• Title/Summary/Keyword: Yi Ko

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Citations of Journal of Korean Neurosurgical Society Assessed by KoMCI-Trends in Recent Five Years

  • Yang, Hee-Jin;Chung, Hyun-Tai;Yi, Min-A;Kim, Dong-Gyu
    • Journal of Korean Neurosurgical Society
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    • v.38 no.5
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    • pp.403-405
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    • 2005
  • The authors analyzed the citation of Journal of Korean Neurosurgical Society, based on Korean Medical Citation Index[KoMCI] from 2000 to 2004. In this analysis the impact factor showed no significant further improvement in 2004 compared to 2003. However, the number of received citations was increased remarkably. If this increase can be kept up, it may have positive effect on impact factors. In the era of open competition of medical journals, the awareness and cooperations of every members of Korean Neurosurgical Society is essential for improvement of the status of our journal in a steady trend.

Apoptosis-associated speck-like protein containing a CARD is not essential for lipopolysaccharide-induced miscarriage in a mouse model

  • Eun Young Oh;Malavige Romesha Chandanee;Young-Joo Yi;Sang-Myeong Lee
    • Korean Journal of Agricultural Science
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    • v.49 no.1
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    • pp.11-18
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    • 2022
  • A disrupted immune system during pregnancy is involved in pregnancy complications, such as spontaneous abortion, preeclampsia, and recurrent pregnancy loss. This study examined the role of toll-like receptor (TLR) 4 and ASC (apoptosis-associated speck-like protein containing a CARD [c-terminal caspase recruitment domain]) in pregnancy complications using a lipopolysaccharide (LPS)-induced miscarriage mice model. Incidences of miscarriage and embryonic resorption were examined at 9.5 days of pregnancy in wild-type (WT), ASC knockout (KO), and TLR4 KO mice after injecting them with LPS. The fetuses and placenta were obtained after sacrifice at 15.5 days of pregnancy. A significantly lower frequency of fetus absorption was found in TLR4 KO mice, whereas corresponding absorption outcomes were strongly induced in the WT and ASC KO mice upon an LPS injection. As expected, TLR4 KO mice were resistant to LPS-induced abortion. A histological analysis of the miscarried placenta showed increasing levels of the eosin staining of spongiotrophoblast cells without any obvious difference between WT and ASC KO mice. These results suggest that TLR4 KO mice are resistant to LPS, which affects pregnancy persistence, whereas WT and ASC KO mice show high miscarriage rates due to LPS. Moreover, the ASC adaptor is not directly involved in LPS-induced miscarriages, and the NLRP3 inflammasome can be activated by other proteins in the absence of ASC.

Alpha 1,3-Galactosyltransferase Deficiency in Miniature Pigs Increases Non-Gal Xenoantigens

  • Min, Gye-Sik;Park, Jong-Yi
    • Reproductive and Developmental Biology
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    • v.35 no.4
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    • pp.511-518
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    • 2011
  • To avoid hyperacute rejection of xenografts, ${\alpha}1,3$-galactosyltransferase knock-out (GalT KO) pigs have been produced. In this study, we examined whether Sia-containing glycoconjugates are important as an immunogenic non-Gal epitope in the pig liver with disruption of ${\alpha}1,3$-galactosyltransferase gene. The target cells were then used as donor cells for somatic cell nuclear transfer (scNT). A total of 1,800 scNT embryos were transferred to 10 recipients. One recipient developed to term and naturally delivered two piglets. Real-time RT-PCR and glycosyltransferase activity showed that ${\alpha}2,3$-sialyltransferase (${\alpha}2,3ST$) and ${\alpha}2,6$-sialyltransferase (${\alpha}2,6ST$) in the heterozygote GalT KO liver have higher expression levels and activities compared to controls, respectively. According to lectin blotting, sialic acidcontaining glycoconjugate epitopes were also increased due to the decreasing of ${\alpha}$-Gal in heterozygote GalT KO liver, whereas GalNAc-containing glycoconjugate epitopes were decreased in heterozygote GalT KO liver compare to the control. Furthermore, the heterozygote GalT KO liver showed a higher Neu5Gc content than control. Taken together, these finding suggested that the deficiency of GalT gene in pigs resulted in increased production of Neu5Gc-bounded epitopes (H-D antigen) due to increase of ${\alpha}2,6$-sialyltransferase. Thus, this finding suggested that the deletion of CMAH gene to the GalT KO background is expected to further prolong xenograft survival.

Mathematics Anxiety Analysis using Topological Data Analysis (위상수학적 데이터 분석법을 이용한 수학학습 불안 분석 사례)

  • Ko, Ho Kyoung;Park, Seonjeong
    • East Asian mathematical journal
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    • v.34 no.2
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    • pp.177-189
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    • 2018
  • Recently, Topological Data Analysis (TDA) has attracted attention among various techniques for analyzing big data. Mapper algorithm, which is one of TDA techniques, is used to visualize the cluster diagram. In this study, students were clustered according to the characteristics and degree of mathematics anxiety using a mapper, and students were visualized according to mathematics anxiety. In order to do this, Mathematical Anxiety Scale (Ko & Yi, 2011) in the aspect of mathematical instability in terms of teaching - learning, ie, Nature of Mathematics, Learning Strategy, Test/Performance is used. And the number of questions that measure the anxiety of mathematics can be extracted by extracting the most relevant items among the items that measure the anxiety of mathematics.

Micro-optics Components for Liquid Crystal Displays Applications

  • Shieh, Han Ping D.;Huang, Yi Pai;Chien, Ko Wei
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.379-382
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    • 2004
  • Microoptics has become the key technology in liquid crystal display systems due to its capabilities of miniaturization and design flexibility. We successfully demonstrate five different microoptical components for enhancing the image quality, providing better functions, increasing light efficiency, and generating 3D images in LCD applications.

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