• Journal of Pharmaceutical Investigation
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• v.34 no.3
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• pp.161-168
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• 2004

5-Fluorouracil (5-FU) is an antimetabolite anticancer agent active against many types of solid tumors. Tegafur (TF), a prodrug of 5-FU, is frequently used in combination with uracil as dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine. We studied the stability of 5-FU and TF in biological fluids of rats and determined their bioavailability (BA) and excretion into bile, and urine. The drug concentrations were analyzed by an HPLC method. At room temperature, there was a 14-30% decrease in the concentration of 5-FU and TF in bile, urine, and plasma specimen at 10 and $100\;{\mu}g/ml$ over 240 min. No significant difference was noted among the sample types or between two different concentrations of 10 and $100{\mu}g/ml$. The decrease in drug concentration was significantly less in samples kept on ice (6-12%) for both drugs. These data indicate that biological fluid samples containing 5-FU or TF in plasma, urine, or bile should be placed on ice during the sample collection. Following these storage guidelines, samples were collected after administration 50 mg/kg of each drug via i.v. or oral route. BA was 1.5 folds greater for TF (60%) than that of 5-FU (42%). Approximately 0.52 and 3.3% of the i.v. doses of 5-FU and TF was excreted into bile, respectively. Renal clearance of 5-FU was about 16% of its total body clearance. These results suggest that instability of 5-FU and TF in biological fluids should be considered in pharmacokinetic or pharmacogenomic studies.

• Journal of Arbitration Studies
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• v.13 no.2
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• pp.181-209
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• 2004

This Study is divided into 5 separate Parts and an Abstract. Part Ⅰ, Ⅱ consist mostly of a collection of problems, current status, motives and the future of ADR. In Pert Ⅲ was described ADR as policies of judicial settlements. We must accept that a diversity of legal culture will always continue to exist. Accordingly we must learn to accommodate those differences of 'culture' around us and to harmonize conflicting laws. This recognition of our reality should in no way be confused with pessimism. In fact if one accepts this perspective of the world ,the study of law seems enriched and becomes academically more challenging. Recently, in the United States, interest in alternative settlement mechanism has increased greatly, which leads me to wonder why such a phenomenon has taken place. In the first place, I'm amazed at the extent to which conciliation or mediation-or the new word, I guess, is alternative dispute resolution, which by now has its own acronym, "A.D.R,"-have gained attention here recently. When 35 years ago, there was virtually no interest in conciliation in this country at the time. What interest there was, was no in the law schools. But looking at the situation now, we have a spate of publications on the subject; we have organizations that are established for no other reason than to promote alternative dispute settlement. We have courses in the law schools. The American Association of Law Schools and the American Bar Association also have active programs. So we have to ask ourselves why. The difference between now and 35 years are striking. On the other hand, I think the interest of the public in ADR has probably been greatly enhanced by the politics of the so-called "poverty programs." I think that many of these assistance programs for the poor-and I do think the "poor" have become a rather expansive political movement beyond simply taking care of the most marginal people of society-have generated money to explore this kind of dispute resolution.

• Journal of Electrochemical Science and Technology
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• v.1 no.1
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• pp.50-56
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• 2010

$La_{0.6}Sr_{0.4}Co_{0.2}Fe_{0.8}O_{3-\delta}$ (LSCF) powders with different particle sizes, synthesized through a citrate complexation method and a gel-casting technique, are used to fabricate porous LSCF cathodes with graded microstructures via tape casting. To create porous electrodes with desired porosity and pore structures, graphite and starch are used as pore former for different layers of the graded cathode. Examination of the microstructures of the as-prepared LSCF cathode using an SEM revealed that both grain size and porosity changed gradually from the catalytically active layer (near the electrodeelectrolyte interface) to the current collection layer (near the electrode-interconnect interface). Impedance analysis showed that a 3-layer LSCF cathode with graded microstructures exhibited much-improved performance compared to that of a single-layer LSCF cathode, corresponding to interfacial resistance of 0.053, 0.11, and 0.27 $\Omega{\cdot}cm^2$ at 800, 750, and $700^{\circ}C$ respectively.

• Journal of Korean Academy of Nursing
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• v.24 no.1
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• pp.96-114
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• 1994

This study was carried out to describe and analyze experimental studies conducted in graduates nursing degree. Of 170 experimental studies conducted during the past three decades between 1962 and August 1991, 150 studies were available, including 124 master’s and 26 doctoral theses. This study examined their general characteristics and detailed research methods using percentiles. The results were as follows 1. Most of the studies adopted a quasi-experimental design. 2. The subjects of the studies were chosen by convenience sampling except for two studies whose subjects were drawn by randomization. Studies comparing experimental and control groups were in the highest proportion and the most frequent sample sizes of each group were 21 to 30 for both experimental and control groups. 3. As to measurement, physiological measures were most frequent followed by psychsociological measures and active report questionnaires. Each study, on average, adopted two kind of measurement tools. Studies in which the data collection period was of 1~2 months were in the highest pro-portion. 4. All doctoral theses and 67.0% of master’s theses examined specific research hypotheses. Of these studies, the results of 92.5% supported the hypotheses. 5. Parametric statistics were the major analytical methods. In particular, t-test was used most frequently followed by Chi square, F-test, and Pearson Correlation Coefficients. 6. Patients were the most frequent study subjects. Frequent nursing interventions were information and education followed by support, distraction, and nursing treatments. 7. With regards to the dependent variables, “feelings” such as anxiety, pain, and depression were most frequent. In addition “exchanging” such as restoring, metabolism, cardiopulmonary function, infection and vital signs were adopted as the dependent variables in 29.1％ of the studies examined, while 12.3% of the studies selected “choosing” such as stress, health behavior, or role performance.

• The KIPS Transactions:PartD
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• v.8D no.3
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• pp.241-246
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• 2001

Area of software measurement in software engineering is active more than thirty years. There is a huge collection of researches but still no a concrete software cost estimation model. If we want to measure the cost-effort of a software project, we need to estimate the size of the software. A number of software metrics are identified in the literature ; the most frequently cited measures are LOC(line of code) and FPA(function point analysis). The FPA approach has features that overcome the major problems with using LOC as a measure of system size. This paper presents an neural networks(NN) models that related software development effort to software size measured in FPs and function element types. The research describes appropriate NN modeling in the context of a case study for 24 software development projects. Also, this paper compared the NN model with a regression analysis model and found the NN model has better estimative accuracy.

• Journal of the Korea Society of Computer and Information
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• v.16 no.11
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• pp.219-232
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• 2011

The purpose of this study is to give implications for cooperative network building for general corporate IT staffs as well as operational improvement of the IT organization which is a specialized unit in general company though analysis of characteristics of communication networks of the IT organization. 39 IT employees of company "A" were surveyed and interviewed, and the data collected were analyzed in a network analysis method. The analysis shows that a variety of networks were built across employees - e.g. strong/weak ties or centralized/decentralized structure - by each communication area. IT competency network was found weak ties. Career-rela ted network showed centralized and hierarchical characteristics. At the center of each network was positioned manager of each team. To address improvement of the findings, I presented the followings: more active networking over IT competency, enhancement of work centralization and collection of research data as to communication network of IT organization.

• The Journal of the Convergence on Culture Technology
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• v.4 no.1
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• pp.119-128
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• 2018

In this paper, The purpose of this qualitative research was to explore the experience of a nursing simulation practice focused on patients with cardiac arrest with 50 4th-year nursing students who participated the simulation practical education. The data collection period was from 12/4/2017 to 12/6. Subjects were asked to write a self-reflection journals with a narrative style in order to explore the cardiac arrest simulation practice experience. Data were analyzed using Thematic Analysis by Braun & Clarke. The results were "Expectation for types of simulation education", "A great deal of regret", "Pre-experience in cardiac arrest situation", "Cognition in the importance of team interaction", "Active reaction", "Extended role from a nursing student to a nurse." The results indiate that understanding the experience of a nursing simulation education for nursing students will be able to be used as baseline data which is needed to manage the method of the simulation education effectively.

• STI Policy Review
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• v.3 no.2
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• pp.92-110
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• 2012

An active policy role is suggested for collaboration that will enhance national level Science and Technology (S&T) capabilities. In contrast, some studies see a limited role of policy support for collaborative S&T research at the individual level (including research groups or institutional levels) due to their self-organizing nature. Two views on S&T collaboration look at different levels but existing research largely ignores the context of developing countries. This paper shows how S&T collaborations between Brazil and Korea have developed over the past two decades. The paper indicates the gaps between initiation and the actual establishment of collaborative research at national and individual levels, differences in the focus areas of research, differences in resources and project planning, and the nature of collaborations. Collaborative research activities at the national level were initiated before the individual level but activated later than the individual level; in addition, the focus areas of research were laid down earlier at the national level with individual collaborations focused on different areas. Project types remained different at each level (i.e. top-down and bottom-up) or with a slightly changing mix. This study suggests appropriate policy measures (such as the timely and effective information collection of activities at different levels and proactive coordination) that could reduce the gaps in the timing and alignment of research areas. This paper also alludes to an evolutionary model to develop S&T collaboration among developing countries.

• Journal of Gifted/Talented Education
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• v.19 no.1
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• pp.119-140
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• 2009

This paper examined its possibility and made its new definition by finding relevant bases in order to make a close inquiry into its Identity and direction at this point when cyber-based gifted education academy is established and operated again by its necessity And 4 models which can be used in special education for the gifted were developed making a link with special education for the gifted by collecting and re-classifying cyber educational methods developed by basic research as priority of the educational method which is considered to be the most urgent issue in practical cyber learning. It is a project-type cooperation education model, an information collection-type research education model, a community-type discussion education model, and a problem focus-type e-PBL education model. To apply developed leaching-learning models to reality, students at gifted education academy in Gyeonggi Cyber Gifted Province were imputed models in different ways respectively for 4 months. As a result of analysis and statistical data of activity level and satisfaction level of students who participated in learning activity, it appeared that high level of satisfaction and active activity level were induced compared to the previous method based on tasks. It is expected that this paper will provide the bases when each cyber-based gifted education academy plans operation plan later on, and it will provide proper methods when cyber guidance teachers plan class activities.

• The KIPS Transactions:PartD
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• v.9D no.4
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• pp.603-612
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• 2002

Area of software measurement in software engineering is active more than thirty years. There is a huge collection of researches but still no concrete software development effort and cost estimation model. If we want to measure the effort and cost of a software project, we need to estimate the size of the software. A number of software metrics are identified in the literature; the most frequently cited measures are LOC (line of code) and FPA (function point analysis). The FPA approach has features that overcome the major problems with using LOC as a measure of system size. This paper presents simple linear regression model that related software development effort to software size measured in FP. The model is derived from the plotting of the effort and FP relation. The experimental data are collected from 789 software development projects that were recently developed under the various development environments and development methods. Also, the model is compare with other regression analysis model. The presented model has the best estimation ability among the software effort estimation models.