• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.130-135
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• 2000

The characteristics of two different modes of perfusion culture, intermittent and continuous bleedings, were investigated by culturing the hybridoma cells producing von Willebrand Factor (vWF) monoclonal antibody (McAb) in a 15 L bioreactor without clogging the filter. Both culture methods exhibited similar profiles of cell density and metabolite concentrations during the culture period at the cell concentration of around 1${\times}$107 cells/mL. When the perfusion rate was increased, the intermittrnt bleeding culture showed problems of ammonia accumulation and decrease of cell viability. The continuous bleeding culture in terms of nutrient consumption and metabolite production kinetics. But the analysis of specific oxygen consumption rate showed that the specific oxygen consumption rate of intermittent bleeding culture was similar to that of exponential growth phase. The continuous bleeding culture showed higher specific oxygen consumption rate of intermittent bleeding culture. finally we proved the possibility of long-term operation of continuous bleeding culture and produced approximately 40 g of vWF McAb in a 15L bioreactor after one-month operation.

• Korean Journal of Clinical Pharmacy
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• v.25 no.2
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• pp.111-119
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• 2015

Background: It is thought that drug use of parents is related to that of young children. The status of drug among young children's parents and a correlation of with parents and their children on drug use was surveyed by questionnaire. Method: The questionnaire is composed of 34 items, and the data was collected by 108 parents of young children from March to April of 2012. Results: On the basis of the analysis results, the following conclusions were drawn. About half of parents thought the minimum use of drug was better for health, and 44% parents thought drug is essential for cure. When parents had queries on prescription, they mostly consult with doctors and pharmacists. Most parents had a household medicine. A fever reducer was the most common household medicine (92.5%). They pick the household medicine by consulting with pharmacist. Parents usually checked the expiration date of drug before they use and they dumped the drugs when the expiration date was due (82.4%). Over half of young children and their parents took a dietary supplements. They got an information about a dietary supplement by associates (30.5%) and internet (19.4%). Most parents tried to follow the directions as prescribed. However, more than half of the parents stopped taking the drug when the symptoms disappeared. Conclusion: Drug use of parents and that of young children had a very strong positive correlation, suggesting that correct drug use of parents have an impact on their young children's drug use.

• Journal of the Korean Society of Industry Convergence
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• v.19 no.4
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• pp.237-244
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• 2016

This paper investigates the possibility to increase the economic value of the thinned young apple trough fermentation process. It is studies the optimal fermentation condition of thinned young apple by manipulating preparation treatment and sugar content. To do this following steps are done. Firstly, different preparation treatment for thinned young apple such as whole apple, cutting apple, and blending apple were done. The different sugar content such as $24^{\circ}Brix$, $15^{\circ}Brix$ and $4^{\circ}Brix$ was added. Secondly, the sugar contents and pH level were measured during fermentation process. Finally, statistical analysis was used to examine the relation between the preparation treatment, sugar content and pH level during the fermentation process. The experimental result shows that the different preparation treatment influences to the fermentation process. The blending apple treatment gave lower pH level compared to other kind treatments. The sugar content of thinned young apple was decrease during the fermentation process. The statistical analysis shows that the manipulation preparation treatment and sugar content affect the final pH level and whole fermentation process. Experimental result shows that the thinned young apple fermentation could be proposed as new alternative product in the market. The best fermentation process was obtained from blending thinned young apple treatment with $24^{\circ}Brix$.

• Journal of Periodontal and Implant Science
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• v.48 no.4
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• pp.261-271
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• 2018

Purpose: Few studies have examined periodontal pathogens from saliva samples in periodontally healthy young adults. The purposes of this study were to determine the prevalence of periodontopathic bacteria and to quantify periodontal pathogens in saliva samples using real-time polymerase chain reaction (PCR) assays in periodontally healthy Korean young adults under 35 years of age. Methods: Nine major periodontal pathogens were analyzed by real-time PCR in saliva from 94 periodontally healthy young adults. Quantification of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum, Campylobacter rectus, Peptostreptococcus anaerobius, and Eikenella corrodens was performed by DNA copy number measurement. Results: F. nucleatum and E. corrodens were detected in all subjects; the numbers of positive samples were 87 (92.6%), 91 (96.8%), and 90 (95.7%) for P. gingivalis, P. anaerobius, and C. rectus, respectively. Other pathogens were also detected in periodontally healthy subjects. Analysis of DNA copy numbers revealed that the most abundant periodontal pathogen was F. nucleatum, which was significantly more prevalent than all other bacteria (P<0.001), followed by P. anaerobius, P. gingivalis, E. corrodens, C. rectus, and T. denticola. There was no significant difference in the prevalence of each bacterium between men and women. The DNA copy number of total bacteria was significantly higher in men than in women. Conclusions: Major periodontal pathogens were prevalent in the saliva of periodontally healthy Korean young adults. Therefore, we suggest that the development of periodontal disease should not be overlooked in periodontally healthy young people, as it can arise due to periodontal pathogen imbalance and host susceptibility.

• Journal of radiological science and technology
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• v.30 no.1
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• pp.61-65
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• 2007

The attempt to enhance the environment of hospitals has increased recently to minimize young patients' anxiety about tests and inspections. This gives more satisfaction with the medical service to kids and young patients. The department of radiology endeavors to improve the conditions of existing radiography rooms to help young patients psychologically feel relaxed. This facilitates the process of inspections. This paper examines the relationship between the environment of radiography rooms and its effect on young patients' state of mind. 94 patients at the age of five were observed before and after the improvement of environment of the hospital. Positive results about the psychological state of the young patients were shown after the change of the environment. The result of this paper gives an idea that the modification of hospital environment has a critical importance to the young patients' psychological state. By this conclusion it may help to improve the quality of the medical service.

• The Korean Journal of Community Living Science
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• v.24 no.3
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• pp.301-312
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• 2013

The purpose of this study was to investigate the differences between attentional networks according to sex and reflection-impulsivity in the cognitive styles of young children. The subjects of the study were 78 5-year-old children from the kindergarten or daycare center in Busan(with 40 in the reflection group, and 38 in the impulsivity group). The tests were conducted by using the Mating Familiar Test and the Attentional Network Test for young children. The study has used two independent t-tests to find out the differences between attentional networks according to sex, and reflection-impulsivity in the cognitive styles of young children. The results of this study were as follows. First, the boys with reflection cognitive style were significantly slower than the girls with the same style(t=2.18, p<.05). Second, young children with reflection cognitive style were significantly faster in the case of alerting effects than those with impulsivity cognitive style(t=-2.53, p<.05). The young children with reflection cognitive style were slower than those with impulsivity cognitive style in the case of orienting effect(t=2.04, p<.05). Children with a combination of both conflict effect and reflection cognitive style were significantly faster than those with impulsivity cognitive style(t=-2.89, p<.01). The results of the study suggested that there was a difference between attentional networks according to sex and reflection-impulsivity cognitive styles of young children.

• Journal of Nutrition and Health
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• v.28 no.2
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• pp.95-106
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• 1995

The effects of various n-6/n-3 ratios(about 2, 4, 6, 8) of dietary fatty acids on various lipid levels and prostaglandin production were studied at the constant P/S ratio (1.5-1.6) in young (5 weeks old) and adult(8 months old) Sprague-Dawley rats using palm oil, safflower oil and sardine oil. The concentration of serum cholesterol tended to increase with the increasing n-6/n-3 ratio. The tendency of HDL-cholesterol levels was similar to serum cholesterol levels. These were not apparent differences between young and adults rats. Serum triglyceride levels increased according to increasing n-6/n-3 ratio in young rats. These were generally high in the adult rats compared with the young rats. Though liver cholesterol level tended to increase according to the increasing n-6/n-3 ratio in the young rats. The liver triglyceride level did not change according to the n-6/n-3 ratio. However, these levels were apparently higher in the adult than in the young rats. The fatty acid compositions of phosphatidylcholine(PC) were similar in serum and liver. The arachidonate/linoleate ratios in tissue PC were influenced by the n-6/n-3 ratio. They tended to be lower in the adult rats compared with the young rats. It was suggested that the activity of $\Delta$6-desturase was decreased by aging. Production of platelet thromboxane A2(TXA2)and aortic prostacyclin(PGI2) was not apparently influenced with n-6/n-3 ratio. Whereas the ratio of TXA2/PGI2 was the lowest value at 3.8 of n-6/n-3 ratio, expecially in the young rats. Thus this ratio seemed to be a desirable level to protect atherosclerosis. These results indicate that the lipid level and prostaglandin production were influenced not only by n-6/n-3 ratio(under constant P/S ratio) but by aging, particulary triglycerde level and arachidonic/linoleic acid ratio.

• The Journal of Korean Association of Computer Education
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• v.13 no.4
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• pp.41-50
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• 2010

So far, the researches about the Internet addiction testing are diverse and enormous. However, since the testing factors have the same importance, there is no discrimination among the factors. In our paper, we analyze the problems of the existing researches by using Lisrel and data mining algorithms. Next, we propose an alternative for the Internet addiction testing. In order to accomplish these, we make an questionnaire consisted of Young's test and then, we asked to 440 primary and secondary school students. In addition, we analyzed the problems of Young's test with factor analysis and then, we distinguish more important items from others with J48 and PART. Finally, based on this analysis, we propose a method to diagnose addicted students and prescribe them.

• Journal of Digital Convergence
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• v.16 no.2
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• pp.403-413
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• 2018

The purpose of this study was to analyze differences in general characteristics, loss experience, aging anxiety, and depression between young-old and old-old and to investigate the difference between the two groups in the effect of loss experience on aging anxiety and depression. The subjects were 65 elderly living in Seoul and Gyeonggi area. First, the young-old were more likely to have spouses than the old-old. Second, old-old experience more loss of health, relationships, economy, and role than young-old. And old-old had higher aging anxiety and lower depression than young-old. Third, for young-old, loss of health, economy, and role affected depression. And for old-old, loss of role affected aging anxiety and depression, and loss of economy affected aging anxiety. This study is meaningful as a basic data for preparing policy and system to supplement loss experience suitable for young-old and old-old.

• Journal of Gastric Cancer
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• v.2 no.4
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• pp.200-204
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• 2002

Purpose: The aim of this study was to compare the clinicopathological characteristics and postoperative prognosis of two age groups with gastric cancer in order to establish the proper treatment strategy in these groups of patients. Materials and Methods: Among patients with gastric cancer who underwent a gastrectomy between 1990 and 1996 at the Department of Surgery, Kyungpook National University, the clinicopathological characteristics, including the postoperative survival, of patients younger than 40-years old were compared with those of patients over 69-years old. Results: During that period 1,125 gastric cancer patients underwent a gastrectomy. Among them, 111 patients ($9.9\%$) were less than 40-years old, and 96 patients ($8.5\%$) were over 69-years old. In the young group, 79 patients ($71.2\%$) had a poorly differentiated adenocarcinoma, and 59 patients from the elderly group ($61.5\%$) had a well- or moderately differentiated adenocarcinoma (P<0.05). Curative surgery was performed for 88 ($79.3\%$) patients in the young group and 78 ($81.3\%$) patients in the elderly group. This difference was not statistically significant. There was no statistically significant difference in the 5-year survival rates between the young and the elderly ($66.3\%\;vs.\;47.2\%$) groups, but the 5-year survival rate of the young group was significantly higher than that of the elderly group after a curative resection ($83.2\%\;vs.\;53.3\%$; P<0.05). Also the 5-year survival rate of the elderly group was significantly higher than that of the young group after a non-curative resection ($20.4\%\;vs.\;4.6\%$; P<0.05). Conclusions: For young patients, more efforts are needed to detect gastric cancer in its early stages so that a curative surgery can be performed. However, for the elderly, surgical treatment is recommended at any stage because of the relatively high survival rate, even after non-curative surgery.