Studies on predicting arrhythmia using machine learning have been actively conducted with increasing number of arrhythmia patients. Existing studies have predicted arrhythmia based on multivariate data of feature variables extracted from RR interval data at a specific time point. In this study, we consider that the pattern of the heart state changes with time can be important information for the arrhythmia prediction. Therefore, we investigate the usefulness of predicting the arrhythmia with multivariate time series data obtained by extracting and accumulating the multivariate vectors of the feature variables at various time points. When considering 1-nearest neighbor classification method and its ensemble for comparison, it is confirmed that the multivariate time series data based method can have better classification performance than the multivariate data based method if we select an appropriate time series distance function.
Journal of Elementary Mathematics Education in Korea
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v.10
no.2
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pp.171-194
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2006
As it is not long since the gifted education was implemented in elementary school, it is necessary to accumulate the practical studies on the mathematically gifted education. This paper focused on enhancing creativity by providing the various and divergent thinking activities for mathematically gifted students. For this purpose, I prepared two mathematics problems, and , and let the mathematically gifted 5th grade students solve them. After that, I investigated to analyse their reactions in detail and tried to find the methods for assessing their divergent products. Finally, I found that they could pose various and meaningful calculating equations and also identify the various relations between two numbers. I expect that accumulating these kinds of practical studies will contribute to the developments of gifted education, in particular, instructions, assessments, and curriculum developments for the mathematically gifted students in elementary schools.
The aim of this study is to provide a direction for future research by examining research trends on women in social welfare field in recent years. This study has theoretical significance in terms of expanding the horizon of social welfare knowledge by accumulating new research results based on previous research results on this topic. Using content analysis, we analyzed 37 studies on women published in Korean Journal of Social Welfare during 2009 ~ 2017 focusing on research subjects, research topics, and methods. The results of analyzing the research subjects indicated that women were described as client, family, and worker. In terms of the research topics, the results revealed a total of thirteen themes. In addition, the results showed that empirical research methods were dominant. It is suggested that more efforts should be made in future studies to broaden the scope of research subjects, topics, and methodologies in this filed.
Yan, Sheng;Yim, Lok Yan;Lu, Liwei;Lau, Chak Sing;Chan, Vera Sau-Fong
IMMUNE NETWORK
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v.14
no.3
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pp.138-148
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2014
MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.
This paper reports the project of arranging archives of Administrative Headquarters of the Jogye Order. It illustrates the whole process of preliminary survey, arrangement, appraisal and description of the archives. One of the distinctive features of the project lies in its focus on practical considerations. In other words, it has avoided blindly following theoretical recommendations made by previous efforts. First step of the project has been to review the current state of the archives through preliminary survey as well as analysis of related regulations. Second step has followed to establish actual process of classifying, appraising, describing, filing and designing storage facility management as well as a computerized archival management system. In this process, every concern has been given to prevent records and archives from physical damage and to ensure their intellectual order kept so that archival information could be re-constructed and usability and efficiency of the records could be secured. Major contributions made by the project can be found in that it has reviewed the volume of administrative archives created and held by Jogye Order and improved the overall efficiency of as well as information sharing among personnel at the Headquarter. The most notable accomplishment could be, however, found in that the project has helped the personnel to rediscover their own history from their records, rather than from their memory. From the theoretical perspective of archival science, the meaning of the project can also be found in that it has provided with the starting point toward establishing organizing methodology for organizational archives including religious archives. Arranging archives of an organization requires archivists to respect theories and principles, but at the same time, adequate attention should be paid to reflect idiosyncratic characteristics of the organization. General methods applicable to a wider range of archives could be derived from the very endeavor. Though impossible in a short period of time, it could be accomplished by accumulating theoretical and practical knowledge and experience.
Brand orientation is a relatively new paradigm in marketing which was first introduced in the 1990s. Since then, an accumulating body of research has addressed the strategic importance of brand orientation. Although there is a growing body of literature on brand orientation, there have been no empirical studies examining the mediation effect of brand orientation on market orientation-performance relationship to date. Moreover, most studies on brand orientation have been carried out in the context of large enterprises. Hence, the aim of this research is to extend the literature and address market orientation, brand orientation, and firm performance against the backdrop of Korean SMEs. The authors empirically investigate the impact of market/brand orientation on organizational performance and the mediating role of brand orientation. They utilize 178 usable responses to test the four research hypotheses. The hypothesized model predicts that there is a positive association among market orientation, brand orientation, and firm performance. It is also expected that brand orientation mediates the relationship between market orientation and organizational performance. The statistical results based on PLS analysis confirm our prediction among the constructs in the research model. The empirical evidence provides significant theoretical and managerial implications for brand orientation among SMEs. The first theoretical implication is that we provide empirical evidence regarding the important role of brand orientation in explaining the multi-trait perspectives of strategic orientation. The second theoretical implication is that the concept of brand orientation can be empirically validated in the context of SMEs. In terms of managerial implications, managers of SMEs should attempt to build a brand-oriented corporate culture or mindset that places brand values and brand norms as the top priority among their company's tasks. In addition, managers should recognize that brand orientation is critical for SMEs as well as large enterprises. In the last section, the authors address limitations of the study and provide directions for further research.
The trend of seeking knowledge or information has been increasingly shifting towards the digital implementation on the web rather than relying on analog printed media such as books or publications. This shift is driven by the perception that using digital resources, particularly digital dictionaries, is more effective and time-saving compared to traditional paper dictionaries. Consequently, the construction of a semantic network for vocabulary has emerged as a significant issue for linguists, computational linguists, and natural language processing specialists. To address this, linguists have conducted numerous studies to find methods for structuring and classifying the meanings and concepts of vocabulary. In these studies, specialized terminology for constructing vocabulary semantic networks is as crucial as common language. However, in the process of finding and accumulating specialized terminology, there is still a manual step where individuals directly verify and extract specialized terms from paper documents or vast digital datasets. In this paper, we propose an automated program to extract the specialized terms that users desire from digital materials, aiming to compensate for errors in human-operated tasks and streamline the process.
Purpose - This study aims to overcome the limitations of existing studies, which linearly determine the precedence factors of competency in overseas subsidiaries. The research objectives are as follows. First, what kind of nonlinear effects does the level of control held by Korean headquarters over foreign subsidiaries have in terms of competency in the subsidiaries? Second, what kind of nonlinear effects do the local experiences of overseas subsidiaries have on their competency? Design/methodology - With data on Korean multinational corporations (MNCs), this paper analyzes the effects of control levels of headquarters (HQs) and host-country experiences of foreign subsidiaries regarding competency in overseas subsidiaries. In particular, this study focuses on nonlinear models, differentiating it from previous studies. In order to examine research hypotheses, this study conducted a survey of overseas subsidiaries of Korean corporations. Surveys were conducted through various methods including e-mail, online questionnaires, fax, and telephone calls. Copies of the questionnaire were distributed to a total of 2,246 overseas subsidiaries, and 409 completed responses were collected. Excluding 15 copies that were insufficiently answered, responses from a total of 394 copies were used for analysis. Findings - This study presents the following results. First, there is a U-shaped relationship between levels of HQ control and competency in foreign subsidiaries. This means that higher levels of HQ control negatively impact the competency levels of subsidiaries because strict control undermines autonomy in subsidiaries. However, if the level of HQ control exceeds a certain point, then the transfer of knowledge between HQs and subsidiaries is facilitated. Knowledge transferred from HQs can be used as prior knowledge by foreign subsidiaries to the benefit of all parties. Accordingly, knowledge transfer negates the negative effects of excessive HQ control and positively affects competency in subsidiaries. Second, there is an inverted U-shaped relationship between the local (host-country) experiences of subsidiaries and competency in foreign subsidiaries. This means that foreign subsidiaries can overcome the liabilities of foreignness and contribute to capability building by accumulating unique knowledge about their host countries. However, if local experiences accumulate excessively beyond a certain point, then the host country-specific experiences of foreign subsidiaries will offset the benefits discussed above. Excessive local experiences not only increase organizational inertia, but also create a problem of goal incongruence due to information asymmetry between HQs and subsidiaries. Therefore, excessive local experiences have negative effects on competency in foreign subsidiaries. Originality/value - This study suggests the following implications. First, unlike existing studies based mainly on linear models, this study presents important theoretical implications in its focus on nonlinear models and its analysis of the effects of HQ control and local experiences on competency in foreign subsidiaries from perspectives of organizational learning theory and agency theory. Second, in terms of practical implications, the results of this study suggest that optimally raising levels of HQ control and managing the local experiences of subsidiaries without increasing organizational inertia is important for enhancing competency in foreign subsidiaries.
In the present work, the capacity ratings of steel truss bridges have been carried out incorporating dynamic effect of moving vehicles and its accumulating effect as fatigue. Further, corrosion in the steel members has been taken into account to examine the rating factor. Dynamic effect has been considered in the rating procedure making use of impact factors obtained from simulation studies as well as from codal guidelines. A steel truss bridge has been considered to illustrate the approach. Two levels of capacity ratings- the upper load level capacity rating (called operating rating) and the lower load level capacity rating (called inventory rating) were found out using Load and Resistance Factor Design (LRFD) method and a proposal has been made which incorporates fatigue in the rating formula. Random nature of corrosion on the steel member has been taken into account in the rating by considering reduced member strength. Partial safety factor for each truss member has been obtained from the fatigue reliability index considering random variables on the fatigue parameters, traffic growth rate and accumulated number of stress cycle using appropriate probability density function. The bridge has been modeled using Finite Element software. Regressions of rating factor versus vehicle gross weight have been obtained. Results show that rating factor decreases when the impact factor other than those in the codal provisions are considered. The consideration of fatigue and member corrosion gives a lower value of rating factor compared to those when both the effects are ignored. In addition to this, the study reveals that rating factor decreases when the vehicle gross weight is increased.
The objective of this study was to describe a radiofrequency (RF) coil design for in vivo sodium magnetic resonance imaging (MRI) for use in small animals. Accumulating evidence has indicated the importance and potential of sodium imaging with improved magnet strength (> 7T), faster gradient, better hardware, multi-nucleus imaging methods, and optimal coil design for patient and animal studies. Thus, we developed a saddle-shaped sodium volume coil with a diameter/length of 30/30 mm. To evaluate the efficiency of this coil, bench-level measurement was performed. Unloaded Q value, loaded Q value, and ratio of these two values were estimated to be 352.8, 211.18, and 1.67, respectively. Thereafter, in vivo acquisition of sodium images was performed using normal mice (12 weeks old; n = 5) with a two-dimensional gradient echo sequence and minimized echo time to increase spatial resolution of images. Sodium signal-to-noise ratio in mouse kidneys (renal cortex, medulla, and pelvis) was measured. We successfully acquired sodium MR images of the mouse kidney with high spatial resolution (approximately 0.625 mm) through a combination of sodium-proton coils.
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