• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.2
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• pp.71-80
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• 2021

Parkinson's disease is one of the typical neurodegenerative disease and it is caused by the destruction of substantia nigra in brain leading to lack of dopamine secretion, and it presents 4 major motor symptoms such as tremor, bradykinesia, stiffness, postural instability. Furthermore, it causes many non-motor symptoms such as anosmia, REM sleep conduct disorder, orthostatic hypotension, dementia and autonomic ataxia such as lack of adjusting blood pressure, hyperhydrosis, constipation. Dopaminergic therapy is the most commonly used strategy, but long term treatment of levodopa induce various adverse effects. Thus, many people are focusing on new therapies other than established therapies, and there are many tries and approaches with paradigm shift. Our medical team was able to get 4 cases of PD patients who are hospitalized in our hospital, treated by Whole Body Gi-Hyeol Therapy consisting of acupuncture therapy, herbal therapy, and mental therapy, and their conditions improved in perspective of Unified Parkinson's Disease Rating Scale(UPDRS), Heart Rate Variability(HRV), and Quality of life. Among all 4 cases, UPDRS score and quality of life score is gotton better, and among 2 cases SDNN, RMS-SD, TP, LF, HF scores are finely increased. And PDQ-39 score which shows quality of life is also improved. However, in spite of these improvements and positive results, there were no meaningful improvement in a hurt from a fall which is important to the aged, muscular atrophy which causes bone fracture and SMI(Skeletal Muscle Mass Index) which is indicator of osteoporosis. Thus, supplementary treatment about Whole Body Gi-Hyeol Therapy such as more active nutrition intervention, safe and effective kinesitherapy is needed, and from now on continuous case reports and systematic clinical research which has control group must be carried out.

• Journal of the Korean Applied Science and Technology
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• v.36 no.2
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• pp.592-599
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• 2019

This study is to stabilize insoluble and unstable active ingredient which is Idebenone (INCI name: hydroxydecyl ubiquinone) in a multi-lamellar vesicle (MLV) and to stabilize it in the skin care cosmetics. Idebenone is good effective raw material in the treatment of Alzheimer's disease in the medical field and a powerful antioxidant in dermatology. It is well known as a substance that inhibits the formation of melanin and cleans the skin pigment. However, it did not dissolve in any solvent and it was difficult to apply in cosmetic applications. Niosome vesicle was able to develop a nano-particle by making a multi-layer of idebenone encapsulated with a nonionic surfactant, hydrogenated lecithin and glycine soja (soybean) sterols and passing it through a high pressure microfluidizer. Idebenone niosome vesicle (INV) has been developed to have the ability to dissolve transparently in water and to promote transdermal penetration. The appearance of the INV was a yellowish liquid having specific odor, and the particle size distribution of INV was about 10~80 nm. The pH was 5~8 (mean=6.8). This capsulation with idebenone was stored in a $45^{\circ}C$ incubator for 3 months and its stability was observed and quantitatively measured by HPLC. As a result, the stability of the sample encapsulated in the niosome vesicle (97.5%) was about 66.3% higher than that of the non-capsule sample of 32.5%. Idebenone 1% INV was used for the efficacy test and clinical trial evaluation as follows. The anti-oxidative activity of INV was 38.2%, which was superior to that of 12.8% tocopherol (control). The melanin-reducing effect of B16 melanoma cells was better than INV (17.4%) and Albutin (control) (9.6%). Pro-collagen synthesis rate was 128.2% for INV and 89.3% for tocopherol (control). The skin moisturizing effect was 15.5% better than the placebo sample. The elasticity effect was 9.7% better than the placebo sample. As an application field, INV containing 1% of idebenone is expected to be able to develop various functional cosmetic formulations such as skin toner, ampoule essence, cream, eye cream and sunblock cream. In addition, it is expected that this encapsulated material will be widely applicable to emulsifying agents for skin use in the pharmaceutical industry as well as the cosmetics industry.

• Korea and Global Affairs
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• v.3 no.1
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• pp.39-76
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• 2019

This paper is to analyze the trend and implications of the publication of China's defense and security white papers. To this end the paper is composed of 5 chapters titled instruction; publication details and composition of China's defense and security white paper; the gist of the white paper on national defense and security during the Chinese president Xi Jinping era; the implications of Chinese white paper on national defense and security during the Chinese president Xi Jinping era; and conclusion. The Chinese Ministry of National Defense had published seven books every two years since 1998 to 2010. In 1995, the ministry published a white paper titled 'China's arms control and disarmament' for the first time. In 2013, it published a white paper titled 'The Diversified Employment of China's Armed Forces' and 'China's Military Strategy' in 2015. All have the common characteristic of being a propaganda policy reflecting China's strategic calculations. It seems that China has began to publish defense white papers in a proactive manner, due to the following factors: (1)pressure on China to demand military transparency from neighboring countries such as the United States; (2)the erosion of the 'China threat.' and (3)confidence in the achievement of China's military modernization. The 'active defensive strategy' and the 'strong defense strategy' of Si Jinping are implied in the words "China's dream is a dream of a powerful country and dream of a strong nation is essential to construct a strong nation." His these strategies have raised security concerns for neighboring countries. We need to maintain and reinforce strong ROK-US security cooperation, and hedging strategies to harmoniously promote ROK-China economic cooperation.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.24 no.1
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• pp.1-14
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• 2021

The Ministry of Environment of Korea has been releasing Asiatic black bears since 2004 at Jirisan National Park. It exceeded the target number of Asiatic black bears in 2018. As of July 2020, in addition to 67 traceable bears, many Asiatic black bears are dispersed outside Jirisan National Park. Jirisan National Park is a very dense place with more than 3 million visitors every year. In this study, the roads and trails through Jirisan National Park were considered to be the main dispersion factors of Asiatic black bears, and the fragmentation analysis was conducted. As of July 2017, the length of roads and trails in Jirisan National Park was 363.4km. Based on this, Jirisan National Park was fragmented into 163 patches. There is only one place that maintains a single area of more than 50㎢ that is suitable for large mammals to inhabit, and 141 places are less than 5㎢. There are 6 patches of 24 to 200㎢ area suitable for living of large mammals including Asiatic black bears, in Jirisan National Park. Compared to the announcement made by the Korea National Park Service in 2014, activities of Asiatic black bears were rare in areas below 5㎢ area and the frequency of activities was high in more than 20㎢ area. This shows that human activities in protected areas such as national parks can directly affect the activities of wild animals, including Asiatic black bears. Therefore, efforts should be made to improve the habitat of Asiatic black bears by reducing the pressure of visiting for Jirisan National Park. In addition, as a result of analyzing the fragmentation of the park's natural conservation zone 107.7km, 45% of the trail of Jirisan National Park, was opened, which is more fragmentation than other use zones. The park nature conservation zone accounts for about 32% of the total area of Jirisan National Park, but the average patch area is only 2.93㎢ and seven large shelters are located. Therefore the Asiatic black bears are negatively affected. This is the result of inconsistent national park use zone setting and actual park management. In overseas countries, research is active on the negative effects of human activity on ecosystems in protected areas. However, there is a lack of research of that in Korea. Thus, that research is required for protection area management in the future.

• Journal of the Korea Fashion and Costume Design Association
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• v.24 no.2
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• pp.117-129
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• 2022

In terms of junior high school girls' growth patterns during early adolescence, unlike childhood when relatively balanced growth patterns are found and high school years in which the normal adult body type is almost reached, junior high school girls display imbalanced and rapid growth. In fact, diverse size changes by body part occur with a significant difference among individuals. Therefore, it has been difficult for junior high school students to select their exact size when buying a school uniform. This study attempted to develop winter blouse and skirt patterns reflecting the latest comfortable and active school uniform trends, using middle school girl avatars of various body shapes. Skirt and blouse pattern-drawing methods and margins differed. Based on such results, research prototypes were prepared. Then, virtual wear prospective drawings, clothing pressure, and appearance were assessed by body shape. Skirts were assessed with 22 factors while blouses were analyzed with 25 factors. Then, correlations between skirts and blouses were analyzed. According to the analysis, the reason why the dart & pleats position and margin were rated low was confirmed. In a virtual wear assessment on skirt patterns by body shape, a significant difference was found in all categories except for position of the hip circumference, margin of the hips, width of the skirt, and appropriateness of waist line position. The virtual wear assessment on the blouse patterns by body shape also revealed a significant difference in all categories but fit and shape pf the back part. In blouses, a significant difference was observed around shoulders and waist in type 1 and around the belly in type 2. On the contrary, for skirts, a significant difference was found around the hips and waists in type 1 and type 2. Therefore, these factors should be considered in making blouses and skirts. The above results suggested that skirt and blouse patterns should vary by body shape. It is anticipated that there should be further studies comparing brand-name school uniforms for high school girls and school uniforms by body shape.

• Journal of Conservation Science
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• v.37 no.6
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• pp.821-830
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• 2021

The weapons excavated from the de-militarized zones (DMZ) of Korea are vulnerable to corrosion due to the immediate and drastic environmental change. Especially, the chloride ions (Cl^-) in iron weapons cause active corrosion and require removal. In this study, conservation treatment and de-salination was performed for the discovered weapons from excavation sites of soldiers killed in action during the Korean War. Furthermore, an attempt was made to prepare the most stable plan for conservation treatment through the comparative study of soaking weapons in distilled water without chemicals and in a solution of sodium (SSC) at different temperatures. In the preliminarily experiments, the comparison of the eluted Cl^- ions according to different conditions of de-salination showed that the highest number of ions were detected from the de-salination with SSC at a temperature of 100℃, and its duration was much smaller, i.e., 1~2 weeks. Accordingly, for the parts from the guns and rifles amongst other objects, a six-time de-salination was conducted in the SSC solution for 8 hours at 100℃ and subsequently, for 16 hours at room temperature during which the distilled water and SSC were exchanged every week. However, in the case of a loaded rifle, the de-salination was not conducted, considering the risk that the high temperature and pressure by impregnation in vacuum could cause an explosion

• The Korean Journal of Food And Nutrition
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• v.36 no.1
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• pp.6-16
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• 2023

To investigate the anti-inflammatory activity of submerged culture using Cordyceps militaris mycelium, culture-including mycelia was extracted and lyophilized into postbiotics (hot-water extract; CM-HW). HW was fractionated into crude polysaccharide (CM-CP) by ethanol precipitation, and CM-CP was further dialyzed into CM-DCP by dialysis with running water using 12~14 kDa dialysis tube. When the cytotoxicity of subfractions against cells was assessed, no subfraction had a cytotoxic impact that was substantially different from the control groups. In an inflammatory model using LPS-stimulated RAW 264.7 cells, CM-DCP significantly decreased IL-6 and MCP-1 production levels compared to the LPS-control group. CM-DCP also inhibited IL-6 and IL-8 secretion in HaCaT keratinocytes stimulated with TNF-α and IFN-γ. In the meanwhile, the neutral sugar content and mannose ratio of anti-inflammatory CM-DCP were higher than the other fractions, and CM-DCP contained β-1,3/1,6-glucan of 216.1 mg/g. High pressure size exclusion chromatography revealed that CM-DCP contained molecules with a molecular weight range of 5.6 to 144.0 kDa. In conclusion, postbiotics of C. militaris mycelium significantly promoted anti-inflammatory activity, suggesting that neutral polysaccharides including Glc and Man contribute to the anti-inflammation in RAW 264.7 or HaCaT cells.

• Journal of the Korean Geosynthetics Society
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• v.22 no.3
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• pp.11-25
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• 2023

In this study, the design and numerical analysis method of the inclined self-supported wall using cement treated soil were studied. In the case of the inclined self-supported wall, the active earth pressure decreased due to the decrease in the coefficient, Ka according to the slope (angle) and the weight decreasing effect, thereby increasing the overall stability. The wall with the slope caused a change in failure mode from overturning to sliding on the excavation side, and the optimal slope was evaluated to be about 10°. Compared to the strength reduction method, the overall stability in numerical analysis results in conservative results in limit equilibrium analysis, so it was found that this method should be attended when designing. As a result of the parameteric study, the stability on bearing capacity and compression failure did not significantly increase above the slope of 10° when the surcharge was small (about 20kPa or less). In the case of cohesion of the backfill, The results similar to numerical analysis were found to consider cohesion. It was evaluated that stability on sliding, oveturning, shear, and tension failure increases in proportion to the thickness of the wall, but there is no significant change in the stability on the bearing capacity and compressive failure regardless of the thickness of the wall above a certain angle (about 10°).

• Journal of Naturopathy
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• v.12 no.1
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• pp.7-15
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• 2023

Background: As a result of analyzing the components of wild Conyza canadensis, it contains physiologically active ingredients, so it is necessary to identify the compound. Purposes: It was to study the compound's molecular structure; a previous study showed that C. canadensis contains antioxidant substances. Methods: The ultrasonic pulverized lysate of C. canadensis stem and leaves was first extracted with 90% methanol and then five organic solvents. Next, the extracts was fractionated by HPLC, LC/MS chromatography, and NMR analyzers identified the molecular structure. Results: 100 g of dry C. canadensis was sonicated in 90% methanol and concentrated under reduced pressure to 11.96 g of a crude extract. Then, this crude was extracted with five types of solvents to obtain 123.8 mg of n-hexane, 448.2 mg of dichloromethane, 1047.7 mg of ethyl acetate (EA), 2563.8 mg of butanol, and 7.04 g of water. The EA extracts were fractionated by LC-MS and then re-fractionated to obtain F1 to F20. Next, the F15 was further fractionated to obtain nine fine fractions. Finally, the F17 fraction was re-fractionated to obtain ten fine fractions. As a result of LC-MS and NMR spectrometer analysis of the F15-7, the structure of this compound was confirmed as 3,5-dicaffeoylquinic acid. As a result of examining the structures of the F17-4 and F17-5 fractions, Quercetin-3-o-β-galactose was identified. In addition, the form of the F17-10 was confirmed to be 1,3,4-tri-caffeoylquinic acid. Conclusions: This study demonstrated that C. canadensis contained phenolic antioxidants, and its utilization may be expected.

• Journal of the Korean Geotechnical Society
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• v.24 no.5
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• pp.129-137
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• 2008

An active application of concrete track is being expected far the future constructions of Korean railroad. In comparison with the existing ballasted tract, a concrete track is very susceptible for the settlement, since its rehabilitation requires much time and cost. When a concrete track is constructed on fine-grained subgrade soil, excessive cumulative plastic settlements due to repetitive train road may occur. In this case, the settlement of the concrete track may be effectively reduced by installing a small number of small-diameter piles beneath the track. This paper presents the effect of pile installation on the reduction of cumulative plastic settlement of concrete track. A method combining experiential equation and numerical method is proposed. Using an existing experiential equation and the estimated earth pressure distribution, the cumulative plastic strain was calculated. From the results, it is verified that the effects of the pile installation is significant to effectively reduce the cumulative plastic settlement of concrete track. The reduction effects of the cumulative plastic settlement according to the pile number and pile arrangement are presented.