• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8279-8285
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• 2014

A meta-analysis incorporating 34 case-control studies from 19 articles involving 12,197 cases and 13,488 controls was conducted to assess the effects of three genetic variants of Toll-like receptor 9 (TLR9): rs187084, rs352140, and rs5743836. Studies on associations between TLR9 polymorphisms and cancer risk were systematically searched in electronic databases. The reported odds ratios (OR) and 95% confidence intervals (CI) were pooled to assess the strength of any associations. The results showed that the rs187084 polymorphism was significantly associated with an increased risk of cancer (CC vs TC+TT: OR=1.14, 95% CI=1.02-1.28), specifically cervical cancer (C vs T: OR=1.19, 95% CI=1.05-1.34; TC vs TT: OR=1.32, 95% CI=1.10-1.58; CC vs TT: OR=1.31, 95% CI=1.03-1.68; CC+TC vs TT: OR=1.32, 95% CI=1.11-1.56), and that this association was significantly positive in Caucasians (CC vs. TC+TT: OR=1.18, 95% CI=1.01-1.38). The rs352140 polymorphism had a protective effect on breast cancer (GA vs GG: OR=0.77, 95% CI=0.66-0.89), whereas the rs5743836 polymorphism was likely protective for digestive system cancers (CC+TC vs TT: OR=0.81, 95% CI=0.66-0.98). In conclusion, our results suggest that the rs187084 polymorphism may be associated with an elevated cancer risk, whereas polymorphisms of rs352140 and rs5743836 may play protective roles in the development of breast and digestive system cancers, respectively. From the results of this meta-analysis further large-scale case-control studies are warranted to verify associations between TLR9 polymorphisms and cancer.

• 대한지역사회영양학회지
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• 제12권2호
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• pp.189-197
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• 2007

Low glycemic index (GI) foods have been reported to be very important in the control of blood glucose levels in diseases such as diabetes mellitus and obesity, which are becoming more prevalent in Korea. Bread consumption at breakfast and as a snack is also on the rise. To provide low GI alternatives, breads supplemented with dietary fibers-fructooligosaccharide (FOS), ground whole rye, and 2 types of resistance starch (RS2 and RS4)-were developed. The GIs for these breads were evaluated with 13 healthy college students (M6, F7) and sensory tests were done. Four kinds of breads were made through the modification of a basic recipe for white bread (the control, B) as follows: for Bf, the entire amount of sugar was replaced with FOS. For Ryef, 50% of the white wheat flower was replaced with roughly ground wholerye (20 mesh: 12-20 mesh = 1 : 3) in addition to replacing sugar with FOS. For RS2f and RS4f, 20% of the white wheat flower was replaced with RS2 or RS4, in addition to replacing sugar with FOS. The overall preference score of Bf was similar to that of B, while those of Ryef, RS2f and RS4f were lower than that of B, but showed the acceptable degree of the overall preference. The glycemic indices of Ryef and RS2f were 46.1 and 45.9 respectively, which were significantly lower than the GI of B, 67.8. The GIs of Bf and RS4f were, however, 66.7 and 80.5 respectively, showing no significant difference compared to B. The glycemic loads for a 30 g serving were 9.5, 5.9, 6.2, 11.0 and 9.0 for B, Bf, Ryef, RS2f and RS4f, respectively. In conclusion, addition of RS2 or roughly ground whole rye to the dough formula significantly lowered the GI. Since the preferences shown for those two breads were acceptable, they may be recommended as a substitute for white bread fir persons who need blood glucose management. More studies on the bread making process are required to improve preference and acceptance. Although GI lowering effects for F and RS4 were not found in this study, further studies are needed to verify their effects.

• 벤처혁신연구
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• 제1권1호
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• pp.197-210
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• 2018

본 연구는 최첨단 친환경의 인덕션 렌지를 매립한 음식점 테이블의 인덕션 서비스스케이프와 이용자 만족 및 재구매 의도의 영향관계에 대한 선행연구의 내용을 바탕으로 연구모형을 설계하고, 변수들 간의 영향관계를 분석하였다. 본 논문의 주요 분석결과는 다음과 같다. 조사 대상자의 인구 통계학적 특성으로서 남성 응답자가 104명, 여성 응답자가 106명으로, 남·여의 비율이 거의 비슷하게 참여하였으며, 응답자들의 직급 및 직책으로는 레스토랑 대표가 68명, 레스토랑 운영자 혹은 관리자가 142명이었다. 인덕션 렌지를 매립한 음식점들의 종업원 숫자 또한 5명 이상의 음식점이 62.4％로 나타나 일반 음식점 평균(2.8명) 보다 대형매장의 형태로 확실히 구분되어 나타났다. 회귀분석에 의한 가설 검증결과 ①레스토랑의 친환경 기능 인덕션 서비스스케이프가 이용자 만족에 유의한 영향을 미치는 것으로 나타났으며, ②레스토랑의 친환경 기능 인덕션 서비스스케이프가 재구매 의도에 유의한 영향을 미치는 것으로 나타났고, ③레스토랑의 친환경 기능의 인덕션을 매립한 음식점운영·관리자의 만족이 재구매 의도에 유의한 영향을 미치는 것으로 나타나 본 연구에서 제시되었던 가설은 채택 되었다.

• 한국치위생학회지
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• 제7권2호
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• pp.197-211
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• 2007

The purpose of this study was to examine the image of dental hygienists. The subjects in the study were 396 patients and their caregivers who visited 14 dental hospitals and dentists' offices in and around Seoul. After a survey was conducted, the following findings were given: 1. The people investigated gave a mean of 4.0 to the image of dental hygienists. Dental hygienists rated highest in terms of looking neat and tidy(4.33), and were given the lowest marks in arbitrary job performance(3.46). 2. There appeared four different types of dental hygienist images, which made a 59.824 prediction of the image of dental hygienists in general. A typical image(4.11) was most dominant, followed by professional one(4.07), personal one(4.01) and social one(3.73). 3. The relations between the general characteristics of the respondents and their image of dental hygienists could be described as below: 1) By age, those who were in their 60s(4.12) had the best image of dental hygienists, and the teenagers(3.90) had the worst image of them. 2) By gender, the men(4.05) looked at dental hygienists more positively than the women(3.96). They had a significantly different opinion on the social image of dental hygienists according to gender(pE0.05). 3) By marital status, the married people(4.00) had a better image of dental hygienists than the unmarried ones(3.95). 4) As for the influence of the type of dental institutions, they had a more favorable image of dental hygienists in dentists' offices(4.13) than in dental hospitals(3.88). There was a broad significant difference in the way they looked at the professional and personal images of dental hygienists according to the type of dental institutions(pE0.001). 5) As to the impact of educational level, those who received community-college or higher education(4.01) had the best image of dental hygienists, and those who received middle-school or lower education(3.91) had the worst image of them. 6) By occupation, the government workers and students(4.07) had the best image of dental hygienists, and the company employees(3.90) had the worst image of them. They took a significantly different view of the social image of dental hygienists according to occupation(pE0.05). 7) Concerning the impact of the frequency of receiving dental treatment, the respondents who had received it seven times or more(4.16) had the best image of dental hygienists, and those who hadn't(3.79) the worst image of them. There was a wide significant gap according to that frequency. The way they looked at the typical, social and professional images of dental hygienists was quite different significantly according to that frequency as well(pE0.001). 8) As for the influence of whether they were accompanied by caregivers or not, the people who weren't accompanied by caregivers(3.99) had a better image of dental hygienists than those who were(3.97).

• 지구물리와물리탐사
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• 제13권3호
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• pp.187-197
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• 2010

우리나라의 단층에 대한 고지진학적 연구는 1994년 이후 양산단층과 울산단층대를 따라 본격적으로 시작되었다. 양산단층대의 경우, 평해, 유계, 언양-통도사 등에서 부분적으로 고지진 활동을 나타내지만, 울산단층대의 경우 단층의 북부와 남부 일부를 제외하고 전 구간에서 단층운동 기록이 나타난다. 고지진에 의한 단층운동의 이력을 보면 양산단층의 경우 유계지역 일부를 제외하고 주로 20여만년 이전 기록이 대부분이다. 한편, 울산단층의 경우 운동 시기는 30만년 전 이후 수천년 전까지로 매우 최신까지의 기록이 나타나, 양산단층보다 최근까지 활동해오고 있음을 알 수 있다. 단층운동의 특성은 양산단층은 주로 우수주향이동이 우세하며, 울산단층은 역단층운동이 우세하였다. 이는 이 지역 일대에서 최근 발생하고 있는 지진들의 단층운동 감각과 유사함을 보인다. 평균변위율을 통해 단층의 활동도를 평가하는 일본의 경우에 대비할 경우, 양산단층의 평균변위율인 0.1~0.04 m/ka은 C 등급에 해당하며, 울산단층대의 평균변위율인 0.2~0.06 m/ka는 B-C 경계 등급에 해당한다. 각 단층대의 일부 구간에서 외국의 최대변위-규모 경험식에 기초하여 구한 최대 지진규모는 양산단층대의 유계단층에서는 평균 6.8, 울산단층대의 갈곡단층에서는 7.0의 값을 얻었다. 앞으로 이들 단층대의 분절화, 역사지진과의 관계 등 많은 해결과제가 남아있다.

• 대한방사선기술학회지:방사선기술과학
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• 제36권3호
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• pp.219-225
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• 2013

본 연구는 CIMT에 영향을 미치는 요인, 대사증후군 유병률과 위험요소들이 CIMT에 미치는 영향에 대한 연구로 2012년 6월부터 12월까지 건강검진을 목적으로 건강검진센터에 내원하여 경동맥 초음파를 시행한 279명(남자: 187명, 여자: 92명) 중 심혈관계 질환이 없는 사람을 대상으로 하였다. 피검자의 평균연령은 $50.3{\pm}12.3$세(30 ~ 79세)이었고, 남자 $49.5{\pm}11.7$세, 여자 $51.9{\pm}13.4$세였다. 피검자에 대한 일반적인 건강상태를 확인하기 위해 혈압과 신체계측을 하였고 8시간 금식 후 혈액을 채취하여 공복혈당, 총콜레스테롤, 중성지방 등을 측정하였다. 수집된 자료는 t-test, one-way ANOVA, 피어슨 카이제곱검정, 다중 로지스틱 회귀분석을 실시하였다. 연구결과 CIMT는 여자보다 남자가 유의하게 증가 되었고, 특히 연령이 CIMT에 큰 영향을 미쳤다. 전체대상자의 대사증후군 유병률은 30.5%이었고 정상군과 비교하여 대사증후군에서 CIMT가 통계적으로 유의하게 높았다. 또한 대사증후군의 대사 이상 및 대사 이상 항목 군집성이 증가 할수록 CIMT에 유의한 영향을 미쳤다. 심혈관질환 위험인자와 관련이 있는 구성요소를 가진 대사증후군과 CIMT는 양의 상관관계(r=0.378, P<0.01)가 있었고, 대사증후군과 Abnormal CIMT에 대한 다중 로지스틱 회귀분석을 실시한 결과 Abnormal CIMT는 대사증후군과 유의한 관련성을 보였다(Exp(B)=2.725, p<0.05). 이상의 결과는 대사증후군에서 심혈관질환의 효과적인 일차 예방 전략으로 B-mode 초음파를 이용하여 측정된 CIMT가 중요한 역할을 할 것이므로 경동맥 초음파 검사가 적극적으로 권고되어야 한다고 사료된다.

• 한국치위생학회지
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• 제3권1호
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• pp.13-24
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• 2003

The researcher worked with a total of 158 high school girls visiting the scaling practice room at the department of dental hygiene in Jinju Health college from November 11, 2002 to December 4, 2002, having their teeth scaled, observing their teeth and interviewing them with the aid of questionnaires. The findings can be summarized as follows. 1. The survey on the understanding of dental health and the attitudes of the subjects shows the following results : "I have never learned how to brush teeth" (65.8%: 104 girls); "I brush my teeth twice a day" (57.0%: 90 girls) : "I brush my teeth for 2 minutes"(44.3%: 70 girls): "I brush my teeth vertically and horizontally" (53.2%: 84 girls): "( brush my teeth, gum and tongue" (462%: 73 girls): "I use one brush for two months" (40.5%: 64 girls); "I don't have any floss" (582%: 92 girls): "I have never had my teeth scaled" (84.2%: 133girls) : "Smoking is bad for the teeth" (77.8%: 123 girls): "Drinking is bad for the teeth" (48.7%: 77 girls): "I have ever visited dental clinics" (92.4%: 146 girls). 2. The study on part of the teeth most exposed to caries shows the following results : Mandibular right first molar(79.8%: 126 girls): Mandibular left first molar(77.5%: 124 girls), Mandibular left second molar(70.2%: 111 girls). Mandibular right second molar(65.7%: 104 girls). Maxillary left first molar(59.5%: 94 girls): Maxillary left second molar(59.5%: 94 girls): Maxillary right first molar(58.2%: 92 girls). Maxillary right second molar(50.7%: 80 girls) 3. The statistics on the subjects' caries show the following results: DMF rate: 943%: DMFT rate: 25.61%: DMFT index: 7.17 teeth : DT rate: 4651%: FT rate: 52.25%: MT rate: 124% 4. The survey on dental caries statistics, dental health, dental health behavior, and the subjects' attitudes shows the following results: The worse the subjects' dental health was(r=-327, p<.001), the more they visited dental clinics(r=.195, p<.05), the higher DMT rate, DMFT index were; The more the subjects visited dental clinics(r =.359, p<.001), the higher DT rate was; The worse the subjects teeth went(r=-.197, p<.05), the higher MT rate was. It is necessary that systematic and substantial dental health education for high school students should be carried out in regard to plaque control, fluoride application, diet control, pit & fissure sealant as a part of developing national health policies designed for the dental health of the teenagers.

• Reproductive and Developmental Biology
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• 제35권3호
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• pp.197-201
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• 2011

This study was conducted to investigate the effects of donor cell treatments on the production of transgenic cloned piglets. Ear fibroblast cell obtained from NIH MHC Inbred minipig was used as control. The GalT knock-out/CD45 knock-in (GalT/CD46) transgenic cell lines were established and used as donor cells. The reconstructed GalT/CD46 embryos were surgically transferred into oviduct of naturally cycling surrogate sows (Landrace ${\times}$ Yorkshire) on the second day of standing estrus. Unlike control (1.2 kV/cm, 75.4%), the fusion rate of the GalT/CDl6 donor cells was significantly higher in 1.5 kV/cm, (84.5%) than that of 1.25 kV/cm, (20.2%) (p<0.01). When the number of the transferred embryos were more than 129, the pregnancy and delivery rates were increased to 13/20 (65%) and 5/20 (25%) compared to less then 100 group [1/6 (16.7%) and 0/6 (0%)], respectively. To analyze the effect of donor cell culture condition on pregnancy and delivery rates, the GalT/CD46 donor cells were cultured with DMEM or serum reduced medium. In serum reduced medium group, the pregnancy and delivery rates were improved to 8/12 (66.7%) and 5/12 (41.7%) compared to DMEM group [3/7 (42.9%) and 0/7 (0%)], respectively. In conclusion, it can be postulated that an appropriate fusion condition and culture system is essential factors to increase the efficiency of the production of transgenic cloned piglets.

• 한국식생활문화학회지
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• 제13권3호
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• pp.197-206
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• 1998

본 연구는 서울과 경기 지방의 주부들을 대상으로 식생활 행동과 편의식에 대한 인식도를 조사함으로써, 한국형 건강 편의식 개발 방향 도출에 필요한 기초 자료를 얻고자 시도되었다. 본 연구를 위하여 710명의 주부들이 응답한 설문지가 통계학적으로 분석되었다. 설문지는 일반 사항, 식생활 및 식품 구매 행동과 편의식에 대한 인식도에 관한 문항들로 구성되었다. 일반 사항 중 연령, 취업 여부, 라이프스타일이 응답자의 식행동과 편의식에 대한 인식에 유의적인 영향을 미치는 인자임이 규명되었다. 식생활 전반에 대한 책임을 맡고 있는 것은 주부들이었으나, 이들의 대부분이 식사준비에 대해 즐겁다기보다 부담을 느끼고 있는 것으로 나타났다. 이러한 태도는 다른 연령군, 취업 여부, 라이프 스타일군에서 유의적인 차이를 보였다. 장보기 빈도는 필요할 때마다 1주일에 $2{\sim}3$번이 가장 높았다. 또한 미리 식단 계획을 하기보다는 장볼 때 즉흥적으로 하는 경향이 뚜렷했다. 식품 구입시 가격보다는 품질을 중요시하고 있었다. 소비자들은 현재 시판되고 있는 손질된 야채나 조리된 식품에 대해 만족하지 못하고 있었다. 그러나 품질이 우수한 편의식 개발에 대한 요구도는 높은 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.5077-5081
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• 2014

To clarify whether gastric cancer patients can benefit from laparoscopy-assisted surgery completed by junior surgeons under supervision of expert surgeons, data of 232 patients with gastric cancer underwent operation performed by inexperienced junior surgeons were reviewed. Of the 232 patients, 137 underwent laparoscopy-assisted resection and in 118 cases this approach was successful. All of these 118 patients were assigned to laparoscopic group in this study, 19 patients who were switched to open resection were excluded. All laparoscopic operations were performed under the supervision of expert laparoscopic surgeons. Some 95 patients receiving open resection were assigned to the open group. All open operations were completed independently by the same surgeons. Short-term outcomes including oncologic outcomes, operative time intra-operative blood loss, time to first flatus, time to first defecation, postoperative hospital stay and perioperative complication were compared between the two groups. The numbers of lymph nodes harvested in the laparoscopic and open groups were $21.1{\pm}9.6$ and $18.2{\pm}9.7$ (p=0.029). There was no significant difference in the length of margins. The mean operative time was $215.9{\pm}32.2$ min in laparoscopic group and $220.1{\pm}34.6min$ in the open group (p=0.866), and the mean blood loss in laparoscopic group was obviously less than that in open group ($200.9{\pm}197.0ml$ vs $291.1{\pm}191.4ml$; p=0.001). Time to first flatus in laparoscopic and open groups was $4.0{\pm}1.0$ days and $4.3{\pm}1.2$ days respectively and the difference was not significant (p=0.135). Similarly no statically significant difference was noted for time to first defecation ($4.7{\pm}1.6$ vs $4.8{\pm}1.6$, p=0.586). Eleven patients in the laparoscopic group and 19 in the open group suffered from peri-operative complications and the difference between the two groups was significant (9.3% vs 20.0%, p=0.026). The conversion rate for laparoscopic surgery was 13.9%. Patients with gastric cancer can benefit from laparoscopy-assisted operations completed by inexperienced junior surgeons under supervision of expert laparoscopic surgeons.