with obesity and eating disorders involving binge eating. This study discusses the cases of two adolescent patients who presented with anorexia nervosa. During the recovery phase of anorexia nervosa, binge eating was observed, and the patterns of binge eating significantly differed between patients, with and without food addiction. Therefore, healthcare professionals treating eating disorders should be aware of food addiction and modify their treatment strategies accordingly.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.10 no.1
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• pp.129-135
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• 2010

This study practically analyzed the relationships of Internet addiction, self-esteem, interpersonal relations and maladjusted behaviors according to family types and in particular, made a practical analysis about whether self-esteem, interpersonal relations and maladjusted behaviors have mediation effects in the relationship between family types and Internet addiction. As a result of regression analysis, the Internet addiction according to family types was a negative relationship and significant. Family types were positively related to self-esteem. As for interpersonal relations, family types were significant as a positive relationship. On the other hand, maladjusted behaviors were proved that they have a negative relationship with family types like the Internet addiction. That is to say, even the mediation effects that family types through self-esteem, interpersonal relations and maladjusted behaviors related to Internet addition were verified. As a result, it was concluded that self-esteem, interpersonal relations and maladjusted behavior factors play mediator roles between family types and Internet addiction.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.7
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• pp.509-517
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• 2020

The study seeks to understand the effects of boredom proneness on impulse purchasing and smartphone addiction of young consumers. Moreover, the possible mediating role of smartphone addiction is tested for the effect of boredom proneness on impulse purchasing. Nowadays, the effect of emotions on human behavior is generally accepted, and boredom is one of the important and common problematic feelings or moods at various levels of life due to factors like unemployment, not being able to work in a suitable job, not getting appropriate education matching individual abilities, monotony of tasks, and feeling life is meaningless. Investigating the effect of boredom on specific consumer behavior would increase our knowledge about consumer behavior. For the research, a survey was conducted 313 students from Kirikkale University, Keskin Vocational High School; the data were collected by convenience sampling method. The data were processed through statistical tools like exploratory factor analysis, coefficient alphas, and regression analysis. The results of the study reveal that boredom proneness affects impulse purchasing and smartphone addiction. In addition, it is understood that smartphone addiction plays a mediating role in the effect of boredom proneness on impulse purchasing. These results indicate that boredom can be an important factor affecting certain negative consumer behaviors.

• Journal of the Korea Society of Computer and Information
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• v.19 no.8
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• pp.177-185
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• 2014

The purpose of this study is to suggest some policy implications for the youth through empirical study about the moderating effects of high school students' family stress in the relationship of Oiettolie propensity and game addiction behaviors including bullies, social phobia and emotional instability. For the purpose of this study, this study established a causal model about the relationships among the research variables through review of previous studies and surveyed high school students for empirical research. The results of this study shows that Oiettolie propensity impacts on youth's game addiction and brings about game addiction behaviors like bullies, social phobia and emotional instability. Especially, this study shows that Oiettolie propensity impacts on social phobia most. Also, family stress has a moderating effects for the relationships among the variables. This study presents some policy implications for the youth.

• Biomolecules & Therapeutics
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• v.30 no.3
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• pp.238-245
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• 2022

Previous reports have demonstrated that genetic mechanisms greatly mediate responses to drugs of abuse, including methamphetamine (METH). The circadian gene Period 2 (Per2) has been previously associated with differential responses towards METH in mice. While the behavioral consequences of eliminating Per2 have been illustrated previously, Per2 overexpression has not yet been comprehensively described; although, Per2-overexpressing (Per2 OE) mice previously showed reduced sensitivity towards METH-induced addiction-like behaviors. To further elucidate this distinct behavior of Per2 OE mice to METH, we identified possible candidate biomarkers by determining striatal differentially expressed genes (DEGs) in both drug-naïve and METH-treated Per2 OE mice relative to wild-type (WT), through RNA sequencing. Of the several DEGs in drug naïve Per2 OE mice, we identified six genes that were altered after repeated METH treatment in WT mice, but not in Per2 OE mice. These results, validated by quantitative real-time polymerase chain reaction, could suggest that the identified DEGs might underlie the previously reported weaker METH-induced responses of Per2 OE mice compared to WT. Gene network analysis also revealed that Asic3, Hba-a1, and Rnf17 are possibly associated with Per2 through physical interactions and predicted correlations, and might potentially participate in addiction. Inhibiting the functional protein of Asic3 prior to METH administration resulted in the partial reduction of METH-induced conditioned place preference in WT mice, supporting a possible involvement of Asic3 in METH-induced reward. Although encouraging further investigations, our findings suggest that these DEGs, including Asic3, may play significant roles in the lower sensitivity of Per2 OE mice to METH.

• Biomolecules & Therapeutics
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• v.26 no.5
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• pp.425-431
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• 2018

Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, $Ca^{2+}$/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and ${\gamma}$-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an antidepressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression.