• Bulletin of the Korean Chemical Society
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• v.30 no.11
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• pp.2739-2748
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• 2009

Hologram and three dimensional quantitative structure activity relationship (3D QSAR) studies for a series of anilinobipyridine JNK3 inhibitors were performed using various alignment-based comparative molecular field analysis (COMFA) and comparative molecular similarity indices analysis (CoMSIA). The in vitro JNK3 inhibitory activity exhibited a strong correlation with steric and electrostatic factors of the molecules. Using four different types of alignments, the best model was selected based on the statistical significance of CoMFA ($q_2\;=\;0.728,\;r_2\;=\;0.865$), CoMSIA ($q_2\;=\;0.706,\;r_2\;=\;0.960$) and Hologram QSAR (HQSAR: $q_2\;=\;0.838,\;r_2\;=\;0.935$). The graphical analysis of produced CoMFA and CoMSIA contour maps in the active site indicated that steric and electrostatic interactions with key residues are crucial for potency and selectivity of JNK3 inhibitors. The HQSAR analysis showed a similar qualitative conclusion. We believe these findings could be utilized for further development of more potent and selective JNK3 inhibitors.

• Journal of Korea Multimedia Society
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• v.20 no.1
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• pp.43-50
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• 2017

According to living environment, the number of deaths due to thyroid diseases increased. In this paper, we proposed an algorithm for recognizing a thyroid detection using texture analysis based on shape, gray level co-occurrence matrix and gray level run length matrix. First of all, we segmented the region of interest (ROI) using active contour model algorithm. Then, we applied a total of 18 features (5 first order descriptors, 10 Gray level co-occurrence matrix features(GLCM), 2 Gray level run length matrix features and shape feature) to each thyroid region of interest. The extracted features are used as statistical analysis. Our results show that first order statistics (Skewness, Entropy, Energy, Smoothness), GLCM (Correlation, Contrast, Energy, Entropy, Difference variance, Difference Entropy, Homogeneity, Maximum Probability, Sum average, Sum entropy), GLRLM features and shape feature helped to distinguish thyroid benign and malignant. This algorithm will be helpful to diagnose of thyroid nodule on ultrasound images.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.11a
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• pp.385-386
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• 2009

활성 윤곽선 모델은 스네이크 모델이라고도 하며 영상에서 물체의 경계를 검출하기위한 효과적인 방법으로 사용되고 있다. 본 논문에서는 초기 윤곽선 문제와 효과적인 경계선 검출을 위해 다해상도 기반의 유전자 알고리즘을 이용한 활성 윤곽선 모델을 제안한다. 입력영상의 해상도를 영상 피마리드 기법으로 저해상도로 축소시키고 초기 윤곽선을 설정한다. 설정된 윤곽선상의 연속된 두 좌표를 유전인자로 선택하고, 유전 연산자를 적용하여 물체의 경계를 찾아간다. 경계가 검출된 저해상도 영상을 단계적으로 확대하여, 보간될 영역의 국부적 활성 윤곽선 에너지를 계산하여 최소 에너지를 갖는 위치에 새로운 윤곽선 좌표를 삽입하여 경계를 형성한다. 제안된 방법은 초기 윤곽선의 위치에 상관없이 경계선을 검출했으며, 형태가 복잡한 물체의 경우에도 효과적으로 경계선을 검출하고 계산 복잡도를 감소시켰다.

• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.4
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• pp.562-567
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• 2009

As a key mechanism of the human emotion interaction, Facial Expression is a powerful tools in HRI(Human Robot Interface) such as Human Computer Interface. By using a facial expression, we can bring out various reaction correspond to emotional state of user in HCI(Human Computer Interaction). Also it can infer that suitable services to supply user from service agents such as intelligent robot. In this article, We addresses the issue of expressive face modeling using an advanced active appearance model for facial emotion recognition. We consider the six universal emotional categories that are defined by Ekman. In human face, emotions are most widely represented with eyes and mouth expression. If we want to recognize the human's emotion from this facial image, we need to extract feature points such as Action Unit(AU) of Ekman. Active Appearance Model (AAM) is one of the commonly used methods for facial feature extraction and it can be applied to construct AU. Regarding the traditional AAM depends on the setting of the initial parameters of the model and this paper introduces a facial emotion recognizing method based on which is combined Advanced AAM with Bayesian Network. Firstly, we obtain the reconstructive parameters of the new gray-scale image by sample-based learning and use them to reconstruct the shape and texture of the new image and calculate the initial parameters of the AAM by the reconstructed facial model. Then reduce the distance error between the model and the target contour by adjusting the parameters of the model. Finally get the model which is matched with the facial feature outline after several iterations and use them to recognize the facial emotion by using Bayesian Network.

• Journal of Korean Tunnelling and Underground Space Association
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• v.10 no.2
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• pp.105-118
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• 2008

Shotcrete is one of the main support materials in tunnelling. Its bonding state on excavated rock surfaces controls the safety of the tunnel: De-bonding of shotcrete from an excavated surface decreases the safety of the tunnel. Meanwhile, the bonding state of shotcrete is affected by blasting during excavation at tunnel face as well as bench cut. Generally, the bonding state of shotcrete can be classified as void, de-bonded, or fully bonded. In this study, the state of the back-surface of shotcrete is investigated using impact-echo (IE) techniques. Numerical simulation of IE technique is performed with ABAQUS. Signals obtained from the IE simulations were analyzed at time, frequency, and time-frequency domains, respectively. Using an integrated active signal processing technique coupled with a Short-Time Fourier Transform (STFT) analysis, the bonding state of the shotcrete can be evaluated accurately. As the bonding state worsens, the amplitude of the first peak past the maximum amplitude in the time domain waveform and the maximum energy of the autospectral density are increasing. The resonance frequency becomes detectable and calculable and the contour in time-frequency domain has a long tail parallel to the time axis. Signal characteristics with respect to ground condition were obtained in case of fully bonded condition. As the ground condition worsens, the length of a long tail parallel to the time axis is lengthened and the contour is located in low frequency range under 10 kHz.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.4
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• pp.1665-1673
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• 2013

Recently, the interest and demand on free formed structure providing aesthetic value as well as functionality has been increasing. Formwork has numerous advantages such as high strength, convenience, accuracy and good quality of surface roughness. Nevertheless, it increases construction cost and period to build complex shapes. For these purpose, deposition construction systems such as Contour Crafting and Concrete Printing have been developed with active collaboration between university and industry by applying the rapid prototyping technology to the construction industry in USA and England. Since there has been no related research in Korea, the possibility of spin-off technology and its fusion cannot be expected. In this paper, design elements including mechanical system and control system related to automatic deposition construction system prototype for constructing a free curved structure without mold are described. As for an appropriate material for the system, fiber reinforced mortar was selected by experiments on compressive strength, fluidity, viscosity and setting time. By performing transfer and extrusion experiments, the possibility of the development of deposition construction system was demonstrated. Based on this research results, it is required to keep the automatic deposition construction system improve and extend it into the new application area in construction industry.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.38 no.3
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• pp.283-289
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• 1993

Effect of sulfur dioxide gas on the growth and yield of soybean growing in the On-San Industrial Complex area was evaluated using the isoquant contour lines of the sulfur dioxide in air of the area. Average concentration of sulfur dioxide monitored in the Industrial Complex from July 17 to September 17 was 0.77mg / 100cm$^2$ PbO$_2$/day. Soil pH ranged from 4.2 to 6.5. Yield losses were estimated by 5～30% due to the effect of sulfur dioxide. Liming could relieve the yield reduction to some extent. The cumulative $SO_2$ concentration, as measured by PbO$_2$ method, for two months of active vegetative growth to early ripening stage has shown a good negative correlation with soybean yield. But, pod number and 100 grain weight did not show the correlation with the concentration of sulfur dioxide. These results suggest that sulfur dioxide affect chronically and cumulatively the growth of soybean plants.

• Journal of the Korean Geosynthetics Society
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• v.11 no.4
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• pp.1-8
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• 2012

In this study, the earth pressure, displacement and strain were compared with reinforcement types at segmental retaining wall through full scale model test. The test results found that the measurement of earth pressure and displacement at wall for the fully reinforced retaining wall are different from those for the partly reinforced retaining wall. The analyses of these results would suggest that the used of geoogrid allowed the vertical earth pressure and displacement at wall to be reduced. The horizontal earth pressure in upper and lower part of wall can change with reinforcement type and earth deformation and were larger than the active and the rest pressure. Also, the lateral earth pressure and displacement of wall have a very high a correlation. It was found that the strain contour distribution of reinforcements was occurred a large strain at cental part of wall in segmental retaining wall system.

• Journal of Society of Preventive Korean Medicine
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• v.20 no.1
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• pp.75-87
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• 2016

Objectives : This study aims to classify and analyze literature related to moire topography, as a diagnostic device of Korean medicine, discuss research trends and major results, and demonstrate the value of moire topography. Methods : To investigate moire topography research trends, Korean keywords that signify 'moire' were searched in a Korean journal search engine. Initially, 2,988 papers were found in the research, and, after classifying them and removing those that are duplicate in other databases, only 37 papers were applicable for the literature review in this study. To analyze research trends, the 37 papers were analyzed based on the publication year, research field, journal, and research type, and, clinical articles were classified based on the diagnosis purpose, subject characteristics, diagnosis method, test method, and test result, for analysis. Results : Moire topography research in South Korea was first conducted in 1995 and most active in 2003, mostly in the field of Korean medicine. In the journal analysis, The Journal of Korea CHUNA Manual Medicine for Spine & Nerves published the highest number of papers, most of which were clinical articles and the rest were literature review. And, in the analysis of clinical papers, based on the diagnosis purpose, muscle somatotype measurement was most common, followed by diagnosis of scoliosis. In terms of subjects, most studies focused on elementary, middle, and high school students, and, in terms of the diagnosis method, other tests were used in most studies. The analysis of moire topography methods showed that most studies measured the shoulder, back, and hip, and the most common measurement method in the studies measured the difference in contour lines on the left and right by designating a central line of the body. In terms of the result, most moire topography brought about significant diagnosis results, and many studies demonstrated its use for musculoskeletal diseases in particular. Conclusions : Moire topography is believed to be highly significant for diagnosis and treatment of musculoskeletal diseases and further research will be needed to support it.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.11
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• pp.123-132
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• 1998

This paper presents a road detection technique for spaceborne synthetic aperture radar (SAR) images. Roads are important cartographic features. We incorporate an active contour model called snake as a model for the road and define a new external energy for snake which is appropriate for the road. Detecting roads in spaceborne SAR images is very difficult without other information. In this paper, digital maps are utilized to obtain the initial position and shape for snake. Only approximate geodetic location of roads appearing in SAR images can be known through geocoding process and usual digital maps also have location errors. Therefore, there exist large location offsets between the two data. By introducing initial matching procedure, the errors are reduced significantly. Then we initialize the snake's shape using the roads extracted from digital map and minimize the energies of all snake points to detect roads. We outline two problems in detection and propose a method that mitigates them.