Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
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Anti-obesity Effect of Yeoldahanso-tang on Obesity Mice

고지방식이로 유도된 비만 생쥐모델에서 열다한소탕의 항비만효과

  • Go, Ga-Yeon (Dept. of Sasang Constitutional Medicine, College of Korean Medicine) ;
  • Park, Jung-hwan (Dept. of Sasang Constitutional Medicine,Cheonan Oriental Hospital of Daejeon University) ;
  • Kwak, Jin-Young (Dept. of Sasang Constitutional Medicine,Cheonan Oriental Hospital of Daejeon University) ;
  • Ahn, Taek-Won (Dept. of Sasang Constitutional Medicine,Cheonan Oriental Hospital of Daejeon University)
  • 고가연 (대전대학교 한의과대학 사상체질의학교실) ;
  • 박정환 (대전대학교 천안한방병원 사상체질의학교실) ;
  • 곽진영 (대전대학교 천안한방병원 사상체질의학교실) ;
  • 안택원 (대전대학교 천안한방병원 사상체질의학교실)
  • Received : 2017.05.18
  • Accepted : 2017.06.14
  • Published : 2017.06.30
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Abstract

Objectives This study was conducted to evaluate the effects of Yeoldahanso-tang on obesity in rats induced by high fat diet experimentally. Methods The experiment was conducted with rats divided into 5 groups. Rats were evaluated for change of weight, hematologic and serum biochemical parameters. Results Yeoldahanso-tang group showed significant reductions in FER, body weight, adipose tissue weight and size. The level of Creatinine, glucose, ALP, T-cholesterol, Triglyceride, LDL-cholesterol, Leptin and IGF-1 of Yeoldahanso-tang group was significantly lower than those in HFD-CTL group. The level of HDL-cholesterol, free fatty acid and Adiponectin in Yeoldahanso-tang group was significantly higher than those in HFD-CTL group. As compared with HFD-CTL group, AMPK-${\alpha}1$, UCP2 and adiponectin mRNA in liver of Yeoldahanso-tang group were significantly increased and AP2/FABP4, AMPK-${\alpha}2$ and PPAR-${\gamma}$ mRNA in liver of Yeoldahanso-tang group was significantly decreased. Conclusion These results suggest that Yeoldahanso-tang has inhibitory effects on obesity in high fat diet induced obese mice.

Keywords

References

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