• 대한전자공학회논문지SD
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• 제41권4호
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• pp.75-82
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• 2004

압축 과정 중에 빠른 처리율을 보여주는 렘펠-짚 알고리즘의 결합에 의하여 채널 전송율은 증가한다. 영상정보의 압축 과정동안 처리율을 향상시키기 위하여 ICMEP 알고리즘을 제안하였으며 HDTV에 적용시켜 엔트로피 부호화기를 설계하였으며 이를 검증하였다. ICMEP 엔트로피 암호기는 top-down 방식을 이용하여 설계하였으며 VHDL을 이용하여 회로 합성 및 모의실험을 수행하였다. 모의실험 결과, 구현된 ICHEP 엔트로피 부호화기는 메모리 포화방지 및 압축률 증가로 인하여 전체적인 시스템 효율이 향상됨을 확인하였다.

• 한국한의학연구원논문집
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• 제15권3호
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• pp.45-51
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• 2009

Objectives : The objective of this article is to compare acupuncture treatment of stroke in the medical documents of the Chosun-Korea dynasty. Through such inquisition, the development process of acupuncture of stroke treatment could be found. Methods : We used Cross-comparison analysis of the contents of five medical books, HyangYakZipSungBang (HYZSB), UiRimChwarYo(URCY), DongEuiBoGam(DEBG), ChimGuGyungHumBang(CGGHB) and Saam-Acupuncture(SA) of the Chosun-Korea dynasty. Results & Conclusion : 1. Distinction between Stroke of Viscera and Stroke of Bowel was important. Firts two books divided stroke into three type. But last three books separated into Stroke of Viscera and Stroke of Bowel. 2. They emphasized Symptoms of Five Visceral Disease. They devised Symptoms of Five Visceral Disease for Stroke of Viscera treatment. This method appears very rarely in clinical medicine. 3. They used common important acupoint for treatment of stroke. Most of these acupoints exist at the limbs. 4. They chose acupoints on the opposite side against the symptom.

• Bulletin of the Korean Chemical Society
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• 제25권12호
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• pp.1769-1774
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• 2004

Jun/Fos, a crucial factor in transmitting the tumor-promoting signal from the extracellular environment to the nuclear transcription machinery, has a dimerization interface possessing several coiled structural properties. Jun and Fos can interact with the DNA regulatory region, AP-1 (Activator Protein-1), which is composed of 5'-TGAC/GTCA-3'.$^1$ Curcumin is a well-known anticancer and anti-inflammatory compound.$^{2,3}$ It also acts as an inhibitor of the Jun-Fos function. c-Fos and c-Jun with a bZIP region are overexpressed in BL21 E. coli and purified with an $Ni^{2+}$ affinity column. The inhibitors of Fos-Jun-AP-1 complex formation were searched through the EMSA (electrophoresis mobility shift assay) experiment, and new curcuminoids were synthesized and investigated as to their inhibitory effect on the same system. Two curcuminoids showed a stronger inhibitory effect than curcumin. This inhibitory activity was quantified with EMSA. 1,7-bis(4-methyl)-1,6-heptadiene-3,5-dione (BJC003) and 1,7-bis(4-hydroxy-5-methoxy-3-nitrophenyl)-1,6-heptadiene-3,5-dione (BJC005) showed remarkably high inhibitory activities. $IC_{50}$ of 1,7-bis(4-methyl)-1,6-heptadiene-3,5-dione (BJC003) and 1,7-bis(4-hydroxy-5-methoxy-3-nitrophenyl)-1,6-heptadiene-3,5-dione (BJC005) are 8.98 ${\mu}M$ and 5.40 ${\mu}M$, respectively. However, 1,7-bis(4-methyl-3-nitrophenyl)-1,6-heptadiene-3,5-dione (BJC004) did not show inhibitory activity.

• Molecules and Cells
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• 제42권11호
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• pp.783-793
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• 2019

When endoplasmic reticulum (ER) functions are perturbed, the ER induces several signaling pathways called unfolded protein response to reestablish ER homeostasis through three ER transmembrane proteins: inositol-requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK), and activating transcription factor 6 (ATF6). Although it is important to measure the activity of ATF6 that can indicate the status of the ER, no specific cell-based reporter assay is currently available. Here, we report a new cell-based method for monitoring ER stress based on the cleavage of $ATF6{\alpha}$ by sequential actions of proteases at the Golgi apparatus during ER stress. A new expressing vector was constructed by using fusion gene of GAL4 DNA binding domain (GAL4DBD) and activation domain derived from herpes simplex virus VP16 protein (VP16AD) followed by a human $ATF6{\alpha}$ N-terminal deletion variant. During ER stress, the GAL4DBD-VP16AD(GV)-$hATF6{\alpha}$ deletion variant was cleaved to liberate active transcription activator encompassing GV-$hATF6{\alpha}$ fragment which could translocate into the nucleus. The translocated GV-$hATF6{\alpha}$ fragment strongly induced the expression of firefly luciferase in HeLa Luciferase Reporter cell line containing a stably integrated 5X GAL4 site-luciferase gene. The established double stable reporter cell line HLR-GV-$hATF6{\alpha}$(333) represents an innovative tool to investigate regulated intramembrane proteolysis of $ATF6{\alpha}$. It can substitute active pATF6(N) binding motif-based reporter cell lines.

• 한국기록관리학회지
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• 제16권4호
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• pp.79-120
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• 2016

변화하는 컴퓨팅 환경에 따라 공문서 생산 환경이 G-클라우드 및 클라우드 온-나라 시스템으로 전환하고 있다. 더불어 공문서 포맷도 독자 포맷인 HWP을 대신하여 개방형 규격인 ODF가 정착할 것으로 전망된다. 이에 본 연구는 현행 공문서 장기보존 전략을 재검토 하고, ODF 생산 문서 보존에 적합한 문서보존포맷과 장기보존포맷 설계 방향을 제시하고자 한다. 생산 포맷이 ODF인 기록은 문서보존포맷으로의 변환 없이 기록관리 메타데이터를 추가한 확장 ODF 포맷을 제안하고자 하며 독자포맷의 보존에도 ODF를 검토하였다. 장기보존 포맷, 즉 NEO 포맷 변환 현황을 알아보고 BagIt 규격 패키지를 ISO21320으로 제정된 ZIP을 적용하여 장기보존포맷을 설계하였다.

• 한국의류산업학회지
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• 제17권5호
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• pp.781-792
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• 2015

This study aims to develop a spring/fall motorcycle jacket for quick service transporter. Depending on the results of the previous research, this study produced the tested jacket which was improved in material, pattern, and design. For the tested jacket, 100% polyester fabric excellent in strength, durability and abrasion-resistance was selected as a major material, and Cordura was used as a partial material to improve the strength and abrasion-resistance of the sleeve side lines, elbow and shoulder areas. The retro-reflection material was applied partially in order to improve visibility of the jacket in the night or in a dark place. A total of 7 pockets were composed in the jacket for the sufficient storage spaces. The functional design elements such as the 2-way zipper and the placket at the center front, the action pleats at the upper part of back armholes, the pit-zip at armpit were applied. In addition, the sleeve pattern was bent with the shape of elbow curvature in time of driving and the back length of the jacket was lengthened 4cm. As a result of the appearance assessment, there was a significant difference from the existing jacket in all items but chest size, shoulder width, cuffs circumference, and jacket hemline circumference. In motion adaptability and field activity appropriateness assessments, the assessment grade for all items was found to be commonly higher than that of the existing jacket, and thus, the tested jacket was assessed to be suitable for a motorcycle jacket design for the quick service transporters.

• Restorative Dentistry and Endodontics
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• 제13권1호
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• pp.161-171
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• 1988

The purpose of this study was to examine the morphological changes of different simulated canals according to the preparation procedures. With the use of clear casting resin, simulated straight and curved canals were created so that canal preparation procedures could be directly visualized and compared. Thirty clear polyester casting resin blocks which contained four simulated canals divided into three groups; Group A($0^{\circ}$), Group B($15^{\circ}$), and Group C($30^{\circ}$). In each block, 3 canals were prepared different preparation techniques, which were conventional method, step-back method, and giromatic filing. But, one canal was not prepared as a control group. The results were as follows: 1. There was no difference on canal shape among three canal preparation methods in straight canals (Group A). 2. When conventional method and Giromatic filing were used in curved canals (Group B, C), elbow, zip and hour-glass shape were formed in apical third. 3. When conventional method and Giromatic filing were used in curved canals (Group B, C), tear-drop appearance developed at the site of the canal exit in curved canals. 4. In curved canals (Group B, C), file tend to straighten within the canal. 5. There was no difference on canal shape according to curved angle in step-back method (p > 0.1). But there was significant difference on canal shape according to curved angle in conventional method and Giromatic filing (p < 0.001). 6. Step-back method was significantly more effective than conventional method and Giromatic preparation in morphologic aspects of apical third of original canals.

• 대한교통학회지
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• 제27권4호
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• pp.207-215
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• 2009

도로구간에서의 주행조건은 연속적인 도로축 상에서 구간별로 변하게 되고 이에 따라 도로에서의 교통사고는 도로 기하구조 변수뿐만 아니라 도로주변 환경변수, 교통조건 변수 그리고 기타 다양한 변수들에 의해서 발생하게 된다. 따라서 본 연구는 현장조사를 통해 얻어진 다양한 도로기하구조 요소를 고려하여 동질성을 갖춘 구간 분할 후에 도로를 구성하는 도로 기하구조, 교통조건, 도로주변 환경 그리고 기타 다양한 요소들을 복합적으로 반영하고자 한다. 이를 반영하기 위해 본 연구에서는 도로구간의 주행조건을 결정짓는 주요인들에 의해서 주행조건 동질구간을 결정하고, 각 동질구간에서의 도로 및 교통조건 등을 고려하여 사고예측 모형을 개발하였다. 모형 개발을 위해 사용된 자료는 대도시권 외곽과 평지 및 구릉지를 대표할 수 있는 수도권 외곽내에 지방부 도로구간과 전라북도 지방부 도로구간에서 수집되었다. 본 연구에서는 연속된 도로구간에서 사고건수가 "0"인 구간수가 매우 높게 나타나므로 이에 대한 과대 예측을 방지하기 위해 ZIP(Zero Inflated Poisson) 모형을 이용하였다. 사고예측모형 개발 결과 지방부 다차로 도로구간에서 교통사고에 영향을 미치는 변수로는 교통량과 도로구간 길이를 포함한 EXPO($365{\times}ADT{\times}Length{\times}Year/10^{-6}$), 곡선반경, 종단구배변화, 가드레일, 지형(산악지), 횡단보도개수, 버스정류장 개수가 지방부 다차로 도로구간에서의 차대차 사고에 영향을 미치는 주요 설명변수로 나타났다.

• Biomolecules & Therapeutics
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• 제10권4호
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• pp.293-302
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• 2002

The classical concept for iron uptake into mammalian cells has been the endocytosis of transferrin( $T_{f}$ )-bound F $e^{3+}$ via the $T_{f}$ - $T_{f}$ receptor cycle. In this case, we could not explain the uptake of F $e^{2＋}$ ion and the export of iron from endosome. Studies on iron transport revealed that other transport system exists in epithelial cells of the intestine. One of non- $T_{f}$ -receptor-mediated transport systems is Nramp2/DMT1/DCT1 which transports M $n^{＋＋}$, $Mg^{＋＋}$, Z $n^{＋＋}$, $Co^{＋＋}$, N $i^{＋＋}$ or C $u^{＋＋}$ ion as well as F $e^{+2}$ ion. DMT1 was cloned from intestines of iron-deficient rats and shown to be a hydrogen ion-coupled iron transporter and a protein regulated by absorbed dietary iron. DMT1 is founded in other cells such as cortical and hippocampal glial cells as well as endothelial cells in duodenum. Two F $e^{3+}$ ion bound to transferrin( $T_{f}$ ) are taken up via the $T_{f}$ - $T_{f}$ receptor cycle in the intestinal epithelial cell. F $e^{3+}$ in endosome was converted to F $e^{2＋}$ ion, and then exported to cytosol via DMT1. F $e^{2＋}$ ion is taken up into cytosol via DMT1. Several other transporters such as FET, FRE, CCC2, AFT1, SMF, FTR, ZER, ZIP, ZnT and CTR have been reported recently and dysfunction of the transporters are related with diseases containing Wilson's disease, Menkes disease and hemochromatosis. Evidences from several studies strongly suggest that DMT1 is the major transporter of iron in the intestine and functions critically in transport of other metal ions.

• Molecules and Cells
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• 제27권4호
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• pp.409-416
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• 2009

ADAP is an AP2-domain protein that interacts with ARIA, which, in turn, interacts with ABF2, a bZIP class transcription factor. ABF2 regulates various aspects of the abscisic acid (ABA) response by controlling the expression of a subset of ABA-responsive genes. Our expression analyses indicate that ADAP is expressed in roots, emerging young leaves, and flowers. We found that adap knockout mutant lines germinate more efficiently than wild-type plants and that the mutant seedlings grow faster. This suggests that ADAP is involved in the regulation of germination and seedling growth. Both germination and post-germination growth of the knockout mutants were partially insensitive to ABA, which indicates that ADAP is required for a full ABA response. The survival rates for mutants from which water was withheld were low compared with those for wild-type plants. The result shows that ADAP is necessary for the response to stress induced by water deprivation. Together, our data indicate that ADAP is a positive regulator of the ABA response and is also involved in regulating seedling growth. The role of ADAP is similar to that of ARIA, which is also a positive regulator of the ABA response. It appears that ADAP acts through the same ABA response pathway as ARIA.