IMMUNE NETWORK

  • 제9권3호
  • /
  • Pages.84-89
  • /
  • 2009
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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DOI QR코드

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CD137-CD137 Ligand Interactions in Inflammation

  • 투고 : 2009.06.05
  • 심사 : 2009.06.10
  • 발행 : 2009.06.30
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초록

The main stream of CD137 studies has been directed to the function of CD137 in $CD8^+$ T-cell immunity, including its anti-tumor activity, and paradoxically the immunosuppressive activity of CD137, which proves to be of a great therapeutic potential for animal models of a variety of autoimmune and inflammatory diseases. Recent studies, however, add complexes to the biology of CD137. Accumulating is evidence supporting that there exists a bidirectional signal transduction pathway for the CD137 receptor and its ligand (CD137L). CD137/CD137L interactions are involved in the network of hematopoietic and nonhematopoietic cells in addition to the well characterized antigen-presenting cell-T cell interactions. Signaling through CD137L plays a critical role in the differentiation of myeloid cells and their cellular activities, suggesting that CD137L signals trigger and sustain inflammation. The overall consequence might be that the amplified inflammation by CD137L enhances the T-cell activity together with CD137 signals by upregulating costimulatory molecules, MHC molecules, cell adhesion molecules, cytokines, and chemokines. Solving this outstanding issue is urgent and will have an important clinical implication.

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참고문헌

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피인용 문헌

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  3. 4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages vol.2012, pp.None, 2012, https://doi.org/10.1155/2012/972629
  4. 4-1BB Ligand-Mediated Imbalance of Helper 17 T Cells and Regulatory T Cells in Patients with Allergic Asthma vol.40, pp.3, 2009, https://doi.org/10.1177/147323001204000323
  5. Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation vol.109, pp.1, 2009, https://doi.org/10.1073/pnas.1112256109
  6. Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach vol.2013, pp.None, 2013, https://doi.org/10.1155/2013/708659
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  11. The Inhibitory Effect of Quercetin on Adipose Tissue Inflammation in Mice Fed on a High-fat Diet vol.23, pp.3, 2014, https://doi.org/10.7570/kjo.2014.23.3.170
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  14. The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response? vol.19, pp.5, 2009, https://doi.org/10.3390/ijms19051283
  15. Tumor-Localized Costimulatory T-Cell Engagement by the 4-1BB/HER2 Bispecific Antibody-Anticalin Fusion PRS-343 vol.25, pp.19, 2009, https://doi.org/10.1158/1078-0432.ccr-18-3654
  16. Immuno-comparative screening of adult-derived human liver stem/progenitor cells for immune-inflammatory-associated molecules vol.70, pp.2, 2009, https://doi.org/10.1007/s00011-020-01428-9
  17. Recombinant CD137‐Fc, its synthesis, and applications for improving the immune system functions, such as tumor immunotherapy and to reduce the inflammation due to the novel coronavirus vol.122, pp.9, 2009, https://doi.org/10.1002/jcb.29928
  18. Feedback regulation of antioxidant transcription factor NFE2L1 and immunostimulatory factor 41BBL mediates the crosstalk between oxidative stress and tumor immunity vol.141, pp.None, 2009, https://doi.org/10.1016/j.molimm.2021.12.001