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TLC, HPTLC FINGERPRINTING AND ACUTE ORAL TOXICITY EVALUATION OF HABB-E-AZARAQI: A NUX-VOMICA-BASED TRADITIONAL UNANI FORMULATION

  • Ara, Shabnam Anjum;Viquar, Uzma;Zakir, Mohammed;Husain, Gulam Mohammed;Naikodi, Mohammed Abdul Rasheed;Urooj, Mohd;Kazmi, Munawwar Husain
    • CELLMED
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    • v.11 no.3
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    • pp.13.1-13.9
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    • 2021
  • Background and Objective: Nux-vomica based traditional Unani formulation, Habb-e-Azaraqi (HAZ) is an important drug used by Unani physicians since several decades. It possesses Muqawwi-i-A'sab (nervine tonic), Muharrik-i-A'sab (nervine stimulant) properties and is an effective treatment option for diseases like Laqwa (facial palsy), Falij (paralysis), Niqris (gout) and Waja'al-Mafasil (arthritis) etc. The aim of the study is to access and provide information of HAZ for its TLC, HPTLC Fingerprinting defining its clear qualitative perspective and acute oral toxicity evaluation for its safety assessment which was not done earlier, thus contributing in the field of research. Materials and Methods: The chief ingredient, nux-vomica was detoxified as per method mentioned in Unani Pharmacopeia before its use in formulation. TLC and HPTLC was developed under four detection system i.e., UV 366nm, UV 254nm, exposure to iodine vapours and after derivatization with anisaldehyde sulphuric acid. Acute toxicity studies were performed as per OECD Guidelines 425 at a limit dose of 2000 mg/kg. Observations were done for signs of toxicity, body weight, and feed consumption at regular intervals followed by haematological and biochemistry evaluation. Results: The generated data proved the authenticity and established the TLC and HPTLC profile of the formulation. Acute toxicity revealed no significant differences in HAZ-treated animals with respect to body weight gain, feed consumption, haematology, clinical biochemistry evaluation. No significant gross pathological observation was noticed in necropsy. Conclusion: Data of the present study is substantial and scientific proof of HAZ in terms of standardization and toxicity study that can be utilize in future research activities.

A Study on Residence Experiences of Elderly Living in Long-Term Care Facilities (노인요양시설 노인의 시설 거주경험에 관한 연구)

  • Cha, Sooyoun;Hur, Junsoo
    • The Journal of the Korea Contents Association
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    • v.21 no.5
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    • pp.808-823
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    • 2021
  • This study was conducted to explore the experience and its meaning of the elderly residents in long-term care facilities(LTCFs). It is aimed to find the role of family and society for the qualitative care of elderly living in LTCF and to seek social welfare measures. For this purpose, qualitative research data was collected by conducting in-depth interviews and participation observations on 8 elderly residents at 4 LTCFs in Seoul, Incheon, and Gyeonggi Province. The collected data were analyzed using Giorgi's phenomenological research method. The analysis results show that 33 semantic units, 14 subcomponents, and 4 upper components. The 4 upper components showed up as 「Crumbling my existence」, 「The life thrown into an unfamiliar environment」, 「New relationship where discomfort and gratitude coexist」 and 「My life I want to find」. Among them, 「My life I want to find」 was the essence of the living experiences of elderly residents in LTCF. Through this study, it was suggested creating an environment to provide facilities access preparation program for the elderly, developing and activating various family participation programs, providing conditions of Aging in place for the elderly, and developing and activating community resource linkage programs.

Effect of multi-enzymes supplementation on growth performance, meat quality, ileal digestibility, digestive enzyme activity and caecal microbiota in broilers fed low-metabolizable energy diet

  • Yaqoob, Muhammad Umar;Yousaf, Muhammad;Iftikhar, Mubashir;Hassan, Safdar;Wang, Geng;Imran, Safdar;Zahid, Muhammad Umer;Iqbal, Waqar;Wang, Minqi
    • Animal Bioscience
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    • v.35 no.7
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    • pp.1059-1068
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    • 2022
  • Objective: This study was conducted to evaluate the effect of using low energy diet with multi-enzymes supplementation on different biological parameters in broilers. Methods: Three hundred Arbor Acres broiler chicks were randomly divided into three groups (Cont, standard metabolizable energy(ME); L-ME, ME reduced by 50 kcal/kg without enzyme; and L-ME-MES, L-ME diet was supplemented with multi-enzymes) with five replicates per group (20 chicks per replicate) at the start of second week. Grower and finisher diets were formulated according to breed specific guide and offered with free access in respective phase (two weeks for grower [8 to 21 d]; two weeks for finisher [22 to 35 d]). External marker method was used to measure the nutrient digestibility. After feeding trial, fifteen birds (one bird per replicate) were selected randomly and slaughtered for samples collection. Results: The results exhibited no effect (p>0.05) of dietary treatments on all parameters of growth performance, carcass traits, relative weight of internal organs except bursa and overall parameters of thigh meat quality. Relative weight of bursa was significantly (p<0.05) higher in L-ME than control. Multi-enzymes supplementation in low-ME diet significantly (p<0.05) improved the breast meat pH 24 h, digestibility of crude protein, duodenum weight and length, jejunal morphology, counts of Lactobacillus spp. and Bifidobacterium spp., lipase and protease activities than control. Jejunum length was increased in both L-ME and L-ME-MES treatments than that of the control (p<0.05). Breast meat cooking loss and color lightness was lower in L-ME (p<0.05) than control. Conclusion: It can therefore be concluded that broilers could be reared on low energy diet with supplementation of multi-enzymes without compromising the growth performance. In addition, it is beneficial for other biological parameters of broilers.

Partitioning Interwell Tracer Test and Analysis Method for Estimating Oil Pollutants in the Underground (지중 유류오염량 추정을 위한 분배추적자 시험 및 해석방법)

  • Jeong, Chan-Duck;Kim, Yong-Cheol;Myeong, Woo-Ho;Bang, Sung-Su;Lee, Gyu-Sang;Song, Sung-Ho
    • Journal of Soil and Groundwater Environment
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    • v.27 no.spc
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    • pp.99-112
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    • 2022
  • From early 2000, many researchers in the groundwater and soil environment remediation project tried to calculate the pollution level and pollution remediation cost and reflect it in the design. In addition, by identifying the movement characteristics of oil pollutants in the underground environment, many researchers tried to derive design factors necessary for pollution purification. However, although the test should be conducted in an area contaminated with oil, the toxicity and risk are too great for testing by deliberately leaking pollutants that are harmful to the human body. And as oil-contaminated areas are promoted by military units such as returned US military bases, there is a limit to access by the general public. In addition, since the indoor simulation test and the field application test have been carried out separately from each other, it was difficult to compare and review various simulation tests Therefore, in this study, PITT (Partitioning Interwell Tracer Test) and analysis methods were specifically presented through actual tests so that field workers could easily use them with the help of the military base and the Korea Rural Community Corporation Soil Environment Restoration Team. However, in order to directly reflect the distribution tracer test results in the pollution remediation design, it is necessary to reduce the analysis errors by comparing the analysis results of the existing soil pollution survey, physical exploration, and numerical modeling. In addition, it is judged to be cautious in the analysis because errors can easily occur due to various factors such as the type of oil at the polluted site, the hydraulic conductivity of the aquifer, and the skill of the researcher.

The Usage of Modern Information Technologies for Conducting Effective Monitoring of Quality in Higher Education

  • Oseredchuk, Olga;Nikolenko, Lyudmyla;Dolynnyi, Serhii;Ordatii, Nataliia;Sytnik, Tetiana;Stratan-Artyshkova, Tatiana
    • International Journal of Computer Science & Network Security
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    • v.22 no.1
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    • pp.113-120
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    • 2022
  • Information technologies in higher education are the basis for solving the tasks set by monitoring the quality of higher education. The directions of aplying information technologies which are used the most nowadays have been listed. The issues that should be addressed by monitoring the quality of higher education with the use of information technology have been listed. The functional basis for building a monitoring system is the cyclical stages: Observation; Orientation; Decision; Action. The monitoring system's considered cyclicity ensures that the concept of independent functioning of the monitoring system's subsystems is implemented.. It also ensures real-time task execution and information availability for all levels of the system's hierarchy of vertical and horizontal links, with the ability to restrict access. The educational branch uses information and computer technologies to monitor research results, which are realized in: scientific, reference, and educational output; electronic resources; state standards of education; analytical materials; materials for state reports; expert inferences on current issues of education and science; normative legal documents; state and sectoral programs; conference recommendations; informational, bibliographic, abstract, review publications; digests. The quality of Ukrainian scientists' scientific work is measured using a variety of bibliographic markers. The most common is the citation index. In order to carry out high-quality systematization of information and computer monitoring technologies, the classification has been carried out on the basis of certain features: (processual support for implementation by publishing, distributing and using the results of research work). The advantages and disadvantages of using web-based resources and services as information technology tools have been discussed. A set of indicators disclosed in the article evaluates the effectiveness of any means or method of observation and control over the object of monitoring. The use of information technology for monitoring and evaluating higher education is feasible and widespread in Ukrainian education, and it encourages the adoption of e-learning. The functional elements that stand out in the information-analytical monitoring system have been disclosed.

Change Detection Using Deep Learning Based Semantic Segmentation for Nuclear Activity Detection and Monitoring (핵 활동 탐지 및 감시를 위한 딥러닝 기반 의미론적 분할을 활용한 변화 탐지)

  • Song, Ahram;Lee, Changhui;Lee, Jinmin;Han, Youkyung
    • Korean Journal of Remote Sensing
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    • v.38 no.6_1
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    • pp.991-1005
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    • 2022
  • Satellite imaging is an effective supplementary data source for detecting and verifying nuclear activity. It is also highly beneficial in regions with limited access and information, such as nuclear installations. Time series analysis, in particular, can identify the process of preparing for the conduction of a nuclear experiment, such as relocating equipment or changing facilities. Differences in the semantic segmentation findings of time series photos were employed in this work to detect changes in meaningful items connected to nuclear activity. Building, road, and small object datasets made of KOMPSAT 3/3A photos given by AIHub were used to train deep learning models such as U-Net, PSPNet, and Attention U-Net. To pick relevant models for targets, many model parameters were adjusted. The final change detection was carried out by including object information into the first change detection, which was obtained as the difference in semantic segmentation findings. The experiment findings demonstrated that the suggested approach could effectively identify altered pixels. Although the suggested approach is dependent on the accuracy of semantic segmentation findings, it is envisaged that as the dataset for the region of interest grows in the future, so will the relevant scope of the proposed method.

A research on the Construction and Sharing of Authority Record-focusing on the Case of Social Networks and Archival Context Project (전거레코드 구축 및 공유에 관한 연구 SNAC 프로젝트 사례를 중심으로)

  • Lee, Eun Yeong
    • The Korean Journal of Archival Studies
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    • no.71
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    • pp.49-89
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    • 2022
  • This study suggests the necessity and domestic application plan a national authority database that promotes an integrated access, richer search, and understanding of historical information sources and archival resources distributed among cultural heritage institutions through the "Social Networks and Archive Context" project case. As the SNAC project was transformed into an international cooperative organization led by NARA, it was possible to secure a sustainable operating system and realize cooperative authority control. In addition, SNAC authority records have the characteristics of providing richer contextual information about life and history and social and intellectual network information compared to libraries. Through case analysis, First, like SNAC, a cooperative body led by the National Archives and having joint ownership of the National Library of Korea should lead the development and expand the scope of participating institutions. Second, in the cooperative method, take a structure in which divisions are made for each field with special strengths, but the main decision-making is made through the administrative team in which the two organizations participate. Third, development of scalable open source software that can collect technical information in various formats when constructing authority data, designing with the structure and elements of archival authority records, designing functions to control the quality of authority records, and building user-friendly interfaces and the need for a platform design reflecting content elements.

Appropriate Smart Factory : Demonstration of Applicability to Industrial Safety (적정 스마트공장: 산업안전 기술로의 적용 가능성 실증)

  • Kwon, Kui-Kam;Jeong, Woo-Kyun;Kim, Hyungjung;Quan, Ying-Jun;Kim, Younggyun;Lee, Hyunsu;Park, Suyoung;Park, Sae-Jin;Hong, SungJin;Yun, Won-Jae;Jung, Guyeop;Lee, Gyu Wha;Ahn, Sung-Hoon
    • Journal of Appropriate Technology
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    • v.7 no.2
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    • pp.196-205
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    • 2021
  • As industrial safety increases, various industrial accident prevention technologies using smart factory technology are being studied. However, small and medium enterprises (SMEs), which account for the majority of industrial accidents, are having difficulties in preventing industrial accidents by applying these smart factory technologies due to practical problems. In this study, customized monitoring and warning systems for each type of industrial accident were developed and applied to the actual field. Through this, we demonstrated industrial accident prevention technology through appropriate smart factory technology used by SMEs. A customized monitoring system using vision, current, temperature, and gas sensors was established for the four major disaster types: worker body access, short circuit and overcurrent, fire and burns due to high temperature, and emission of hazardous gas. In addition, a notification method suitable for each work environment was applied so that the monitored risk factors could be recognized quickly, and real-time data transmission and display enabled workers and managers to understand the disaster risk effectively. Through the application and demonstration of these appropriate smart factory technologies, the spread of these industrial safety technologies is to be discussed.

A Delphi Study for Deriving Directions for Future Elementary School Science Textbook (미래 초등 과학 교과용도서 방향성 도출을 위한 델파이 연구)

  • Chae, Dong-Hyun;Shin, Jung-Yun;Kim, Eun-Ae
    • Journal of the Korean Society of Earth Science Education
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    • v.14 no.1
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    • pp.59-68
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    • 2021
  • The purpose of this study is to provide basic data to derive the direction of future elementary science curriculum books through delphi study of science education experts. To this end, a panel of 18 experts was formed and two delphi investigations were conducted. By analyzing the mean, median, and CVR values for each item in the Delphi survey, the priorities of changes in science education for the future society and the validity of each item's implementation method were verified. In addition, by synthesizing this, the direction of future elementary science textbooks was derived. As a result, the future elementary science textbook can be 'fun and interesting science study', 'exploration performance-oriented learning' and 'science that enjoys and participates even as an adult'. It should be developed to prepare for culture. For this, it is necessary to use materials in real life, and it is necessary to present an experiment that stimulates curiosity and easy access using materials and preparations with high accessibility. In addition, it is necessary to develop a textbook for learning that science is a discipline that is highly connected with real life, and that it is also related to future career paths.

Deriving AR Technologies and Contents to Establish a Safety Management System in Railway Infrastructure (철도 인프라 안전 관리 시스템 구축을 위한 AR 기술 및 콘텐츠 도출)

  • Jeon, Hae-In;Yu, Young-Su;Koo, Bon-Sang;Seo, Hyeong-Lyel;Kim, Ji-Hwan
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.42 no.3
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    • pp.427-438
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    • 2022
  • With the recent growing importance over safety management the need for advanced and technical approaches for on-site safety inspection methods has increased. Railway construction is subject to its own particular set of temporal and spatial challenges due to its unique facilities and equipment. This study aimed to investigate the field characteristics of railway infrastructure and improve the conventional field safety management methods by identifying the most appropriate features of AR technology. Group interviews and surveys were conducted with field safety experts to derive the major problems and inspection needs. Subsequently, various features of AR, such as BIM model projection, and remote conferencing, were investigated to determine their applicability to address safety issues. As a result, four problems in the current safety management process, such as 'lack of time due to the conventional inspection method and inspection of areas that are difficult to access', and three major inspection types, such as 'observance of work procedures, status of installation, adequate dimensional spacing', were identified to be improved when adopting AR based techniques. Furthermore, AR technology utilizing plans to solve safety inspection problems and effectively manage major inspection types were proposed, and a follow up survey was conducted with the same field safety experts to derive the priority of technology development.