• Journal of Sasang Constitutional Medicine
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• v.29 no.2
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• pp.154-173
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• 2017

Objectives This study was conducted to evaluate the effects of Yeoldahanso-tang on obesity in rats induced by high fat diet experimentally. Methods The experiment was conducted with rats divided into 5 groups. Rats were evaluated for change of weight, hematologic and serum biochemical parameters. Results Yeoldahanso-tang group showed significant reductions in FER, body weight, adipose tissue weight and size. The level of Creatinine, glucose, ALP, T-cholesterol, Triglyceride, LDL-cholesterol, Leptin and IGF-1 of Yeoldahanso-tang group was significantly lower than those in HFD-CTL group. The level of HDL-cholesterol, free fatty acid and Adiponectin in Yeoldahanso-tang group was significantly higher than those in HFD-CTL group. As compared with HFD-CTL group, AMPK-${\alpha}1$, UCP2 and adiponectin mRNA in liver of Yeoldahanso-tang group were significantly increased and AP2/FABP4, AMPK-${\alpha}2$ and PPAR-${\gamma}$ mRNA in liver of Yeoldahanso-tang group was significantly decreased. Conclusion These results suggest that Yeoldahanso-tang has inhibitory effects on obesity in high fat diet induced obese mice.

• Journal of Sasang Constitutional Medicine
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• v.24 no.2
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• pp.71-77
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• 2012

1. Objectives : The Purpose of this case is to report that a Tae-eumin patient diagnosed as Herpes Zoster was treated with Yeoldahanso-tang and then his symptoms improved. 2. Methods : We diagnosed the patient as Tae-eumin-Kanyeol-byung(太陰人肝熱病). So we treated him With Yeoldahanso-tang, and used Visual Analogue Scale(VAS) and pictures of the affected part for the assessment. 3. Results : After we treated the patient with Yeoldahanso-tang, the vesicles were cleared and his symptoms improved. 4. Conclusions : This case study show an efficient result of using Yeoldahanso-tang in Tae-eumin diagnosed to Herpes Zoster.

• Journal of Sasang Constitutional Medicine
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• v.21 no.1
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• pp.247-253
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• 2009

1. Objectives This study was designed to andyze the acute toxicity and safety of Yeoldahanso-tang 2. Methods We investigated the acute toxicity for water-extracted Yeoldahanso-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yeoldahanso-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Yeoldahanso-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Yeoldahanso-tang was over 5000 mg/kg and it is very safe to mice.

• Journal of Sasang Constitutional Medicine
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• v.23 no.1
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• pp.132-138
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• 2011

1. Objectives: This case study reports a Taeumin patient with Gastro-esophageal reflux disease who had suffered from chest pain, heartburn, acid regurgitation and dyspepsia who improved after Yeoldahanso-tang(Reduohanshao-tang) medication. 2. Methods: This patient had started treatment with Yeoldahanso-tang(Reduohanshao-tang), three times per day for three months and assessed the changes of the main symptoms such as chest pain, heartburn and acid regurgitation from baseline to post-treatment using a questionnaire with visual analogue scale(VAS). Electrogastrography(EGG) was also performed for assessment of gastric function from baseline to post-treatment. 3. Results: After the treatment, symptoms of GERD such as chest pain, heartburn, and acid regurgitation are almost disappeared. The patient don't need to take the proton pump inhibitor therapy. There was significant increase of % bradygastria parameters in fed EEG after treatment with Yeoldahansotang(Reduohanshao-tang). And significant increase of the power ratio after treatment was shown (20.5), compared with initial EGG(0.0). 4. Conclusions: This results show Yeoldahanso-tang(Reduohanshao-tang) can be used to treat GERD with Dry-heat symptom of Taeumin. This results suggest that Sasang Constitutional treatment for GERD patients who has a chronic condition with highly recurrence rate, might be a candidate for a therapeutic agent. Also effects of Yeoldahanso-tang(Reduohanshaotang) on GERD need further studies such as clinical trials.

• Journal of Sasang Constitutional Medicine
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• v.16 no.3
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• pp.133-138
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• 2004

1. Objectives Facial Palsy(Bell's palsy) is a common disease in oriental medicine. In Sasang Constitutional Medicine, Taeumin have a basic condition by Ganyeol as their inherent symptomatic phamacology. This case is a study about Taeumin's facial palsy in Ganyeol conditions. 2. Methods In treatment of facial palsy, especially in acute stage, We prescribe Yeoldahanso-tang(熱多寒少湯) when a patient with facial palsy is diagnosed as Taeumin by their own characters. 3. Conclusions This case-study shows an efficient results by using Yeoldahanso-tang(熱多寒少湯) in treatment of facial palsy compared with other known treatments.

• Korean Journal of Oriental Medicine
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• v.14 no.2
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• pp.101-106
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• 2008

Objective: The purpose of this study is to examine the characteristics and the improvement in the symptoms of the patients who showed improvement after the administration of Yeoldahanso-tang and Cheongpyesagan-tang. Methods: The patients whose Sasang Constitution were examined by an expert at six Oriental medical hospitals and three regional Oriental-medicine clinics, 89 showed a predetermined symptom improvement when Yeoldahanso-tang and Cheongpysagan-tang were administered to them from November 2007 to July 2008. The traits of the patients and the effects of their treatment were examined. Results and Conclusions: 1. There were about as many male patients as there were female patients, but 21.3% of the patients who were female and who were in their 40's showed the most improvement, which makes them the biggest category in this study. 2. The main syndromes in which the patients showed improvement were hemi-paralysis, vertigo, and headache, and the ordinary symptoms in which the patients showed improvement were diarrhea, fatigue, and dry mouth. 3. The average food intake of the patients was highest and their feces had intermediate hardness (semi-soft). 4. The amount of the patients' sweat was either high(38.2%) or appropriate(38.2%) and they showed a dislike of heat over coldness. 5. Among the diseases that the patients previously had, high blood pressure. The above results show that Yeoldahanso-tang and Cheongpyesagan-tang can be considered beneficial to females in their 40's and to stroke patients whose food intake is normal, whose sweat level is either copious or appropriate, who dislike heat and who are suffering from high blood pressure.

• Journal of Sasang Constitutional Medicine
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• v.17 no.3
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• pp.128-134
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• 2005

1. Objectives The primary purpose of this case is to report that a Taeurnin patients with Chorea originated after Cerebral infarction was treated with 'Yeoldahanso-tang(熱多寒少湯)' and then her symptoms improved 2. Methods We diagnosed her as Chorea originated after Cerebral infarction. So we treated her with 'Yeoldahanso-tang(熱多寒少湯)'. 3. Results After we treated her with 'Yeoldahanso-tang(熱多寒少湯)', her symptoms improved. 4. Conclusions 'Yeoldahanso-tang(熱多寒少湯)' may have an effect on Treatment Chorea originated after Cerebral infarction of Taeurnin.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.217-226
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• 2007

1. Objectives The purpose of this study was to evaluate whether use of Yeoldahanso-tang(熱多寒少湯) may injure the liver function. We clinically studied the change of liver function rest in patients who were admitted in Dongseo Oriental Medical Hospital. 2. Methods We analyzed rhe serum alkaline phosphatase(AIP), aspartate aminotransferase(AST), alanine aminotransferase(ALT), ${\gamma}$-glutamyl transpeptidase(${\gamma}$-GT), total bilirubin of 25 patients from 1st. July. 2004 to 15th. October. 2007 admitted in Dongseo Oriental Medical Hospital. Liver function test were done on admission and before discharge. 3. Results For most patients, the values of AIP, AST, ALT, ${\gamma}$-GT and total bilirubin were within normal range or decreased. 4. Conclusions This study suggests that Yeoldahanso-tang(熱多寒少湯) does not injure liver function of human.

• The Journal of the Society of Stroke on Korean Medicine
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• v.14 no.1
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• pp.115-121
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• 2013

A 67 year-old Taeeumin(太陰人) female patient with Thalamic pain Syndrome(Dejerine-Roussy Syndrome) was treated. She was suffering from rt. side numbness, pain and weakness, rt. facial palsy, dizziness, dysarthria and lassitude. She was diagnosed as Cerebral lacunar infarction(Lt. thalamus) by Brain MRI(Magnetic Resonance Imaging) and adminstered Yeoldahanso-tang(熱多寒少湯). After taking Yeoldahanso-tang(熱多寒少湯), her symptoms had improved. Result suggest that Yeoldahanso-tang(熱多寒少湯) is an effective for Taeeumin Thalamic pain Syndrome. Though, results support a role for oriental medical treatment for Cerebrovascular Accident(CVA) connected Sasang Constitution, further research into the effectiveness of oriental medical treatments for CVA connected Sasang Constitution is needed.

• Journal of Sasang Constitutional Medicine
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• v.21 no.3
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• pp.209-215
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• 2009

1. Objects: This case study reports a liver injury in treatment of constipation with Yeoldahanso-tang plus Rheum rhabarbarum. 2. Methods: The patient's subjective symptoms and the laboratory data including aspartate transaminase(AST), alanine transaminase(ALT), alkaline phosphatase(ALP), and gamma($\gamma$)-glutamyl transpeptidase(GGT) were observed before and after liver injury. We used the Roussel Uclaf Causality Assessment Method(RUCAM) scale in order to find out whether if Yeoldahanso-tang plus Rheum rhabarbarum was related with the liver injury. 3. Results: The patient's AST and ALT were elevated more than twice after a 3week administration period of herbal medicine. After discontinuation of the herbal medicine and administration of hepatic protective medication, AST and ALT decreased. The patient's general condition improved during hospitalization. The RUCAM score was estimated at 8. 4. Conclusions: This case is presented to bring more attention to the toxicity of herbal medicine.