• Archives of Pharmacal Research
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• 제15권2호
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• pp.162-168
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• 1992

Release characteristics of five different types of hydrophilic albumin microspheres (HAM) containing different ratios of methotrexate-albumin (MTX-HSA) conjugates to free MTX: 1 : 0 (HAMC), 3 :1 (HAMC 3F), 1 :1 (HAMCF), 1:3 (HAMCF3) and 0 : 1 (HAMF) were investigated in the absence or presence of protease using dissolution tester. In all the HAMs studied except HAMC, the MTX was released bi-exponentially in the absence of protease; an initial fast release period up to approximately 6h, and thereafter the release rate was very much slower. The fast release of MTX from the HAMs (such as HAMC3F, HAMCF, HAMCF3 and HAMF) at the initial phase in probably due to the release of "physically associated" MTX from the core of the HAMs. The initial rate constants were 7.2, 8.7, 8.5 and 5.9 times greater than the second rate constants for HAMF, HAMCF3, HAMCF and HAMC3F, respectively. MTX release from HAMC was very slow and mono-phasic. It was at most 2.2% of the total entrapped amount by 24 h. The protease accelerated the release of MTX from the HAMs. The percentages of MTX released from HAMs up to 24 h were 100, 89.0, 75.0, 66.0 and 61.0% for HAMF, HAMCF3, HAMCF, HAMC3F and HAMC, respectively in the presence of protease and the corresponding values in the absence of protease were 30.2 19.0, 10.0, 6.5 and 2.2%, respectively. In vitro release of MTX in the presence of protease varied according to the ratios of MTX-HSA conjugates to MTX; the data set from HAMF, HAMCF3 and HAMCF fits better to monophasic first-order profile more adequately than to zero-order profile, that of HAMC3 monophasic first-order, and that of HAMC to bi-phasic zero-order. Above results suggested that zero-order release rate can be achieved by adjusting the ratio of MTX-HSA conjugates to MTX in the preparation of HAMs such as HAMC3F.as HAMC3F.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2003년도 추계학술발표회
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• pp.87-90
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• 2003

This research examines the feasibility of using laboratory-synthesized nano scale zero-valent iron particles to remove arsenic from aqueous phase. Batch experiments were performed to determine arsenic sorption rates as a function of the nano scale zero-valent iron solution concentration. Rapid adsorption of arsenic was achieved with the nano scale zero-valent iron. Typically 1 mg $L^{-1}$ arsenic (III) was adsorbed by 5 g $L^{-1}$ nano scale zero-valent iron below the 0.01 g $L^{-1}$ concentration within 7min. The kinetics of the arsenic sorption followed pseudo-first-order reaction kinetics. Observed reaction rate constants ( $K_{obs}$) varied between 11.4 to 129.0 $h^{-1}$ with respect to different concentrations of nano scale zero-valent iron. A variety of analytical techniques were used to study the reaction products including HGAAS (hydride generator atomic adsorption spectrophotometer), SEM (scanning electron microscopy) and TEM (transmission electron microscopy). Our experimental results suggest novel method for efficient removal of arsenic Iron groundwater.r.

• Communications for Statistical Applications and Methods
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• 제25권5호
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• pp.471-488
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• 2018

In this paper, we propose extending proportional hazards frailty models to allow a discrete distribution for the frailty variable. Having zero frailty can be interpreted as being immune or cured. Thus, we develop a new survival model induced by discrete frailty with zero-inflated power series distribution, which can account for overdispersion. This proposal also allows for a realistic description of non-risk individuals, since individuals cured due to intrinsic factors (immunes) are modeled by a deterministic fraction of zero-risk while those cured due to an intervention are modeled by a random fraction. We put the proposed model in a Bayesian framework and use a Markov chain Monte Carlo algorithm for the computation of posterior distribution. A simulation study is conducted to assess the proposed model and the computation algorithm. We also discuss model selection based on pseudo-Bayes factors as well as developing case influence diagnostics for the joint posterior distribution through ${\psi}-divergence$ measures. The motivating cutaneous melanoma data is analyzed for illustration purposes.

• 충청수학회지
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• 제19권2호
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• pp.133-139
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• 2006

By combining the classical Newton's method with the pseudo-secant method, pseudo-secant-Newton's method is constructed and its order and rate of convergence are investigated. Given a function $f:\mathbb{R}{\rightarrow}\mathbb{R}$ that has a simple real zero ${\alpha}$ and is sufficiently smooth in a small neighborhood of ${\alpha}$, the convergence behavior is analyzed near ${\alpha}$ for pseudo-secant-Newton's method. The order of convergence is shown to be cubic and the rate of convergence is proven to be $\(\frac{f^{{\prime}{\prime}}(\alpha)}{2f^{\prime}(\alpha)}\)^2$. Numerical experiments show the validity of the theory presented here and are confirmed via high-precision programming in Mathematica.

• Advances in Energy Research
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• 제4권2호
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• pp.147-161
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• 2016

To start with, finding a sustainable method to produce sweet water and electricity by using renewable energies is one of the most important issues at this time. So, experimental and theoretical analysis of the performance of a closed solar powered still, which is jointed to photovoltaic cells and vacuum pump and equipped by nano plate, as the principle stage of zero discharge desalination process is investigated in this project. Major goal of this work is to reuse the concentrated brine of the Mobin petrochemical complex in order to produce potable, sweet water from effluent saline wastewater and generating electricity in the same time by using solar energy instead of discharging them to the environment. It is observed the increase in brackish water temperature increases the average daily production of solar desalination still considerably. Therefore, the nano plate and vacuum pump are added to augment the evaporation rate. The insolation rate, evaporation rate, the average brackish temperature, ambient temperature, density are investigated during a year 2013. In addition to obtain the capacity of solar powered still, the highest and lowest amount of water and electricity generation are reported during a twelvemonth (2013). Results indicate the average daily production is increased 16%, which represents 7.78 kW.h energy saving comparing with traditional solar still.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2002년도 추계학술발표회
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• pp.187-190
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• 2002

Reductive dechlorination of endosulfans was studied with zero valent metals (ZVMs) and bimetals in aqueous batch reactors. The effect of surfactants was evaluated. Endosulfan was successfully dechlorinated with zero valent iron. However, a bimetal, palladium coated iron (Pd/Fe) showed a highly enhanced reactivity for both endosulfan I and II indicating palladium act as a dechlorination catalyst on the iron. The effect of surfactants on degradation with ZVM has been very controvertible. Variable concentration of a nonionic surfactant, Triton X-100 and an anionic surfactant, SDS were added into the reactor with ZVM. The reaction rates of endosulfan were increased with both surfactants. In the case of Triton X-100, the reaction rate was increased with the increasing surfactant concentration up to 400 mg/L. Addition of small amount of surfactant under the CMC, the reaction rate was increased. However, the enhancing effect was diminished when a higher concentration of surfactant (1,000 mg/L) was used. Current study implicate that the surfactant adsorbed on the metal surface might increase the surface concentration of endosulfan resulting in the increased reaction rate. However, partitioning of endosulfan into the micelle formed at the high concentration of surfactant diminish the enhancing effect by reducing the contact chance between target compound and the metal surface.

• 반도체디스플레이기술학회지
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• 제12권2호
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• pp.67-72
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• 2013

Temperature is a critical parameter in yield improvement for wafer manufacturing. In chemical vapor deposition (CVD) equipment, crack defect in ceramic heater leads to yield reduction, however, there is no suitable ceramic heater fault detection system for conventional CVD equipment. This paper proposes a short-time zero-crossing rate based fault detection method for the ceramic heater in CVD equipment. The proposed method measures the output signal ($V_{pp}$) of RF filter and extracts the zero-crossing rate (ZCR) as feature vector. The extracted feature vectors have a discriminant power and Gaussian mixture model (GMM) based fault detection method can detect fault in ceramic heater. Experimental results, carried out by measured signals provided by a CVD equipment manufacturer, indicate that the proposed method detects effectively faults in various process conditions.

• 한국태양에너지학회 논문집
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• 제39권5호
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• pp.29-40
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• 2019

In response to the rapid climate change, in order to save energy in the field of buildings, the country is planning not only zero energy buildings but also zero energy cities. In the Urban Development Project, the Energy Use Plan Report is prepared and submitted by predicting the amount of energy demand at the planning stage. However, due to the activation of zero-energy buildings and the increase in the supply of new and renewable energy facilities, the energy consumption behavior of buildings in the city is changing from the previous ones. In this study, to estimate urban energy demand of Zero Energy City, building energy demand forecasts based on "Passive plans for use of energy based primary energy consumption", "Actual building energy usage data from Korea Appraisal Board" and "data from Certification of Building Energy Efficiency Rating" as well as demand forecast according to existing "Consultation about Energy Use Plan Code" were calculated and then applied to Multifunctional Administrative City 5-1 zone to compare urban total energy demand forecasts.

• 한국건설관리학회논문집
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• 제11권2호
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• pp.64-73
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• 2010

본 연구는 현행 국민주택 공급 및 건설용역에 대한 부가가치세 면세제도의 한계를 분석하고, 주택건설업체 아파트 건설현장 부가가치세 신고 사례분석을 통하여 국민주택에 대한 부가가치세 매입세액 불공제 규모를 산출하였다. 매입세액을 공제하고 건설업체의 유동성을 지원하기 위한 개선방안으로 부가가치세 영세율을 적용하는 경우 그 효과를 분석하기 위한 목적으로 수행하였다. 국민주택 면세제도가 갖고 있는 한계를 근원적으로 제거하기 위해서는 영세율 제도 도입이 필요하며, 영세율 제도 적용의 효과를 분석한 결과, 국민주택 공급 및 건설과정에서 부담한 매입세액이 공제되며, 건설원가의 6.06%에 상당하는 매입세액 공제로 건설업체의 유동성 개선과 이로 인한 차입금 규모 축소, 이자비용 감소 등으로 경영성과를 높일 수 있다. 또한 유동성 개선으로 국민주택 공급을 현재보다도 늘리려 할 것이며, 현재보다 국민주택 건축비 분양가를 최소 4.59% 인하할 수 있을 것으로 기대된다

• Journal of applied mathematics & informatics
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• 제4권1호
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• pp.47-62
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• 1997

This paper is concerned with investigating the global as-ymptotic behavior of the zero solution of the initial-boundary value problem for a nonlinear fourth order wave equation, Moreover an esti-mate of the rate of decay of the solutions is obtained.