• 대한물리치료과학회지
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• 제27권1호
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• pp.18-25
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• 2020

Purpose: The purpose of this study was to investigate the improve on brain activity during action observation training for cerebral palsy of diplegia. Design: Randomized controlled trial. Methods: 18 subjects were divide into two groups: action observation training group and a control group. Action observation group practiced repeatedly the action with their motor skill and control group practiced conventional physical therapy. The subjects participated in eighteen 30-min sessions, 3 day a week, for 6week. To confirm the effects on brain activity were evaluated. Results: The results show that the Mu-rhythm was statistically significant increase on the C3 of the action observation training group (p<0.05). Conclusion: The action observation training improves brain activity of a cerebral palsy with diplegia. These results suggest that the action observation training is feasible and beneficial for improving brain activation for the cerebral palsy with diplegia. In the future, I think we need to be actively utilized to the action observation training program in the clinical with the neuromuscular development treatment. And the study on the various the action observation training program that can improve the function of the children with cerebral palsy is thought necessary.

• 과학교육연구지
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• 제46권1호
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• pp.30-39
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• 2022

이 연구의 목적은 중등학생의 자기조절 과정에서 동화, 갈등, 조절의 세부 과정에 대한 뇌 활성을 비교하고 분석하는 것이다. 자기조절 과제는 생물학적 계통발생 과제로 제시되었고, 뇌활성은 fNIRS로 측정 및 분석되었다. 그 결과 동화 과정과 비교하여 갈등 과정에서 좌측 DLPFC, OFC, FP 영역에서 유의미한 활성이 발견되었고, 조절 과정에서는 DLPFC, VLPFC에서 유의미한 활성화가 발견되었다. 중등학생의 학년이 높아질수록 갈등 과정에서도 DLPFC가 증가하고 동화 과정에서도 VLPFC가 증가한다. 또한, 갈등과 조절 과정을 비교한 결과, 7학년 학생들은 오른쪽 VLPFC에서 유의미한 뇌 활동을 보였고, 9학년 학생들은 조절 과정에서 왼쪽 FP와 DLPFC 영역에서 유의미한 뇌 활동을 보였지만, 11학년 학생들은 이 과정에서 유의미한 뇌 활동을 보이지 않았다. 이러한 결과는 신경학적 연구 방법이 인지 활동과 강의실 교육 상황과 관련된 교육 연구에 적용될 수 있음을 보여준다.

• 대한물리의학회지
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• 제18권1호
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• pp.87-97
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• 2023

PURPOSE: The purpose of this study was to investigate the effect of multimodal intervention through VR (virtual reality)-based immersion program on the cognitive function and brain activity of patients with mild cognitive impairment. METHODS: The subjects of the study were 10 people in the experimental group who applied a complex intervention that performed cognitive tasks using the movement of the upper extremities through the VR program, and 10 people in the control group who received traditional occupational therapy. After the study intervention was applied 5 times a week, 30 minutes a day for a total of 8 weeks, LOTCA-G(Lowenstein Occupational Therapy Cognitive Assessment for Geriatric Population) and NIRSIT LITE were used to compare. RESULTS: Significant differences in cognitive function and brain activity were noted between the pre- test and post-test in the experimental group. Brain activity showed statistically significant differences in four channels of the working memory domain and one channel of the metacognitive domain (p < . 05). Comparative analysis of the difference between the two groups revealed statistically significant differences in cognitive function and brain activity. The brain activity showed statistically significant differences in three channels of the working memory domain and one channel of the metacognitive domain (p < .05). CONCLUSION: Through the results of this study, it was found that the complex intervention of performing cognitive tasks using upper extremity movements through the VR program had a positive effect on the cognitive function of patients with mild cognitive.

• 대한전기학회논문지:전력기술부문A
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• 제48권4호
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• pp.478-485
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• 1999

The purpose of this paper was the determination of the relationship between the chaotic charateristics and various levels of brain activities. Assuming that EEG(eletroencephalogram), which is generated by a nonlinear electiecal behavior of billions of neurons in the brain, has chaotic characteristics, it was confirmed by frequency spectrum analysis, log frequency spectrum analysis, correlation dimension analysis and Lyapunov exponents analysis. Chaotic characteristics are related to the degree of brain activity. The slope of log frequency spectrum increased and the correlation dimension decreased with respect to the brain activities, while the lagrest Lyapunov exponent has some rough correlation.

• Biomolecules & Therapeutics
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• 제28권6호
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• pp.512-518
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• 2020

Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA₅ activity with its specific antagonist can attenuate acute brain injuries after ischemic stroke. However, it is unclear whether suppressing LPA₅ activity can also attenuate chronic brain injuries after ischemic stroke. Here, we explored whether effects of LPA₅ antagonist, TCLPA5, could persist a longer time after brain ischemic stroke using a mouse model challenged with tMCAO. TCLPA5 was administered to mice every day for 3 days, starting from the time immediately after reperfusion. TCLPA5 administration improved neurological function up to 21 days after tMCAO challenge. It also reduced brain tissue loss and cell apoptosis in mice at 21 days after tMCAO challenge. Such long-term neuroprotection of TCLPA5 was associated with enhanced neurogenesis and angiogenesis in post-ischemic brain, along with upregulated expression levels of vascular endothelial growth factor. Collectively, results of the current study indicates that suppressing LPA₅ activity can provide long-term neuroprotection to mice with brain ischemic stroke.

• Journal of Ginseng Research
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• 제18권1호
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• pp.1-9
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• 1994

Sprague-Dawley rats were given freely with 15% ethanol (control) and 15% ethanol containing (1) 0.1% ginseng saponin, (2) 0.02% ginsenoside $Rb_1$, and (3) $Rg_1$ (tests) instead of water for 7 days and aldehyde dehydrogenase (ALDH) and monoamine oxidase (MAO) activity in different regions of brain were examined. In control group, total ALDH activity with indoleacetaldehyde and acetaldehyde as substrate in all different regions was lower than that of normal group except in the hippocampus. The inhibitory effect on the activity was prominent in the corpus striatum and was not in the hippocampus. However, low-$K_m$ ALDH activity in all different regions was much lower than that of normal group. A considerable decrease in mitochondria ALDH activity in cerebellum and striatum was also observed in control group. In test groups total, low-$K_m$, and mitochondria AkDH activities in all different regions were higher than those in control group. Although ALDH activity in the striatum of test group was higher than control group, it was relatively depressed as compared with normal. There was not found a remarkable difference in extent of stimulating effect on the AkDH activity according to the ginseng saponin components. When biogenic aldehydes were used as substrate, ALDH activity with 3,4-dihydroxy-phenylacetaldehyde (DOPAL) in all brain regions of control group was lower than that using 5-hydroxy-indoleacetaldehyde (HIAL) and 3,4-dihydroxyphenylglycolaldehyde (NORAL) as substrate. In control group, ALDH activity with biogenic aldehydes above mentioned was markedly inhibited in the striatum contrary to other regions. The higher ALDH activity with biogenic aldehydes in test group than in control was found in the striatum, cerebrum, and cerebellum. MAO activity in the cerebellum was inhibited in control group and slightly increased in test group. The results of present study suggest that the corpus striatum is significantly affected by ethanol exposure while the hippocampus is not and that ginseng saponin fraction and ginsenosid es might have a preventive effect against depression of brain ALDH activity by chronic administration of ethanol.

• 응용통계연구
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• 제35권1호
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• pp.161-175
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• 2022

뇌활동으로 발생하는 전기신호는 다시 자기신호로 유도되는데 센서로 측정한 것을 뇌자도(magnetoencephalography, MEG)라고 한다. MEG 기술은 비접촉, 비침습적인 측정방법이고 시간분해능과 공간분해능력이이 우수하기 때문에 뇌의 기능적인 정보를 얻는데 유용하게 사용될 수 있다. 또한 MEG 신호를 측정하고 분석하여 뇌신경전류의 활동을 이해할 수 있고 나아가 정밀한 뇌기능 연구가 가능하다. 본 연구에서는 뇌 활동(brain activity) 현상에 관한 궁극적 정보를 얻기위해 MEG 데이터의 특성을 설명하고 통계적 문제를 다루어 앞으로 뇌연구에 통계학의 필요성과 뇌정보학의 중요성을 강조하고자 한다.

• Archives of Pharmacal Research
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• 제21권5호
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• pp.549-554
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• 1998

Tissue factor (TF), a principal initiator of the veertebrate coagulation cascade, is expressed in organ tissues, cells and blood. TF is konwn to be induced in endothelial cells, monocytes and macrophages by inflammatory stimuli and in many pathologic conditions. By using the modified method for in vido TF activity assay, we found that turpentine oil injection as an inflamatory stimulus also induced the TF activity in lung and brain tissues of rats. And the age-related increase in Tf activity was observed in healthy rat brain tissue.

• Journal of Nutrition and Health
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• 제29권1호
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• pp.32-40
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• 1996

To investigate the effect of dietary docosahexaenoic acid(DHA) and environmental enrichment on brain fatty acid composition and acetylcholinesterase(AChE) activity, two groups of was fed isocaloric diets containing 10 or 12% dietary lipids for 7 weeks. A third group was fed 10% (w/w) dietary lipids with supplemented 2% DHA-rich fish oil. Each diet group was housed either in a stainless steel cage individually or in a large enriched cage with toys where 7 rats were kept together. The fatty acid composition of plasma and brain was significantly affected by dietary lipid composition but not by environmental enrichment. Fish oil supplementation significanlty decreased plasma levels of monounsaturated fatty acids(MUFA) and increased polyunsaturated fatty acids(PUFA). Fish oil supplemented groups also maintained lower plasma n-6 fatty acids and higher n-3 fatty acids levels than unsupplemented groups. The fish oil supplementation significantly decreased arachidonic acid and increased eicosapentaenic, docosapentaenoic acids, and DHA in brain fatty acid composition. In addition, brain DHA level in supplemented groups tended higher than the unsupplemented. Brain, AChE activity significantly increased by the environmental enrichment but not by the fish oil supplementation. These finding suggest that the 2% fish oil (0.57% DHA & 0.31% EPA, per diet weigth) supplementation is enough to accumulate n-3 fatty acids and to change the n-6 n-3 ratio in brain and environmental enrichment might promote the learning ability.

• 대한한의학회지
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• 제32권6호
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• pp.41-53
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• 2011

Objectives: This study was performed to investigate the effect of Jaeumgeonbigagamtang (JGT) onrestraint-induced oxidative stress in the mouse brain. Methods: After treatment with JGT, CBC, ROS, MDA, TAC, SOD, activity of catalase, and total GSH content were analyzed. Results: JGT had a strong antioxidant activity by in vitro assay as presented GEAC. JGT treatment significantly ameliorated decrease of blood WBC and increase of platelet count. JGT (50mg/kg) treatment significantly ameliorated increase of MDA and GSH content level in brain tissue. JGT (100mg/kg) treatment significantly ameliorated increase of MDA and activity of TAC level in brain tissue. JGT (200mg/kg) treatment significantly ameliorated increase of ROS, MDA, activity of TAC level and depletion of catalase level in brain tissue. Conclusion: The present study demonstrated antioxidant activity in brain tissue. This result would be consistent with the long clinical efficacy of JGT, and this finding may provide a strong possibility of JGT as a drug candidate for brain-specific multiple disorders and symptoms.