1 |
Kwon B, Lee HW, Kwon BS: New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells. Trends Immunol 23;378-380, 2002
DOI
ScienceOn
|
2 |
Takahashi C, Mittler RS, Vella AT: Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol 162;5037-5040, 1999
PUBMED
|
3 |
Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellström KE, Mittler RS, Chen L: Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 3;682-685, 1997
DOI
ScienceOn
|
4 |
Shao H, Fu Y, Liao T, Peng Y, Chen L, Kaplan HJ, Sun D: Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells. Invest Ophthalmol Vis Sci 46;596-603, 2005
DOI
ScienceOn
|
5 |
Fukushima A, Yamaguchi T, Ishida W, Fukata K, Mittler RS, Yagita H, Ueno H: Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice. J Immunol 175;4897-4903, 2005
PUBMED
|
6 |
Sun Y, Blink SE, Liu W, Lee Y, Chen B, Solway J, Weinstock J, Chen L, Fu YX: Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation. J Immunol 177;814-821, 2006
PUBMED
|
7 |
Heinisch IVWM, Bizer C, Volgger W, Simon H-W: Functional CD137 receptors are expressed by eosinophils form patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE mediated eosinophilic disorders. J Allergy Clin Immunol 108;21-28, 2001
DOI
ScienceOn
|
8 |
Saiki H, Suzuki J-I, Kosuge H, Hiraguchi G, Ishihara T, Haga T, Maejima Y, Isobe M, Uede T: Blockade of the 4-1BB pathway attenuates graft arterial disease in cardiac allografts. Int Heart 49;105-118, 2008
DOI
ScienceOn
|
9 |
Langstein J, Michel J, Fritsche J, Kreutz M, Andreesen R, Schwarz H: CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. J Immunol 160;2488-2494, 1998
PUBMED
|
10 |
Jiang D, Yue PS, Drenkard D, Schwarz H: Induction of proliferation and monocytic differentiation of human cells by CD137 ligand signaling. Stem Cells 26;2373-2381, 2008
|
11 |
Seo SK, Park HY, Choi JH, Kim WY, Kim YH, Jung HW, Kwon B, Lee HW, Kwon BS: Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol 171;576-583, 2003
DOI
PUBMED
|
12 |
Lee SW, Vella AT, Kwon BS, Croft M: Enhanced CD4 T cell responsiveness in the absence of 4-1BB. J Immunol 174;6803-6808, 2005
DOI
PUBMED
|
13 |
Vinay DS, Choi BK, Bae JS, Kim WY, Gebhardt BM, Kwon BS: CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J Immunol 173;4218-4229, 2004
DOI
PUBMED
|
14 |
Pauly S, Broll K Witmann M, Giegerich G, Schwarz H: CD137 is expressed by follicular dendritic cells and costimulates B lymphocytes in germinal centers. J Leukocyte Biol 72;35-42, 2002
|
15 |
Schwarz H: Biological activities of reverse signal transduction through CD137 ligand. J Leukoc Biol 77;281-286, 2005
DOI
PUBMED
ScienceOn
|
16 |
Heinisch IVWM, Daigle I, Knopfli B, Simon H-W: CD137 activation abrogates granulocyte-macrophage colony-stimulating factor-mediated anti-apoptosis in neutrophils. Eur J Immunol 30;3441-3446, 2000
DOI
ScienceOn
|
17 |
Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS: 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186;47-55, 1997
DOI
ScienceOn
|
18 |
Polte T, Foell J, Werner C, Hoymann HG, Braun A, Burdach S, Mittler RS, Hansen G: CD137-mediated immunotherapy for allergic asthma. J Clin Invest 116;1025-1036, 2006
DOI
ScienceOn
|
19 |
Haga T, Suzuki J-I, Kosuge H, Ogawa M, Saiki H, Haraguchi G, Maejima Y, Isobe M, Uede T: Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. J Mol Cell Cardiol 46;719-727, 2009
DOI
ScienceOn
|
20 |
Sun M, Fink PJ: A new class of reverse signaling costimulators belongs to the TNF family. J Immunol 179;4037-4312, 2007
|
21 |
Cho HR, Kwon B, Yagita H, La S, Lee EA, Kim JE, Akiba H, Kim J, Suh JH, Vinay DS, Ju SA, Kim BS, Mittler RS, Okumura K, Kwon BS: Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.Transpl Int 17;351-361, 2004
DOI
ScienceOn
|
22 |
McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collin M, Byrne MC: immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16;311-323, 2002
DOI
ScienceOn
|
23 |
Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX: Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 8;1405-1413, 2002
DOI
ScienceOn
|
24 |
Kim J, Kim HJ, Park K, Kim J, Yagita H, Nam SK, Cho HR, Kwon B: Costimulatory molecule-targeted immunotherapy of chronic graft-versus-host disease. Blood 110;776-782, 2007
DOI
ScienceOn
|
25 |
Saito K, Ohara N, Hotokezaka H, Fukumoto F, Yuasa K, Naito M, Fujiwara T, Nakayama K: Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis. J Biol Chem 279;13555-13563, 2004
DOI
ScienceOn
|
26 |
Kim J, Choi WS, La S, Suh J-H, Kim B-S, Cho HR, Kwon BS, Kwon B: Stimulation with 4-1BB inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor T cells. Blood 105;2206-2213, 2005
DOI
ScienceOn
|
27 |
Croft M: The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 9;271-285, 2009
DOI
PUBMED
ScienceOn
|
28 |
Drenkard D, Becke FM, Langstein J, Spruss T, Kunz- Schughart LA, Tan TE, Lim YC, Schwarz H: CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J 21;456-463, 2007
DOI
ScienceOn
|
29 |
Lee S-C, Ju S-A, Pack H-N, Heo S-K, Suh J-H, Park S-M, Choi B-K, Kwon BS, Kim BS: 4-1BB (CD137) is required for rapid clearance of Listeria monocytogens infection. Infect Immun 73;5144-5151, 2005
DOI
ScienceOn
|
30 |
Wang J, Guo Z, Dong Y, Kim O, Hart J, Adams A, Larsen CP, Mittler RS, Newell KA: Role of 4-1BB in allograft rejection mediated by CD8+ T cells. Am J Transplant 3; 543-551, 2003
DOI
ScienceOn
|
31 |
Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B: Gene that distinguishes physiological and pathological angiogenesis. Cancer Cell 11;539-554, 2007
DOI
ScienceOn
|
32 |
Kwon B, Moon CH, Kang S, Seo SK, Kwon BS: 4-1BB: still in the midst of darkness. Mol Cells 10;119-126, 2000
DOI
ScienceOn
|
33 |
Cho YS, Kwon B, Lee T-H, Moon K-A, La S, Lee J, Lee SD, Oh Y-M, Moon H-B: 4-1BB stimulation inhibits allergen specific IgE, airway hyperreactivity, and eosinophilic inflammation in asthmatic mice. Clin Exp Allergy 36;377-385, 2006
DOI
ScienceOn
|
34 |
MacHugh RS: immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16;311-323, 2002
DOI
ScienceOn
|
35 |
Seko Y, Takahashi N, Oshima H: Expression of tumour necrosis factor (TNF) ligand superfamily co-stimultory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxackievirus B3. J Pathol 195;593-603, 2001
DOI
ScienceOn
|
36 |
Kim W, Kim J, Jung D, Kim H, Cho H-J, Cho HR, Kwon B: Induction of lethal graft-versus-host disease by anti-CD137 monoclonal antibody in mice prone to chronic graft-versus-host disease. Biol Blood Marrow Transplant 15;306-314, 2009
DOI
ScienceOn
|
37 |
Kim D-H, Chang W-S, Lee Y-S, Lee K-A, Kim Y-K, Kwon BS, Kang C-Y: 4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation. J Immunol 180;2062-2068, 2008
DOI
PUBMED
|
38 |
Lee S-W, Park Y, So T, Kwon BS, Cheroutre H, Mittler RS, Croft M: Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol 9;917-926, 2008
DOI
ScienceOn
|
39 |
Gavin MA, Clarke SR, Negrou E, Gallegos A, Rudensky A: Homeostasis and anergy of suppressor T cells in vivo. Nat Immunol 3;33-41, 2002
DOI
ScienceOn
|
40 |
Kim D-K, Lee SC, Lee HW: CD137 ligand-memdiated reverse signals increase viability and cytokine expression in murine myeloid cells: involvement of mTOR/p70S6 kinase and AKT. Eur J Immunol (In press)
|
41 |
Nishimoto H, Lee S-W, Hong H, Potter KG, Maeda-Yamaoto M, Kinoshita T, Kawakami Y, Mittler RS, Kwon BS, Ware CF, Croft M, Kawakami T: Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood 106;4241-4248
DOI
ScienceOn
|
42 |
Foell J, Strahotin S, O'Neil SP, McCausland MM, Suwyn C, Haber M, Chander PN, Bapat AS, Yan XJ, Chiorazzi N, Hoffmann MK, Mittler RS: CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice. J Clin Invest 111;1505-1518, 2003
PUBMED
|
43 |
Kang YJ, Kim SO, Shhimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J: Cell surface 4-1BBL mediates sequential signaling pathways 'down-stream' of TLR and is required for sustained TNF production in macrophages. Nat Immunol 8;601-609, 2007
DOI
ScienceOn
|
44 |
Wilcox RA, TAmada K, Strome SE, Chen L: Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic activity. J Immunol 169;4230-4236, 2002
DOI
PUBMED
|
45 |
Cheung CTY, Deisher TA, Luo H, Yanagawa B, Bonigut S, Samra A, Zhao H, Walker EK, McManus BM: Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest 87;651-661, 2007
DOI
ScienceOn
|
46 |
Lippert U, Zachmann K, Ferrari DM, Schwarz H, Brunner E, Nahhub-ul Latif AHM, Neumann C, Soruri A: CD137 lignd reverse signaling has multiple functions in human dendritic cells during an adaptive immune response Eur. J Immunol 38;1024-1032, 2008
|
47 |
Foell JL, Diez-Mendiondo BI, Diez OH, Holzer U, Ruck P, Bapat AS, Hoffmann MK, Mittler RS, Dannecker GE: Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance. Immunology 113;89-98, 2004
DOI
ScienceOn
|
48 |
Olofsson PS, Soderstrom LA. Wagstater D, Sheikine Y, Ocaya P, Lang F, Rabu C, Chen L, Paulsson-Berne GP, Sirsjo A, Hansson GK: CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Cicrulation 117; 1292-1301, 2008
DOI
ScienceOn
|
49 |
Seo SK, Choi JH, Kim YH, Kang WJ, Park HY, Suh JH, Choi BK, Vinay DS, Kwon BS: 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 10;1088-1094, 2004
DOI
ScienceOn
|
50 |
Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, Chen L, Fu YX: Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 168;1457-1465, 2002
PUBMED
|
51 |
Jiang D, Chen Y, Schwarz H: CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol 181;3923-3932, 2008
PUBMED
|