• Applied Microscopy
• /
• v.8 no.1
• /
• pp.1-8
• /
• 1978

The aim of this research was to discover the action mechanism of various antituberculosis agents (isoniazid, paraaminosalicylic acid and streptomycin) which act on Mycobacteria tuberculosis hominis $H_{37}R_v$ and also to study the relationship of ultrastructural changes and the growth pattern in Mycobacterium tuberculosis hominis. The ultrastructural change was observed with an electron microscope while the growth pattern was studied through in vitro culture. The results are summarized as follows: 1. The ultrastructural changes found in the group treated only with isoniazid were the loss of nuclear materials and the appearence of electron dense granules. 2. In the group treated with paraaminosalicylic acid, thickening of nuclear filaments and meso some arrangement disorders were observed. 3. In the group treated with streptomycin, the ribosome particles appeared indistinct and the cytoplasm was denaturalized. 4. In the group cross treated with all three agents, all the ultrastructural changes mentioned above could be observed in the cell just as they appeared in the single treated groups. 5. In all of the single and in the crossly treated group, there were no significant changes note in the cell wall or cytoplasmic membranes of any of the cells observed. 6. In the cultural data in vitro, through the crossly treated group and single treated group. growth was observed in 3-5 weeks of culture.

• Proceedings of the KIPE Conference
• /
• 2000.07a
• /
• pp.207-210
• /
• 2000

In this paper a theoretical formulation of the direct control relating the action exerted by the inverter space vectors on the stator flux and the torque of Induction motor is analyzed. From the equation the scheme of the inverter switching is proposed and influence of the stator flux and the electromagnetic torque in each switching pattern is also analyzed.

• Biomolecules & Therapeutics
• /
• v.11 no.2
• /
• pp.133-138
• /
• 2003

The vascular relaxant and antihypertensive effects of newly developed salts of amlodipine-maleate and camsylate-were evaluated on isolated aorta from rats and in spontaneously hypertensive rats, and compared with those of amlodipine besylate, a standard drug. Amlodipine besylate concentration-dependently inhibited $Ca^{2＋}$-induced contraction in depolarised rat aorta($IC_{50}$/: 4.17 nM), with a very slow onset of action. Amlodipine maleate and amlodipine camsylate also showed vascular relaxant effect with a pattern and a potency similar to those of amlodipine besylate($IC_{50}$/: 3.62 and 3.28 nM, respectively). Amloclipine besylate produced a dose-dependent and long-lasting(>10∼24h) antihypertensive effect with a slow onset of action (ED$_{20}$: 2.31 mg/kg) in spontaneously hypertensive rats. Amlodipine maleate and amlodipine camsylate also exerted antihypertensive effects with a pattern and a potency similar to those of amlodipine besylate(ED$_{20}$: 2.09 and 2.21 mg/kg, respectively). These results suggest that amlodipine maleate and amlodipine camsylate are not statistically differ with amlodipine besylate in relaxant effect of $Ca^{2＋}$-induced contraction in depolarised rat aorta and in antihypertensive effect in spontaneously antihypertensive rats.

• The KIPS Transactions:PartB
• /
• v.16B no.5
• /
• pp.411-426
• /
• 2009

Most of the metaheuristics are made by imitating the action of the animals. In this paper, we proposed Mine Algorithm. The Mine Algorithm is a metaheuristic that imitates the action of the human being. Speaking of search, the field in which the know-how and the heuristics of the human being are melted best is the mining industry. In the Mine Algorithm we formalize the action pattern of the human being by focusing the mine business. The Mine Algorithm uses various searching techniques fluently and shows equally good performance for broad problems. That is, it has good generality. We show the improved generality of the Mine Algorithm by the comparing experiments with the conventional metaheuristics.

• The Journal of Korean Academy of Prosthodontics
• /
• v.30 no.3
• /
• pp.379-400
• /
• 1992

The purpose of this study was to analyze the magnitude and distribution of stress using a photoelastic model from the mandibular distal extension removable partial dentures with the mesial or distal placement of the occlusal rest and the mesial or distal connection in the back-action clasp with the five various designs of the back-action clasp, that is, the mesial connection and the distal rest, the distal connection and mesial rest, the mesial connection and mesial rest, the distal connection and the mesial and distal rest, and the mesial connection, and the mesial and distal rest. A photoelastic model was made of the epoxy resin(PC-1) and the hardner(PLH-1) with the acrylic resin teeth used and was coated with the plastic cement-1 at the lingual surface of the model and then five kinds of the removable partial dentures on the photoelastic model were set. A unilateral vertical load of 12.5 kg was applied on the central fossa of the first molar with the use of specially designed loading device and the pattern and distribution of the stress of the photoelastic model under each condition was analyzed by the reflective circular polariscope. The following results were obtained. 1. In the back-action clasp with the mesial connection and mesial rest of the case 3, the effect of the stress distribution was the most favorable. 2. In the back-action clasp with the mesial and distal rest, of the case 4 and 5, the stress distribution was more greatly showed in the terminal abutment. 3. Generally, the stress distribution was more favarable in the mesial connection than in the distal connection. 4. In the back-action clasp with the mesial connection of the case 1, 3 and 5, the stress distribution was the most favorable in the mesial rest.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.18 no.6
• /
• pp.45-54
• /
• 2004

Usually, according as accumulation degree of semi-conductor element increases, dynamic mistake test time increases sharply, and use of pattern generator is essential at manufacturing process to solve these problem. In this paper, we designed the PLD(Programmable Logic Device) circuit of pattern generator to examine dynamic mistake of semi-conductor element. Such all item got result that is worth verified action of return trip and function through simulation, and satisfy.

• The Korean Journal of Pharmacology
• /
• v.11 no.1 s.17
• /
• pp.55-60
• /
• 1975

An animal which is placed in a new environment displays a complex behavioral pattern consisting of locomotion, grooming and rearing. This behavioral pattern is influenced by endogenous and exogenous stimuli, such as hormonal secretion, level of neurohumoral transmitters, drugs and light. It is widely known that the most tranquilizers depressed spontaneous motor activity although their mechanisms of action were different, while antidepressants stimulated except imipramine which showed various action. Until the present time, the hole-board apparatus, which gives rather subjective data, has been used extensively to study the effects of drugs on general activity and exploratory behavior in mice. Recently a new apparatus for mobility measurements, called a 'Selective Activity Meter' has been introduced. This instrument supposedly produces more objective data on activity and behavior. The purpose of the present experiment was to study the influence of psychotropics on motor activity using the Selective Activity Meter. In the experiment, various psychotropic agents such as major tranquilizers(chlorpromazine, haloperidol); minor tranquilizers(meprobamate, diazepam); and antidepressants(amphetamine, imipramine) were used. In each experiment, the drug was administered to five mice and their activity was recorded. Each experiment was run five or more times and the results are based on the mean of each trial. The results are summarized as follows: 1. The group of mice treated with chlorpromazine showed markedly inhibited motor activity in comparison with controls and the inhibitory action of chlorpromazine was shown to be more intense than any of the other drugs used in the test. Haloperidol administration yielded similar results until 60 minutes, but mice showed less inhibition of motor activity than with chlorpromazine after 90 minutes. 2. In the group treated with diazepam, there was strong inhibition of motor activity until 30 minutes, but after 60 minutes the mice showed less inhibition than with chlorpromazine. In the meprobamate group, motor activity was inhibited in a manner similar to that of other tranquilizers, but the inhibition was less than that of diazepam. 3. In the group treated with imipramine, the inhibition developed gradually after ten minutes. 4. The effects of amphetamine did not appear until 30 minutes after administration, but then there was a significant increase in the motor activity.

• Journal of Biomedical Engineering Research
• /
• v.22 no.3
• /
• pp.249-257
• /
• 2001

The voluntary contracted EMG signal of spinal cord injured patients is very small because the information from central nervous system is not sufficiently transmitted to $\alpha$ motor neuron or muscle fiber. Therefore the acquisited EMG signal from needle or surface electrodes can not be identified obvious voluntary contraction pattern by muscle movement. In this paper we propose the extraction technique of voluntary muscle contraction and relaxation pattern from EMG signal of spinal cord injured patient whose EMG signal is composed of the linear sum of mo색 unit action potentials with two noise sources, additive noise assumed to be white Gaussian noise and high frequency discharge assumed to be not motor unit action potential but impulsive noise. In order to eliminate impulsive noise and additive noise from voluntary contracted EMG signal, we use the FatBear filter which is a nonarithmetic piecewise constant filter, and multiscale nonlinear wavelet denoising processing, respectively. The proposed technique is applied to the EMG signal acquisited from transverse myelitis patients to extract voluntary muscle contraction pattern.

• Journal of Families and Better Life
• /
• v.20 no.2
• /
• pp.43-56
• /
• 2002

While there is universal agreement that the ecosystems approach to family resource management is the must influential currently, questions have arisen about the broad applicability of the Deacon & Firebaugh (1988) ecosystems framework. Engberg (1996) has characterized the dominant approach in family resource management as technical and argued that a technical approach substantially restricts feasible actions in much of the world and should not be used in ethical practice. The purpose of the present paper is to compare the family resource management patterns by dual role manager of business owning families in Korea and The United States. Such a comparison is an essential step in the assessment of the usefulness of the Deacon & Firebaugh framework, in particular, and the ecosystems framework, more generally. Korean respondents are 105 family and business managers interviewed in 2000 as part of a survey of owners of small to medium size family business enterprises in Seoul. U.S. respondents are 259 dual role managers in the National Family Business Survey (NFBS 1997). Chi squared statistics indicated country differences on each of the ten(goal setting, standard setting, demand clarification, resource assessment, action sequencing, actuating, checking, adjusting, demand responses, resource change)management practices. Mean responses on eight of the practices(goal setting, standard setting, action sequencing, actuating, checking, adjusting, demand responses, resource changes) were significantly different between two countries. U.S. total score means of family resource management were higher than Korea. Factor analysis of the management scale items yielded different patterns for Korea, and the United States. Korean dual role manager of family business were categorized into three different patterns as classic oriented manager, goal oriented manager, action oriented manager and U.S. were categorized into Process oriented manager and Production oriented manager. Both the number of managerial strategies and the types of strategies used varied in the two countries.

• The Korean Journal of Physiology and Pharmacology
• /
• v.4 no.2
• /
• pp.81-90
• /
• 2000

The types of $K^+$ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary $GH_3$ cells. Heterogeneous pattern of SAP activities was changed into more regular mode with elongation of activity duration and afterhyperpolarization by treatment of TEA (10 mM). Under this condition, exposure of the class III antiarrhythmic agent E-4031 $(5\;{\mu}M)$ to $GH_3$ cells hardly affected SAP activities. On the other hand, the main $GH_3$ stimulator thyrotropin-releasing hormone (TRH) still produced its dual effects (transient hyperpolarization and later increase in SAP frequency) in the presence of TEA. However, addition of $BaCl_2$ (2 mM) in the presence of TEA completely blocked SAP repolarization process and produced membrane depolarization in all tested cells. This effect was observed even in TEA-untreated cells and was not mimicked by higher concentration of TEA (30 mM). Also this barium-induced membrane depolarization effect was still observed after L-type $Ca^{2+}$ channel was blocked by nicardipine $(10\;{\mu}M).$ These results suggest that barium-sensitive current is important in SAP repolarization process and barium itself may have some depolarizing effect in $GH_3$ cells.