• 정보처리학회논문지B
• /
• 제12B권5호
• /
• pp.595-606
• /
• 2005

개발비용이 70억원에서 200억원에 이르는 블록버스터 게임들이 자주 등장하면서 전반적으로 게임개발 규모가 급속히 커지고 있다. 이로 인해 게임의 기술요소들이 집중되어 있는 게임메카닉스의 품질관리가 중요하게 되었다. 본 논문에서는, 설계단계에서, 게임메카닉스의 공학적 품질 분석을 정확하고 경제적으로 할 수 있는 컴퓨터 시뮬레이터를 구현하여 제안하였다. 제안하는 시뮬레이터는 모델링을 편리하게 할 수 있도록, Petri net[7,8]과 Smalltalk[9]을 지원한다. 기존 방법들은, 실제의 게임플레이 환경을 고려하지 않는, 제한된 범위의 품질분석이 가능했지만, 제안하는 시뮬레이터는 플레이어의 게임플레이 행동패튼과 게임의 배경맵과 아이템 DB를 사용하기 때문에 그 평가 결과가 매우 실제적이다. 제안하는 시뮬레이터의 성능을 검증하기 위해 Dungeon & Dragon[13,14]의 게임메카닉스와 게임 배경맵과 아이템 DB를 사용하여 시뮬레이션을 총 80회 실시하였다. 실험 결과에 의하면, 제안하는 시뮬레이터는 무결성, 최적화, 밸런스 품질을 모두 평가할 수 있고, 다른 방법보다 품질평가 능력이 우수하였다.

• 국제물리치료학회지
• /
• 제5권1호
• /
• pp.675-682
• /
• 2014

The objective of this study was to examine the effects of auditory biofeedback training and kicking training on walking times in patients with hemiplegia to determine if the effects of such training would be maintained even after stopping the intervention. Thirty hemiplegia patients were selected and randomly assigned to a control group of 10 patients to receive general exercise treatment; an auditory biofeedback training group of 10 patients to receive auditory biofeedback training, along with general exercise; and a kicking training group to receive kicking training, along with general exercise. All the patients received their respective training 12 times in total, three times per week for four weeks. In addition, all those in the control and experimental groups received the same general exercise treatment 12 times in total, three times per week for four weeks, and underwent follow-up tests thereafter. The patients' 10m walking times were measured using a stopwatch. The significance was analyzed using repeated-ANOVAs. In cases where there were interactions between measuring times and groups, in each group were examined using repeated-ANOVAs. In cases where there were differences, post-hoc tests were conducted using repeated of contrast test. The 10m walking times of the control and experimental groups were significant differences in 10m walking times were shown between measurement times(p<.05), and significant differences in the interactions between measuring times and groups were shown between the groups(p <.05). However, no significant differences in 10m walking times were shown between the groups(p>.05). The auditory biofeedback training group showed significant decreases in walking times four weeks after the beginning of the intervention(p<.05) and significant increases eight weeks after the beginning of the intervention(p<.05). The kicking training group showed significant decreases in walking time four weeks after the beginning of the intervention(p<.05) and maintained the walking times without showing any significant differences eight weeks after the beginning of the intervention(p>.05). The walking speeds of only the kicking training group were maintained until eight weeks after the beginning of the intervention.

• 한국임상수의학회지
• /
• 제26권5호
• /
• pp.472-475
• /
• 2009

A 3-year old, female Cocker Spaniel dog was referred to Seoul National University Hospital for Animals with depression and vomiting. The dog was diagnosed as hypoadrenocorticism based on the typical electrolyte alteration and the result of adrenocorticotropic hormone (ACTH) stimulation test. Initial treatment with oral fludrocortisone at a dose rate of 0.02 mg/kg/q24h for 6 weeks period was ineffective at maintaining serum electrolyte concentrations within normal limits. Although a dose rate of oral fludrocortisone was significantly increased up to 0.06 mg/kg/q24h during 24 weeks period, the treatment was still ineffective. Moreover, the patient showed side effects related to the glucocorticoid excess including PU/PD, weight gain and lipemia. After alternation with desoxycorticosterone pivalate (DOCP, 2.2 mg/kg, IM) every 25 day, the clinical signs was disappeared and the electrolyte balance was maintain with no side effect. Therefore, DOCP may be suggested as an effective drug in canine hypoadrenocorticism uncontrolled with oral fludrocortisone.

• 한국식품조리과학회지
• /
• 제26권3호
• /
• pp.300-306
• /
• 2010

Arabica coffee has been classified for trading according to the New York Board of Trade (NYBOT) green coffee classification. The aim of the present study is to evaluate the physiochemical and sensorial characteristics of coffees classified by NYBOT as NY2 (specialty coffee), NY3/4 and NY4/5 (commercial coffee). The density of green coffee was higher for the NY2 sample. The amount of total solids in brewed coffee increase as the green coffee grade decreased and the pH levels decreased as the coffee grade decreased. Descriptive analysis using a 15cm line scale was carried out by 12 trained panelists prepared by espresso coffee and consumer preference tests were carried out by 168 consumers. The NY2 sample had the highest fruity, acidity, sweetness and aftertaste characteristics. In addition, green, rio, sour and astringency characteristics increased as the coffee grade decreased. Acceptance of aroma, flavor, taste balance and overall were higher for the NY2 sample. In the consumer preference test, the NY2 and NY4/5 samples had a similar distribution, but consumers between the ages of 20 to 30 who like to drink brewed coffee more than instant coffee preferred the NY2 than sample over the NY3/4 sample. In conclusion, significant differences were observed among the three groups of green coffee classification in all physicochemical and sensory parameters.

• 한국항공우주학회지
• /
• 제40권8호
• /
• pp.711-717
• /
• 2012

스포츠급 경항공기 개념 설계 단계에서 항공기의 정적 안정성 분석을 위해 1/5 축소모델로 풍동시험을 수행하였다. 제안된 경항공기의 동체 단독 및 동체에 주익, 수평꼬리날개, 수직꼬리날개 등을 조합한 6개 형상에 작용하는 공력을 내장형 밸런스를 이용하여 측정하고 정안정 미계수를 도출하여 기본 양항력 공력특성 및 각 요소가 세로 방향 가로 정안정 특성에 미치는 효과를 분석하였다. 풍동시험 결과로부터 특히, 수평꼬리날개와 수직꼬리날개 그리고 고익형태와 상반각을 갖는 주익 등이 각각 세로, 방향, 가로 정안정성에 미치는 기여정도를 정량적으로 파악하였으며, 본 시험결과는 항공기 각 형상 구성품 조합의 정안정 특성에 관한 유용한 실험자료로 활용될 수 있을 것이다.

• 동의생리병리학회지
• /
• 제19권3호
• /
• pp.671-676
• /
• 2005

In this study, we investigated the antioxidant effect of extract from Monascus pillosus, on the human wild-type p53 and p21 expressing A549 lung epithelial cell line and MCF-7 mammary adenocarcinoma cell line stimulated by NO. $P21^{waf/cip1}$ was identified as a gene induced in senescent cells. It is a cyclin-dependent kinase inhibitor and has been shown to cause cell cycle arrest and apoptosis. While p53-regulated stimulation of p21 appears to be central for the permanent growth-arrest, the role of p21 in p53-triggered cell death is unclear. Low dose of sodium nitroprusside (SNP) induced the development of senescence associated with increased expression of p53 and p21 in A549 cells. Inhibition of p21 transactivating activity requires high level correlates with the amount of p53 necessary to cause cell death. Association of p21 and p53 results in inhibition of p21-stimulated transcription. This requires a higher p53 level than is necessary for transcriptional activation of endogenous p53-responsive gene but correlates well with the level of p53 necessary to cause cell death. Exposure to W-1 inhibited oxidative stresses-induced senescence-like arrest, resulting in a significant reduction in p53 and p21 steady state levels. These results suggest that p53 and p21 play a central role in the onset of senescence. Thus, it is important to emphasize control of oxidative balance in tumor prevention and aging.

• Journal of Biosystems Engineering
• /
• 제40권3호
• /
• pp.296-304
• /
• 2015

Purpose: The balance between miscanthus production and its cost effectiveness depends greatly on its moisture content during post processing. The objective of this research was to measure the moisture content using a non-destructive and non-contact methodology for in situ applications. Methods: The moisture content of comminuted miscanthus was controlled using a closed chamber, a humidifier, a precision weigher, and a real-time monitoring software developed in this research. A CMOS sensor equipped with $50{\times}$ magnifier lens was used to capture magnified images of the conditioned materials with moisture content level from 5 to 30%. The hypothesis is that when light is incident on the comminuted particles in an inclined manner, higher moisture content results in light being reflected with a higher intensity. Results: A linear regression analysis for an initiative hypothesis based on general histogram analysis yielded insufficient correlations with low significance level (<0.31) for the determination coefficient. A significant relationship (94% confidence level) was determined at level 108 in a reverse accumulative histogram proposed based on a revised hypothesis. A linear regression model with the value at level 108 in the reverse accumulative histogram for a magnified image as the independent variable and the moisture content of comminuted miscanthus as the dependent variable was proposed as the estimation model. The calibrated linear regression model with a slope of 92.054 and an offset of 32.752 yielded 0.94 for the determination coefficient (RMSE = 0.2%). The validation test showed a significant relationship at the 74% confidence level with RMSE 6.4% (n = 36). Conclusions: To compensate the inconsistent significance between calibration and validation, an estimation model robust against various systematic interferences is necessary. The economic efficiency of miscanthus, which is a promising energy resource, can be improved by the real-time measurement of its crucial material properties.

• 한국항해학회지
• /
• 제20권1호
• /
• pp.59-79
• /
• 1996

Waterfront redevelopment is an element in the process of inner-city regeneration now widespread in many ports of the world. Academic interest in the processes involved has yielded a literature biased towards specific locations rather than towards the analysis of processes and issues. The redevelopment of urban waterfronts does not, of course, occur exclusively in port cities but is found as a continuous process in most places where settlement and water are juxtaposed, whether or not commercial port activity is or was present. Port cities, however, as a result of the concentration and juxtaposition of urban and maritime influences, generally present the major issues involved in waterfront redevelopment most clearly. In this context, the general aim is to explore Korean dimensions of waterfront redevelopment in a range of port cities in a context of inner-urban renewal; and a specific objective is to examine the views of decision-makers in Korean port cities on the processes involved by a questionnaire method. The focus is on comparative strategies, and in particular upon the factors affecting the balance between social goals and commercial interests. To test the response of four categories of decision-makers in Korean port cities on a number of issues perceived as underpinning the processes involved in waterfront redevelopment, four catergories of respondents-port authority representatives(PO), urban planners(UP), port specialists(PS) and city-government official(GO)-were asked to fill in a questionnaire form. In three out of ten cases, the overall result broadly confirmed the a priori expectation; in six cases the confirmation was partial; and in one other the view of respondent was generally contrary to those anticipated. In many, but by no means all, cases there was substantial agreement between the four categories of respondents, but the range of scores was generally much wider than expected.

• 한국발생생물학회지:발생과생식
• /
• 제16권1호
• /
• pp.53-58
• /
• 2012

Circadian rhythmicity (e.g. secretory pattern of hormones) plays an important role in the control of reproductive function. We hypothesized that the alteration of feeding pattern via meal time shift/restriction might disrupt circadian rhythms in energy balance, and induce changes in reproductive activities. To test this hypothesis, we employed simple animal model that not allowing $ad$ $libitum$ feeding but daytime only feeding. The animals of $ad$ $libitum$ feeding group (Control) have free access to food for 4 weeks. The day feeding (=reverse feeding, RF) animals (RF group) have restricted access to food during daytime (0900-1800) for 4 weeks. After completing the feeding schedules, body weights, testis and epididymis weights of animals from both group were not significantly different. However, the weights of seminal vesicle (control : RF group = $0.233{\pm}0.014g$ : $0.188{\pm}0.009g$, $p$<0.01) and prostate (control : RF group = $0.358{\pm}0.015g$ : $0.259{\pm}0.015g$, $p$<0.001) were significantly lower in RF group animals. The mRNA levels of pituitary common alpha subunit ($C{\alpha}$; control : RF group = $1.0{\pm}0.0699$ AU : $0.1923{\pm}0.0270$ AU, $p$<0.001) and $FSH{\beta}$ (control : RF group = $1.0{\pm}0.1489$ AU : $0.5237{\pm}0.1088$ AU, $p$<0.05) were significantly decreased in RF group. The mRNA levels of ACTH were not significantly different. We were unable to find any prominent difference in the microstructures of epididymis, and there were slight alterations in those of seminal vesicles after 4 weeks of reversed feeding when compared to control samples. The present study demonstrates that the shift and/or restriction of feeding time could alter the pituitary gonadotropin expression and the weights of seminal vesicle and prostate in rats. These data suggest the lowered gonadotropin inputs may decrease androgen secretion form testis, and consequently results in poor response of androgen-dependent tissues such as seminal vesicle and prostate.

• 자원환경지질
• /
• 제29권3호
• /
• pp.325-333
• /
• 1996

폐기물 매립지 내에셔 가스 흐름을 추정하기 위하여 수치 모델을 개발하였다. 가스 흐름은 밀도에 영향 받는 밀도류이고 매립지 내의 매체는 매우 불균질하므로 단순한 수학적 해법으로 가스 흐름을 추정하기 어렵다. Darcy 방정식과 절량 보존의 법칙을 결합하고 이상 기체 방정식을 도입하여 지배방정식을 만들어지고, 이 지배방정식을 유한요소법으로 풀이하였다. 정류상태 모의의 결과는 AIRFLOW 모델에 의한 모의 결과와 일치한다. 부정류 상태 모의 결과는 질량 보존 평가와 일정 시간 후의 결과를 정류상태의 결과와 비교하여 간접적으로 결과의 신뢰성을 평가하였다. 대우건설에서 1993년에 실시한 난지도 매립지 가스 추출 시험 결과를 모델을 사용하여 분석하였다. 개발된 모델은 1994년 재단법인 한국컴퓨터 프로그램 보호회에 등록되었다.