• Toxicological Research
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• 제20권2호
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• pp.153-158
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• 2004

To evaluate the genotoxicity of CJ-11555, an anti-cirrhotic agent, the reverse mutation test, chromosomal aberration test and in vivo micronucleus test in rats were performed. In the reverse mutation test, the treatment of CJ-11555 at doses of 33.3, 100, 333, 1000, 3330 and 5000 $\mu\textrm{g}$/plate with and without 89 did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli (E. call) WP2uvrA. In chromosomal aberration test, CJ-11555 did not induce structural a chromosomal aberration in Chinese hamster ovary (CHO) cells with and without metabolic activation at all doses. In micronucleus test, CJ-11555 did not induce any statistically significant increases in micronucleated polychromatic erythrocyte (MNPCE) at doses of 500, 1000, and 2000 mg/kg. These results suggest that CJ-11555 might not have a mutagenic potential under the conditions in this study.

• 대한본초학회지
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• 제25권1호
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• pp.1-7
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• 2010

Objectives : We investigated genetic toxicity of HMCO5 in relation to chromosome aberration test on Cultured Chinese Hamster Lung (CHL) in the presence and absence of S-9 mix. Methods : Experimental groups were divided into two groups: with S-9mix (+S) or without S-9 mix (-S). -S group was also divided 2 series by treatment hours (6 hr: 6-S; or 24 hr; 24-S). Each group treated with vehicle only (complete culture medium), HMCO5 (1,250, 2,500, $5,000\;{\mu}g/ml$), and cyclophosphamide monohydrate (CPA) and ethylmethanesulfonate (EMS), respectively. Results : HMC05 did not show any aberrant metaphase. However, there were significant (p < 0.01) aberrant metaphases with CPA in S+ and with EMS in S-. Conclusions : These results indicate that HMC05 formula does not show any toxicity in chromosome aberration test.

• Journal of the Optical Society of Korea
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• 제13권4호
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• pp.451-455
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• 2009

We present a numerical procedure that compensates for tilt phase aberration in in-line digital holography by computing the period of interference patterns in the reconstructed phase image. This method enables the reconstruction of correct and accurate phase information, even if strong tilt aberrations exist. Example applications of tilt aberration compensation are shown for a tilted plate, a micro-lens array, and a thin film transistor. This method is convenient because it uses only one hologram and no hardware to minimize the tilt aberration.

• 한국정밀공학회지
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• 제20권10호
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• pp.191-198
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• 2003

In this study, aberration free aspherical lens design method named ray reverse tracing method is introduced. Differently from the traditional design method, the ray reverse tracing method traces the shape and location of a real object by use of its virtual image. From the result, especially spherical aberration free aspherical lens could be designed by use of the ray reverse tracing method. Furthermore, it could reduce the degree of dependence of optical characteristics on designer's ability, because deformation terms and optimization can be eliminated, which has been performed in conventional lens design process.

• Current Optics and Photonics
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• 제6권1호
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• pp.23-31
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• 2022

Heterodyne efficiency is an indicator to evaluate the performance of space coherent laser communication systems. It is affected by signal light and local oscillator (LO) light amplitude, phase and polarization state. In this paper, based on the common heterodyne efficiency, a heterodyne efficiency model that can reflect polarization aberration of optical system is proposed. The heterodyne efficiency is analyzed when the signal light and the LO light are linearly polarized or circularly polarized. For a coherent communication optical system, when the incident signal light is right-circularly polarized light and the incident LO light is 45° linear polarized light. Based on the three-dimensional ray tracing theory and the heterodyne efficiency proposed in this paper, the change of polarization states and the distribution of heterodyne efficiency of the signal light and LO light influenced by the optical system's polarization aberration are analyzed. Analysis shows that the heterodyne efficiency model proposed in this paper can be used to evaluate coherent communication systems and reflect the influence of optical system polarization aberration.

• International Journal of Internet, Broadcasting and Communication
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• 제16권3호
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• pp.77-84
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• 2024

Aberration is still a problem for making augmented reality displays. The existing methods to solve this problem are either slow and inefficient, consume too much battery, or are too complex for straightforward implementation. There are still some problems with image quality, and users may suffer from eye strain and headaches because the images provided to each eye lack accuracy, causing the brain to receive mismatched cues between the vergence and accommodation of the eyes. In this paper, we implemented a computer simulation of an optical aberration using Zernike polynomials which are defocus, trefoil, coma, and spherical. The research showed that these optical aberrations impact the Point Spread Function (PSF) and Modulation Transfer Function (MTF). We employed the phase conjugate technique to mitigate aberrations. The findings revealed that the most significant impact on the PSF and MTF comes from the influence of spherical aberration and coma aberration.

• 디지털융복합연구
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• 제10권10호
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• pp.301-306
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• 2012

본 논문은 머신비전시스템에서 정확한 이미지 획득을 위한 방법을 제안한다. 각종 렌즈에서 요구되는 가장 중요한 기능으로는 실물과 동일한 고품질의 결상을 구현하는 광학적 역할이다. 그러나 머신비전시스템의 입력부에서는 렌즈의 수차로 인하여 왜곡현상이 발생한다. 이러한 문제를 해결하기 위해 실세계 좌표계와 영상 좌표계 간의 변환 관계를 정의해주는 매핑 기능으로, 행렬연산을 통하여 두 좌표간의 거리를 계산하여 정확한 위치를 지정하게 된다. 레이저 정밀 가공작업에서도 Galvanometer를 사용하면 비구면 초점 렌즈에 의하여 발생되고 있는 렌즈 수차를 보정하여야 가공 오차를 개선 할 수 있다. 비구면 렌즈의 수차는 2차원 곡선의 형태를 가지고 있으나, 기존의 렌즈 보정 방법인 선형방법은 매우 많은 점들을 검사하여 보정시간이 많이 소요되는 문제점이 있었다. 가공장비에서 렌즈의 수차로 인하여 발생하는 가공오차를 감소시키기 위하여 Bilinear interpolation 기법을 적용하는 방법을 제안하였다. 제안한 방법은 기존 선형방법과 비교하여 위치 오차의 평균값과 표준편차가 향상되었음 실험을 통하여 입증하였으며 실제 레이저 응용업무에 적용하고 있다.

• Archives of Pharmacal Research
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• 제28권9호
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• pp.1079-1085
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• 2005

The purpose of this study was to investigate the safety of chitosan oligosaccharide and the effects of chitosan oligosaccharide on mercury induced genotoxicity in mice using the micronuclei and chromosome aberration. The micronuclei test was performed by microscopic examination $(\times1,000,\;stained\;using\;a\;May-Grunwald\;solution)$ after administering 0.01, 0.1, and $1\%(10\;mg/mL)$ chitosan oligosaccharide for 7, 60, and 180 days ad libitum in mice. Total micronuclei of 1,000 polychromatic erythrocytes were recorded for each group. There was no difference between the untreated and experimental groups. The intake periods and concentrations of chitosan oligosaccharide did not affect the occurrence of micronuclei in bone marrow cells (P>0.05). The chromosomal aberration test was performed by microscopic examination $({\times}1,000,\;stained\;using\;a\;4\%\;Giemsa\;solution)$ after administering the same concentration of chitosan oligosaccharide to mice, in $F_1,\;F_2,\;F_3$ generations and parents. The frequency of chromosomal aberrations was defined as [Ydr=(D+R)/total number of counted lymphocytes]. Similar to the micronuclei test, there was no difference between the untreated and treated groups. These results showed that the intake periods and concentrations of chitosan oligosaccharide did not affect chromosomal aberrations in bone marrow cells (P>0.05). To investigate the effect of chitosan oligosaccharide on mercury-induced chromosome aberration, mice in each condition were supplied with $^{203}HgCl_2$ and chitosan oligosaccharide ad libitum. Chitosan oligosaccharide significantly inhibited $^{203}HgCl_2-induced$ chromosome aberration in mice. Based on the results of this study, it may be concluded that the chitosan oligosaccharide is a nontoxic material that could be used as a suppressor of heavy metal-induced genotoxicity.

• 한국안광학회지
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• 제13권3호
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• pp.61-64
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• 2008

목적: 정시안의 임상자료를 기초로 설계한 개별모형안의 파장에 따른 수차 변화를 분석하였다. 방법: 측정된 안구의 임상 자료를 기초로 설계한 모형안은 4개의 굴절면과 균일한 굴절률을 갖는 형태로 설계하였다. 설계한 12안의 개별모형안에 대하여 프라운호퍼선 6개의 파장 변화를 주어 그에 따른 수차 변화를 분석하였다. 결과: 각 모형안에 대하여 파면수차의 파장에 따른 변화를 Zernike 계수로 분석한 결과 파장이 짧을수록 Defocus는 증가하였고 구면수차(spherical aberration)와 RMS는 개별모형안간의 편차가 크게 나타났다. 결론: 파장의 변화에 따른 Defocus양은 12안의 개별모형안이 비슷한 기울기로 짧을수록 크게 나타났고, 구면수차(spherical aberration)와 RMS는 대부분의 모형안의 경우 변화가 적었으며, 변화가 크게 나타난 일부 모형안은 성능 저하가 발생될 수 있다.

• Applied Microscopy
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• 제45권1호
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• pp.1-8
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• 2015

We have developed a new HD-2700 (Hitachi High-Technologies Corp., Japan) scanning transmission electron microscope (STEM) that includes an automatic aberration correction function, and a large-solid-angle energy-dispersive X-ray spectroscopy detector that enables high-resolution and sensitive analysis. For observation with atomic resolution, using spherical-aberration-corrected STEM, in order that satisfactory performance of the device can be achieved readily, and within a short time, irrespective of the operator's skill level, a spherical-aberration-correction device with an automatic aberration-correction function was developed. This automatic aberration-correction function carries out the entire correction-related process (aberration measurement, selection and correction) automatically, with automatic selection of the aberrations that require correction, and automatic measurement of the appropriate corrections.