The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effect of Jaeumgeonbigagamtang (JGT) on Restraint-induced Oxidative Stress in Mouse Brain

  • Yoon, Jung-Hun (Department of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • An, Joung-Jo (Department of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Jo, Hyun-Kyung (Department of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Son, Chang-Gue (Department of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Yoon-Sik (Department of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Seol, In-Chan (Department of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Ho-Rhyong (Department of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University)
  • Received : 2011.08.16
  • Accepted : 2011.09.26
  • Published : 2011.11.30
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Abstract

Objectives: This study was performed to investigate the effect of Jaeumgeonbigagamtang (JGT) onrestraint-induced oxidative stress in the mouse brain. Methods: After treatment with JGT, CBC, ROS, MDA, TAC, SOD, activity of catalase, and total GSH content were analyzed. Results: JGT had a strong antioxidant activity by in vitro assay as presented GEAC. JGT treatment significantly ameliorated decrease of blood WBC and increase of platelet count. JGT (50mg/kg) treatment significantly ameliorated increase of MDA and GSH content level in brain tissue. JGT (100mg/kg) treatment significantly ameliorated increase of MDA and activity of TAC level in brain tissue. JGT (200mg/kg) treatment significantly ameliorated increase of ROS, MDA, activity of TAC level and depletion of catalase level in brain tissue. Conclusion: The present study demonstrated antioxidant activity in brain tissue. This result would be consistent with the long clinical efficacy of JGT, and this finding may provide a strong possibility of JGT as a drug candidate for brain-specific multiple disorders and symptoms.

Keywords

References

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