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http://dx.doi.org/10.7730/JSCM.2017.29.2.154

Anti-obesity Effect of Yeoldahanso-tang on Obesity Mice  

Go, Ga-Yeon (Dept. of Sasang Constitutional Medicine, College of Korean Medicine)
Park, Jung-hwan (Dept. of Sasang Constitutional Medicine,Cheonan Oriental Hospital of Daejeon University)
Kwak, Jin-Young (Dept. of Sasang Constitutional Medicine,Cheonan Oriental Hospital of Daejeon University)
Ahn, Taek-Won (Dept. of Sasang Constitutional Medicine,Cheonan Oriental Hospital of Daejeon University)
Publication Information
Journal of Sasang Constitutional Medicine / v.29, no.2, 2017 , pp. 154-173 More about this Journal
Abstract
Objectives This study was conducted to evaluate the effects of Yeoldahanso-tang on obesity in rats induced by high fat diet experimentally. Methods The experiment was conducted with rats divided into 5 groups. Rats were evaluated for change of weight, hematologic and serum biochemical parameters. Results Yeoldahanso-tang group showed significant reductions in FER, body weight, adipose tissue weight and size. The level of Creatinine, glucose, ALP, T-cholesterol, Triglyceride, LDL-cholesterol, Leptin and IGF-1 of Yeoldahanso-tang group was significantly lower than those in HFD-CTL group. The level of HDL-cholesterol, free fatty acid and Adiponectin in Yeoldahanso-tang group was significantly higher than those in HFD-CTL group. As compared with HFD-CTL group, AMPK-${\alpha}1$, UCP2 and adiponectin mRNA in liver of Yeoldahanso-tang group were significantly increased and AP2/FABP4, AMPK-${\alpha}2$ and PPAR-${\gamma}$ mRNA in liver of Yeoldahanso-tang group was significantly decreased. Conclusion These results suggest that Yeoldahanso-tang has inhibitory effects on obesity in high fat diet induced obese mice.
Keywords
Yeoldahanso-tang; anti-obesity; High fat diet; anti-hyperlipidemia;
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Times Cited By KSCI : 13  (Citation Analysis)
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