• Natural Product Sciences
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• v.26 no.3
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• pp.183-190
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• 2020

Genome mining has recently emerged as a powerful strategy to discover novel microbial secondary metabolites. However, more than 50% of biosynthetic gene clusters are not transcribed under standardized laboratory culture condition. Several methods have been applied to activate silent biosynthetic gene clusters in the microbes so far. Among the regulatory systems for production of secondary metabolites, global regulators, which affect transcription of genes through regulatory cascades, typically govern the production of small molecules. In this review, global regulators to affect production of microbial secondary metabolites were discussed.

• Journal of the Ergonomics Society of Korea
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• v.2 no.1
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• pp.13-21
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• 1983

Small group activity in Korea was introduced from the United States as QC circle, ZD group movements and the like, but it has developed into a Korean style from so-called factory saemaul panel activities contributing much to the management of enterprises. Based on human motivation theory, the principles to activate small group activity is suggested on which a new diagnosis of small group activity is proposed here. It is consisted of checklist and radarchart. The factor to activate small group activity have been obtained in terms of multivariate analysis for data from the new diagnosis.

• The Mathematical Education
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• v.40 no.1
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• pp.53-66
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• 2001

The purpose of this work is to activate mathematics class in the extra curricular activity under the 7th curriculum. For that purpose, we investigate the current management of the extra curricular activity in the secondary school mathematics, and analysis the result. We suggest the main counterplan to activate mathematics class of extra curricular activity as following; (1) Develope teaching materials and programs for mathematics class. (2) Get the mathematics laboratory.

• International conference on construction engineering and project management
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• 2005.10a
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• pp.403-408
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• 2005

Being in a knowledge-based industry, many construction organizations are seeking to manage their own knowledge in an effective way. To manage knowledge, the organizations must motivate in-house people to share their knowledge. However, some barriers to knowledge sharing do exist and researches on these barriers considering construction organizations' characteristics seem rare. This study aims to identify key barriers to knowledge sharing considering the characteristics of construction organizations. Based on the identification, strategic responses to each key barrier are presented in two perspectives of technical and behavioral approach to activate knowledge sharing.

• Hwankyungkyoyuk
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• v.18 no.2 s.27
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• pp.23-30
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• 2005

The purpose of this study is to develop School Agenda 21 to activate environmental education at schools. In detail, this study is intended to develop operating procedures, major issue areas or domains, and instructions on the preparation for School Agenda 21. School Agenda 21 means the action plan which students, teachers, parents, and other concerned parties (including office of education, local municipal bodies, and NGOs) write under agreement with respect to their respective roles in order to activate environmental educations oriented toward sustainable development. The results of this study are as follow. First, the operating procedures for School Agenda 21 consist of seven steps; organization, diagnosis of problems, setup of targets or objectives, development of codes of behavior, system establishment, practices and reviews, and evaluation and feedbacks. Second, major issue areas for School Agenda 21 are classified into six; school management, class operation, independent subject activity, separate subject activity, non-subject activity, and external relations of school. Third, instructions of the preparation of School Agenda 21 address these 10 concepts; balance, unification, continuity, daily routine, linkage, environmental justice, participation, peculiarity of schools and classes, regional peculiarity, and concreteness, which consider 7 principles for environmental education, levels of learners, regional features, and concreteness. School Agenda 21 developed from this study converts existing environmental education toward sustainable development environmental education, and developed for the purpose to activate school environmental education, but ultimate purpose of this study are realizing sustainable society, sustainable future to realize education for sustainable development. So School Agenda 21 is expected to important performance way making possible Local Agenda 21, National Agenda 21, Agenda 21 as if education, public recognition and discipline contents of the 36 chapter of Agenda 21.

• Journal of Korean Academy of Nursing Administration
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• v.9 no.3
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• pp.415-427
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• 2003

Purpose: The purpose of this study was to investigate the degree and pattern of knowledge management process, and to identify the relationship between knowledge management process and organizational effectiveness in clinical nurses. Method: Participants were 665 regular clinical nurses who had worked for over 1 year in general units of 9 tertiary medical hospitals including 2 national university hospitals, 5 university hospitals, and 2 hospitals founded by business enterprises. Data were collected from March to May 2003 through questionnaires. Four structured instruments were used to collect the data: Knowledge Management Process Scale(Jeong, Lee, Lee, & Kim, 2003), cCommitment Questionnaire(Mowday, Steers, & Porter, 1979), General Satisfaction Scale(CooK, Hepworth, Wall, & Warr, 1981), and one for general characteristics. The data were analyzed using factor analysis, reliability analysis, descriptive analysis, cluster analysis, one-way ANOVA, Scheffe test, correlation analysis with the SPSS for Windows 10.0 program. Result: 1) The average score for knowledge management process in nurses was $3.08{\pm}.54$ on a 5-point Likert scale. In order from highest mean score, the elements of knowledge management process, were Knowledge $Utilization(3.35{\pm}.57)$, Knowledge $Sharing(3.07{\pm}.58)$, Knowledge $Creation(2.99{\pm}.63)$, and Knowledge $Storage(2.91{\pm}.82)$. 2) Four knowledge management patterns for nurses, which were derived from cluster analysis, were inactivate pattern, delayed pattern, activate pattern, and high-activate pattern of knowledge management. 3) The degree of knowledge management process activation and 4 elements of knowledge management process, Knowledge Creation, Knowledge Storage, Knowledge Sharing, and Knowledge Utilization, were significantly correlated with nurses' organizational commitment and job satisfaction(p=.000). 4) The nurses' organizational commitment and job satisfaction showed significant differences according to the knowledge management patterns derived from cluster analysis of high-activate pattern, activate pattern, delayed pattern, inactivate pattern(p=.000). Conclusion: These results suggest that there are four knowledge management patterns for nurses, and knowledge management process positively affects the nurses' organizational commitment and job satisfaction. From the above findings, knowledge management process is empirically verified as a useful and effective method to increase organizational effectiveness, and develop the organization.

• Journal of Mechanical Science and Technology
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• v.15 no.1
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• pp.10-20
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• 2001

The leak before break(LBB) concept is difficult to apply to a structure with a thin tube that is immersed in a water environment. A heat exchanger in a nuclear power plant is such a structure. The present paper addresses an application of the LBB concept to a heat exchanger in a nuclear power plant. The minimum leaked coolant amount(approximately 37.9 liters) containing the radioactive material which can activate the radiation detector device installed in near the heat exchanger is assumed. A postulated initial flaw size that can not grow to a critical flaw size within the time period to activate the radiation detector is justified. In this case, the radiation detector can activate the warning signal caused by coolant leakage from initially postulated flaws of the heat exchanger. The nuclear plant can safely shutdown when this occurs. Since the postulated initial flaw size can not grow to the critical flaw size, the structural integrity of the heat exchanger is not impeded. Particularly the informational scenario presented in this paper discusses an actual nuclear plant.

• Journal of Korean society of Dental Hygiene
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• v.14 no.2
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• pp.269-279
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• 2014

Objectives : The purpose of this study was to investigate the oral health center operation and to activate the program development of public oral health center. Methods : Delphi analyses were utilized by the recruited expert panel from August to September in 2012. Results : The difficulty in operation of the oral health centers is the human resources management. In order to solve the human resources operation, utilization of the local human resources is the best choice of the solution. The next choice was the designation of the oral health expert in Ministry of Health and Welfare. So the expert can activate the public oral health care system for the disabled and the underprivileged classes in the long term. Conclusions : In order to activate the oral health centers, Ministry of Health and Welfare should promote the public health center function connected with the cooperation of the Association of dental hygienists.

• Molecules and Cells
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• v.37 no.6
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• pp.441-448
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• 2014

Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes. These multiprotein complexes activate inflammatory caspases (i.e., caspase-1) which in turn catalyze the maturation of select pro-inflammatory cytokines, including interleukin (IL)-$1{\beta}$ and IL-18. Activation of the NLRP3 inflammasome typically requires two initiating signals. Toll-like receptor (TLR) and NOD-like receptor (NLR) agonists activate the transcription of pro-inflammatory cytokine genes through an NF-${\kappa}B$-dependent priming signal. Following exposure to extracellular ATP, stimulation of the P2X purinoreceptor-7 ($P2X_7R$), which results in $K^+$ efflux, is required as a second signal for NLRP3 inflammasome formation. Alternative models for NLRP3 activation involve lysosomal destabilization and phagocytic NADPH oxidase and /or mitochondria-dependent reactive oxygen species (ROS) production. In this review we examine regulatory mechanisms that activate the NLRP3 inflammasome pathway. Furthermore, we discuss the potential roles of NLRP3 in metabolic and cognitive diseases, including obesity, type 2 diabetes mellitus, Alzheimer's disease, and major depressive disorder. Novel therapeutics involving inflammasome activation may result in possible clinical applications in the near future.

• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.4
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• pp.492-500
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• 2014

The defense industry export of Korea has been steadily risen since 2006. It is attained $340million, the highest export amounts ever, in 2013. As the defense industry export increase, Defense Acquisition Program Administration (DAPA) built defense industry export and import management system to assist export and to protect defense technologies. In this paper, we study factors to activate the defense industry export and import management system using Technology Acceptance Model(TAM) in compulsive usage environment. The significance of this study is as follows: First, we prove the reliability and feasibility of measurement variables in defense industry of compulsive usage environment. Second, we suggest factors to activate the defense industry export and import management system. Third, we present methodology to find factors in computation systems of public institute using TAM.