• Tuberculosis and Respiratory Diseases
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• 제75권2호
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• pp.75-78
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• 2013

Methcillin-resistant Staphylococcus aureus (MRSA) has emerged as an important cause of community-acquired infections, which has been recently designated as community-associated (CA) MRSA. Panton-Valentine leukocidin (PVL)-negative multilocus sequence type 72 (ST72)-staphylococcal cassette chromosome mec (SCCmec) type IV has been reported as the predominat CA-MRSA strain in Korea and is commonly associated with skin and soft tissue infections in addition to healthcare-associated pneumonia. However, community-acquired pneumonia (CAP) for this strain has not yet been reported. We hereby report two cases of CAP caused by PVL-negative ST72-SCCmec type IV strain in patients who had no risk factors for MRSA acquisition. While CA-MRSA infections are not yet prevalent in Korea, our cases suggest that CA-MRSA should be considered in cases of severe CAP, especially for cases associated with necrotizing pneumonia.

• Journal of the Korean Data and Information Science Society
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• 제22권3호
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• pp.389-400
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• 2011

본 연구의 목적은 행정자료를 이용하여 지역사회획득 폐렴 환자의 사망 요인을 분석하기 위해 수행되었다. 2004~2006년 퇴원손상환자 조사자료 중 지역사회획득 폐렴환자 5,353건을 연구대상으로 하였으며, 사망률의 차이분석은 카이제곱 검정을 실시하였고, 사망 요인을 분석하기 위해 데이터마이닝 기법 중 의사결정나무 모형을 이용하였다. 의사결정나무 모형 중 C4.5가 성능이 우수하였는데, 입원경로, 호흡부전, 울혈성심부전을 포함하여 연령, 동반질환, 병상규모 등이 폐렴 사망의 위험 요인으로 나타났다. 본 연구는 행정데이터를 이용하여 지역사회획득 폐렴환자의 사망 위험요인을 밝히고자 하였다. 그러나 향후 병원특성, 지역특성, 의료행태 등에 대한 보다 포괄적인 변수를 포함한 후속 연구가 필요할 것으로 생각된다.

• 한국임상약학회지
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• 제30권2호
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• pp.120-126
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• 2020

Objective: The rising number of carbapenemase-resistant Enterobacteriaceae (CRE) cases has become a concern worldwidely. This study investigated patient characteristics with CRE and analyzed the risk factors associated with its acquisition. Methods: A retrospective review of the electronic medical records of the Kangbuk Samsung Medical Center from May 2016 to April 2019 was performed. The inclusion criterion was hospitalized patients aged ≥18 years with confirmed CRE acquisition. Patients were divided by CRE acquired and non-required patients. CRE acquired patients were those with CRE confirmed by their active surveillance cultures, while non-acquired patients were those with carbapenemase-sensitive Enterobacteriaceae (CSE). If CRE was isolated more than once during hospitalization, only the first isolation was used for data analysis. Patient characteristics, antibiotic used, and the duration of use were compared between two groups using univariate analysis, and the risk factors associated with CRE were analyzed using multiple logistic regression analysis. Results: Among the 73 CRE acquired patients, 44 (60.3%) were positive for carbapenemase-producing Enterobacteriaceae (CPE). Infection from Klebsiella pneumonia (42 cases, 57.5%), Escherichia coli (17 cases, 23.3%), and Enterobacter cloacae (5 cases, 6.8%). The risk of CRE acquisition was significantly increased by 4.99 times [confidence interval (CI), 1.40-17.78; p=0.013] with mechanical ventilation, 3.86 times (CI, 1.59-9.36; p=0.003) with penicillin administration, and 21.19 times (CI, 6.53-68.70; p<0.001) with carbapenem administration. Conclusions: Proper antibiotic use including the selection, frequency, and duration, and patients on mechanical ventilators need close monitoring.

• 대한원격탐사학회지
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• 제36권4호
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• pp.627-635
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• 2020

With the increasing severity of climate change, intense torrential rains are occurring more frequently globally. Flooding due to torrential rain not only causes substantial damage directly, but also via secondary events such as landslides. Therefore, accurate and prompt flood detection is required. Because it is difficult to directly access flooded areas, previous studies have largely used satellite images. Traditionally, water indices such asthe normalized difference water index (NDWI) and modified normalized difference water index (MNDWI) which are based on different optical bands acquired by satellites, are used to detect floods. In addition, as flooding likelihood is greatly influenced by the weather, synthetic aperture radar (SAR) images have also been used, because these are less influenced by weather conditions. In this study, we compared flood areas calculated from SAR images and water indices derived from Landsat-8 images, where the images were acquired at similar times. The flooded area was calculated from Landsat-8 and Sentinel-1 images taken between the end of May and August 2019 at Lijiazhou Island, China, which is located in the Changjiang (Yangtze) River basin and experiences annual floods. As a result, the flooded area calculated using the MNDWI was approximately 21% larger on average than that calculated using the NDWI. In a comparison of flood areas calculated using water indices and SAR intensity images, the flood areas calculated using SAR images tended to be smaller, regardless of the order in which the images were acquired. Because the images were acquired by the two satellites on different dates, we could not directly compare the accuracy of the water-index and SAR data. Nevertheless, this study demonstrates that floods can be detected using both optical and SAR satellite data.

• 한국지능시스템학회논문지
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• 제18권6호
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• pp.797-807
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• 2008

본 논문은 복잡한 도로 영상에서 차량 검출의 효율성을 높이기 위해 체인코드를 이용한 차선의 검출로부터 도로 영역을 찾아 차량이 존재하는 차량 영역의 추출 기법을 제안한다 먼저, 복잡한 도로 영상에서 정확한 차선을 검출하기 위해 체인코드를 이용하여 에지 화소들간의 연결성을 고려한다. 주행 차량의 방향과 일치하는 차선을 검출한 후, 중앙의 차선으로부터 차도의 폭과 차선의 소실점을 찾아 인접하는 차도를 찾는다. 마지막으로 주행 차선과 인접 차선을 포함하는 도로 영역 내에 차량의 에지 정보를 이용하여 차량이 존재하는 차량 영역을 추출한다 따라서, 제안하는 차량 영역의 추출 기법은 복잡한 배경을 갖는 도로 영상에서 차량의 검출율을 높이고 추출된 차량 영역에 한정할 수 있기 때문에 차량을 검출하는데 매우 효율적이다. 본 논문은 제안하는 차량 영역의 추출 기법의 우수성을 복잡한 도로 영상에서 차량 검출율의 실험을 통해 검증하였다.

• 한국태양에너지학회 논문집
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• 제33권5호
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• pp.51-59
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• 2013

It is usual to evaluate the performance of the cool roof by measuring in-site rooftop temperature using thermal infra-red camera. The principal advantage of rooftop thermal infrared image acquired in oblique vantage point of super high-rise building as a remote sensor is to provide, in a cost-effective manner, area-wide information required for a scattered rooftop target with different colors, utilizing wide view angle and multi-temporal data coverage. This research idea was formulated by incorporating the concept of traditional remote sensing into rooftop temperature monitoring. Correlations between infrared image of super high-rise building and in-situ data were investigated to compare rooftop surface temperature for a total of four different rooftop locations. The results of the correlations analyses indicate that the rooftop surface temperature by the infrared images of super high-rise building alone could be explained yielding $R^2$ values of 0.951. The visible permanent record of the oblique thermal infra-red image was quite useful in better understanding the nature and extent of rooftop color that occurs in sampling points. This thermal infrared image acquired in oblique vantage point of super high-rise made it possible to identify area wide patterns of rooftop temperature change subject to many different colors, which cannot be acquired by traditional in-site field sampling. The infrared image of super high-rise building breaks down the usual concept of field sampling established as a conventional cool roof performance evaluation technique.

• Biomolecules & Therapeutics
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• 제23권4호
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• pp.320-326
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• 2015

The clinical benefits of oncogenic BRAF inhibitor therapies are limited by the emergence of drug resistance. In this study, we investigated the role of a negative regulator of the MAPK pathway, Spry2, in acquired resistance using BRAF inhibitor-resistant derivatives of the BRAF-V600E melanoma (A375P/Mdr). Real-time RT-PCR analysis indicated that the expression of Spry2 was higher in A375P cells harboring the BRAF V600E mutation compared with wild-type BRAF-bearing cells (SK-MEL-2) that are resistant to BRAF inhibitors. This result suggests the ability of BRAF V600E to evade feedback suppression in cell lines with BRAF V600E mutations despite high Spry2 expression. Most interestingly, Spry2 exhibited strongly reduced expression in A375P/Mdr cells with acquired resistance to BRAF inhibitors. Furthermore, the overexpression of Spry2 partially restored sensitivity to the BRAF inhibitor PLX4720 in two BRAF inhibitor-resistant cells, indicating a positive role for Spry2 in the growth inhibition induced by BRAF inhibitors. On the other hand, long-term treatment with PLX4720 induced pERK reactivation following BRAF inhibition in A375P cells, indicating that negative feedback including Spry2 may be bypassed in BRAF mutant melanoma cells. In addition, the siRNA-mediated knockdown of Raf-1 attenuated the rebound activation of ERK stimulated by PLX4720 in A375P cells, strongly suggesting the positive role of Raf-1 kinase in ERK activation in response to BRAF inhibition. Taken together, these data suggest that RAF signaling may be released from negative feedback inhibition through interacting with Spry2, leading to ERK rebound and, consequently, the induction of acquired resistance to BRAF inhibitors.

• 디지털융복합연구
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• 제16권12호
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• pp.625-634
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• 2018

본 연구는 성인기에 장애라는 외상을 경험한 중도장애인들의 장애정체성이 외상 후 성장에 영향을 미치는지, 이러한 과정에서 레질리언스가 조절효과를 가지는지를 검증하는 것을 목적으로 하였다. 이를 위하여 본 연구에서는 만 18세 이후에 장애를 갖게 된 중도장애인 203명을 대상으로 설문조사를 하였고, 수집된 자료를 가지고 이어 각각 표준 다중회귀분석과 위계적 다중회귀분석을 실시하였다. 연구의 결과는 다음과 같다. 첫째, 장애정체성이 높을수록 외상 후 성장의 수준이 높은 것으로 나타났다. 둘째, 장애정체성이 높아질수록 외상 후 성장이 높아지는데, 이 때 레질리언스 수준이 높아지면 외상 후 성장의 수준이 더욱 높게 나타났다. 이에 연구 결과들을 바탕으로, 긍정적인 장애정체성을 형성하고 레질리언스를 강화하기 위한 앞으로의 과제에 대하여 논의하였다.

• International Journal of Computer Science & Network Security
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• 제23권1호
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• pp.147-152
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• 2023

Mostly in motor fault detection the instantaneous values 3 axis vibration and 3phase current in time domain are acquired and converted to frequency domain. Vibrations are more useful in diagnosing the mechanical faults and motor current has remained more useful in electrical fault diagnosis. With having some experience and knowledge on the behavior of acquired data the electrical and mechanical faults are diagnosed through signal processing techniques or combine machine learning and signal processing techniques. In this paper, a single-layer LSTM based condition monitoring system is proposed in which the instantaneous values of three phased motor current are firstly acquired in simulated motor in in health and supply imbalance conditions in each of three stator currents. The acquired three phase current in time domain is then used to train a LSTM network, which can identify the type of fault in electrical supply of motor and phase in which the fault has occurred. Experimental results shows that the proposed single layer LSTM algorithm can identify the electrical supply faults and phase of fault with an average accuracy of 88% based on the three phase stator current as raw data without any processing or feature extraction.

• 한국의학물리학회지:의학물리
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• 제25권2호
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• pp.95-99
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• 2014

병원을 포함해서서 방사선 물질을 사용하는 모든 사업장에서 방사선 물질의 모니터링은 방사선 안전에 가장 중요한 요소의 하나이다. 본 연구는 방사선 모니터링 시스템에 있어서 GEM 검출기의 활용 가능성을 알아보기 위한 선행 연구로서, GEM 검출기를 제작하고 CdTe 검출기와의 상대적 효율을 구한 결과, 베타와 감마선에 대한 평균 상대 효율이 각각 72%와 4%로서 매우 우수한 성능을 나타냄을 보였다.