• Title/Summary/Keyword: abuse and misuse

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The Necessity of Education of Veterinary Drug Formulary and Animal Pharmacy's Awareness For Pharmacists (약사의 동물약국 인지 및 동물용의약품에 대한 교육의 필요성)

  • Lee, Young Ah;Lim, Sung Cil
    • YAKHAK HOEJI
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    • v.58 no.2
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    • pp.91-98
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    • 2014
  • Pharmacists must be aware of veterinary drugs to prevent abuse and misuse of the drugs, and to ensure the safety of livestock under the veterinarian prescription system. In this study, the awareness of animal pharmacies was surveyed in order to find out the role of animal pharmacies and the necessity of veterinary drug education for pharmacists. Surveys were conducted by 187 animal owners and 115 community pharmacists. 80% of the animal owners had purchased drugs for their animals. 63% of respondents were not aware of the existence of animal pharmacies. The best selling drug class for animals was antiparasitic. The most common drug that respondents wanted to buy in animal pharmacies was also antiparasitic. About 80% of respondents answered affirmatively on the question of whether they would buy the drugs from animal pharmacies regardless of the location of the pharmacies. Most community pharmacists were aware of the existence of animal pharmacies. 70% of pharmacists had considered trading in veterinary drugs. 41% of respondents answered that they did not trade in them because they were not familiar with veterinary drugs. 80% of respondents answered that what they needed most was education in order to increase the number of animal pharmacies. Pharmacies for animal will expand the choice of animal owners, and enable pharmacists to improve their specialty as well as to diversify the pharmacy services. To achieve this, promotion of animal pharmacies and education about veterinary drugs for pharmacists would be needed in regular education system.

Study on The Regulation on Poisonous Medicinal Herbs (독성 한약재의 법적 규제에 관한 연구)

  • Kweon, Kee-Tae
    • The Korean Society of Law and Medicine
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    • v.11 no.1
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    • pp.271-296
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    • 2010
  • Objective: Poisonous Medicinal herbs can be considered as a risk factor to public health unless they are prescribed by Doctor of traditional Korean medicine. The proper method to manage them should be prepared to prevent risk factors caused by misuse and abuse of the poisonous medicinal herbs and enhance public health. Methods: In this dissertation (paper), the definition, scope, management status, data about pharmacology and toxicity and media release regarding adverse reaction were understood after organizing documents, laws and regulations concerning poisonous medicinal herbs. Also, management methods are suggested by analyzing related examples and regulations in China, Japan and Hong Kong, where the use of herbal medicine is general. Results: Methods for items for poisonous medicinal herbs, safety information management, management based on standardization of traditional processing methodology and reorganization and revision of related laws and regulations are established. Conclusion: Proper laws and regulations are not yet established to manage poisonous medicinal herbs in Korea. In this regard, it is urgent to establish laws and regulations which can apply independently. The purpose of the laws and regulations should be to enhance management of poisonous medicinal herbs and prevent incidence of addiction and death, improving the public health.

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Development of a Simultaneous Detection and Quantification Method of Anorectics in Human Urine Using GC-MS and its Application to Legal Cases (GC-MS를 이용한 사람 뇨시료 중 비만치료제 분석 및 비만치료제 남용 현황의 법과학적 고찰)

  • Choi, Hyeyoung;Lee, Jaesin;Jang, Moonhee;Yang, Wonkyung;Kim, Eunmi;Choi, Hwakyung
    • YAKHAK HOEJI
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    • v.57 no.6
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    • pp.420-425
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    • 2013
  • Phentermine (PT) and phenmetrazine (PM) have been widely used as anti-obesity drugs. These drugs should be used with caution due to its close relation to amphetamine in its structure and toxicity. PT and PM, amphetamine-type anorectics, have recently been considered as alternatives for methamphetamine abuse in Korea. In addition, the misuse and abuse of PT and PM obtained by illegal sources such as the internet become a serious social problem. In the present study, a simultaneous detection and quantification method for determining PT and PM in human urine was developed and validated according to the international guidelines. The urine samples were screened using a fluorescence polarization immunooassay and analyzed by gas chromatography mass spectrometry (GC-MS) after extraction using automatic solid phase extraction (SPE) with a mixed-mode cation exchange cartridge and derivatization with pentafluoropropionic anhydride (PFPA). The validation results for selectivity, linearity, limits of detection (LOD) and quantification (LOQ), intra- and inter-assay precision and accuracy and recovery were satisfactory. The validated method was successfully applied to authentic urine samples collected from 38 drug abuse suspects. PT and/or PM were identified with or without methamphetamine in urine samples. Abuse of PT and PM have increased continuously in Korea, therefore, closer supervision of the inappropriate use of anoretics is necessary.

Effect of Methylphenidate on Learning in Normal Population (정상인에서 메칠페니데이트가 학습에 미치는 영향)

  • Na, Kyoung-Sae;Lee, So-Young Irene
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.23 no.2
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    • pp.49-56
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    • 2012
  • Methylphenidate is a widely used stimulant for treatment of attention-deficit hyperactivity disorder (ADHD). In addition to core symptoms of attention and behavioral symptoms, methylphenidate is even effective for executive functions. However, abuse and misuse of stimulants, including methylphenidate, for the purpose of cognitive enhancement is an issue of concern worldwide. Some prejudices and misunderstandings against methylphenidate are popular ; however, little attention has been given to the neuropsychiatric evidence of methylphenidate for enhancement of cognitive function among healthy populations. In this article, our aim was to conduct a review of previous studies investigating the effect of methylphenidate in healthy populations. Findings from several recent studies have demonstrated the effectiveness of methylphenidate for enhancement of cognitive function in healthy populations. The mechanisms of cognitive enhancement are thought to be associated with motivation and the reward circuit in the brain. However, when considering the risk to benefit, an official discussion of the use of methylphenidate among healthy members of the population would be premature. Instead, investigation of epidemiological studies of the prevalence of misuse of stimulants among healthy members of the population, particularly adolescents and college students, is needed. In addition, based on achievements reported in previous studies, investigation of the effect of an approach using non-pharmacological enhancing motivation, which will in turn result in increased cognitive function would be helpful.

Qunntitation of Fentanyl Remaining in Used Patches (Fentanyl Patch의 사용후 잔량분석)

  • Bae, Yang Soo;Ahn, Jung Soon;Choi, Kyung Eob
    • Korean Journal of Clinical Pharmacy
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    • v.6 no.2
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    • pp.24-27
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    • 1996
  • In order to determine whether there was a clinically sufficient amount of drug remaining in used fentanyl patches, quantitative analysis of two different types of patches, each containing 2.5 mg (n=36) and 5 mg (n=20) was performed. After being used for approximately 72 hours by patients with cancer, each patch was put in the plastic bag and stored at $4^{\circ}C$ until analysis. Fentanyl remaining in patches was extracted with 50 ml methanol, diluted with water, and counted twice in a $\gamma-Counter$ (expressed as CPM). Patches that originally contained 2.5 mg and 5 mg of fentanyl were shown to have $0.48{\sim}1.86\;mg\;(mean:\;1.03\;mg,\;41.16\%)\;and\;0.37{\sim}3.95\;mg\;(mean:\;2.37\;mg,\;47.33\%)$ after use, respectively. A wide interpatient variability was observed in the rate of fentanyl release from patches although the application period was standardized to 72 hours. Since a significant amount of drug remained in the discarded patches, it is highly recommended that patients dispose used ones under supervision to prevent abuse or misuse of the narcotic drug.

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Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents

  • Cha, Hye Jin;Song, Min Ji;Lee, Kwang-Wook;Kim, Eun Jung;Kim, Young-Hoon;Lee, Yunje;Seong, Won-Keun;Hong, Sa-Ik;Jang, Choon-Gon;Yoo, Han Sang;Jeong, Ho-Sang
    • Biomolecules & Therapeutics
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    • v.22 no.6
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    • pp.558-562
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    • 2014
  • Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents

  • Cha, Hye Jin;Lee, Hyun-A;Ahn, Joon-Ik;Jeon, Seol-Hee;Kim, Eun Jung;Jeong, Ho-Sang
    • Biomolecules & Therapeutics
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    • v.21 no.4
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    • pp.307-312
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    • 2013
  • Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.

A study of the subtitles abuse cases of entertainment programs (예능프로그램의 보조자막 오남용에 관한 연구)

  • Yun, Na-Ra;Kang, Hyo-Soon
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2011.10a
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    • pp.869-871
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    • 2011
  • For people who live in 'the Media Age', contact with the media is indispensable. In various mass media, especially TV, it is the most familiar and influential media, because it is easy to access and used regardless of age or gender. However, in many recent TV programs the subtitles of the misuse and abuse problems are pointed out. In the popular entertainment programs, and dramas, the problems are the most serious. Many entertainment programs organized during prime time have largely a family audience. Thus, the effects and responsibilities according to subtitles should be accompanied. The subtitles are an element that make up the entertainment program. In this study, the abuse cases of subtitle usage were analyzed. This study is aimed at maximizing the proper function of the subtitles, and creating fun and laughter through reducing misuses in various entertainment programs.

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Rapid Screening Method for the Solid-Phase Extraction and GC/MS analysis of Diazepam.

  • Choi, Hwa-Kyung;Lee, Ju-Seon;Choi, Hye-Young;Woo, Sang-Hee;Park, Yoo-Sin;Chung, Hee-Sun
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.118.3-119
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    • 2003
  • Diazepam (DZ) is one of the most frequently prescribed drugs as an antianxiety agent, muscle relaxant, and anticovulsant and sometimes causes intoxication due to accidental overdose, misuse or abuse. Screening or confirmation methods for DZ and NDZ in plasma are very important for clinical and toxicological studies and in forensic cases. GC/MS assay with SPE was developed for the determination of diazepam and its metabolite, nordiazepam in human plasma. Diazepam in plasma was extracted by a rapid and sensitive procedure based on C18 bonded-phase extraction. (omitted)

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The Type and Importance of Oriental Health Promotion Services and Nursing - By Delphi Method - (한방 건강증진 서비스 및 간호의 종류와 중요도 - 델파이방법을 이용하여 -)

  • Jang, Soon Yang;Park, Jeong Sook
    • Korean Journal of Adult Nursing
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    • v.18 no.1
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    • pp.62-70
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    • 2006
  • Purpose: To identify the agreed opinion of experts on oriental health promotion services and nursing in Korea. Method: The study is based on the 3-round Delphi method. As a Delphi panel, a total of 28 people with at least three years of experience in the area of oriental medicine consisted of this. Results: The experts suggested that Yangsaeng, lectures on prevention of CVA, correct understanding of the misuse/abuse of oriental medicine, daily health care, meridian/acupoints massage, and Kigong therapy should be included in the promoting oriental health nursing servies. Conclusion: The agreed opinions by the experts on the oriental health promotion services and nursing, can help enhance the understanding of oriental health promotion. The curriculum should be developed further and tested with the development of the Korean oriental nursing intervention methods which is appropriate to Korean culture.

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