• 한국신뢰성학회지:신뢰성응용연구
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• 제14권3호
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• pp.203-207
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• 2014

Electrodeless lamp is famous for its long life. But its reliability is dependent not only on electrodes but also on materials and structures. To evaluate end product's reliability, we studied high temperature durability by $60^{\circ}C$, $75^{\circ}C$ and $90^{\circ}C$ temperature tests, and predicted failure times by an exponential model through regression analysis. However, the test showed that temperature does not affect degradation of electrodeless lamps. Their luminous outputs degrade during the early time of the test (till 250 hours) and then converge to a saturation points. Also, '410nm ~ 530nm' spectrum degrades more than other spectra.

• 한국신뢰성학회지:신뢰성응용연구
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• 제5권4호
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• pp.487-500
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• 2005

MEMS devices usually have micro actuators contained in a cavity, If the pressure level of testing chamber is higher than that of cavity, moisture will ingress into the cavity, which may cause critical failure such as stiction of the moving parts. To design an accelerated life test based on high temperature and high humidity, such a phenomena should be considered. In this study, a throughput model that can estimate the amount of moisture ingress is used to decide the testing time and conditions of a high temperature and high humidify test.

• Genomics & Informatics
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• 제21권3호
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• pp.28.1-28.13
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• 2023

Mild cognitive impairment (MCI) is a clinical syndrome characterized by the onset and evolution of cognitive impairments, often considered a transitional stage to Alzheimer's disease (AD). The genetic traits of MCI patients who experience a rapid progression to AD can enhance early diagnosis capabilities and facilitate drug discovery for AD. While a genome-wide association study (GWAS) is a standard tool for identifying single nucleotide polymorphisms (SNPs) related to a disease, it fails to detect SNPs with small effect sizes due to stringent control for multiple testing. Additionally, the method does not consider the group structures of SNPs, such as genes or linkage disequilibrium blocks, which can provide valuable insights into the genetic architecture. To address the limitations, we propose a Bayesian bi-level variable selection method that detects SNPs associated with time of conversion from MCI to AD. Our approach integrates group inclusion indicators into an accelerated failure time model to identify important SNP groups. Additionally, we employ data augmentation techniques to impute censored time values using a predictive posterior. We adapt Dirichlet-Laplace shrinkage priors to incorporate the group structure for SNP-level variable selection. In the simulation study, our method outperformed other competing methods regarding variable selection. The analysis of Alzheimer's Disease Neuroimaging Initiative (ADNI) data revealed several genes directly or indirectly related to AD, whereas a classical GWAS did not identify any significant SNPs.

• Corrosion Science and Technology
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• 제14권1호
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• pp.1-11
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• 2015

Local wall thinning and integrity degradation caused by several mechanisms, such as flow accelerated corrosion (FAC), cavitation, flashing and/or liquid drop impingements, are a main concern in carbon steel piping systems of nuclear power plant in terms of safety and operability. Thinned pipe management program (TPMP) had been developed and optimized to reduce the possibility of unplanned shutdown and/or power reduction due to pipe failure caused by wall thinning in the secondary side piping system. This program also consists of several technical elements such as prediction of wear rate for each component, prioritization of components for inspection, thickness measurement, calculation of actual wear and wear rate for each component. Decision making is associated with replacement or continuous service for thinned pipe components. Establishment of long-term strategy based on diagnosis of plant condition regarding overall wall thinning is also essential part of the program. Prediction models of wall thinning caused by FAC had been established for 24 operating nuclear plants. Long term strategies to manage the thinned pipe component were prepared and applied to each unit, which was reflecting plant specific design, operation, and inspection history, so that the structural integrity of piping system can be maintained. An alternative integrity assessment criterion and a computer program for thinned piping items were developed for the first time in the world, which was directly applicable to the secondary piping system of nuclear power plant. The thinned pipe management program is applied to all domestic nuclear power plants as a standard procedure form so that it contributes to preventing an accident caused by FAC.

• 아태비즈니스연구
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• 제9권4호
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• pp.157-180
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• 2018

This paper empirically analyzes how working conditions of employees and executives affect Korean companies' survival. To this end, a survival analysis based on the accelerated failure time model is conducted from the end of December 2012 to the end of September 2018 on the 2012 year-end financial data for corporations whose common stocks have ever been listed either in the KOSPI market or in the KOSDAQ market with fiscal year ending at the end of December. The analysis shows that the average wage level per employee and the number of executives relative to the number of employees threaten while the average duration of service for female employees prolongs firm survival. Here, the average wage level per employee has turned out to worsen firm survivability regardless of the gender of employees in question while the average duration of service improves firm survivability only in case the employees are female: the average duration of service for male employees or the entire employees has turned out not to have any statistically significant influence on firm survival. The average compensation per executive and the percentage of temporary employees have turned out not to have any statistically significant influence on firm survival while the percentage of female employees has shown statistically significant positive influence on firm survival in some, although not all, models employed in our study. These results are expected to be a good reference in the course of our reaching agreements regarding the improvement of working conditions either between firms and employees or among the members of the entire society.

• Nuclear Engineering and Technology
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• 제53권9호
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• pp.3068-3084
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• 2021

Investigations of large commercial aircraft impact effect on nuclear power plant (NPP) buildings have been drawing extensive attentions, particularly after the 9/11 event, and this paper aims to experimentally assess the damage and vibrations of NPP buildings subjected to aircraft crash. In present Part I, two shots of reduce-scaled model test of aircraft impacting on NPP building were carried out. Firstly, the 1:15 aircraft model (weighs 135 kg) and RC NPP model (weighs about 70 t) are designed and prepared. Then, based on the large rocket sled loading test platform, the aircraft models were accelerated to impact perpendicularly on the two sides of NPP model, i.e., containment and auxiliary buildings, with a velocity of about 170 m/s. The strain-time histories of rebars within the impact area and acceleration-time histories of each floor of NPP model are derived from the pre-arranged twenty-one strain gauges and twenty tri-axial accelerometers, and the whole impact processes were recorded by three high-speed cameras. The local penetration and perforation failure modes occurred respectively in the collision scenarios of containment and auxiliary buildings, and some suggestions for the NPP design are given. The maximum acceleration in the 1:15 scaled tests is 1785.73 g, and thus the corresponding maximum resultant acceleration in a prototype impact might be about 119 g, which poses a potential threat to the nuclear equipment. Furthermore, it was found that the nonlinear decrease of vibrations along the height was well reflected by the variations of both the maximum resultant vibrations and Cumulative Absolute Velocity (CAV). The present experimental work on the damage and dynamic responses of NPP structure under aircraft impact is firstly presented, which could provide a benchmark basis for further safety assessments of prototype NPP structure as well as inner systems and components against aircraft crash.

• 한국산업정보학회논문지
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• 제29권2호
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• pp.119-131
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• 2024

2019년 금융위원회의 온라인 대출 중개 서비스 도입 허용에 따라 핀다와 토스같은 핀테크 대출중개 플랫폼들이 가파르게 성장하였다. 하지만 대출중개 플랫폼으로 대출을 받은 고객들은 기존의 모집법인을 통해 대출을 받은 고객들보다 채무불이행 위험도가 더 높은 것으로 보고되었다. 본 연구는 생존분석 기법을 통해 신용대출을 받기 위해 대출중개 플랫폼을 통해 대출을 받은 고객들과 모집법인을 통해 대출을 받은 고객들의 채무불이행 위험도를 비교하고 각 대출중개 플랫폼별로 고객들의 채무불이행에 영향을 주는 특성들을 비교하였다. 분석을 위해 국내 캐피털사의 고객 데이터를 활용하였으며 카플란-마이어 분석 및 AFT 모형을 활용하였다. 모집법인을 통해 대출을 받은 고객들에 비해 대출중개 플랫폼을 통해 대출을 받은 고객들은 개인사업자보다 일반 대출자의 비중이 높고 부동산을 소유하고 있을 확률이 높았으며 대출진행기간이 더 짧았다. 또한 대출진행기간 중앙값(385일)을 기준으로 채무불이행 발생 비율이 더 높았다. AFT 모형을 통해 채무불이행 발생 시기를 분석한 결과 대출중개 플랫폼은 모두 모집법인에 비해 채무불이행 발생 확률이 높은 것으로 나타났다. 또한 대출중개 플랫폼을 통해 대출을 받은 고객의 특성들이 채무불이행 발생 시기에 주는 영향은 플랫폼별로 상이하게 나타났다. 이 결과는 대출중개 플랫폼별로 고객의 리스크 차이를 고려한 맞춤형 전략이 필요함을 보여준다.

• Elastomers and Composites
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• 제47권1호
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• pp.9-17
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• 2012

본 연구에서는 클로로프렌 고무의 열 및 해수에 의한 노화 현상에 따른 물성 변화 및 사용 수명을 예측하였다. 가속 스트레스 수준은 열노화 $80^{\circ}C$, $100^{\circ}C$, $120^{\circ}C$, 해수침지노화 $40^{\circ}C$, $60^{\circ}C$, $80^{\circ}C$에서 2년 3개월(20,000Hr)동안 가속노화를 통해 인장시험을 수행하여 신장률, 인장강도, 경도를 통한 물성변화 측정을 하였다. 분석 결과신장율 저하가 가장 주된 고장지배모드임을 알 수 있었다. 아레누이스 식을 이용한 노화수명 예측 결과 열노화된 CR의 예측 수명은 $23^{\circ}C$에서 125년이며, 해수침지노화된 CR의 예측수명은 $23^{\circ}C$에서 9년이었다. SEM과 SEMEDS 분석 결과, 해수노화시편이 균열과 SEM-EDS에서는 산소의 농도가 증가하였으며, 이를 바탕으로 FT-IR에서는 해수와의 반응에 의하여 C-O와 C=O 결합이 생성되었음을 관찰하였다. 또한 DSC와 TGA 분석에서는 해수침지노화에 의하여 유리전이온도가 상승하며 분해온도가 낮아짐을 관찰하였다.

• Childhood Kidney Diseases
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• 제14권1호
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• pp.32-41
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• 2010

목 적 : 사구체신염은 흔히 단백뇨를 보이며 특이 치료법이 없고, 만성 신부전으로 발전하는 경우가 많다. 몇몇 연구에서 중간엽 줄기세포(Mesenchymal stem cell, MSC)를 실험적 사구체신염에 투여하여 단백뇨가 호전된 것을 보고한 바 있으나, 이는 신염을 일으키는 약제와 중간엽 줄기세포를 함께 투여하거나 신장에 직접 투여한 것이었다. 본 연구에서는 실험적 신병증에서 단백뇨가 발현된 시점에서 정주 요법으로 MSC를 투여함으로써 MSC의 임상적인 적용 가능성을 탐색하였다. 방 법 : 실험용 생쥐에 Adriamycin을 투여하여 신병증(ADR-GN)을 유발한 후, 2주 후에 대량의 단백뇨를 확인하고 MSC를 생쥐 꼬리의 정맥에 주사하였다. MSC에 의한 질병 완화의 기전을 확인하기 위한 in vitro 실험으로 mixed lymphocyte culture(MLC)에 MSC를 투여하였을 때의 염증 관련 cytokine인 IFN-$\gamma$ and IL-10의 변화를 측정하였다. 결 과 : 실험용 생쥐에 ADR-GN를 유발하고 단백뇨가 보일 때 MSC를 정주한 군에서는 단백뇨의 소실이 더 먼저 관찰되었다. 또한 MSC를 투여받은 군에서의 생존률이 더 나은 경향이 관찰되었다. MLC 에 MSC를 투여하였을 때, 염증을 유발하는 cytokine인 IFN-$\gamma$ 는 감소하고 염증을 억제하는 cytokine인 IL-10는 증가하였다. 결 론 : 이 연구는 이전의 보고들에서 관찰되었던 사구체신염에서의 MSC의 질병완화 효과가 좀더 임상적으로 적용 가능한 방법으로 투여된 경우, 즉 단백뇨가 있을 때 정주 요법으로 투여한 경우에도 관찰됨을 확인하였다. 이러한 효과의 기전과 임상적용에 요구되는 안전성 등에 대한 확인을 위해서는 추가 연구가 필요하겠다.