• 대한수의학회지
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• 제53권2호
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• pp.125-127
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• 2013

Canine Subcorneal pustular dermatosis (CSPD) represents a sterile, superficial, pustular skin disease of unknown cause but may be a variant of pemphigus foliaceus. A 7-year-old, intact female, mixed dog presented with 3-month history of pruritic multiple pustules and crusts. Direct smears from intact pustules revealed numerous nondegenerate neutrophils, some acantholytic cells, and bacterial culture was negative. Histologic examination of lesional skin showed subcorneal pustules filled with neutrophils and acantholytic cells. The direct immunofluorescence tests stained with IgG, IgA, IgM, C3 were negative. Oral administration of dapsone (1 mg/kg/q8h) was initiated and it was reduced to 1 mg/kg/q12h with good control of the lesions.

• 대한수의학회지
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• 제46권2호
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• pp.165-169
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• 2006

A 6-year-old female Jindo dog weighing 20 kg was presented to the Veterinary Medical Teaching Hospital of Seoul National University for the formation of crust and erosion of the nasal bridge and planum, and for alopecia of ear margin. Erythema, crusts, alopecia and erosions were present in the nasal planum and the bridge of the nose on physical examination. There were no abnormalities on CBC, serum chemistry, and basic dermatologic examination which included skin scraping, bacterial cultures, and fungal cultures. On cytology, the acantholytic cells were surrounded by non-degenerate neutrophils. Biopsy samples obtained from skin lesionswere diagnosedpemphigus erythematosus by histopathology and immunochemical staining. Therefore the dog was initially treated with oral prednisolone as an immunosuppressive dose for tour weeks, but clinical manifestations did not improve so far.

• 한국임상수의학회지
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• 제26권4호
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• pp.340-343
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• 2009

3살령의 중성화 하지 않은 암컷 풍산개가 4개월 동안의 전신 항생제와 글루코 코르티코이드 치료에 반응하지 않는 미란성의 발적을 동반한 피부염을 주증상으로 내원하였다. 신체검사상 귀끝, 콧잔등과 앞다리에서 가피, 미란, 탈모가 관찰되었으며, 농포의 세포학적 검사에서 원형의 극세포해리성 각질세포들이 비퇴행성의 호중구, 호산구와 함께 관찰되었다. 조직병리학적 검사 결과, 표피내 농포에는 다수의 호중구, 소수의 호산구와 고립되거나 군집되어있는 해리성 극세포가 포함되어 있었다. 본 환자는 병력, 임상증상, 세포학적, 조직병리학적 검사를 통해 낙엽성 천포창으로 진단되었으며, 피부병변은 사이클로스포린의 경구 투약으로 개선되었다. 이 증례는 면역 억제제인 사이클로스포린의 단독 사용으로 개에서의 낙엽성 천포창을 치료 관리 할 수 있다는 것을 입증하였다.

• 한국임상수의학회지
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• 제30권1호
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• pp.61-65
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• 2013

An American Cocker Spaniel (3-year-old, intact female, 6.0 kg) was referred to the Veterinary Medical Teaching Hospital of Chungnam National University for evaluation of pustules and crusts in the periocular region, dorsal and ventral region of the trunk, and digits. Complete blood count (CBC) revealed leukocytosis with mature neutrophilia, and a serum biochemistry profile revealed hypoalbuminemia. Tape strip tests identified numerous neutrophils and acatholytic cells. Histopathology identified intraepithelial pustules with neutrophils and acantholytic keratinocytes. Definitive diagnosis of pemphigus foliaceus (PF) was made by direct immunofluorescence (DIF) test with goat anti-canine IgG antibody. The human intravenous immunoglobulin (IVIG) was administered at a rate of 15 ml/h over 6 hours for 4 days. After that, the dog was maintained on prednisolone (2.2 mg/kg, PO, SID) and azathioprine (2.0 m/kg, PO, SID). An infusion of IVIG (0.5 g/kg) was repeated 3 days after 4 weeks. After 10 weeks, the dog showed the remarkable regression of lesions.