• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.5
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• pp.386-393
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• 2015

Bian-zheng(辨證) of Korean Medicine(KM) is based on four examinations(四診) of Korean medical doctor. The interrogation or questioning(問診) provides the most information of four examinations. The symptom obtained from the interrogation or questioning is the main basis of the Bian-zheng. KM is understood in the whole state of the body of a specified time without seeing the disease exist. So the observable symptom is disease itself. Symptom in KM is used as an important basis for the diagnosis. But if the interview when memories are not sure of the correct answer does not get much easier to find exactly the symptoms. So when recording original symptom(素證) and daily subjective symptom can be helpful for care. In this paper, we propose daily living symptom record system as a method that can be applied to the health care according to the importance of collecting the symptom in the KM. Daily living symptom record system can record the symptom in the individual to awaken daily. The system stores the symptom in structure and provides an open shared services. So it can be used as a symptom of other systems, such as PHR, EMR, CDSS. In addition, Doctor may be able to help in the treatment determined by reference to shared symptom.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8887-8891
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• 2014

Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1665-1669
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• 2015

Background: The optimal surgical strategy for the treatment of synchronous resectable gastric cancer liver metastases remains controversial. The aims of this study were to analyze the outcome and overall survival of patients presenting with gastric cancer and liver metastases treated by simultaneous resection. Materials and Methods: Between January 1990 and June 2009, 35 patients diagnosed with synchronous hepatic metastases from gastric carcinoma received simultaneous resection of both primary gastric cancer and synchronous hepatic metastases. The clinicopathologic features and the surgical results of the 35 patients were retrospectively analyzed. Results: The 5-year overall survival rate after surgery was 14.3%. Five patients survived for more than 5 years after surgery. No mortality has occurred within 30 days after resection, although two patients (5.7%) developed complications during the peri-operative course. Univariate analysis revealed that patients with the presence of lymphovascular invasion of the primary tumor, bilateral liver metastasis and multiple liver metastases suffered poor survival. Lymphovascular invasion by the primary lesion and multiple liver metastases were significant prognostic factors that influenced survival in the multivariate analysis (p=0.02, p=0.001, respectively). Conclusions: The presence of lymphovascular invasion of the primary tumor and multiple liver metastases are significant prognostic determinants of survival. Gastric cancer patients without lymphovascular invasion and with a solitary synchronous liver metastasis may be good candidates for hepatic resection. Simultaneous resection of both primary gastric cancer and synchronous hepatic metastases may effectively prolong survival in strictly selected patients.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1917-1921
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• 2012

Background: Colorectal cancer is one of the leading causes of mortality worldwide. Genome wide analysis studies have identified sequence mutations causing loss-of-function that are associated with disease occurrence and severity. Epigenetic modifications, such DNA methylation, have also been implicated in many cancers but have yet to be examined in the East Asian population of colorectal cancer patients. Methods: Biopsies of tumors and matched non-cancerous tissue types were obtained and genomic DNA was isolated and subjected to the bisulphite conversion method for comparative DNA methylation analysis on the Illumina Infinium HumanMethylation27 BeadChip. Results: Totals of 258 and 74 genes were found to be hyper- and hypo-methylated as compared to the individual's matched control tissue. Interestingly, three genes that exhibited hypermethylation in their promoter regions, CMTM2, ECRG4, and SH3GL3, were shown to be significantly associated with colorectal cancer in previous studies. Using heatmap cluster analysis, eight hypermethylated and 10 hypomethylated genes were identified as significantly differentially methylated genes in the tumour tissues. Conclusions: Genome-wide methylation profiling facilitates rapid and simultaneous analysis of cancerous cells which may help to identify methylation markers with high sensitivity and specificity for diagnosis and prognosis. Our results show the promise of the microarray technology in identification of potential methylation biomarkers for colorectal cancers.

• CELLMED
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• v.2 no.2
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• pp.16.1-16.5
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• 2012

Fever in cancer patients is often due to the following causes: evil qi and toxity stagnancy, disorders of qi and blood, deficiencies of zang and fu organs, and the disorder of yin and yang. The treatments given to cancer patients with a fever are according to five: (a) Excessive inner heat and toxicants: remove heat and the toxicant, induce purgation. We use Cheng-Qi-Tang plus Qing-Wen-Bai-Du-Yin. (b) Tangle of damp and heat, and qi stagnancy: remove damp and heat, smooth the qi channel. We use Gan-Lu-Xiao-Du-Dan or San-Ren-Tang. (c) Obvious blood and heat stagnancy: remove heat and blood stasis. We use Xue-Fu- Zhu-Yu-Tang. (d) Deficiency of spleen qi, inner heat caused by a yin deficiency: nourish spleen qi and yin to remove the inner heat. We use Bu-Zhong-Yi-Qi-Tang or Xiao-Jian-Zhong-Tang. (e) Prominent yin deficiency and hectic fever: replenish yin and remove inner heat. We use Qing-Hao-Bie-Jia-Tang or Chai- Qian-Mei-Lian-San. The pathogenesis of fever in cancer patients is complicated. We can see both deficiency and excess in one differentiation. Therefore, we must make sure of it, then we can get the most effective treatment.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10911-10916
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• 2015

Background: Tumor metastases are the main reasons for oncotherapy failure. Paris polyphylla (Chinese name: Chonglou) has traditionally been used for its anti-cancer actions. In this article, we focus on the regulation of human lung cancer A549 cell metastases and invasion by Paris polyphylla steroidal saponins (PPSS). Materials and Methods: Cell viability was evaluated in A549 cells by MTT assay. Effects of PPSS on invasion and migration were investigated by wound-healing and matrigel invasion chamber assays. Adhesion to type IV collagen and laminin was evaluated by MTT assay. Expression and protease activity of two matrix metalloproteinases (MMPs), MMP-2 and MMP-9, were analyzed by Western blotting and gelatin zymography, respectively. Results: PPSS exerted growth inhibitory effects on A549 cells, and effectively inhibited A549 cell adhesion, migration and invasion in a concentration-dependent manner. Western blotting and gelatin zymography analysis revealed that PPSS inhibited the expression and secretion of MMP-2 and MMP-9 in A549 cells. Conclusions: PPSS has the potential to suppress the migration, adhesion and invasion of A549 cells. PPSS could be a potential candidate for interventions against lung cancer metastases.

• International Journal of Industrial Entomology and Biomaterials
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• v.23 no.1
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• pp.129-135
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• 2011

Cathepsins are well-characterized proteases that are ubiquitously expressed in lysosomes. Previous work revealed that $Bombyx$ $mori$ cathepsins B and D are expressed in the fat body and undergo decomposition during larval-pupal metamorphosis. Quantitative RT-PCR was performed to detect cathepsin gene expression at the transcription level when challenged by $B.$ $mori$ nuclear polyhedrosis virus (BmNPV), temperature and hormones (20-hydroxyecdysone (20E) and juvenile hormone analogue (JHA)). mRNAs encoding cathepsins B and D were significantly enhanced after the larvae were infected with BmNPV, and the peak of the induction appeared at 1 day before spinning. This attenuated the inducing effect on cathepsin expression caused by infection. Temperature shock induced cathepsin expression at the later stage of the $5^{th}$ instar, and transcription levels varied with development stage and temperature. Cathepsin B and D mRNA expression in the fat body were significantly induced by JHA at the day before spinning, and with 20E, the expression reached a peak at the last day of the $5^{th}$ instar. Cathepsin B and D mRNA expression exhibited detectable changes post-treatment, without significant differences between or among the hormone concentrations.

• Journal of Haehwa Medicine
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• v.16 no.2
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• pp.109-119
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• 2007

Xu-lao(虛勞) is deficient disease which is weak body and spirit. It occurs many symptoms, for example lack of appetite, dizziness, involuntary emission of semen, wet dream, back and chest pain, night sweat, cough and so on. In oriental medicine, xu-lao(虛勞) is well-known disease and can be treated easily. In general, xu-lao (虛勞) patiences like to be treated by oriental medical doctors. In spite of improving food, house and clothes, xu-lao(虛勞) is on the increase by fatty foods and stress. In most of these cases, the cooperations of heart and kidney are hurted. On Fang-you-ge-bian(脈證方藥合編) which is the famous prescription book in Korea, gu-an-xin-shen-wan(古庵心腎丸) and Jiu-yuan-xin-shen-wan(究原心腎丸) are used well and have good effects in these cases. Gu-an-xin-shen-wan(古庵心腎丸) can treat white hair, palpitation, involuntary emission of semen, amblyopia, buzzing in the ears, backache and so on. Jiu-yuan-xin-shen-wan(究原心腎丸) can treat lack of appetite, dizziness, involuntary emission of semen, wet dream, back and chest pain, diseased sweat, cough, coldness of hands and feet, and so on. The symptoms of Gu-an-xin-shen-wan(古庵心腎丸) are similar with those of Jiu-yuan-xin-shen-wan(究原心腎丸). But, it is very important that Gu-an-xin-shen-wan(古庵心腎丸) can be used in cases of hot deficient disease but Jiu-yuan-xin-shen-wan(究原心腎丸) can be used in cases of cold deficient disease.

• Journal of the Korean Data and Information Science Society
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• v.25 no.6
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• pp.1253-1262
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• 2014

Regression tree is a tree-structured solution in which a simple regression model is fitted to the data in each node made by recursive partitioning of predictor space. There have been many efforts to apply tree algorithms to various regression problems like logistic regression and quantile regression. Recently, algorithms have been expanded to the panel data analysis such as RE-EM algorithm by Sela and Simonoff (2012), and extension of GUIDE by Loh and Zheng (2013). The algorithms are briefly introduced and prediction accuracy of three methods are compared in this paper. In general, RE-EM shows good prediction accuracy with least MSE's in the simulation study. A RE-EM tree fitted to business survey index (BSI) panel data shows that sales BSI is the main factor which affects business entrepreneurs' economic sentiment. The economic sentiment BSI of non-manufacturing industries is higher than that of manufacturing ones among the relatively high sales group.

• Journal of Power Electronics
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• v.19 no.6
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• pp.1505-1514
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• 2019

The permanent magnet synchronous motor (PMSM) is widely used in various fields and the proportional-integral (PI) controller is popular in PMSM control systems. However, the motor parameters are usually unknown, which can lead to a complicated PI controller design and poor performance. In order to design a PI controller with good performance when the motor parameters are unknown, a control algorithm based on stability margin is proposed in this paper. First of all, based on the mathematical model of the PMSM and the least squares (LS) method, motor parameters are estimated offline. Then based on the estimation values of the motor parameters, natural angular frequency and phase margin, a PI controller is designed. Performance indices including the natural angular frequency and the phase margin are used directly to design the PI controller in this paper. Scalar functions of the d-loop and the q-loop are selected. It can be seen that the designed controller parameters satisfy Lyapunov large scale asymptotic stability theory if the natural angular frequencies of the d-loop and the q-loop are large than 0. Experimental results show that the parameter estimation method has good accuracy and the designed PI controller proposed in this paper has good static and dynamic performances.