• 대한안전경영과학회지
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• 제17권1호
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• pp.337-348
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• 2015

This research introduces the Financial Effect Measurement (FEM) models which measures both the improvement and the innovation performance of Quality Control Circle (QCC) and activities of Six Sigma. Concepts and principle of Comprehensive Income Statement (CIS), Balanced Scorecard (BSC), Time-Driven Activity Based-Costing (TDABC) and Total Productive Maintenance (TPM) are applied in order to develop the 4 FEM models presented in this paper. First of all, FEM using CIS depicts the improvement effects of production capacity and yield using relationships between demand and supply, and line balancing efficiency between bottleneck process and non-bottleneck processes. Secondly, cause-and-effect relation of Key Performance Indicator (KPI) is used to present Critical Success Factor (CSF) effects for QC Story 15 steps of QCC and DMAIC (Define, Measure, Analyze, Improve, and Control) of Six Sigma. The next is FEM model for service management innovation activities that uses TDABC to calculate the time-driven effect for improving the indirect activities according to the cost object. Lastly, FEM model for TPM activities presents the interpretation of improvement effect model of TPM Capital Expenditure (CAPEX) and Operating Expenditure (OPEX) maintenance using profit, cash and Economic Added Value (EVA) as metrics of enterprise values. To better understand and further investigate FEMs, recent cases on National Quality Circle Contest are used to evaluate new financial effect measurement developed in this paper.

• 한국초등과학교육학회지:초등과학교육
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• 제38권4호
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• pp.453-464
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• 2019

In this study, the types of inquiry activities in the $5^{th}$ & $6^{th}$ grade science textbooks according to the 2015 revised science national curriculum were analyzed and compared according to grade level and science area. Science textbooks for elementary school $5^{th}$ & $6^{th}$ graders contain quite diverse types of inquiry activities, which are student-centered inquiry activities. There were comparatively higher proportions of inquiry types such as experiment & observation and simulation, but relatively lower of inquiry types of investigation-discourse & presentation, discussion, expression. Elementary science textbooks are expected to cultivate science key competencies for elementary school students. Considering the science area, the motion & energy, substances, earth & space, and integration areas had the most experiment & observation among activity types, while the life area had the most simulation activities. Even in some area of the 6th grade science textbook, there was little or no data interpretation, discussion, and simulation activities. In order to achieve the goal of elementary science education, science textbooks should be developed considering the revision of future elementary science curriculum.

• Biomolecules & Therapeutics
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• 제29권1호
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• pp.98-103
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• 2021

The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.

• 한국약용작물학회지
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• 제8권2호
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• pp.94-101
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• 2000

천연물로부터 새로운 항산화물질을 구명하기 위하여 국내에서 생산된 약용작물 38종을 수집하여 항산화 활성물질을 탐색한 결과 가시오갈피, 구절초, 건강, 목단, 시호, 산수유, 삼백초, 산사, 유근피, 작약, 천궁, 홍화씨, 및 황금등 13종이 항산화 활성이 높은 생약재로 선발되었다. 선발된 13종의 생약재중 홍화씨에 대한 활성물질을 추적, 분리하여 NMR로 물질구조를 동정한 결과 N-feruloylserotonin이 항산화 물질이라는 것을 처음 밝혀냈다. DPPH radical소거 활성에 의한 기존 항산화제인 ${\alpha}$-tocopherol, BHA 및 BHT를 N-feruloylserotonin과 항산화력를 비교한 결과 N-feruloylserotonin이 $6.6{\mu}g/ml$로 활성이 가장 높은 것으로 밝혀졌다.

• 과학교육연구지
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• 제43권1호
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• pp.43-63
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• 2019

2015 개정 과학과 교육과정의 생명과학II 교과서에 수록된 탐구활동 유형을 추출하여 6개의 대단원과 5종의 출판사별로 비교 분석하였다. 탐구활동 유형 중 조사 토의 및 발표(IP)의 수가 많이 늘어난 것과 표현하기(EX)가 각 단원마다 수록되어 있다는 것은 2015 개정 교육과정에서 지향하는 교실 수업을 학생중심활동으로 전환하기에 충분한 것으로 해석할 수 있다. 실험 관찰, 모의 활동, 조사 토의 및 발표 등의 학생중심 활동 영역의 탐구활동 유형이 2009 개정 교육과정의 약 27% 정도를 차지한 것보다 증가한 약 41% 정도를 차지하였다. 그러나 여전히 자료 해석 유형이 가장 많기 때문에 앞으로 교과서 개발이 필요할 때 학생들의 창의성과 사고력을 신장시키기 위해서 자료 해석의 유형을 줄이고 모의 활동이나 표현하기의 유형이 더 늘어나도록 해야 할 것이다. 교사들은 생명공학 기술의 발전뿐만 아니라 교과서마다 각기 다른 다양한 과학 소재를 재구성한 후 학생들에게 활용하여 균형 잡힌 사고를 유도하고, 표현력, 창의력, 논리력, 비판적 사고력을 신장시키기 위한 노력이 필요하다.

• 천문학회지
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• 제37권5호
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• pp.381-385
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• 2004

Similarly to other cluster of galaxies previously classified as cooling flow systems, the Chandra observation of MKW 3s reveals that this object has a complex X-ray structure hosting both a X-ray cavity and a X-ray filament. Unlike the other clusters, however, the temperature map of the core of MKW 3s shows the presence of extended regions of gas heated above the radially averaged gas temperature at any radius. As the cluster does not show evidences for ongoing major mergers Mazzotta et al. suggest a connection between the heated gas and the activity of the central AGN. Nevertheless, due to the lack of high quality radio maps, this interpretation was controversial. In this paper we present the results of two new radio observations of MKW 3s at 1.28 GHz and 604 MHz obtained at the GMRT. Together with the Chandra observation and a separate VLA observation at 327 MHz from Young, we show unequivocal evidences for a close connection between the heated gas region and the AGN activity and we briefly summarize possible implications.

• 천문학회보
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• 제38권2호
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• pp.44.1-44.1
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• 2013

We investigate the origin of radio emission in nearby early-type galaxies using the European VLBI Network (EVN) at 1.4 GHz. The sample included NGC 1277, which was found to have an over-massive black hole of $1.7{\times}10^{10}M_{\odot}$, and four other early-type galaxies in the Perseus cluster. All the sources were detected above $5{\sigma}$. They show compact radio cores and high brightness temperatures, $10^7{\sim}10^9K$, which implies that radio emission in these objects is non-thermal. While the observed radio luminosities could be consistent with star formation (${\sim}1M_{\odot}yr^{-1}$), the small source size would imply a specific star formation rate (sSFR) of ${\sim}10^6M_{\odot}yr^{-1}kpc^{-2}$. Such a high sSFR rules out ongoing star formation. Supernovae (SNe) are ruled out as well because it is unlikely that we see SNe in all galaxies at the same time, and there is no significant radio variability either. The most plausible scenario is that these galaxies show low luminosity AGN activity in the radio, although there is no sign of AGN activity in other bands. If our interpretation is correct, then regular early-type galaxies may harbor active AGN more often than suspected from observations at other wavelengths.

• 생약학회지
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• 제30권2호
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• pp.202-206
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• 1999

The MeOH extracts obtained from the leaves of Eucommia ulmoides were solvent-fractionated with EtOAc, n-BuOH, and $H_20$, successively. From the EtOAc extract showing Grab2-Shc inhibitory activity, a flavonol and a lignan compounds were isolated through repeated silica gel column chromatographies. By interpretation of several spectral data and adaptation of acetylation method, the chemical structures of the compounds were determined as 5,7,3',4'-tetrahydroxy-flavonol (quercetin), and 4,4',8',9-tetrahydroxy-3,3'-dimethoxy-7,9'-cyclolignan {(-)-olivil)}, respectively. The compounds exhibited $IC_{50}$ values in Grb2-Shc inhibitory activity to be 93 and $210\;{\mu}mole/l$, respectively.

• Natural Product Sciences
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• 제18권4호
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• pp.273-278
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• 2012

Further phytochemical investigation on the whole plant of Thyrsanthera suborbicularis, collected in Cambodia, led to kaempferol (1), vitexin (2), apigenin-7-O-neohesperidoside (3), chrysoeriol-7-O-${\beta}$-D-glucopyranoside (4), isorhamnetin 3-O-rutinoside (5), kaempferol-3-O-[${\alpha}$-L-rhamnopyranosyl-(13)-${\alpha}$-L-rhamnopyranosyl-(16)-${\beta}$-D-galactopyranoside (6), kaempferol-3-O-${\alpha}$-L-rhamnopyranosyl(12)-O-[${\alpha}$-L-rhamnopyranosyl (16)]-${\beta}$-D-glucopyranoside (7), kaempferol-3-O-[6"-O-(E)-p-coumaroyl]-${\beta}$-D-glucopyranoside (8), kaempferol-3-O-[6"-O-(E)-p-coumaroyl]-${\beta}$-D-galactopyranoside (9), and amentoflavone (10). All the structures were confirmed by the interpretation of NMR (1D and 2D) and MS data, and comparison with the published values. Of the isolated compounds 1 - 10, compounds 8 and 10 displayed the inhibitory activity against NO production in LPS-induced Raw 264.7 cells with $IC_{50}$ values, 3.56 and $15.73{\mu}M$, respectively.

• 농촌지도와개발
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• 제8권1호
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• pp.41-58
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• 2001

The purpose of this study was to develop plans for activating the 4-H clubs in Korea. Data for this study were collected from 125 members in 4-H clubs and 140 extension educators who participated in 4-H activity. Total of 265 responses were analyzed after data screening. The Statistical Package for Social Sciences(SPSS) for Windows for the personal computer were used to analyze the data. Frequency, percentage, ANOVA, and LSD test for post-hoc interpretation were employed to analyze the data with a statistical significance level of .05. Based on the conclusions of this study, following recommendations were offered: To activate rural youth organizations, especially 4-H clubs in Korea the following measures should be included in the plans for activation; 1) To classify membership into student and non-student clubs to focus on the needs of active members; 2) To establish clear objectives for club activities; 3) To enhance field-oriented operation of clubs; 4) To develop various activity programs that members could be fascinated; 5) To promote subject matter specialists in order to support club activities effectively; and 6) To clarify functions and roles of extension service centers and non-governmental organizations in order to support club activites.