• Title/Summary/Keyword: activity interpretation

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Development of Financial Effect Measurement(FEM) Models for Quality Improvement and Innovation Activity (품질개선 및 혁신활동에서 재무성과 측정모형의 개발)

  • Choi, Sungwoon
    • Journal of the Korea Safety Management & Science
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    • v.17 no.1
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    • pp.337-348
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    • 2015
  • This research introduces the Financial Effect Measurement (FEM) models which measures both the improvement and the innovation performance of Quality Control Circle (QCC) and activities of Six Sigma. Concepts and principle of Comprehensive Income Statement (CIS), Balanced Scorecard (BSC), Time-Driven Activity Based-Costing (TDABC) and Total Productive Maintenance (TPM) are applied in order to develop the 4 FEM models presented in this paper. First of all, FEM using CIS depicts the improvement effects of production capacity and yield using relationships between demand and supply, and line balancing efficiency between bottleneck process and non-bottleneck processes. Secondly, cause-and-effect relation of Key Performance Indicator (KPI) is used to present Critical Success Factor (CSF) effects for QC Story 15 steps of QCC and DMAIC (Define, Measure, Analyze, Improve, and Control) of Six Sigma. The next is FEM model for service management innovation activities that uses TDABC to calculate the time-driven effect for improving the indirect activities according to the cost object. Lastly, FEM model for TPM activities presents the interpretation of improvement effect model of TPM Capital Expenditure (CAPEX) and Operating Expenditure (OPEX) maintenance using profit, cash and Economic Added Value (EVA) as metrics of enterprise values. To better understand and further investigate FEMs, recent cases on National Quality Circle Contest are used to evaluate new financial effect measurement developed in this paper.

An Analysis of the Inquiry Activity Types Presented in the 5th & 6th Grade Elementary Science Textbooks (초등 5~6학년군 과학 교과서에 제시된 탐구 활동 유형 분석)

  • Song, Shin-Cheol;Shim, Kew-Cheol
    • Journal of Korean Elementary Science Education
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    • v.38 no.4
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    • pp.453-464
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    • 2019
  • In this study, the types of inquiry activities in the $5^{th}$ & $6^{th}$ grade science textbooks according to the 2015 revised science national curriculum were analyzed and compared according to grade level and science area. Science textbooks for elementary school $5^{th}$ & $6^{th}$ graders contain quite diverse types of inquiry activities, which are student-centered inquiry activities. There were comparatively higher proportions of inquiry types such as experiment & observation and simulation, but relatively lower of inquiry types of investigation-discourse & presentation, discussion, expression. Elementary science textbooks are expected to cultivate science key competencies for elementary school students. Considering the science area, the motion & energy, substances, earth & space, and integration areas had the most experiment & observation among activity types, while the life area had the most simulation activities. Even in some area of the 6th grade science textbook, there was little or no data interpretation, discussion, and simulation activities. In order to achieve the goal of elementary science education, science textbooks should be developed considering the revision of future elementary science curriculum.

Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells

  • Ryu, Min-Ji;Baek, Eun-Ki;Kim, Soyeon;Seong, Chi Nam;Yang, Inho;Lim, Kyung-Min;Nam, Sang-Jip
    • Biomolecules & Therapeutics
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    • v.29 no.1
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    • pp.98-103
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    • 2021
  • The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.

Examination and Isolation of Natural Antioxidants from Korean Medicinal Plants (국내산 약용식물의 항산화물질 탐색 및 분리)

  • Song, Jung-Choon;Park, Nam-Kyu;Hur, Han-Sun;Bang, Myun-Ho;Baek, Nam-In
    • Korean Journal of Medicinal Crop Science
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    • v.8 no.2
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    • pp.94-101
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    • 2000
  • On the purpose of development of antioxidative compounds from natural sources, 38 plants known to have antioxidant activity have been examined concerning DPPH radical scavenging activity. Among 13 plants exhibiting the activity, the seed of Carthamus tinctorius L, was selected as resources to search for active compounds due to rareness of study. The seed of the plant has been used as edible oil or preventive and remedial drugs for osteoporosis, arthritis. To reveal the principal component manifesting the antioxidant activity, the MeOH extracts was successively solvent-fractionated with EtOAc, n-BuOH and water. In order to isolate active component from the EtOAc fractions, application of silica gel column chromatographies and activity tests were repeated for a active component to be isolated. Its chmical structure was determined to be N-feruloylserotonin, a conjugated serotonin compound, by the interpretation of spectral data, NMR. MS and the adaptation of chemical reactions.

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Analysis of Inquiry Activity Types in the High School Life Science II Textbooks according to the 2015 Revised Science Curriculum (2015 개정 과학과 교육과정에 따른 고등학교 생명과학II 교과서의 탐구활동 유형 분석)

  • Jeong, Soo Yeon;Chang, Jeong Ho
    • Journal of Science Education
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    • v.43 no.1
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    • pp.43-63
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    • 2019
  • The types of inquiry activities included in Life Science II textbooks under the 2015 revised science curriculum were extracted and compared with those of six major and five different publishing companies. The fact that the number of investigation discussions and presentations (IP) increased and the expressions (EX) were included in each unit was interpreted as sufficient to transform the classroom instruction in the 2015 revised science curriculum into student-centered activities. The type of inquiry activities in student-centered activities such as experiment observation, simulation activities, investigation discussions, and presentations accounted for about 41% more than the 27% of 2009 revised science curriculum. However, since data interpretation type is still the largest, it is necessary to reduce the types of data interpretation and to increase the number of types of simulation activities and expressions in order to expand students' creativity and thinking ability when textbook development is needed in the future. In addition to the development of biotechnology, teachers need to reconstruct diverse science materials for each textbook and then use them for students to induce balanced thinking, and try to expand expressive power, creativity, logic, and critical thinking skills.

HEATED INTRACLUSTER GAS AND RADIO CONNECTIONS: THE SINGULAR CASE OF MKW 3S

  • MAZZOTTA PASQUALE;BRUNETTI GIANFRANCO;GIACINTUCCI SIMONA;VENTURI TIZIANA;BARDELLI SANDRO
    • Journal of The Korean Astronomical Society
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    • v.37 no.5
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    • pp.381-385
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    • 2004
  • Similarly to other cluster of galaxies previously classified as cooling flow systems, the Chandra observation of MKW 3s reveals that this object has a complex X-ray structure hosting both a X-ray cavity and a X-ray filament. Unlike the other clusters, however, the temperature map of the core of MKW 3s shows the presence of extended regions of gas heated above the radially averaged gas temperature at any radius. As the cluster does not show evidences for ongoing major mergers Mazzotta et al. suggest a connection between the heated gas and the activity of the central AGN. Nevertheless, due to the lack of high quality radio maps, this interpretation was controversial. In this paper we present the results of two new radio observations of MKW 3s at 1.28 GHz and 604 MHz obtained at the GMRT. Together with the Chandra observation and a separate VLA observation at 327 MHz from Young, we show unequivocal evidences for a close connection between the heated gas region and the AGN activity and we briefly summarize possible implications.

Low Luminosity AGNs at the center of the Perseus Cluster

  • Park, Songyoun;Yang, Jun;Oonk, Raymond;Paragi, Zsolt
    • The Bulletin of The Korean Astronomical Society
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    • v.38 no.2
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    • pp.44.1-44.1
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    • 2013
  • We investigate the origin of radio emission in nearby early-type galaxies using the European VLBI Network (EVN) at 1.4 GHz. The sample included NGC 1277, which was found to have an over-massive black hole of $1.7{\times}10^{10}M_{\odot}$, and four other early-type galaxies in the Perseus cluster. All the sources were detected above $5{\sigma}$. They show compact radio cores and high brightness temperatures, $10^7{\sim}10^9K$, which implies that radio emission in these objects is non-thermal. While the observed radio luminosities could be consistent with star formation (${\sim}1M_{\odot}yr^{-1}$), the small source size would imply a specific star formation rate (sSFR) of ${\sim}10^6M_{\odot}yr^{-1}kpc^{-2}$. Such a high sSFR rules out ongoing star formation. Supernovae (SNe) are ruled out as well because it is unlikely that we see SNe in all galaxies at the same time, and there is no significant radio variability either. The most plausible scenario is that these galaxies show low luminosity AGN activity in the radio, although there is no sign of AGN activity in other bands. If our interpretation is correct, then regular early-type galaxies may harbor active AGN more often than suspected from observations at other wavelengths.

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Isolation of Grb2-Shc Interaction Inhibitory Compounds from the Leaves of Eucommia ulmoides O. (두충(Eucommia ulmoides O.)잎으로부터 Grb2-Shc 결합저해 활성물질의 분리)

  • Hahn, Jae-Taek;Ahn, Eun-Mi;Bang, Myun-Ho;Nam, Ji-Youn;Kwon, Byoung-Mog;Baek, Nam-In
    • Korean Journal of Pharmacognosy
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    • v.30 no.2
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    • pp.202-206
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    • 1999
  • The MeOH extracts obtained from the leaves of Eucommia ulmoides were solvent-fractionated with EtOAc, n-BuOH, and $H_20$, successively. From the EtOAc extract showing Grab2-Shc inhibitory activity, a flavonol and a lignan compounds were isolated through repeated silica gel column chromatographies. By interpretation of several spectral data and adaptation of acetylation method, the chemical structures of the compounds were determined as 5,7,3',4'-tetrahydroxy-flavonol (quercetin), and 4,4',8',9-tetrahydroxy-3,3'-dimethoxy-7,9'-cyclolignan {(-)-olivil)}, respectively. The compounds exhibited $IC_{50}$ values in Grb2-Shc inhibitory activity to be 93 and $210\;{\mu}mole/l$, respectively.

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Flavonoids from Thyrsanthera suborbicularis and Their NO Inhibitory Activity

  • Song, Hyuk-Hwan;Khiev, Piseth;Chai, Hee-Sung;Lee, Hyeong-Kyu;Oh, Sei-Ryang;Choi, Young Hee;Chin, Young-Won
    • Natural Product Sciences
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    • v.18 no.4
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    • pp.273-278
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    • 2012
  • Further phytochemical investigation on the whole plant of Thyrsanthera suborbicularis, collected in Cambodia, led to kaempferol (1), vitexin (2), apigenin-7-O-neohesperidoside (3), chrysoeriol-7-O-${\beta}$-D-glucopyranoside (4), isorhamnetin 3-O-rutinoside (5), kaempferol-3-O-[${\alpha}$-L-rhamnopyranosyl-(13)-${\alpha}$-L-rhamnopyranosyl-(16)-${\beta}$-D-galactopyranoside (6), kaempferol-3-O-${\alpha}$-L-rhamnopyranosyl(12)-O-[${\alpha}$-L-rhamnopyranosyl (16)]-${\beta}$-D-glucopyranoside (7), kaempferol-3-O-[6"-O-(E)-p-coumaroyl]-${\beta}$-D-glucopyranoside (8), kaempferol-3-O-[6"-O-(E)-p-coumaroyl]-${\beta}$-D-galactopyranoside (9), and amentoflavone (10). All the structures were confirmed by the interpretation of NMR (1D and 2D) and MS data, and comparison with the published values. Of the isolated compounds 1 - 10, compounds 8 and 10 displayed the inhibitory activity against NO production in LPS-induced Raw 264.7 cells with $IC_{50}$ values, 3.56 and $15.73{\mu}M$, respectively.

A Study on the Activation Plan of 4-H Club in Korea (농촌 청소년조직(4-H)의 활성화 방안에 관한 연구)

  • Yang, Seung Choon;Choi, Chang Wook
    • Journal of Agricultural Extension & Community Development
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    • v.8 no.1
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    • pp.41-58
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    • 2001
  • The purpose of this study was to develop plans for activating the 4-H clubs in Korea. Data for this study were collected from 125 members in 4-H clubs and 140 extension educators who participated in 4-H activity. Total of 265 responses were analyzed after data screening. The Statistical Package for Social Sciences(SPSS) for Windows for the personal computer were used to analyze the data. Frequency, percentage, ANOVA, and LSD test for post-hoc interpretation were employed to analyze the data with a statistical significance level of .05. Based on the conclusions of this study, following recommendations were offered: To activate rural youth organizations, especially 4-H clubs in Korea the following measures should be included in the plans for activation; 1) To classify membership into student and non-student clubs to focus on the needs of active members; 2) To establish clear objectives for club activities; 3) To enhance field-oriented operation of clubs; 4) To develop various activity programs that members could be fascinated; 5) To promote subject matter specialists in order to support club activities effectively; and 6) To clarify functions and roles of extension service centers and non-governmental organizations in order to support club activites.

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