• Tuberculosis and Respiratory Diseases
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• 제59권3호
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• pp.326-329
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• 2005

4년간 크기가 변하지 않은 고립성 폐결절에서 폐암으로 진단된 51세 여자 증례를 보고하였다. 수술적 폐쐐기절제술을 시행받았고 수술장 동결조직검사에서 선암으로 진단하여 우상엽절제술과 완전 림프절절제술을 시행받았다. 저자들은 폐암으로 진행할 위험인자들이 있는 고립성 폐결절은 조기에 수술적 시술이 필요하다고 사료된다.

• 대한한방내과학회지
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• 제25권3호
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• pp.640-647
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• 2004

Pregnancy related stroke is significant because it has dire impact on both mother and the fetus. Pregnant or puerperal women are reported to have about 13-fold more risk of stroke compared to non-pregnant women. Pregnancy-related stroke must be differentiated from stroke in elderly patients, because it is different in pathophysiological etiologies and recurrence rates and also diagnostic and therapeutic methods may affect the fetal health status. Because the VI cranial nerve manages lateral rectus muscles, it' s palsy causes sudden onset of double vision. The eyes turn medially. In this article, one case of paralytic strabismus resulting from pontine hematoma during puerperium is reported. It was treated with herb medicine and acupuncture. Symptoms improved. This case is submitted with a brief overview of related lit.

• 한국강구조학회 논문집
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• 제18권5호
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• pp.655-664
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• 2006

본 연구는 하중비, 피복유무의 주요변수를 고려한 iTECH 합성보의 내화성능을 해석적 연구를 통해서 규명한 것이다. 합성보 구조는 개별적인 구조부재보다 내화성능이 우수할 것으로 기대되므로 해석적 연구에 의해서 안전하고 경제적인 내화설계를 제시할 수 있다. 열전달 해석은 범용 유한요소 프로그램인 ANSYS 10.0을 이용하여 ISO표준화재에 대해서 수행하였으며, EC1 Part 2.2와 EC4 Part1.2에서 제시된 모멘트 능력식과 강재와 콘크리트의 열적특성에 근거하여 내력해석을 수행하였다. 해석의 적절성을 검증하기 위해 실제적으로 수행된 실험결과와 비교를 통해서 그 적절성을 검증하였다.

• 한국강구조학회 논문집
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• 제19권3호
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• pp.335-344
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• 2007

기존 합성기둥의 장점을 유지하면서 콘크리트 충전 시 거푸집 공사의 절감과 충전상태의 육안 확인이 가능한 철골 콘크리트 합성기둥(이하 SC 합성기둥)에 대한 연구가 활발히 진행되고 있다. SC 합성기둥은 콘크리트가 철골의 웨브를 둘러싸고 있어 화재 발생시 높은 열이 웨브까지 전달되는 시간을 지연시켜 뛰어난 내화성능을 가질 것으로 예상할 수 있다. 본 연구에서는 SC 합성기둥에 대해 열전달 해석을 수행하였고, 이를 바탕으로 P-M 상관 곡선을 이용하여 내화성능을 평가를 하였고, 이때의 해석변수는 콘크리트 면적비와 내화피복두께로 하였다. 또한 열전달 해석 방법을 검증하기 위해서 실제 수행된 실험 결과와 비교하여 이의 적절성을 검증하였다.

• 보건행정학회지
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• 제16권4호
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• pp.128-146
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• 2006

The objective of this paper is to examine the proportion and characteristics of non-emergent patients at emergency departments. The observational survey was conducted using a structured form used by emergency medicine specialists or senior residents on June 7-20, 2005. 1,526 patients at ten emergency centers took part in this study. The structural form contained type of insurance, route and means of emergency department (ED) visit, triage based on the Manchester Triage Scale(MTS)-modified criteria, emergency level based on the government defined rule, type of emergency centers (Regional Emergency Medical Center; REMC, Local Emergency Medical Center; LEMC, Local Emergency Agency; LEA), as well as patient's general information. Data were analyzed using SAS statistical program(V.8.2). Descriptive analysis was performed to describe the magnitude of non-emergent patients. ${\chi}^2-analysis$ and logistic regression analysis was performed to identify the nonurgent patients' characteristics. In the MTS-modified criteria, we found a 15.3% rate of non-emergent patients. This rate differed from that of non-emergent patients obtained using government's rule. In particular, there were inaccuracies in the definition of government rule on non-emergent patients, so it is necessary to apply the new government rule regarding classification of non-emergent patients. There were significant differences in the rate of non-emergent patients according to type of ED, means of ED visit, time to visit, and insurance. Non-emergent patients are more likely to visit a D-type ED(LEA having less than 20,000 patients annually), not to use ambulance, to have 'Automobile Insurance, Industrial Accident Compensation Insurance, or pay out-of-pocket'. Non-emergent patients tend to visit ED due to illness rather than injury. Further studies on the development' of triage scale and reexamination of the government's rule on emergency visits are required for future policy in this area.

• 해양환경안전학회지
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• 제21권6호
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• pp.770-777
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• 2015

본 논문에서는 전동기 구동장치를 선정하여 리액터 용량 및 종류, 부하의 크기에 따라 고조파 왜형률 변화추이를 검토하여 선박 및 해양플랜트에 적용 가능한 최적의 용량선정 근거를 마련하였다. AC라인 리액터와 DC링크 리액터는 가변주파수 구동장치 입력전류의 고조파를 크게 저감시키는 역할을 하며, 동일한 효과를 얻기 위한 DC링크 리액터의 인덕턴스가 AC라인 리액터 인덕턴스의 약 1.7배가 되어야 한다는 것을 시뮬레이션을 통하여 고찰하였다. 소프터웨어 PSIM을 활용하여 각 상황에 따른 전류 고조파 왜형률을 분석하였다.

• 한국자원식물학회지
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• 제19권1호
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• pp.174-179
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• 2006

본 연구에서는 인삼 잎으로부터 정제한 mRNA를 이용하여 cDNA library를 제작하였다. 이 cDNA library로 부터 349개의 에너지 대사 관련 유전자를 선발 하였다. 에너지 대사 관련 유전자의 평균 사이즈는 0.49 kb이며, 에너지 관련 유전자들의 세부 기능별 발현을 분석한 결과 aerobic respiration(48.4%), accessory proteins of electron transport and membrane associated energy conservation(17.2%), glycolysis and gluconeogenesis(3.4%), electron transport and membrane associated energy conservation(2.9%), respiration(2.0%), glycolysis methylglyoxal byp-ass(1.7%), metabolism of energy reserves(0.6%)와 alcohol fermentation(0.3%)의 분포를 보였다. 인삼 잎에서 발현되는 유전자중 가장 많이 발현된 Chlorophyll a/b binding protein of IhcII type I(36.6%), Photosystem II oxygen-evolving complex protein(6.6%) 등이 발현되었다.

• Molecules and Cells
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• 제19권1호
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• pp.60-66
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• 2005

Low density lipoproteins (LDL) play important roles in the pathogenesis of atherosclerosis. Diabetes is associated with accelerated atherosclerosis leading to cardiovascular disease in diabetic patients. Although LDL stimulates the proliferation of arterial smooth muscle cells (SMC), the mechanisms are not fully understood. We examined the effects of native LDL and glycated LDL on the extracellular signal-regulated kinase (ERK) pathway. Addition of native and glycated LDL to rat aorta SMCs (RASMCs) stimulated ERK phosphorylation. ERK phosphorylation was not affected by exposure to the $Ca^{2+}$ chelator BAPTA-AM but inhibition of protein kinase C (PKC) with GF109203X, inhibition of Src kinase with PP1 ($5{\mu}M$) and inhibition of phospholipase C (PLC) with U73122/U73343 ($5{\mu}M$) all reduced ERK phosphorylation in response to glycated LDL. In addition, pretreatment of the RASMCs with a cell-permeable mitogen-activated protein kinase kinase (MEK) inhibitor (PD98059, $5{\mu}M$) markedly decreased ERK phosphorylation in response to native and glycated LDL. These findings indicate that ERK phosphorylation in response to glycated LDL involves the activation of PKC, PLC, and MEK, but is independent of intracellular $Ca^{2+}$.

• The Korean Journal of Physiology and Pharmacology
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• 제11권5호
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• pp.197-206
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• 2007

The aim of the present study was to investigate the effects of 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine(SKF81297), a selective agonist of dopaminergic $D_1$ receptor, on the secretion of catecholamines(CA) evoked by cholinergic stimulation and membrane-depolarization in the isolated perfused rat adrenal gland, and also to elucidate the mechanism involved. SKF81297($10{\sim}100{\mu}M$) perfused into an adrenal vein for 60 min produced dose- and time-dependent inhibition of CA secretory responses evoked by ACh(5.32 mM), high $K^+$(56 mM), DMPP($100{\mu}M$) and McN-A-343($100{\mu}M$). Also, in adrenal glands loaded with SKF81297($30{\mu}M$), the CA secretory responses evoked by Bay-K-8644($10{\mu}M$), an activator of L-type $Ca^{2+}$ channels and cyclopiazonic acid($10{\mu}M$), an inhibitor of cytoplasmic $Ca^{2+}$-ATPase were also inhibited. However, in the presence of the dopamine $D_1$ receptor antagonist, (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-benzazepine-7-ol(SCH23390, $3{\mu}M$), which is a selective antagonist of dopaminergic $D_1$ receptor, the inhibitory responses of SKF81297($30{\mu}M$) on the CA secretion evoked by ACh, high $K^+$, DMPP, McN-A-343, Bay-K-8644, and cyclopiazonic acid were significantly reduced. Collectively, these experimental results suggest that SKF81297 inhibits the CA secretion from the rat adrenal medulla evoked by cholinergic stimulation(both nicotininc and muscarinic receptors) and membrane depolarization. This inhibitory of SKF81297 seems to be mediated by stimulation of dopaminergic $D_1$ receptors located on the rat adrenomedullary chromaffin cells, which are relevant to extra- and intracellular calcium mobilization. Therefore, it is thought that the presence of the dopaminergic $D_1$ receptors may be involved in regulation of CA release in the rat adrenal medulla.

• 혜화의학회지
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• 제13권2호
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• pp.221-229
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• 2004

1.Purpose Stroke is the most frequent cause of mortality and morbidity rate in Korea with ischemic heart disease and cancer. Recent recurrence rate of stroke is high, but little attention had been given to the features of its' cause. The purpose of this studies is to examine the hematologic states in Korean normal adults through premature-examination of stroke(PES). 2.Method The study group consisted of 326 cases that they had no significant results by CT through premature examination of stroke(PES) in Cheonan oriental hospital of Daejeon university. We tested RBC, hemoglobin, hematocrit, WBC, PT, PTT, PLT, total protein, albumin, total bilirubin, direct bilirubin, GOT, GPT, $\gamma$-GTP, total cholesterol, triglyceride, HDL-C, glucose, BUN, creatinine, Na, K and evaluated by cross sectional study. 3.Result In the PES, there were many patients with low RBC(11%), shorten PT(26.7%), delayed PTT(19.3%), high TP, GPT, ${\gamma}$ -GTP(respective1y 16.9%, 14.4%, 13.5%), high cholesterol level and triglyceride level(respectively 18.7%, 28.2%). We didn't found significant cases in hemoglobin, hematocrit, WBC, PLT, albumin, total bilirubin, direct bilirubin, GOT, HDL-C, glucose, BUN, creatinine, Na, K. 4.Conclusion In this study, we demonstrated that short PT, high triglyceride level are special views in PES. Also prospective studies are needed continuously to search the preventing methods of the CVA.