• Fisheries and Aquatic Sciences
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• v.6 no.4
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• pp.213-219
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• 2003

Experiments were carried out to investigate the accumulation and elimination changes in the tissue of juvenile rockfish (Sebastes schlegeli) after sub-chronic dietary Cu (0, 50, 125, 250 and 500 mg/kg) exposure for 60 days and depuration for 30 days. The profile of Cu accumulation in the tissue of rockfish was dependent on the exposure periods and Cu concentration. Liver of rockfish is a more important storage tissue than other tissues, and the order of Cu accumulation in tissues was liver > intestine > kidney > gill > muscle. The accumulation factors were increased with the exposure period in gill, intestine, liver, kidney and muscle. An inverse relationship was observed between the accumulation factor and the exposure concentrations in the gill, kidney and muscle. Cu elimination in tissues of rockfish were decreased with periods for the 30 days of depuration except kidney and muscle. The order of Cu elimination in organs during depuration was intestine > liver > gill.

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.40-48
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• 1993

Intravenous administration of saponin extracted from the root of Panax ginseng lowered the blood pressure dose-dependently (10-200 mg/kg, B.W) in anesthetized rats. Therefore, experiments were designed to study the hypothesis that the lowering of blood pressure is associated with the release of endothelium-derived relaxing factor and the accumulation of guanosine 3, 5-cyclic monophosphate (cGMP). Rings of thoracic aorta with and without endothelium were suspended for the measurement of isometric tension in organ chamber and the tissue content of cGMP was measured by radioimmunoassay. All experiments were performed in the presence of $indomethacin(10^{-5}M).$ Ginseng saponin $(10^{-5}-3{\times}10^{-6}g/ml)$ relaxed contractions induced by phenylephrine $10^{-6}M)$ in the aorta with endothelium but not in that without endothelium. Treatment of aortic rings with $N^G$ monomethyl-L-arginine (L-NMMA, $10^{-4}M$ for 30 min), a competitive inhibitor of nitric oxide synthase, and methylene blue $(MB,\;3{\times}10^{-7}M$ for 30 min). an inhibitor of soluble guanylate cyclase, diminished the relaxation induced by Ginseng saponin. Ginseng saponin $10^{-4}g/ml$ for 2 min) increased the accumulation of cGMP in rings with endothelium. L-NMMA and MB inhibited the accumulation of cGMP induced by Ginseng saponin. These data suggest that vascular relaxations induced by Ginseng saponin are mediated by release of endothelium-derived relaxing factor and the accumulation of cGMP. The effect of Ginseng saponin on endothelial function in hypercholesterolemic rabbits was examined. In hypercholesterolemic rabbits fed with $2\%$ cholesterol for 8 weeks, relaxation of aortic rings to acetylcholine was impaired. The impaired relaxations of aortic rings in hypercholesterolemic rabbits were improved by dietary supplementation of Ginseng saponin, probably because of an improved release of endothelium - derived relaxing factor.

• Fisheries and Aquatic Sciences
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• v.14 no.3
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• pp.210-217
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• 2011

Olive flounder, Paralichthys olivaceus were exposed to waterborne Cu (control, 50, 80, 150, and 320 ${\mu}g$/L) for 30 days and then depurated for 20 days to investigate the effects of waterborne Cu exposure on growth, accumulation, and elimination. The weight-specific growth rate was significantly negatively related to waterborne Cu concentrations at 150 and 320 ${\mu}g$/L. The order of Cu accumulation in different tissues of exposed fish was liver>intestines>gills>kidneys>muscle, suggesting that the liver is more important than other tissues for the storage of Cu in olive flounder. The accumulation factor for the gills, intestines, liver, and muscle increased with increasing exposure time, and accumulation was negatively related to exposure concentration for the gills, kidneys, and muscle. Cu concentrations in the gills, intestines, and liver continuously decreased for 20 days of depuration. The fastest elimination rate occurred in the intestines at all exposure concentrations, and the order of Cu elimination in the different tissues was intestines>liver>gills.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.1
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• pp.96-102
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• 2004

For sensitivity enhancement, the general assisted-GPS acquisition method adopts not only the coherent accumulation technique but also the non-coherent accumulation technique since the long coherent accumulation period increases the number of frequency search cells. But the non-coherent accumulation technique causes tile squaring loss, which is a dominant factor among the acquisition losses of assisted GPS dealing with weak GPS signals. This paper derives the squaring loss of the previous assisted-GPS acquisition method and proposes an assisted-GPS acquisition method for solving the problem of squaring loss in weak signal environment. In this paper, it is explained that the proposed assisted-GPS acquisition method prevents the squaring loss using a coupled coherent accumulation technique and the number of search cells of the proposed assisted-GPS acquisition method is much smaller than that of the previous assisted-GPS acquisition method. Finally, through the simulation by the GPS simulator, the acquisition success rate of the proposed assisted-GPS acquisition method is compared with that of the previous assisted-GPS acquisition method and the acquisition improvements are shown in weak signal environment.

• Journal of Microbiology and Biotechnology
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• v.32 no.11
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• pp.1406-1415
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• 2022

The formation of macrophage foam cells stimulated by oxidized low-density lipoprotein (ox-LDL) is deemed an important cause of atherosclerosis. Transcription factor Yin Yang 1 (YY1), which is a universally expressed multifunctional protein, is closely related to cell metabolism disorders such as lipid metabolism, sugar metabolism, and bile acid metabolism. However, whether YY1 is involved in macrophage inflammation and lipid accumulation still remains unknown. After mouse macrophage cell line RAW264.7 cells were induced by ox-LDL, YY1 and proprotein convertase subtilisin/kexin type 9 (PCSK9) expressions were found to be increased while low-density lipoprotein receptor (LDLR) expression was lowly expressed. Subsequently, through reverse transcription-quantitative polymerase chain reaction (RT-qPCR), Western blot analysis, Oil Red O staining and cholesterol quantification, it turned out that silencing of YY1 attenuated the inflammatory response and lipid accumulation in RAW264.7 cells caused by ox-LDL. Moreover, results from the JASPAR database, chromatin immunoprecipitation (ChIP) assay, luciferase reporter assay and Western blot analysis suggested that YY1 activated PCSK9 by binding to PCSK9 promoter and modulated the expression of LDLR in the downstream of PCSK9. In addition, the results of functional experiments demonstrated that the inhibitory effects of YY1 interference on ox-LDL-mediated macrophage inflammation and lipid accumulation were reversed by PCSK9 overexpression. To sum up, YY1 depletion inhibited its activation of PCSK9, thereby reducing cellular inflammatory response, cholesterol homeostasis imbalance, and lipid accumulation caused by ox-LDL.

• New & Renewable Energy
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• v.5 no.3
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• pp.49-55
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• 2009

Human resource for the new and renewable energy technology is an important factor in the respect of the sustainable growth and energy security. In this paper, we focused on measuring the economic effect of human resource development on new and renewable energy development programs. The human capital accumulation model developed by Mincer (1974) was modified in terms of the rate of the researchers' investment in human capital. As a result of a empirical case study, the value of human capital was estimated by 102 million Korean won per year worth 18% of the project labor cost. In case of the assumption of 100% participation of researchers, the level of human capital accumulation increased to 914 million Korean won per year. These results imply that the new and renewable energy development programs has been successful, on the concept of learning by doing, in terms of providing the researchers with opportunities to accumulate human capital.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 1998.10a
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• pp.237-242
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• 1998

Salt accumulation is frequently experienced in soils under protected cultivation. Since protected cultivation does not have rainfall and resulting infiltration, salt accumulation in the soils is inevitable. In this study, analyzed were chemical charecteristics of soils under protected cultivation to investigate the factors which may contribute the salt accumulation. Soil samples were collected from 99 protected cultivation facilities around An-sung Gun, Gyungki-Do and analyzed for electrical conductivity, pH, organic matter con-tents. The results showed that there was no significant trend of changes in electrical conductivity and pH along cultivation years. the only factor influencing salt accumulation was irrigation type. Soils in facilities using drip irrigation showed higher electrical conductivity than those using diversion-hose type irrigation.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.50 no.3
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• pp.130-135
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• 2001

In this paper, the distribution characteristics of salt contaminants with the distance from sea in East coast, from Sokcho to Pusan of Korea peninsula were investigated to evaluate the design standard of KEPCO. To get the equivalent salt deposit density(ESDD), conventional brush wiping method was used. As the measuring period is comparatively short, and the measuring interval is long to check the maximum value, acquired ESDD data is very lower than the recommended value in the standard. The measured data didn't follow normal distribution, so it should take the statistical treatment. Through normalizing method, we could get a reliable probability data. In the past investigation, the accumulation characteristics of Japan is consulted to set the criterion, but the climatic condition of Korea is different to Japan. With the comparison of precipitation data and some measured data for long tern accumulation, we could set appropriate accumulation factor.

• Molecules and Cells
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• v.41 no.4
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• pp.351-361
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• 2018

Sucrose is a crucial compound for the growth and development of plants, and the regulation of multiple genes depends on the amount of soluble sugars present. Sucrose acts as a signaling molecule that regulates a proton-sucrose symporter, with its sensor being the sucrose transporter. Flavonoid and anthocyanin biosynthesis are regulated by sucrose, and sucrose signaling can affect flavonoid and anthocyanin accumulation. In the present study, we found a Myb transcription factor affecting accumulation of anthocyanin. AtMyb56 showed an increase in its expression in response to sucrose treatment. Under normal conditions, anthocyanin accumulation was similar between Col-0 (wild type) and atmyb56 mutant seedlings; however, under sucrose treatment, the level of anthocyanin accumulation was lower in the atmyb56 mutant plants than in Col-0 plants. Preliminary microarray analysis led to the investigation of the expression of one candidate gene, AtGPT2, in the atmyb56 mutant. The phosphate translocator, which is a plastidial phosphate antiporter family, catalyzes the import of glucose-6-phosphate (G-6-P) into the chloroplast. AtGPT2 gene expression was altered in atmyb56 seedlings in a sucrose-dependent manner in response to circadian cycle. Furthermore, the lack of AtMyb56 resulted in altered accumulation of maltose in a sucrose-dependent manner. Therefore, the sucrose responsive AtMyb56 regulates AtGPT2 gene expression in a sucrose-dependent manner to modulate maltose and anthocyanin accumulations in response to the circadian cycle.