• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.57 no.3
• /
• pp.215-224
• /
• 2008

In this paper, we introduced a linear motor-based transfer system with an active pid controller which can be replaced with an automated guided vehicle (AGV) for the port automation. This system, which is named LMCTS(liner motor-based container transfer system), is based on PMLSM (permanent magnetic linear synchronous motor) which basically consists of stator modules on the rail and shuttle car. Therefore more progressive and adaptive control mechanisms should be required to control a system with large variation of container weight, the difference of each characteristic of stator modules, a stator module's trouble etc. We introduced an active control mechanism with an online tuning scheme using modified evolutionary strategy. Some computer simulations are implemented to assess the robustness of the proposed system.

• Clinical and Experimental Pediatrics
• /
• v.58 no.7
• /
• pp.239-244
• /
• 2015

The complement system is part of the innate immune response and as such defends against invading pathogens, removes immune complexes and damaged self-cells, aids organ regeneration, confers neuroprotection, and engages with the adaptive immune response via T and B cells. Complement activation can either benefit or harm the host organism; thus, the complement system must maintain a balance between activation on foreign or modified self surfaces and inhibition on intact host cells. Complement regulators are essential for maintaining this balance and are classified as soluble regulators, such as factor H, and membrane-bound regulators. Defective complement regulators can damage the host cell and result in the accumulation of immunological debris. Moreover, defective regulators are associated with several autoimmune diseases such as atypical hemolytic uremic syndrome, dense deposit disease, age-related macular degeneration, and systemic lupus erythematosus. Therefore, understanding the molecular mechanisms by which the complement system is regulated is important for the development of novel therapies for complement-associated diseases.

• Reproductive and Developmental Biology
• /
• v.34 no.2
• /
• pp.111-115
• /
• 2010

Erythropoietin (EPO), a glycoprotein hormone produced from primarily cells of the peritubular capillary endothelium of the kidney, is responsible for the regulation of red blood cell production. We have been investigating the roles of glycosylation site added in the biosynthesis and function of recombinant protein. In this study, we analyzed by immunohistochemical methods adaptive mechanisms to excessive erythrocytosis in transgenic (tg) mice expressing dimeric human erythropoietin (dHuEPO) gene. Splenomegaly was observed over 11~21 times in the tg mice. The 2,672 candidate spleen-derived genes were identified through the microarray analysis method, and decreased genes were higher than increased genes in the spleen. The specific proteins in the increased and decreased genes were analyzed by immunohistochemical methods. Our results demonstrate that problems of abnormal splenomegaly would solve in tg mice overexpressing dHuEPO gene.

• Herbal Formula Science
• /
• v.7 no.1
• /
• pp.65-76
• /
• 1999

According to the study of literature on RADIX STEMONAE about its efficacy, pharmacological action, and clinical adaptive disease, the results are as follows; 1. About the efficacy of RADIX STEMONAE, it is known as moistening the lungs to arrest cough, and intestinal parasites from ancient to now, and dispelling phlegm is also known. 2. The clinical adaptation of RADIX STEMONAE is chronic bronchitis, pertussis, pulmonary tuberculosis in respiratory disease, and ascaricide for Ascaris, Enterobius vermicularis or eczema, pruritus, destroy louse for endermic liniment. 3. The pharmacological action of RADIX STEMONAE are antitussive, tuberculostatic, anthelmintic, antibacterial, antivirus, antifungal. 4. The antitussive mechanism of RADIX STEMONAE is central inhibitor for cough center of medulla oblongata, and the mechanisms of bronchial smooth muscle relax, and expectorant is also known.

• Proceedings of the IEEK Conference
• /
• 2000.07a
• /
• pp.454-457
• /
• 2000

In this paper, an efficient rate control algorithm based on rate prediction is proposed for maintaining a smooth buffer variation and a small buffer size. The proposed method adjusts the quantization scaling factor by using the predicted bit-rate to meet the target bit budget exactly. Experimental result show that the proposed prediction-based rate control scheme can regulate the bit-rate across scene changes more effectively and achieve better PSNR performance than existing rate control mechanisms such as the MPEG-2 Test Model 5 (TM5) and the Adaptive Scene Analysis (ASA).

• The Transactions of the Korean Institute of Electrical Engineers
• /
• v.40 no.2
• /
• pp.217-223
• /
• 1991

Most common applications of neural networks to control problems are the automatic motor controls using the artificial perceptual function. These control mechanisms are similar to those of the intelligent and pattern recognition control of an adaptive method frequently performed by the animate nature. In this paper, the pole-balancing problem is selected as the control object and an actual cart-pole controller is implemented by a computer interfacing and demonstrated as motor control using the reinforcement learning rule. In the experiment, given a change of the main parameters of cart-pole dynamics, a comparison is made between the LQR scheme and neural network method. The neural network method exhibits a more effecftive control action in a real situation having a large uncertainty than the LQR scheme.

• International Journal of Fuzzy Logic and Intelligent Systems
• /
• v.7 no.3
• /
• pp.176-181
• /
• 2007

This paper presents evolvable neural networks based on a developmental model for navigation control of autonomous mobile robots in dynamic operating environments. Bio-inspired mechanisms have been applied to autonomous design of artificial neural networks for solving practical problems. The proposed neural network architecture is grown from an initial developmental model by a set of production rules of the L-system that are represented by the DNA coding. The L-system is based on parallel rewriting mechanism motivated by the growth models of plants. DNA coding gives an effective method of expressing general production rules. Experiments show that the evolvable neural network designed by the production rules of the L-system develops into a controller for mobile robot navigation to avoid collisions with the obstacles.

• BMB Reports
• /
• v.54 no.1
• /
• pp.31-43
• /
• 2021

Dendritic cells (DC), which consist of several different subsets, specialize in antigen presentation and are critical for mediating the innate and adaptive immune responses. DC subsets can be classified into conventional, plasmacytoid, and monocyte-derived DC in the tumor microenvironment, and each subset plays a different role. Because of the role of intratumoral DCs in initiating antitumor immune responses with tumor-derived antigen presentation to T cells, DCs have been targeted in the treatment of cancer. By regulating the functionality of DCs, several DC-based immunotherapies have been developed, including administration of tumor-derived antigens and DC vaccines. In addition, DCs participate in the mechanisms of classical cancer therapies, such as radiation therapy and chemotherapy. Thus, regulating DCs is also important in improving current cancer therapies. Here, we will discuss the role of each DC subset in antitumor immune responses, and the current status of DC-related cancer therapies.

• BMB Reports
• /
• v.54 no.1
• /
• pp.59-69
• /
• 2021

The ability to read, write, and edit genomic information in living organisms can have a profound impact on research, health, economic, and environmental issues. The CRISPR/Cas system, recently discovered as an adaptive immune system in prokaryotes, has revolutionized the ease and throughput of genome editing in mammalian cells and has proved itself indispensable to the engineering of immune cells and identification of novel immune mechanisms. In this review, we summarize the CRISPR/Cas9 system and the history of its discovery and optimization. We then focus on engineering T cells and other types of immune cells, with emphasis on therapeutic applications. Last, we describe the different modifications of Cas9 and their recent applications in the genome-wide screening of immune cells.

• 제어로봇시스템학회:학술대회논문집
• /
• 1996.10a
• /
• pp.129-132
• /
• 1996

There is a tendency nowadays to produce increasingly miniaturized electronic equipment which incorporate parts that have to be precisely positioned, like lenses, heads and CCD's in scanners, printers, copiers, VCR's, optical fiber modules, etc. In contrast to the production process of precision parts, which is currently being carried out automatically, the assemblage process is still being performed by specially skilled technicians. The assemblage process comprises normally the following steps: firstly, the parts are roughly positioned and partially fixed, secondly, the parts are manually nudged towards the target position and finally glued, screwed or welded. This paper presents a system that uses six piezo Impact Drive Mechanisms for accurate micro positioning within three degrees of freedom (lateral and longitudinal translation and rotation). The system is designed to positioning a printed circuit board with an accuracy better than 3 .mu.m (for translations), 5 mrad (for rotation).