• Journal of Preventive Medicine and Public Health
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• 제46권sup1호
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• pp.3-11
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• 2013

Over the last two decades, significant research attention has been given to the acute effect of a single bout of exercise on postprandial lipaemia. A large body of evidence supports the notion that an acute bout of aerobic exercise can reduce postprandial triacylglycerol (TAG) concentrations. However, this effect is short-lived emphasising the important role of regular physical activity for lowering TAG concentrations through an active lifestyle. In 1995, the concept of accumulating physical activity was introduced in expert recommendations with the advice that activity can be performed in several short bouts throughout the day with a minimum duration of 10 minutes per activity bout. Although the concept of accumulation has been widely publicised, there is still limited scientific evidence to support it but several studies have investigated the effects of accumulated activity on health-related outcomes to support the recommendations in physical activity guidelines. One area, which is the focus of this review, is the effect of accumulating exercise on postprandial lipaemia. We propose that accumulating exercise will provide additional physical activity options for lowering postprandial TAG concentrations relevant to individuals with limited time or exercise capacity to engage in more structured forms of exercise, or longer bouts of physical activity. The benefits of accumulated physical activity might translate to a reduced risk of cardiovascular disease in the long-term.

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 2004년도 추계 학술발표대회 논문집
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• pp.20-21
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• 2004

• 한국산림과학회지
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• 제101권4호
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• pp.656-662
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• 2012

본 연구는 경북 울진군에 조성된 해안방재림을 대상으로 식재된 해송의 생장특성을 조사하고 생장에 영향을 미치는 인자와의 관계를 규명하고자 수행하였다. 총 9개소 3,600본의 해송을 4년간 모니터링 하였으며, 식재위치에 따라 서로 다른 생장량이 조사되었다. 생장에 영향을 미치는 생육환경인자로 풍속과 전기전도도, 토양산도, 토양습도 등의 토양조건을 조사하여 생장량과의 관계를 분석하였다. 연구결과 풍속이 식재된 해송의 생장과 가장 밀접한 관련을 가지는 것으로 분석되었으며, 토양조건 역시 풍속에 따라 크게 영향을 받았다. 따라서 해안방재림으로 조성된 해송의 생장량을 높이기 위해서는 풍속의 효과적인 제어가 가장 중요하며, 향후 이를 위한 퇴사울의 개발과 그 효과에 대한 장기적인 모니터링이 필요할 것으로 사료된다.

• Biomolecules & Therapeutics
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• 제16권2호
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• pp.69-76
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• 2008

Lysophosphatidylcholine (LPC) is an endogenous phospholipid. LPC has various stimulating or modulating activities on immune cells, including lymphocytes, monocytes/macrophages and neutrophils. Studies generally revealed pro-inflammatory activities of LPC, but accumulating evidence indicates that LPC has also anti-inflammatory actions. Here we summarize immunomodulatory actions of LPC.

• BMB Reports
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• 제53권3호
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• pp.125-132
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• 2020

Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors. Later studies revealed that TRP channels mediated the regulation of intracellular calcium. Mutations in TRP channel genes result in abnormal regulation of TRP channel function or expression, and interfere with normal spatial and temporal patterns of intracellular local Ca²⁺ distribution. The resulting dysregulation of multiple downstream effectors, depending on Ca²⁺ homeostasis, is associated with hallmarks of cancer pathophysiology, including enhanced proliferation, survival and invasion of cancer cells. These findings indicate that TRP channels affect multiple events that control cellular fate and play a key role in cancer progression. This review discusses the accumulating evidence supporting the role of TRP channels in tumorigenesis, with emphasis on prostate cancer.

• Journal of Microbiology and Biotechnology
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• 제24권11호
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• pp.1455-1463
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• 2014

In the past, reactive oxygen species (ROS) have been considered a harmful byproduct of aerobic metabolism. However, accumulating evidence implicates redox homeostasis, which maintains appropriate ROS levels, in cell proliferation and differentiation in plants and animals. Similarly, ROS generation and signaling are instrumental in fungal development and host-fungus interaction. In fungi, NADPH oxidase, a homolog of human $gp91^{phox}$, generates superoxide and is the main source of ROS. The mechanism of activation and signaling by NADPH oxidases in fungi appears to be largely comparable to those in plants and animals. Recent studies have shown that the fungal NADPH oxidase homologs NoxA (Nox1), NoxB (Nox2), and NoxC (Nox3) have distinct functions. In particular, these studies have consistently demonstrated the impact of NoxA on the development of fungal multicellular structures. Both NoxA and NoxB (but not NoxC) are involved in host-fungus interactions, with the function of NoxA being more critical than that of NoxB.

• IMMUNE NETWORK
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• 제9권3호
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• pp.84-89
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• 2009

The main stream of CD137 studies has been directed to the function of CD137 in $CD8^+$ T-cell immunity, including its anti-tumor activity, and paradoxically the immunosuppressive activity of CD137, which proves to be of a great therapeutic potential for animal models of a variety of autoimmune and inflammatory diseases. Recent studies, however, add complexes to the biology of CD137. Accumulating is evidence supporting that there exists a bidirectional signal transduction pathway for the CD137 receptor and its ligand (CD137L). CD137/CD137L interactions are involved in the network of hematopoietic and nonhematopoietic cells in addition to the well characterized antigen-presenting cell-T cell interactions. Signaling through CD137L plays a critical role in the differentiation of myeloid cells and their cellular activities, suggesting that CD137L signals trigger and sustain inflammation. The overall consequence might be that the amplified inflammation by CD137L enhances the T-cell activity together with CD137 signals by upregulating costimulatory molecules, MHC molecules, cell adhesion molecules, cytokines, and chemokines. Solving this outstanding issue is urgent and will have an important clinical implication.

• Biomolecules & Therapeutics
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• 제32권1호
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• pp.25-37
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• 2024

Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely linked to the development of AD. There is accumulating evidence demonstrating the beneficial effects of herbal extracts (HEs) on the regulation of inflammatory response in both in vitro and in vivo studies of AD. This review summarizes the anti-atopic effects of HEs and its associated underlying mechanisms, with a brief introduction of in vitro and in vivo experiment models of AD based on previous and recent studies. Thus, this review confirms the utility of HEs for AD therapy.

• 한국환경보건학회지
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• 제36권1호
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• pp.1-13
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• 2010

Evidences supporting gene-environment interaction are accumulating in terms of environmental exposure including lifestyle factors and related genetic variants. One form of defense mechanism against cancer development involves a series of genes whose role is to metabolize (activation/detoxification) and excrete potentially toxic compounds and to repair subtle mistakes in DNA. The purpose of this article is to provide a brief review of the notion of gene-environment interaction, environmental/occupational carcinogens and related cancers, and previous studies of gene-environment interaction on cancers caused by exposure to carcinogenesis. With a number of studies on the interaction between lifestyle factors (e.g., smoking and diet) and genetic polymorphisms in genes involved in xenobiotic metabolism and DNA repair excluded, only several studies have been conducted on the interactive effects between polymorphisms of CYPs, GSTs, ERCCs, XRCCs and environmental/occupational carcinogens such as vinyl chloride, benzo[a]pyrene, and chloroform on carcinogenesis or genotoxicity. Future studies may need to be conducted with sufficient number of subjects and based on occupational cohorts to provide useful information in terms of advanced risk assessment and regulation of exposure level.

• 정신신체의학
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• 제14권2호
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• pp.81-87
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• 2006

많은 연구들이 심혈관 질환의 병인과 병리적 기전에 있어 사회심리학적, 행동학적 위험요인의 역할을 조사해 왔다. A형 행동 유형과 심장 질환의 이환 및 사망과의 관련성을 확인한 여러 전향적 연구들을 바탕으로, A형 행동 유형은 관상동맥질환의 독립적인 위험요인으로 밝혀졌다. 또한 최근 제안된 새로운 성격유형인 D형 인격유형 역시 심혈관 질환의 이환율과사망률의 증가에 관여함이 보고되고 있다. 그러나 국내에서는 아직 이들과 관련된 연구가 부족한 실정이다. 따라서 저자는 심혈관 질환과의 관련성에 대해 널리 연구, 보고되고 있는 A형 행동유형과 D형 인격유형에 초점을 맞추면서 지금까지의 연구 문헌을 정리 검토하여 향후 연구에 도움을 주고자 하였다.