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http://dx.doi.org/10.4062/biomolther.2020.064

Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells  

Ryu, Min-Ji (Department of Chemistry and Nanoscience, Ewha Womans University)
Baek, Eun-Ki (College of Pharmacy, Ewha Womans University)
Kim, Soyeon (College of Pharmacy, Ewha Womans University)
Seong, Chi Nam (Department of Biology, College of Life Science and Natural Resource, Sunchon National University)
Yang, Inho (Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University)
Lim, Kyung-Min (College of Pharmacy, Ewha Womans University)
Nam, Sang-Jip (Department of Chemistry and Nanoscience, Ewha Womans University)
Publication Information
Biomolecules & Therapeutics / v.29, no.1, 2021 , pp. 98-103 More about this Journal
Abstract
The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.
Keywords
Streptomyces sp.; Nine-membered macrolide; Marine natural product; Melanin synthesis inhibitor; Skin whitening agent;
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