Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)
- 1993.09a
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- Pages.40-48
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- 1993
EFFECTS OF GINSENG SAPONIN ON ENDOTHELIUM - DEPENDENT VASCULAR RELAXATION IN RAT AORTA AND HYPERCHOLESTEROLEMIC RABBIT AORTA
- Kim N.D. (College of Pharmacy, Seoul National University) ;
- Kang S.Y. (College of Pharmacy, Seoul National University)
- Published : 1993.09.01
Abstract
Intravenous administration of saponin extracted from the root of Panax ginseng lowered the blood pressure dose-dependently (10-200 mg/kg, B.W) in anesthetized rats. Therefore, experiments were designed to study the hypothesis that the lowering of blood pressure is associated with the release of endothelium-derived relaxing factor and the accumulation of guanosine 3, 5-cyclic monophosphate (cGMP). Rings of thoracic aorta with and without endothelium were suspended for the measurement of isometric tension in organ chamber and the tissue content of cGMP was measured by radioimmunoassay. All experiments were performed in the presence of
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